High impact publications from FyFa

On this page you will find a list of publications with one or several authors from the Department of Physiology and Pharmacology in high impact journals (IF >9).


A prospective clinical study on the mechanisms underlying critical illness myopathy-A time-course approach.
Cacciani N, Skärlén Å, Wen Y, Zhang X, Addinsall AB, Llano-Diez M, Li M, Gransberg L, Hedström Y, Bellander BM, Nelson D, Bergquist J, Larsson L
J Cachexia Sarcopenia Muscle 2022 Oct;():

Global Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-analysis.
Jarach CM, Lugo A, Scala M, van den Brandt PA, Cederroth CR, Odone A, Garavello W, Schlee W, Langguth B, Gallus S
JAMA Neurol 2022 

Alterations in auditory brain stem response distinguish occasional and constant tinnitus.
Edvall NK, Mehraei G, Claeson M, Lazar A, Bulla J, Leineweber C, Uhlén I, Canlon B, Cederroth CR
J Clin Invest 2022 

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss.
T, Pratt S, Quaranta N, Rämö J, Saarentaus E, Sardone R, Satizabal CL, Schweinfurth JM, Seshadri S, Shiroma E, Shulman E, Simonsick E, Spankovich C, Tropitzsch A, Lauschke VM, Sullivan PF, Goedegebure A, Cederroth CR, Williams FMK, Nagtegaal AP et.al.
Am J Hum Genet 2022 

Electrical stimulated GLUT4 signalling attenuates critical illness-associated muscle wasting
Addinsall A B, Cacciani N, Backéus A, Hedström Y, Shevchenko G, Bergquist J, Larsson L.
J Cachexia Sarcopenia Muscle 2022 


A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma.
Milon B, Shulman ED, So KS, Cederroth CR, Lipford EL, Sperber M, Sellon JB, Sarlus H, Pregernig G, Shuster B, Song Y, Mitra S, Orvis J, Margulies Z, Ogawa Y, Shults C, Depireux DA, Palermo AT, Canlon B, Burns J, Elkon R, Hertzano R
Cell Rep 2021 

Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study.
Amanat S, Gallego-Martinez A, Sollini J, Perez-Carpena P, Espinosa-Sanchez JM, Aran I, Soto-Varela A, Batuecas-Caletrio A, Canlon B, May P, Cederroth CR, Lopez-Escamez JA
EBioMedicine 2021

Hearing loss prevalence and years lived with disability, 1990-2019: findings from the Global Burden of Disease Study 2019.
Lancet 2021 

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain.
Kowalski-Jahn M, Schihada H, Turku A, Huber T, Sakmar TP, Schulte G.
Science Advances. 2021

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs. 
Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han G-W, Kowalski-Jahn M, Kozielewicz P, Bowin C-F, Bouvier M, Schulte G¤, Xu F.
Cell Research. 2021

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine.
Zhou Y, Arribas GH, Turku A, Jürgenson T, Mkrtchian S, Krebs K, Wang Y, Svobodova B, Milani L, Schulte G, Korabecny J, Gastaldello S, Lauschke VM.
Science Advances. 2021 

Residue 6.43 defines receptor function in Class F GPCRs.
Turku A, Schihada H, Kozielewicz P, Bowin C-F, Schulte G.
Nature Communications 2021

Perturbed BMP signaling and denervation contributes to muscle wasting in cancer cachexia.
Sartori R., Hagg A., Winbanks C.E., Armani A., Penna F., Zampieri S., Qian H.,  Larsson A.,  Zanchettin G., Pierobon S.E., Da Dalt G., Sperti C., Kustermann M., Thomson R.E., Larsson L., Loveland K., Costelli P., Megighian A., Merigliano S. Gregorevic P., Sandri M. 2021.
Science Translational Medicine. 04  Aug. 13. 

Time trajectories in the transcriptomic response to exercise - a meta-analysis 
David Amar, Malene E. Lindholm, Jessica Norrbom, Matthew T. Wheeler, Manuel A. Rivas & Euan A. Ashley
Nature Communications volume 12, Article number: 3471 (2021)

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Klionsky et al.
Autophagy 2021 Feb 8;1-382. doi: 10.1080/15548627.2020.1797280. Online ahead of print

Quantitative proteomic analysis of temporal lysosomal proteome and the impact of the KFERQ-like motif and LAMP2A in lysosomal targeting.
Kacal M, Zhang B, Hao Y, Norberg E, Vakifahmetoglu-Norberg H
Autophagy 2021 


A New Buzz for Tinnitus-It's in the Genes!
Cederroth CR, Trpchevska N, Langguth B
JAMA Otolaryngol Head Neck Surg 2020 

Deconvolution of WNT-induced Frizzled conformational dynamics with fluorescent biosensors.
Schihada H, Kowalski-Jahn M, Turku A, Schulte G
Biosens Bioelectron 2020 

Eccentric resistance training ameliorates muscle weakness in a mouse model of idiopathic inflammatory myopathies.
Himori K, Ashida Y, Tatebayashi D, Abe M, Saito Y, Chikenji T, Westerblad H, Andersson DC, Yamada T.
Arthritis Rheumatol 2020 

The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
Krassikova L, Zhang B, Nagarajan D, Queiroz AL, Kacal M, Samakidis E, Vakifahmetoglu-Norberg H, Norberg E.
Cell Death Differ 2020 

Fast skeletal muscle troponin activator CK-2066260 mitigates skeletal muscle weakness independently of the underlying cause.
Cheng AJ, Ström J, Hwee DT, Malik FI, Westerblad H
J Cachexia Sarcopenia Muscle 2020 

Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin.
Swist S, Unger A, Li Y, Vöge A, von Frieling-Salewsky M, Skärlén Å, Cacciani N, Braun T, Larsson L, Linke WA
Nat Commun 2020 

Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.
Stebbing J, Krishnan V, de Bono S, Ottaviani S, Casalini G, Richardson PJ, Monteil V, Lauschke VM, Mirazimi A, Youhanna S, Tan YJ, Baldanti F, Sarasini A, Terres JAR, Nickoloff BJ, Higgs RE, Rocha G, Byers NL, Schlichting DE, Nirula A, Cardoso A, Corbellino M; Sacco Baricitinib Study Group
EMBO Mol Med 2020 

A 3D Cell Culture Model Identifies Wnt/β-Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration.
Oliva-Vilarnau N, Vorrink SU, Ingelman-Sundberg M, Lauschke VM
Adv Sci (Weinh) 2020 

Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance.
Azzimato V, Jager J, Chen P, Morgantini C, Levi L, Barreby E, Sulen A, Oses C, Willerbrords J, Xu C, Li X, Shen JX, Akbar N, Haag L, Ellis E, Wålhen K, Näslund E, Thorell A, Choudhury RP, Lauschke VM, Rydén M, Craige SM, Aouadi M
Sci Transl Med 2020

Can CYP Inhibition Overcome Chemotherapy Resistance?
Ingelman-Sundberg M, Lauschke VM
Trends Pharmacol. Sci. 2020 

Structural insight into small molecule action on Frizzleds.
Kozielewicz P, Turku A, Bowin CF, Petersen J, Valnohova J, Cañizal MCA, Ono Y, Inoue A, Hoffmann C, Schulte G. Nat Commun, 21 January 2020

Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome.
Chen YH, Grigelioniene G, Newton PT, Gullander J, Elfving M, Hammarsjö A, Batkovskyte D, Alsaif HS, Kurdi WIY, Abdulwahab F, Shanmugasundaram V, Devey L, Bacrot S, Brodszki J, Huber C, Hamel B, Gisselsson D, Papadogiannakis N, Jedrycha K, Gürtl-Lackner B, Chagin AS, Nishimura G, Aschenbrenner D, Alkuraya FS, Laurence A, Cormier-Daire V, Uhlig HH
J. Exp. Med. 8 January 2020


Medicine in the Fourth Dimension.
Cederroth CR, Albrecht U, Bass J, Brown SA, Dyhrfjeld-Johnsen J, Gachon F, Green CB, Hastings MH, Helfrich-Förster C, Hogenesch JB, Lévi F, Loudon A, Lundkvist GB, Meijer JH, Rosbash M, Takahashi JS, Young M, Canlon B
Cell Metab 2019 

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids.
Cederroth CR, Park JS, Basinou V, Weger BD, Tserga E, Sarlus H, Magnusson AK, Kadri N, Gachon F, Canlon B
Curr Biol 2019 

Sex-Specific Association of Tinnitus With Suicide Attempts.
Lugo A, Trpchevska N, Liu X, Biswas R, Magnusson C, Gallus S, Cederroth CR
JAMA Otolaryngol Head Neck Surg 2019 

Association of Genetic vs Environmental Factors in Swedish Adoptees With Clinically Significant Tinnitus.
Cederroth CR, PirouziFard M, Trpchevska N, Idrizbegovic E, Canlon B, Sundquist J, Sundquist K, Zöller B
JAMA Otolaryngol Head Neck Surg 2019 

Therapeutic Approaches to the Treatment of Tinnitus.
Langguth B, Elgoyhen AB, Cederroth CR
Annu Rev Pharmacol Toxicol 2019 

Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity.
Lauschke VM, Zhou Y, Ingelman-Sundberg M
Pharmacol. Ther. 2019 

Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome.
Risal S, Pei Y, Lu H, Manti M, Fornes R, Pui HP, et al
Nat. Med. 2019 

Life expectancy and disease burden in the Nordic countries: results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017.
Nordic Burden Disease Collaborators
Lancet Public Health 2019 

Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish.
Xie M, Kamenev D, Kaucka M, Kastriti ME, Zhou B, Artemov AV, et al
Proc. Natl. Acad. Sci. U.S.A. 2019 

Targetome analysis of chaperone-mediated autophagy in cancer cells.
Hao Y, Kacal M, Ouchida AT, Zhang B, Norberg E, Vakifahmetoglu-Norberg H
Autophagy 2019 

Medicine in the Fourth Dimension
Cederroth c, Albrecht U, Bass J, Brown SA, Dyhrfjeld-Johnsen J, Gachon F, Green CB, Hastings MH, Helfrich-Förster C, Hogenesch J, Lévi F, Loudon A, Lundkvist GB, Meijer JH, Rosbash M, Takahashi JS, Young M, Canlon B.
Cell Metabolism 6 August 2019, Volume 30 (p. 238-250), https://doi.org/10.1016/j.cmet.2019.06.019

Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring.
Manti M, Fornes R, Pironti G, McCann Haworth S, Zhengbing Z, Benrick A, et al
Cardiovasc. Res. 2019 

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids
Cederroth C, Park J-S, Basinou V, Weger B, Tserga E, Sarlus H, Magnusson A, Kadri N, Gachon F, Canlon B
Current Biology, 25 July 2019

Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.
Bersellini Farinotti A, Wigerblad G, Nascimento D, Bas DB, Morado Urbina C, Nandakumar KS, et al
J. Exp. Med. 2019 

Spatiotemporal structure of cell fate decisions in murine neural crest.
Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L, et al
Science 2019 

Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell.
Sun CW, Yang J, Kleschyov AL, Zhuge Z, Carlström M, Pernow J, et al
Circulation 2019

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.
Prakash V, Carson BB, Feenstra JM, Dass RA, Sekyrova P, Hoshino A, et al
Nat Commun 2019 

Days at Home after Surgery: An Integrated and Efficient Outcome Measure for Clinical Trials and Quality Assurance
Max Bell, Lars I. Eriksson, Tobias Svensson, Linn Hallqvist, Fredrik Granath, Jennifer Reilly, Paul S. Myles
The Lancet, 26 April 2019

Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study
Marin Jukic, Robert L Smith, Tore Haslemo, Espen Molden, and Magnus Ingelman-Sundberg.
The Lancet Psychiatry, online April 15, 2019

A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, et al
Nature 2019 

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.
Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, et al
Nat. Neurosci. 2019 

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.
Wright SC, Kozielewicz P, Kowalski-Jahn M, Petersen J, Bowin CF, Slodkowicz G, et al
Nat Commun 2019 


Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities.
Lauschke VM, Barragan I, Ingelman-Sundberg M
Annu. Rev. Pharmacol. Toxicol. 2018

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, et al
Annu. Rev. Pharmacol. Toxicol. 2018 

Frizzleds as GPCRs - More Conventional Than We Thought!
Schulte G, Wright SC
Trends Pharmacol Sci 2018 

Sarcopenia: Aging-Related Loss of Muscle Mass and Function.
Larsson L, Degens H, Li M, Salviati L, Lee YI, Thompson W, et al
Physiol. Rev. 2019 

Nanothermometry Reveals Calcium-Induced Remodeling of Myosin
Kuhn E, Naik A, Lewis B, Kokovich K, Li M, Stemmler T, Larsson L, Jena B
ACS Nano Letters October 22 2018, DOI: 10.1021/acs.nanolett.8b02989

Therapeutic Approaches to the Treatment of Tinnitus.
Langguth B, Elgoyhen AB, Cederroth CR
Annu. Rev. Pharmacol. Toxicol. 2019 

Double-Strand DNA Sensing Aim2 Inflammasome Regulates Atherosclerotic Plaque Vulnerability.
Paulin N, Viola JR, Maas SL, de Jong R, Fernandes-Alnemri T, Weber C, et al
Circulation 2018 

Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis.
Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelman H, Schumski A, et al
Cell Metab. 2018 

Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients.
Jukić MM, Haslemo T, Molden E, Ingelman-Sundberg M
Am J Psychiatry 2018 

Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities.
Lauschke VM, Barragan I, Ingelman-Sundberg M
Annu. Rev. Pharmacol. Toxicol. 2018 

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, et al
Annu. Rev. Pharmacol. Toxicol. 2018 


Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit.
Yao N, Skiteva O, Zhang X, Svenningsson P, Chergui K
Mol. Psychiatry 2018 

Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort.
Maas IL, Brüggemann P, Requena T, Bulla J, Edvall NK, Hjelmborg JVB, et al
Genet. Med. 2017 

Differential Phase Arrangement of Cellular Clocks along the Tonotopic Axis of the Mouse Cochlea Ex Vivo.
Park JS, Cederroth CR, Basinou V, Sweetapple L, Buijink R, Lundkvist GB, et al
Curr. Biol. 2017

Regenerative medicine: Cartilage stem cells identified, but can they heal?
Chagin A, Medvedeva E
Nat Rev Rheumatol 2017

Mechanical isolation, and measurement of force and myoplasmic free [Ca2+] in fully intact single skeletal muscle fibers.
Cheng AJ, Westerblad H
Nat Protoc 2017 

Adiponectin protects against development of metabolic disturbances in a PCOS mouse model.
Benrick A, Chanclón B, Micallef P, Wu Y, Hadi L, Shelton JM, et al
Proc. Natl. Acad. Sci. U.S.A. 2017

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.
Petersen J, Wright SC, Rodríguez D, Matricon P, Lahav N, Vromen A, et al
Nat Commun 2017 

The immune response of the human brain to abdominal surgery.
Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, et al
Ann. Neurol. 2017 

Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial.
Wu XK, Stener-Victorin E, Kuang HY, Ma HL, Gao JS, Xie LZ, et al
JAMA 2017 

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.
Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, et al
Hepatology 2017

Association of Anesthesia and Surgery During Childhood With Long-term Academic Performance.
Glatz P, Sandin RH, Pedersen NL, Bonamy AK, Eriksson LI, Granath F
JAMA Pediatr 2017 


Precision Medicine and Rare Genetic Variants.
Lauschke VM, Ingelman-Sundberg M
Trends Pharmacol. Sci. 2016 

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.
Lauschke VM, Vorrink SU, Moro SM, Rezayee F, Nordling Å, Hendriks DF, et al
Hepatology 2016 

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment. M M Jukić, N Opel, J Ström, T Carrillo-Roa, S Miksys, M Novalen, et al, . Molecular Psychiatry, 29 november 2016

Association of Anesthesia and Surgery During Childhood With Academic Performance. Pia Glatz, Rolf H Sandin, Nancy L Pedersen, Anna-Karin Bonamy, Lars I Eriksson, et al. JAMA Pediatrics, 7 november 2016

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.
Lauschke VM, Vorrink SU, Moro SM, Rezayee F, Nordling Å, Hendriks DF, et al
Hepatology 2016 

Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression.
Ivanov M, Kals M, Lauschke V, Barragan I, Ewels P, Käller M, et al
Nucleic Acids Res. 2016 

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins.
Cervenka I, Valnohova J, Bernatik O, Harnos J, Radsetoulal M, Sedova K, et al
Proc. Natl. Acad. Sci. U.S.A. 2016 

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction.
Salah H, Li M, Cacciani N, Gastaldello S, Ogilvie H, Akkad H, et al
Sci Transl Med 2016 

Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis.
Bouderlique T, Vuppalapati KK, Newton PT, Li L, Barenius B, Chagin AS
Ann. Rheum. Dis. 2016 

Precision Medicine and Rare Genetic Variants.
Lauschke VM, Ingelman-Sundberg M
Trends Pharmacol. Sci. 2016 


A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.
Sellgren CM, Kegel ME, Bergen SE, Ekman CJ, Olsson S, Larsson M, et al
Mol. Psychiatry 2016 

Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome.
Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JC, Laven JS, Legro RS
Endocr. Rev. 2015

Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism.
Wigerblad G, Bas DB, Fernades-Cerqueira C, Krishnamurthy A, Nandakumar KS, Rogoz K, et al
Ann. Rheum. Dis. 2016

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss.
Krishnamurthy A, Joshua V, Haj Hensvold A, Jin T, Sun M, Vivar N, et al
Ann. Rheum. Dis. 2016 

Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.
Newton PT, Vuppalapati KK, Bouderlique T, Chagin AS
Autophagy 2015 

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise
Placea N, Ivarsson N, Venckunas T, Neyroud D, Brazaitis M, Cheng A, et al
PNASNov 2, 2015

Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring
Hu M, Richard J, Maliqueo M, Kokosar M, Fornes R, Benrick A, et al
PNAS, online Early Edition the week of November 2, 2015

Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis
Ferguson A, Wang L, Altman R, Terry D, Juette M, Burnett B, et al
Molecular Cell ;60:1–12

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.
Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, et al
Nat Commun 2015 

Safety and efficacy of re-treatments with pyronaridine-artesunate in African patients with malaria: a substudy of the WANECAM randomised trial.
Sagara I, Beavogui AH, Zongo I, Soulama I, Borghini-Fuhrer I, Fofana B, et al
Lancet Infect Dis 2016 

The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich O, Reid MB, Van den Berghe G, Vanhorebeek I, Hermans G, Rich MM, Larsson L
Physiological Reviews (Invited review) Jul;95(3):1025-1109

The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data.
Lancet Infect Dis 2015 

Renal autoregulation in health and disease.
Carlström M, Wilcox CS, Arendshorst WJ
Physiol. Rev. 2015 


Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.
Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, et al
Cell 2014

Glial origin of mesenchymal stem cells in a tooth model system.
Kaukua N, Shahidi MK, Konstantinidou C, Dyachuk V, Kaucka M, Furlan A, et al
Nature 2014 

Epigenetic mechanisms of importance for drug treatment.
Ivanov M, Barragan I, Ingelman-Sundberg M
Trends Pharmacol. Sci. 2014 

Neurodevelopment. Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
Dyachuk V, Furlan A, Shahidi MK, Giovenco M, Kaukua N, Konstantinidou C, et al
Science 2014 

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.
Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, et al
Nat Commun 2014 

Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.
Pader I, Sengupta R, Cebula M, Xu J, Lundberg JO, Holmgren A, et al
Proc. Natl. Acad. Sci. U.S.A. 2014 

Olfactory exposure to males, including men, causes stress and related analgesia in rodents.
Sorge RE, Martin LJ, Isbester KA, Sotocinal SG, Rosen S, Tuttle AH, et al
Nat. Methods 2014 

TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea.
Meltser I, Cederroth CR, Basinou V, Savelyev S, Lundkvist GS, Canlon B
Curr. Biol. 2014 

Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene.
Persson A, Sim SC, Virding S, Onishchenko N, Schulte G, Ingelman-Sundberg M
Mol. Psychiatry 2014 

Cognitive impairment and dentate gyrus synaptic dysfunction in experimental parkinsonism.
Bonito-Oliva A, Pignatelli M, Spigolon G, Yoshitake T, Seiler S, Longo F, et al
Biol. Psychiatry 2014 

The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression.
Lavebratt C, Olsson S, Backlund L, Frisén L, Sellgren C, Priebe L, et al
Mol. Psychiatry 2014 

Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness.
Yamada T, Fedotovskaya O, Cheng AJ, Cornachione AS, Minozzo FC, Aulin C, et al
Ann. Rheum. Dis. 2015