Adverse outcome pathways (AOPs)-principles and applications in toxicology and health risk assessment

Course dates

Planned to be given in autumn 2025.

On-line course

The course will be given as an on-line course, with synchronous lectures, exercises and group assignments using online webinar tool Zoom and Karolinska Institutet’s learning management system Canvas. Participants must be able to attend daily at 9-17 CET, and have access to a computer, headset, webcam and internet connection.

Course organiser

The course is organised by the Advanced International Training Programme in Health Risk Assessment at IMM and the Executive and Professional Education Office at Karolinska Institutet, in collaboration with the Global Master’s programme in toxicology.

Learning outcomes

At the end of the course the student should be able to:

- describe the principles and components of Adverse Outcome Pathways (AOPs)
- explain how experimental studies can support the development of AOPs
- discuss how AOPs can be used as a central framework for mechanistic toxicity studies, toxicity testing and health risk assessment


The course will include the concept and principles of Adverse Outcome Pathways (AOPs). Development and assessment of AOPs. Examples of different AOPs. Application of the AOP concept in toxicological research and health risk assessment.

Teaching and learning activities

Teaching and learning activities include lectures, exercises and group assignments. All activities will be on-line using the online webinar tool Zoom and Karolinska Institutet’s learning management system Canvas.  

Course programme

Programme from last course.

Target group

The course is intended for PhD students and other participants from academia as well as participants from authorities and industry.

Course fee

The fee for PhD students is 2000 SEK, other participants from academia 3000 SEK, from authorities 6000 SEK and from industry 9000 SEK, including VAT. Course fee includes course material. Payment of course fee can only be accepted from the participant’s employer, not from individuals.

Course application

Information will be provided later.

Course leader

Annika Hanberg,, Institute of Environmental Medicine, Karolinska Institutet


Johanna Bergman,, Institute of Environmental Medicine, Karolinska Institutet

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