Lars-Gunnar Larsson

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Forskningsbeskrivning

Professor i tumör- och cellbiologi.

Utvalda publikationer

Article: METHODS IN MOLECULAR BIOLOGY. 2021;2318:241-254
Methods to Study Myc-Regulated Cellular Senescence: An Update.
Zhang F; Bazzar W; Alzrigat M; Larsson L-G
Article: ELIFE. 2020;9:e57894
PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer
Brunner A; Rahmanto AS; Johansson H; Franco M; Viiliainen J; Gazi M; Frings O; Fredlund E; Spruck C; Lehtio J; Rantala JK; Larsson L-G; Sangfelt O
Article: SCIENTIFIC REPORTS. 2018;8(1):10064
A selective high affinity MYC-binding compound inhibits MYC: MAX interaction and MYC-dependent tumor cell proliferation
Castell A; Yan Q; Fawkner K; Hydbring P; Zhang F; Verschut V; Franco M; Zakaria SM; Bazzar W; Goodwin J; Zinzalla G; Larsson L-G
Review: GENES. 2017;8(7):E174-174
MYC Modulation around the CDK2/p27/SKP2 Axis
Hydbring P; Castell A; Larsson L-G
Article: ONCOTARGET. 2016;7(3):2837-2854
Interferon-γ-induced p27^KIP1 binds to and targets MYC for proteasome-mediated degradation
Bahram F; Hydbring P; Tronnersjo S; Zakaria SM; Frings O; Fahlen S; Nilsson H; Goodwin J; von der Lehr N; Su Y; Luescher B; Castell A; Larsson L-G
Editorial comment: CANCER DISCOVERY. 2015;5(7):701-703
Targeting MYC Translation in Colorectal Cancer
Castell A; Larsson L-G
Article: CANCER RESEARCH. 2014;74(16):4222-4229
MYC Synergizes with Activated BRAF^V600E in Mouse Lung Tumor Development by Suppressing Senescence
Tabor V; Bocci M; Alikhani N; Kuiper R; Larsson L-G
Article: EMBO MOLECULAR MEDICINE. 2013;5(7):1067-1086
CDK-mediated activation of the SCF^FBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer
Cepeda D; Ng H-F; Sharifi HR; Mahmoudi S; Soto Cerrato V; Fredlund E; Magnusson K; Nilsson H; Malyukova A; Rantala J; Klevebring D; Vinals F; Bhaskaran N; Zakaria SM; Rahmanto AS; Grotegut S; Nielsen ML; Szigyarto CA-K; Sun D; Lerner M; Navani S; Widschwendter M; Uhlen M; Jirstrom K; Ponten F; Wohlschlegel J; Grander D; Spruck C; Larsson L-G; Sangfelt O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(4):E187-E196
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
Menssen A; Hydbring P; Kapelle K; Vervoorts J; Diebold J; Luescher B; Larsson L-G; Hermeking H
Review: SEMINARS IN CANCER BIOLOGY. 2011;21(6):367-376
Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence
Larsson L-G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(1):58-63
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation
Hydbring P; Bahram F; Su Y; Tronnersjo S; Hogstrand K; von der Lehr N; Sharifi HR; Lilischkis R; Hein N; Wu S; Vervoorts J; Henriksson M; Grandien A; Luscher B; Larsson L-G
Article: NATURE CELL BIOLOGY. 2010;12(1):54-59
Cdk2 suppresses cellular senescence induced by the c-myc oncogene
Campaner S; Doni M; Hydbring P; Verrecchia A; Bianchi L; Sardella D; Schleker T; Perna D; Tronnersjo S; Murga M; Fernandez-Capetillo O; Barbacid M; Larsson L-G; Amati B
Article: NATURE METHODS. 2006;3(12):995-1000
Direct observation of individual endogenous protein complexes in situ by proximity ligation.
Söderberg O; Gullberg M; Jarvius M; Ridderstråle K; Leuchowius K-J; Jarvius J; Wester K; Hydbring P; Bahram F; Larsson L-G; Landegren U
Article: NATURE CELL BIOLOGY. 2005;7(3):303-310
c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription
Arabi A; Wu SQ; Ridderstråle K; Bierhoff H; Shiue C; Fatyol K; Fahlén S; Hydbring P; Söderberg O; Grummt I; Larsson LG; Wright APH
Article: MOLECULAR CELL. 2003;11(5):1189-1200
The F-Box protein Skp2 participates in c-Myc protelosornal degradation and acts as a cofactor for c-Myc-regulated transcription
von der Lehr N; Johansson S; Wu SQ; Bahram F; Castell A; Cetinkaya C; Hydbring P; Weidung I; Nakayama K; Nakayama KI; Söderberg O; Kerppola TK; Larsson LG

Artiklar

Article: CELL CYCLE. 2018;17(24):2697-2715
MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts
Zhang F; Zakaria SM; Tabor VH; Singh M; Tronnersjo S; Goodwin J; Selivanova G; Bartek J; Castell A; Larsson L-G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(32):22221-22236
Sin3b Interacts with Myc and Decreases Myc Levels
Garcia-Sanz P; Quintanilla A; Carmen Lafita M; Moreno-Bueno G; Garcia-Gutierrez L; Tabor V; Varela I; Shiio Y; Larsson L-G; Portillo F; Leon J
Article: METHODS IN MOLECULAR BIOLOGY. 2013;1012:99-116
Methods to study MYC-regulated cellular senescence.
Tabor V; Bocci M; Larsson L-G
Article: PLOS ONE. 2012;7(2):e31366
Inhibition of the Intrinsic but Not the Extrinsic Apoptosis Pathway Accelerates and Drives Myc-Driven Tumorigenesis Towards Acute Myeloid Leukemia
Hoegstrand K; Hejll E; Sander B; Rozell B; Larsson L-G; Grandien A
Article: AGING-US. 2010;2(4):244-250
Cdk2: a key regulator of the senescence control function of Myc
Hydbring P; Larsson L-G
Article: PLOS ONE. 2010;5(1):e8924
Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage
Guerra L; Albihn A; Tronnersjo S; Yan Q; Guidi R; Stenerlow B; Sterzenbach T; Josenhans C; Fox JG; Schauer DB; Thelestam M; Larsson L-G; Henriksson M; Frisan T
Article: EXPERIMENTAL CELL RESEARCH. 2009;315(18):3099-3111
TGF-β enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity
Wu S; Hultquist A; Hydbring P; Cetinkaya C; Oberg F; Larsson L-G
Article: METHODS. 2008;45(3):227-232
Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay
Soderberg O; Leuchowius K-J; Gullberg M; Jarvius M; Weibrecht I; Larsson L-G; Landegren U
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;121(12):2615-2621
Drug-induced Myc-mediated apoptosis of cancer cells is inhibited by stress protein Hsp70
Afanasyeva EA; Komarova EY; Larsson L-G; Bahram F; Margulis BA; Guzhova IV
Article: PLANT JOURNAL. 2007;52(6):1192-1198
Sweet delivery - sugar translocators as ports of entry for antisense oligodeoxynucleotides in plant cells.
Sun C; Ridderstråle K; Höglund A-S; Larsson L-G; Jansson C
Article: MOLECULAR CANCER THERAPEUTICS. 2007;6(10):2634-2641
Combined IFN-γ and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells
Cetinkaya C; Hultquist A; Su Y; Wu S; Bahram F; Pahlman S; Guzhova I; Larsson L-G
Article: MOLECULAR CANCER RESEARCH. 2004;2(8):464-476
Mad 1 inhibits cell growth and proliferation but does not promote differentiation or overall survival in human U-937 monoblasts
Hultquist A; Cetinkaya C; Wu SQ; Castel A; Erlandsson A; Larsson LG
Article: CELL CYCLE. 2003;2(5):403-407
Implication of the ubiquitin/proteasome system in Myc-regulated transcription.
von der Lehr N; Johansson S; Larsson L-G
Article: ONCOGENE. 2003;22(3):351-360
Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter.
Wu S; Cetinkaya C; Munoz-Alonso MJ; von der Lehr N; Bahram F; Beuger V; Eilers M; Leon J; Larsson L-G
Article: BLOOD. 2002;99(6):2199-2206
Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27(Kip1).
Dimberg A; Bahram F; Karlberg I; Larsson L-G; Nilsson K; Oberg F
Article: ONCOGENE. 2002;21(3):447-459
Repression of in vivo growth of Myc/Ras transformed tumor cells by Mad1
Cerni C; Skrzypek B; Popov N; Sasgary S; Schmidt G; Larsson LG; Lüscher B; Henriksson M
Article: INTERNATIONAL JOURNAL OF CANCER. 2001;94(1):97-108
Interferon-gamma cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells.
Guzhova I; Hultquist A; Cetinkaya C; Nilsson K; Påhlman S; Larsson LG
Article: LEUKEMIA. 2001;15(2):217-227
Cytokine-induced restoration of differentiation and cell cycle arrest in v-Myc transformed U-937 monoblasts correlates with reduced Myc activity.
Oberg F; Wu S; Bahram F; Nilsson K; Larsson LG
Article: BLOOD. 2000;95(6):2104-2110
c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover.
Bahram F; von der Lehr N; Cetinkaya C; Larsson LG
Article: BLOOD. 1999;93(11):3900-3912
Posttranslational regulation of Myc function in response to phorbol ester/interferon-gamma-induced differentiation of v-Myc-transformed U-937 monoblasts.
Bahram F; Wu S; Oberg F; Lüscher B; Larsson LG
Article: ONCOGENE. 1997;15(6):737-748
Analysis of the DNA-binding activities of Myc/Max/Mad network complexes during induced differentiation of U-937 monoblasts and F9 teratocarcinoma cells.
Larsson LG; Bahram F; Burkhardt H; Lüscher B
Article: BLOOD. 1995;86(7):2747-2753
The hematopoietic transcription factor PU.1 is downregulated in human multiple myeloma cell lines.
Pettersson M; Sundström C; Nilsson K; Larsson LG
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Alla övriga publikationer

Editorial comment: SEMINARS IN CANCER BIOLOGY. 2011;21(6):347-348
Cellular senescence-A barrier against tumor development?
Larsson L-G
Review: CANCER RESEARCH. 2010;70(17):6687-6691
Tipping the Balance: Cdk2 Enables Myc to Suppress Senescence
Hydbring P; Larsson L-G
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1429-1437
The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy
Larsson L-G; Henriksson MA
Editorial comment: EMBO REPORTS. 2007;8(12):1110-1114
The world according to MYC
Lusher B; Larsson L-G
Editorial comment: MOLECULAR CELL. 2006;24(6):811-812
SNIP1: Myc's new helper in transcriptional activation
Larsson L-G
Review: ONCOGENE. 1999;18(19):2955-2966
The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: function and regulation.
Lüscher B; Larsson LG
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 1997;224:191-200
Cytokine-induced inhibition of Myc activity in monocytic cells.
Larsson LG; Bahram F; Wu S; Oberg F; Nilsson K; Lüscher B

Anställningar

Assisterande professor, Uppsala University, 1994-
Anknuten till Forskning, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2023-2024
Senior Lecturer and Associate Professor, The Genetic Center, Swedish University of Agricultural Sciences, 1991-1994

Examina och utbildning

Professor, Molecular Genetics, Swedish University of Agricultural Sciences, 2001
PhD, Tumor Biology, On the role of proto-oncogenes in the differentiation of human hematopoietic tumor cells in vitro, Uppsala University, 1989
Kanidatexamen, Biologi, Uppsala University, 1982

Gästforskning och resestipendier

Post-doctoral fellow, Hannover Medical School, 1991-1994

Forskningsbeskrivning

Utvalda publikationer

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Gästforskning och resestipendier

Nyheter från KI

Kalenderhändelser från KI