Clinical Integration at PRECISE

The ultimate long-term goal is the clinical integration embedding precision diagnostics and personalized treatment directly into routine periconceptional and prenatal care aiming to provide:

• Preimplantation and prenatal genomic diagnostics
  Non-invasive preimplantation diagnosis, rapid WGS/WES for fetal anomalies, NIPT expansion to non-invasive diagnosis of monogenic disorders where indicated.
• Phenotyping
  AI assisted analysis of timelapse embryo images in vitro followed by high-resolution ultrasound imaging in vivo during late embryonic and early fetal stages of development to establish normal reference phenotype of early human development and facilitate early anomaly detection. 
• Less invasive fetal therapy
  Prenatal treatment to reduce the need for intrauterine transfusions for fetal red cell and platelet alloimmunizations, stem cells and gene-based fetal therapy trials. 
• Maternal precision medicine
  Improved management of recurrent implantation failure, early pregnancy loss, polygenic risk scoring, metabolic profiling, and immunological risk assessment. Plasma cfRNA based non-invasive monitoring of placental and maternal immune dynamics in pregnancy.