Stefan Nobel

Om mig
Publikationer
Populärvetenskap och samverkan

Om mig

Jag arbetar som programkoordinator för det strategiska forskningsprogrammet
i diabetes, SRP Diabetes.
Jag har en forskarbakgrund, doktorerat på Karolinska Insitutet, genomfört
postdoktoral träning inom industrin (Merck-Frosst, Montreal och Pharmacia,
Stockholm) samt en forskartjänst på Stockholms Universitet. För
närvarande arbetar jag som program manager för det strategiska
forskningsområdet SRP Diabetes. [1]
[1] https://ki.se/en/srp-diabetes/strategic-research-programme-in-diabetes-srp-diabetes

Artiklar

Article: CHEMOSPHERE. 2020;239:124755

Tissue distribution of 14C-labelled perfluorooctanoic acid in adult mice after 1-5 days of dietary exposure to an experimental dose or a lower dose that resulted in blood levels similar to those detected in exposed humans.

Bogdanska J; Borg D; Bergström U; Mellring M; Bergman Å; DePierre J; Nobel S
Article: CHEMOSPHERE. 2014;98:28-36

Tissue distribution of 35S-labelled perfluorobutanesulfonic acid in adult mice following dietary exposure for 1-5 days.

Bogdanska J; Sundström M; Bergström U; Borg D; Abedi-Valugerdi M; Bergman Å; DePierre J; Nobel S
Article: CHEMOSPHERE. 2012;87(8):865-871

Radiosynthesis of perfluorooctanesulfonate (PFOS) and perfluorobutanesulfonate (PFBS), including solubility, partition and adhesion studies.

Sundström M; Bogdanska J; Pham HV; Athanasios V; Nobel S; McAlees A; Eriksson J; DePierre JW; Bergman Å
Article: TOXICOLOGY. 2011;284(1-3):54-62

Tissue distribution of ³⁵S-labelled perfluorooctane sulfonate in adult mice after oral exposure to a low environmentally relevant dose or a high experimental dose.

Bogdanska J; Borg D; Sundström M; Bergström U; Halldin K; Abedi-Valugerdi M; Bergman A; Nelson B; Depierre J; Nobel S
Article: REPRODUCTIVE TOXICOLOGY. 2010;30(4):558-565

Tissue distribution of (35)S-labelled perfluorooctane sulfonate (PFOS) in C57Bl/6 mice following late gestational exposure.

Borg D; Bogdanska J; Sundström M; Nobel S; Håkansson H; Bergman Å; DePierre JW; Halldin K; Bergström U
Article: PROTEIN EXPRESSION AND PURIFICATION. 2002;26(3):349-356

Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities.

Nobel CSI; Dunås F; Abrahmsén LB
Article: CYTOKINE. 2000;12(5):423-431

Expression of interleukin 1 alpha and beta, and interleukin 1 receptor antagonist mRNA in the rat central nervous system after peripheral administration of lipopolysaccharides.

Eriksson C; Nobel S; Winblad B; Schultzberg M
Article: APOPTOSIS. 2000;5(2):153-163

Inhibition of Na+/K(+)-ATPase may be one mechanism contributing to potassium efflux and cell shrinkage in CD95-induced apoptosis.

Nobel CS; Aronson JK; van den Dobbelsteen DJ; Slater AF
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1998;353(1):73-84

Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species.

Burkitt MJ; Bishop HS; Milne L; Tsang SY; Provan GJ; Nobel CS; Orrenius S; Slater AF
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1997;10(12):1319-1324

Disulfiram is a potent inhibitor of proteases of the caspase family.

Nobel CS; Kimland M; Nicholson DW; Orrenius S; Slater AF
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1997;10(6):636-643

Mechanism of dithiocarbamate inhibition of apoptosis: thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme.

Nobel CS; Burgess DH; Zhivotovsky B; Burkitt MJ; Orrenius S; Slater AF
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(4):522s

REDOX MODULATION OF APOPTOTIC CELL DEATH

Orrenius S; Nobel S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(26):15420-15427

Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody.

van den Dobbelsteen DJ; Nobel CS; Schlegel J; Cotgreave IA; Orrenius S; Slater AF
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(44):26202-26208

Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper.

Nobel CI; Kimland M; Lind B; Orrenius S; Slater AF
Article: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 1995;15(8):721-729

Interleukin-1 receptor antagonist protein and mRNA in the rat adrenal gland.

Schultzberg M; Tingsborg S; Nobel S; Lundkvist J; Svenson S; Simoncsits A; Bartfai T
Article: BIOCHEMICAL JOURNAL. 1995;306 ( Pt 3)(Pt 3):771-778

Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis.

Slater AF; Nobel CS; Maellaro E; Bustamante J; Kimland M; Orrenius S
Article: NEUROIMMUNOMODULATION. 1995;2(2):61-73

Induction of interleukin-1 beta mRNA and enkephalin mRNA in the rat adrenal gland by lipopolysaccharides studied by in situ hybridization histochemistry.

Nobel CS; Schultzberg M

Alla övriga publikationer

Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S147

Perinatal tissue distribution of perfluorooctane sulphonate (PFOS) in mice

Borg D; Bogdanska J; Sundstrom M; Nobel S; Hakansson H; Bergman A; DePierre J; Halldin K; Bergstrom U
Review: FEBS JOURNAL. 2001;268(15):4113-4125

Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones.

Nobel S; Abrahmsen L; Oppermann U
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130-132(1-3):805-814

Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.

Hult M; Nobel CS; Abrahmsen L; Nicoll-Griffith DA; Jörnvall H; Oppermann UC
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(4):1032-1038

Dithiocarbamates and the redox regulation of cell death.

Orrenius S; Nobel CS; van den Dobbelsteen DJ; Burkitt MJ; Slater AF
Review: CELL DEATH AND DIFFERENTIATION. 1996;3(1):57-62

Intracellular redox changes during apoptosis.

Slater AF; Stefan C; Nobel I; van den Dobbelsteen DJ; Orrenius S
Published conference paper: TOXICOLOGY LETTERS. 1995;82-83:149-153

Signalling mechanisms and oxidative stress in apoptosis.

Slater AF; Stefan C; Nobel I; van den Dobbelsteen DJ; Orrenius S
Published conference paper: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1995;1271(1):59-62

The role of intracellular oxidants in apoptosis.

Slater AF; Nobel CS; Orrenius S
Published conference paper: FUNDAMENTAL AND CLINICAL IMMUNOLOGY. 1995;3(2):69-70

REDOX STATE IMBALANCE IN THYMOCYTE APOPTOSIS - INHIBITION BY SPIN TRAP COMPOUNDS

MAELLARO E; SLATER AFG; NOBEL CSI; BUSTAMANTE J; KIMLAND M; ORRENIUS S
Conference publication: JOURNAL OF NEUROCHEMISTRY. 1993;61:S125

INDUCTION OF INTERLEUKIN-1 MESSENGER-RNA IN THE NERVOUS-SYSTEM

SCHULTZBERG M; NOBEL S

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