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Adverse outcome pathways (AOPs)-principles and applications in toxicology and health risk assessment

Course dates

Latest course was on 6-10 November, 2017.

Course organiser

The course is organised by the Advanced International Training Programme in Health Risk Assessment at IMM in collaboration with the Doctoral programme Environmental Factors and Health (EFH) at Karolinska Institutet, course number 2986.

Course credits

The course corresponds to 1.5 ECTS credits.

Learning outcomes

At the end of the course the student should be able to:
- describe the principles and components of Adverse Outcome Pathways (AOPs)
- explain how experimental studies can support the development of AOPs
- discuss how AOPs can be used as a central framework for mechanistic toxicity studies, toxicity testing and health risk assessment


The course will include the concept and principles of Adverse Outcome Pathways (AOPs). Development and assessment of AOPs. Examples of different AOPs. Application of the AOP concept in toxicological research and health risk assessment.

Teaching and learning activities

The course consists of lectures including invited lectures by well-renowned international scientists and group seminars (journal clubs).

Course programme

The course programme from the previous course.

Target group

The course is intended for PhD students and other participants from academia as well as participants from authorities and industry.

Course fee

There is no course fee for PhD students. The fee for participants from academia (except PhD students) is 300 euro, from authorities 600 euro and from industry 900 euro, including VAT. Course fee includes course material, coffee breaks and a get together reception. Payment of course fee can only be accepted from the participant’s employer, not from individuals. The participants must cover their costs for travel and accommodation.

Course application

Information on application procedure to the next course will be available later.

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Course leader

Johanna Zilliacus, Institute of Environmental Medicine, Karolinska Institutet


Johanna Zilliacus

Lecturer senior
Biokemisk toxikologi
C6 Institute of Environmental Medicine