Causes of asthma and allergy
Projects at the Unit of Environmental Epidemiology, Institute of Environmental Medicine (IMM)
From fetal life to early adulthood: tobacco exposure, nutrition and health
Tobacco exposure and diet are important determinants of health. Still, we need to better understand how exposure in fetal life, childhood and adolescence influence health in adulthood. The proposed project will investigate the role of secondhand smoke exposure, cigarette smoking, snus consumption, diet and overweight for respiratory, allergic and cardiovascular outcomes during the first 24 years of life. The research is conducted within a prospective population-based cohort (BAMSE) where 4,089 males and females have been followed repeatedly from infancy. Extensive information on exposures and outcomes are available from questionnaires, clinical examinations and blood samples. The proposed project builds on and extends recent findings from my research group. The project will contribute to the understanding of how tobacco exposure, diet and obesity influence health outcomes in early adulthood, and possibly provide a basis for disease prevention efforts.
Financing
- The Swedish Research Council
- The Swedish Research Council for Health Working Life and Welfare
- Region Stockholm (AFL)
- KID-funding from Karolinska Institutet (KI)
Contact person
Anna Bergström
Senior LecturerPublications
Ekström S, Magnusson J, Kull I, Lind T, Almqvist C, Melén E, Bergström A. Maternal BMI in early pregnancy and offspring asthma, rhinitis and eczema up to 16 years of age. Clin Exp Allergy. 2015 Jan;45(1):283-91.
Thacher J, Gruzieva O, Pershagen G, Neuman Å, Wickman M, Kull I, Melén E, Bergström A. Pre- and Postnatal Exposure to Parental Smoking and Allergic Disease through Adolescence. Pediatrics. 2014 Sep;134(3):428-34
Ekström S, Kull I, Nilsson S, Bergström A. Web-based self-reported height, weight, and body mass index among Swedish adolescents: a validation study. J Med Internet Res. 2015 Mar 18;17(3):e73. doi: 10.2196/jmir.3947.
Thacher J, Gruzieva O, Pershagen G, Neuman Å, van Hage M, Wickman M, Kull I, Melén E, Bergström A. Parental smoking and development of allergic sensitization from birth to adolescence. Allergy. 2016 Feb;71(2):239-48.
Ekström S, Magnusson J, Kull I, Andersson N, Bottai M, Besharat Pour M, Melén E, Bergström A. Body mass index development and asthma throughout childhood. Am J Epidemiol. 2017 Jul 15;186(2):255-263.
Magnusson J, Ekström S, Kull I, Håkansson N, Nilsson S, Wickman M, Melén E, Risérus U, Bergström A. Polyunsaturated fatty acids in plasma at 8 years and subsequent allergic disease. J Allergy Clin Immunol. 2018 Aug;142(2):510-516.e6. doi: 10.1016/j.jaci.2017.09.023.
Ekström S, Hallberg J, Kull I, Protjuder LP, Thunqvist P, Bottai M, Gustafsson PM, Bergström A. Melén E. Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study. Thorax. 2018 Jun;73(6):538-545. doi: 10.1136/thoraxjnl-2017-210716. Epub 2018 Jan 29.
Thacher JD, Gehring U, Gruziewa O, Standl M, Pershgen G, Bauer CB, Berdel D, KellerT, Koletzko S, Koppelman GH, Kull I, Laur S, Lehmann I, Maier D, Schikowski T, Wahn U, Wijga AH, Heinrich J, Bosuquet J, Anto JM, von Berg A, Melén E, Smit H, Keil T, Bergström A. Maternal smoking during pregnancy and early childhood and development of asthma and rhinoconjunctivitis – a MeDALL project. Environ Health Perspect. 2018 Apr 12;126(4):047005.
Feldman LY, Thacher JD, van Hage M, Kull I, Melén E, Pershagen G, Wickman M, To T, Protudjer JLP, Bergström A. Early life secondhand smoke exposure and food hypersensitivity through adolescence. Allergy. 2018 Jul;73(7):1558-1561.
Thacher JD, Schultz ES, Hallberg J, Hellberg U, Kull I, Thunqvist P, Pershagen G, Gustafsson G, Melén E, Bergström A. Tobacco smoke exposure in early life and adolescence in relation to lung function. Eur Respir J. 2018 Jun 7;51(6). pii: 1702111. doi: 10.1183/13993003.02111-2017.
Sdona E, Hallberg J, Andersson N, Ekström S, Rautiainen S, Håkansson N, Wolk A, Kull I, Melén E, Bergström A. Dietary antioxidant intake in school age and lung function development up to adolescence. Eur Respir J. 2020 Feb 20;55(2).
Indoor environment and respiratory health – a longitudinal study from childhood to early adulthood
The overall aim of the project is to investigate the influence of certain indoor environmental factors on respiratory health from childhood to early adulthood. In particular, we will investigate the role of early exposure to mould, dampness, and seccondhand tobacco smoke in asthma and lung function development from childhood to early adulthood. In addition, we will collect urine samples and investigate urinary polycyclic aromatic hydrocarbon (PAH) metabolites in relation to asthma and lung function in young adulthood.
This research is conducted within the Swedish prospective population-based birth cohort BAMSE where 4,089 children have been followed repeatedly from infancy to adolescence (age 16 years). Extensive information on exposures and phenotypes is available based on questionnaires, clinical examinations (including measurement of lung function), and blood samples. The planned project will make use of the already collected data, but also includes a new follow-up of the cohort participants at age 22-24 years.
Although we spend the majority of the time indoors, there is limited information on how early exposure to indoor environmental factors (e.g. mould, dampness, and SHS) affects asthma and lung function into adulthood. Combining analyses of available epidemiological data with urine for biomarkers, the proposed studies will contribute to the understanding of how indoor environment influence respiratory health.
Financing
- The Swedish Research Council FORMAS
- Swedish Environmental Protection Agency
Contact person
Anna Bergström
Senior LecturerPublications
Thacher J, Gruzieva O, Pershagen G, Melén E, Lorentzen J, Kull I, Bergström A. Mold and dampness exposure and allergic outcomes from birth to adolescence: data from the BAMSE cohort. Allergy. 2017 Jun;72(6):967-974.
Thacher JD, Gehring U, Gruziewa O, Standl M, Pershgen G, Bauer CB, Berdel D, KellerT, Koletzko S, Koppelman GH, Kull I, Laur S, Lehmann I, Maier D, Schikowski T, Wahn U, Wijga AH, Heinrich J, Bosuquet J, Anto JM, von Berg A, Melén E, Smit H, Keil T, Bergström A. Maternal smoking during pregnancy and early childhood and development of asthma and rhinoconjunctivitis – a MeDALL project. Environ Health Perspect. 2018 Apr 12;126(4):047005.
Thacher JD, Schultz ES, Hallberg J, Hellberg U, Kull I, Thunqvist P, Pershagen G, Gustafsson G, Melén E, Bergström A. Tobacco smoke exposure in early life and adolescence in relation to lung function. Eur Respir J. 2018 Jun 7;51(6). pii: 1702111.
Can asthma and atopic dermatitis in childhood influence the risk of cardiometabolic conditions in early adulthood?
Allergic diseases such as asthma, atopic dermatitis and rhinitis are the most common non-communicable diseases in childhood. Allergic diseases and their multimorbidity in childhood are often associated with further respiratory problems in adult life, such as lower lung function and higher risk of chronic obstructive pulmonary disease (COPD). In addition, increasing body of literature also suggest that allergic diseases may also influence the development of other non-communicable diseases, for example cardiovascular and metabolic conditions (e.g. obesity, high blood pressure and elevated blood lipids). However, prospective studies ranging from childhood to adulthood and with detailed phenotyping of allergic diseases is needed to better understand these potential associations. The objective of the proposed project is to examine if childhood asthma and atopic dermatitis influence the risk of cardiovascular and metabolic conditions detectable already in early adulthood. The project will be conducted within a prospective population-based cohort (BAMSE) where 4,089 males and females have been followed from infancy.
In the short term, our research will contribute to new knowledge on how childhood asthma and atopic dermatitis may influence the risk of cardiovascular and metabolic conditions in early adulthood. In the long term, our results may have important implications for the treatment standards of children with asthma and atopic dermatitis and thereby contribute to the prevention of cardiometabolic conditions.
Financing
- The Swedish Asthma and Allergy research foundation
Contact person
Anna Bergström
Senior Lecturer
COVID-19 in young adults; risk factors, immunity and long-term health consequences
In this project, we perform a new COVOD-19 focused follow-up of participants in our longitudinal, population-based birth cohort BAMSE (n=4,089, born 1994-96) including repeated serology analyses of coronavirus immunity, risk factor assessment, elucidations of underlying genetic and immunological factor, and new assessment of lung function and cardiometabolic markers to evaluate long term pulmonary and cardiometabolic effects. In the BAMSE study, we have a unique opportunity to study both short-term and long-term health consequences of coronavirus infection, thanks to our rich, longitudinal database and biobank, to evaluate key risk factors and health consequences of coronavirus infection.
Financing
- IMM seed funding
Contact person