Projects: Unit of Lung and Airway Research

Th17-associated cytokines and host defense in smokers

This project characterizes the pathogenic role of Th17-associated cytokines in the increased susceptibility to infections that signifies long-term smokers, in particular in those who suffer from chronic obstructive pulmonary disease (COPD) with or without chronic bronchitis.

Financing

  • The Swedish Heart-Lung Foundation
  • ALF

Contact person

Professor/senior physician

Anders Lindén

Phone: +46-(0)8-524 822 17
Organizational unit: Lung and Airway Research
E-mail: anders.linden@ki.se

 

The IL-36 family of cytokines in chronic obstructive pulmonary disease

This project will assess whether members of the IL-36 family of cytokines are involved in COPD, with and without chronic bronchitis.  Additionally, the project will assess the downstream immunologic effects of IL-36 receptor stimulation in structural lung and immune cells.

Financing

  • European Respiratory Society
  • The Swedish Heart-Lung Foundation

Contact person

Senior researcher

Melissa Kovach

Organizational unit: Lung and Airway Research
E-mail: melissa.kovach@ki.se

 

Cadmium as a pathogenic factor in tobacco smokers

This project explores the pathogenic role of cadmium in the development of COPD, among long-term smokers, in particular the role of cadmium in the distortion of pulmonary host defense.

Financing

  • The Swedish Heart-Lung Foundation
  • ALF

Contact person

Senior lab manager

Bettina Levänen

Phone: +46-(0)8-524 876 02
Organizational unit: Lung and Airway Research
E-mail: bettina.levanen@ki.se

 

Lung development and COPD

This project evaluates how hindered lung development predisposes for the impaired lung function development and the inefficient repair/remodeling process that can be observed in COPD. The project will identify the genetic determinants of lung function development so as to identify the susceptibility genes for COPD, through a mouse to human translational research.

Financing

  • Vinnova
  • ALF

Contact person

Senior researcher

Koustav Ganguly

Organizational unit: Institute of Environmental Medicine (IMM), C6
E-mail: koustav.ganguly@ki.se