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High impact publications from FyFa

On this page you will find a list of publications with one or several authors from the Department of Physiology and Pharmacology in high impact journals (IF >9).

2019

Targetome analysis of chaperone-mediated autophagy in cancer cells.
Hao Y, Kacal M, Ouchida AT, Zhang B, Norberg E, Vakifahmetoglu-Norberg H
Autophagy 2019 Sep;15(9):1558-1571

Medicine in the Fourth Dimension
Cederroth c, Albrecht U, Bass J, Brown SA, Dyhrfjeld-Johnsen J, Gachon F, Green CB, Hastings MH, Helfrich-Förster C, Hogenesch J, Lévi F, Loudon A, Lundkvist GB, Meijer JH, Rosbash M, Takahashi JS, Young M, Canlon B.
Cell Metabolism 6 August 2019, Volume 30 (p. 238-250), https://doi.org/10.1016/j.cmet.2019.06.019

Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring.
Manti M, Fornes R, Pironti G, McCann Haworth S, Zhengbing Z, Benrick A, et al
Cardiovasc. Res. 2019 Aug;():

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids
Cederroth C, Park J-S, Basinou V, Weger B, Tserga E, Sarlus H, Magnusson A, Kadri N, Gachon F, Canlon B
Current Biology, 25 July 2019, DOI: https://doi.org/10.1016/j.cub.2019.06.057

Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.
Bersellini Farinotti A, Wigerblad G, Nascimento D, Bas DB, Morado Urbina C, Nandakumar KS, et al
J. Exp. Med. 2019 Jun;():

Spatiotemporal structure of cell fate decisions in murine neural crest.
Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L, et al
Science 2019 06;364(6444):

Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell.
Sun CW, Yang J, Kleschyov AL, Zhuge Z, Carlström M, Pernow J, et al
Circulation 2019 Jun;139(23):2654-2663

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.
Prakash V, Carson BB, Feenstra JM, Dass RA, Sekyrova P, Hoshino A, et al
Nat Commun 2019 05;10(1):2110

Days at Home after Surgery: An Integrated and Efficient Outcome Measure for Clinical Trials and Quality Assurance
Max Bell, Lars I. Eriksson, Tobias Svensson, Linn Hallqvist, Fredrik Granath, Jennifer Reilly, Paul S. Myles
The Lancet, 26 April 2019

Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study
Marin Jukic, Robert L Smith, Tore Haslemo, Espen Molden, and Magnus Ingelman-Sundberg.
The Lancet Psychiatry, online April 15, 2019, doi: 10.1016/S2215-0366(19)30088-4

A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, et al
Nature 2019 Mar;567(7747):234-238

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.
Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, et al
Nat. Neurosci. 2019 03;22(3):374-385

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.
Wright SC, Kozielewicz P, Kowalski-Jahn M, Petersen J, Bowin CF, Slodkowicz G, et al
Nat Commun 2019 02;10(1):667

2018

Sarcopenia: Aging-Related Loss of Muscle Mass and Function.
Larsson L, Degens H, Li M, Salviati L, Lee YI, Thompson W, et al
Physiol. Rev. 2019 01;99(1):427-511

Nanothermometry Reveals Calcium-Induced Remodeling of Myosin
Kuhn E, Naik A, Lewis B, Kokovich K, Li M, Stemmler T, Larsson L, Jena B
ACS Nano Letters October 22 2018, DOI: 10.1021/acs.nanolett.8b02989

Therapeutic Approaches to the Treatment of Tinnitus.
Langguth B, Elgoyhen AB, Cederroth CR
Annu. Rev. Pharmacol. Toxicol. 2019 Jan;59():291-313

Double-Strand DNA Sensing Aim2 Inflammasome Regulates Atherosclerotic Plaque Vulnerability.
Paulin N, Viola JR, Maas SL, de Jong R, Fernandes-Alnemri T, Weber C, et al
Circulation 2018 Jul;138(3):321-323

Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis.
Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelman H, Schumski A, et al
Cell Metab. 2018 Jul;28(1):175-182.e5

Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients.
Jukić MM, Haslemo T, Molden E, Ingelman-Sundberg M
Am J Psychiatry 2018 05;175(5):463-470

Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities.
Lauschke VM, Barragan I, Ingelman-Sundberg M
Annu. Rev. Pharmacol. Toxicol. 2018 01;58():161-185

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, et al
Annu. Rev. Pharmacol. Toxicol. 2018 01;58():65-82

2017

Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit.
Yao N, Skiteva O, Zhang X, Svenningsson P, Chergui K
Mol. Psychiatry 2018 10;23(10):2066-2077

Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort.
Maas IL, Brüggemann P, Requena T, Bulla J, Edvall NK, Hjelmborg JVB, et al
Genet. Med. 2017 09;19(9):1007-1012

Differential Phase Arrangement of Cellular Clocks along the Tonotopic Axis of the Mouse Cochlea Ex Vivo.
Park JS, Cederroth CR, Basinou V, Sweetapple L, Buijink R, Lundkvist GB, et al
Curr. Biol. 2017 Sep;27(17):2623-2629.e2

Regenerative medicine: Cartilage stem cells identified, but can they heal?
Chagin A, Medvedeva E
Nat Rev Rheumatol 2017 Sep;13(9):522-524

Mechanical isolation, and measurement of force and myoplasmic free [Ca2+] in fully intact single skeletal muscle fibers.
Cheng AJ, Westerblad H
Nat Protoc 2017 Sep;12(9):1763-1776

Adiponectin protects against development of metabolic disturbances in a PCOS mouse model.
Benrick A, Chanclón B, Micallef P, Wu Y, Hadi L, Shelton JM, et al
Proc. Natl. Acad. Sci. U.S.A. 2017 08;114(34):E7187-E7196

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.
Petersen J, Wright SC, Rodríguez D, Matricon P, Lahav N, Vromen A, et al
Nat Commun 2017 08;8(1):226

The immune response of the human brain to abdominal surgery.
Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, et al
Ann. Neurol. 2017 Apr;81(4):572-582

Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial.
Wu XK, Stener-Victorin E, Kuang HY, Ma HL, Gao JS, Xie LZ, et al
JAMA 2017 06;317(24):2502-2514

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.
Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, et al
Hepatology 2017 02;65(2):710-721

Association of Anesthesia and Surgery During Childhood With Long-term Academic Performance.
Glatz P, Sandin RH, Pedersen NL, Bonamy AK, Eriksson LI, Granath F
JAMA Pediatr 2017 Jan;171(1):e163470

2016

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment. M M Jukić, N Opel, J Ström, T Carrillo-Roa, S Miksys, M Novalen, et al, . Molecular Psychiatry, 29 november 2016, doi: 10.1038/mp.2016.204.

Association of Anesthesia and Surgery During Childhood With Academic Performance. Pia Glatz, Rolf H Sandin, Nancy L Pedersen, Anna-Karin Bonamy, Lars I Eriksson, et al. JAMA Pediatrics, 7 november 2016. doi: 10.1001./jamapediatrics.2016.347

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.
Lauschke VM, Vorrink SU, Moro SM, Rezayee F, Nordling Å, Hendriks DF, et al
Hepatology 2016 11;64(5):1743-1756

Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression.
Ivanov M, Kals M, Lauschke V, Barragan I, Ewels P, Käller M, et al
Nucleic Acids Res. 2016 08;44(14):6756-69

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins.
Cervenka I, Valnohova J, Bernatik O, Harnos J, Radsetoulal M, Sedova K, et al
Proc. Natl. Acad. Sci. U.S.A. 2016 08;113(33):9304-9

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction.
Salah H, Li M, Cacciani N, Gastaldello S, Ogilvie H, Akkad H, et al
Sci Transl Med 2016 08;8(350):350ra103

Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis.
Bouderlique T, Vuppalapati KK, Newton PT, Li L, Barenius B, Chagin AS
Ann. Rheum. Dis. 2016 Mar;75(3):627-31

Precision Medicine and Rare Genetic Variants.
Lauschke VM, Ingelman-Sundberg M
Trends Pharmacol. Sci. 2016 Feb;37(2):85-86

2015

A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.
Sellgren CM, Kegel ME, Bergen SE, Ekman CJ, Olsson S, Larsson M, et al
Mol. Psychiatry 2016 10;21(10):1342-50

Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome.
Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JC, Laven JS, Legro RS
Endocr. Rev. 2015 Oct;36(5):487-525

Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism.
Wigerblad G, Bas DB, Fernades-Cerqueira C, Krishnamurthy A, Nandakumar KS, Rogoz K, et al
Ann. Rheum. Dis. 2016 Apr;75(4):730-8

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss.
Krishnamurthy A, Joshua V, Haj Hensvold A, Jin T, Sun M, Vivar N, et al
Ann. Rheum. Dis. 2016 Apr;75(4):721-9

Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.
Newton PT, Vuppalapati KK, Bouderlique T, Chagin AS
Autophagy 2015 ;11(9):1594-607

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise
Placea N, Ivarsson N, Venckunas T, Neyroud D, Brazaitis M, Cheng A, et al
PNASNov 2, 2015

Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring
Hu M, Richard J, Maliqueo M, Kokosar M, Fornes R, Benrick A, et al
PNAS, online Early Edition the week of November 2, 2015

Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis
Ferguson A, Wang L, Altman R, Terry D, Juette M, Burnett B, et al
Molecular Cell ;60:1–12

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.
Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, et al
Nat Commun 2015 Aug;6():7502

Safety and efficacy of re-treatments with pyronaridine-artesunate in African patients with malaria: a substudy of the WANECAM randomised trial.
Sagara I, Beavogui AH, Zongo I, Soulama I, Borghini-Fuhrer I, Fofana B, et al
Lancet Infect Dis 2016 Feb;16(2):189-98

The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich O, Reid MB, Van den Berghe G, Vanhorebeek I, Hermans G, Rich MM, Larsson L
Physiological Reviews (Invited review) Jul;95(3):1025-1109

The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data.
Lancet Infect Dis 2015 Jun;15(6):692-702

Renal autoregulation in health and disease.
Carlström M, Wilcox CS, Arendshorst WJ
Physiol. Rev. 2015 Apr;95(2):405-511

2014

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.
Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, et al
Cell 2014 Sep;159(1):33-45

Glial origin of mesenchymal stem cells in a tooth model system.
Kaukua N, Shahidi MK, Konstantinidou C, Dyachuk V, Kaucka M, Furlan A, et al
Nature 2014 Sep;513(7519):551-4

Epigenetic mechanisms of importance for drug treatment.
Ivanov M, Barragan I, Ingelman-Sundberg M
Trends Pharmacol. Sci. 2014 Aug;35(8):384-96

Neurodevelopment. Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
Dyachuk V, Furlan A, Shahidi MK, Giovenco M, Kaukua N, Konstantinidou C, et al
Science 2014 Jul;345(6192):82-7

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.
Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, et al
Nat Commun 2014 Apr;5():3673

Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.
Pader I, Sengupta R, Cebula M, Xu J, Lundberg JO, Holmgren A, et al
Proc. Natl. Acad. Sci. U.S.A. 2014 May;111(19):6964-9

Olfactory exposure to males, including men, causes stress and related analgesia in rodents.
Sorge RE, Martin LJ, Isbester KA, Sotocinal SG, Rosen S, Tuttle AH, et al
Nat. Methods 2014 Jun;11(6):629-32

TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea.
Meltser I, Cederroth CR, Basinou V, Savelyev S, Lundkvist GS, Canlon B
Curr. Biol. 2014 Mar;24(6):658-63

Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene.
Persson A, Sim SC, Virding S, Onishchenko N, Schulte G, Ingelman-Sundberg M
Mol. Psychiatry 2014 Jun;19(6):733-41

Cognitive impairment and dentate gyrus synaptic dysfunction in experimental parkinsonism.
Bonito-Oliva A, Pignatelli M, Spigolon G, Yoshitake T, Seiler S, Longo F, et al
Biol. Psychiatry 2014 May;75(9):701-10

The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression.
Lavebratt C, Olsson S, Backlund L, Frisén L, Sellgren C, Priebe L, et al
Mol. Psychiatry 2014 Mar;19(3):334-41

Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness.
Yamada T, Fedotovskaya O, Cheng AJ, Cornachione AS, Minozzo FC, Aulin C, et al
Ann. Rheum. Dis. 2015 Oct;74(10):1907-14