Minna Taipale

Article: BRITISH JOURNAL OF CANCER. 2019;120(9):922-930

Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers.

Hänninen UA; Wirta E-V; Katainen R; Tanskanen T; Hamberg J; Taipale M; Böhm J; Renkonen-Sinisalo L; Lepistö A; Forsström LM; Pitkänen E; Palin K; Seppälä TT; Mäkinen N; Mecklin J-P; Aaltonen LA

Article: NATURE COMMUNICATIONS. 2019;10(1):1252

Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans.

Kaasinen E; Kuismin O; Rajamäki K; Ristolainen H; Aavikko M; Kondelin J; Saarinen S; Berta DG; Katainen R; Hirvonen EAM; Karhu A; Taira A; Tanskanen T; Alkodsi A; Taipale M; Morgunova E; Franssila K; Lehtonen R; Mäkinen M; Aittomäki K; Palotie A; Kurki MI; Pietiläinen O; Hilpert M; Saarentaus E; Niinimäki J; Junttila J; Kaikkonen K; Vahteristo P; Skoda RC; Seppänen MRJ; Eklund KK; Taipale J; Kilpivaara O; Aaltonen LA

Article: NATURE. 2018;562(7725):76-81

The interaction landscape between transcription factors and the nucleosome.

Zhu F; Farnung L; Kaasinen E; Sahu B; Yin Y; Wei B; Dodonova SO; Nitta KR; Morgunova E; Taipale M; Cramer P; Taipale J

Article: EMBO MOLECULAR MEDICINE. 2018;10(9):e8552

Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer.

Kondelin J; Salokas K; Saarinen L; Ovaska K; Rauanheimo H; Plaketti R-M; Hamberg J; Liu X; Yadav L; Gylfe AE; Cajuso T; Hänninen UA; Palin K; Ristolainen H; Katainen R; Kaasinen E; Tanskanen T; Aavikko M; Taipale M; Taipale J; Renkonen-Sinisalo L; Lepistö A; Koskensalo S; Böhm J; Mecklin J-P; Ongen H; Dermitzakis ET; Kilpivaara O; Vahteristo P; Turunen M; Hautaniemi S; Tuupanen S; Karhu A; Välimäki N; Varjosalo M; Pitkänen E; Aaltonen LA

Article: NATURE BIOTECHNOLOGY. 2018;36(6):521-529

A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility.

Wei B; Jolma A; Sahu B; Orre LM; Zhong F; Zhu F; Kivioja T; Sur I; Lehtiö J; Taipale M; Taipale J

Article: PLOS GENETICS. 2018;14(3):e1007200

Exome-wide somatic mutation characterization of small bowel adenocarcinoma.

Hänninen UA; Katainen R; Tanskanen T; Plaketti R-M; Laine R; Hamberg J; Ristimäki A; Pukkala E; Taipale M; Mecklin J-P; Forsström LM; Pitkänen E; Palin K; Välimäki N; Mäkinen N; Aaltonen LA

Article: CANCER RESEARCH. 2017;77(15):4078-4088

Comprehensive Evaluation of Protein Coding Mononucleotide Microsatellites in Microsatellite-Unstable Colorectal Cancer.

Kondelin J; Gylfe AE; Lundgren S; Tanskanen T; Hamberg J; Aavikko M; Palin K; Ristolainen H; Katainen R; Kaasinen E; Taipale M; Taipale J; Renkonen-Sinisalo L; Järvinen H; Böhm J; Mecklin J-P; Vahteristo P; Tuupanen S; Aaltonen LA; Pitkänen E

Article: SCIENCE. 2017;356(6337):eaaj2239

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

Yin Y; Morgunova E; Jolma A; Kaasinen E; Sahu B; Khund-Sayeed S; Das PK; Kivioja T; Dave K; Zhong F; Nitta KR; Taipale M; Popov A; Ginno PA; Domcke S; Yan J; Schübeler D; Vinson C; Taipale J

Article: CELL CYCLE. 2017;16(2):189-199

Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion.

Sokolova M; Turunen M; Mortusewicz O; Kivioja T; Herr P; Vähärautio A; Björklund M; Taipale M; Helleday T; Taipale J

Article: PLOS GENETICS. 2016;12(2):e1005850

Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12.

Mäkinen N; Aavikko M; Heikkinen T; Taipale M; Taipale J; Koivisto-Korander R; Bützow R; Vahteristo P

Article: NATURE. 2015;527(7578):384-388

DNA-dependent formation of transcription factor pairs alters their binding specificity.

Jolma A; Yin Y; Nitta KR; Dave K; Popov A; Taipale M; Enge M; Kivioja T; Morgunova E; Taipale J

Article: MOLECULAR ECOLOGY. 2015;24(19):4886-4900

Flight-induced changes in gene expression in the Glanville fritillary butterfly.

Kvist J; Mattila ALK; Somervuo P; Ahola V; Koskinen P; Paulin L; Salmela L; Fountain T; Rastas P; Ruokolainen A; Taipale M; Holm L; Auvinen P; Lehtonen R; Frilander MJ; Hanski I

Article: JOURNAL OF INFECTIOUS DISEASES. 2015;211(11):1842-1851

Whole-Genome Sequencing Identifies STAT4 as a Putative Susceptibility Gene in Classic Kaposi Sarcoma.

Aavikko M; Kaasinen E; Nieminen JK; Byun M; Donner I; Mancuso R; Ferrante P; Clerici M; Brambilla L; Tourlaki A; Sarid R; Guttman-Yassky E; Taipale M; Morgunova E; Pekkonen P; Ojala PM; Pukkala E; Casanova J-L; Vaarala O; Vahteristo P; Aaltonen LA

Article: CANCER GENETICS. 2015;208(1-2):35-40

Systematic search for rare variants in Finnish early-onset colorectal cancer patients.

Tanskanen T; Gylfe AE; Katainen R; Taipale M; Renkonen-Sinisalo L; Järvinen H; Mecklin J-P; Böhm J; Kilpivaara O; Pitkänen E; Palin K; Vahteristo P; Tuupanen S; Aaltonen LA

Article: BRITISH JOURNAL OF CANCER. 2014;111(8):1657-1662

Identification of 33 candidate oncogenes by screening for base-specific mutations.

Tuupanen S; Hänninen UA; Kondelin J; von Nandelstadh P; Cajuso T; Gylfe AE; Katainen R; Tanskanen T; Ristolainen H; Böhm J; Mecklin J-P; Järvinen H; Renkonen-Sinisalo L; Andersen CL; Taipale M; Taipale J; Vahteristo P; Lehti K; Pitkänen E; Aaltonen LA

Article: NATURE COMMUNICATIONS. 2014;5:4737

The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera.

Ahola V; Lehtonen R; Somervuo P; Salmela L; Koskinen P; Rastas P; Välimäki N; Paulin L; Kvist J; Wahlberg N; Tanskanen J; Hornett EA; Ferguson LC; Luo S; Cao Z; de Jong MA; Duplouy A; Smolander O-P; Vogel H; McCoy RC; Qian K; Chong WS; Zhang Q; Ahmad F; Haukka JK; Joshi A; Salojärvi J; Wheat CW; Grosse-Wilde E; Hughes D; Katainen R; Pitkänen E; Ylinen J; Waterhouse RM; Turunen M; Vähärautio A; Ojanen SP; Schulman AH; Taipale M; Lawson D; Ukkonen E; Mäkinen V; Goldsmith MR; Holm L; Auvinen P; Frilander MJ; Hanski I

Article: INTERNATIONAL JOURNAL OF CANCER. 2014;135(3):611-623

Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.

Cajuso T; Hänninen UA; Kondelin J; Gylfe AE; Tanskanen T; Katainen R; Pitkänen E; Ristolainen H; Kaasinen E; Taipale M; Taipale J; Böhm J; Renkonen-Sinisalo L; Mecklin J-P; Järvinen H; Tuupanen S; Kilpivaara O; Vahteristo P

Article: PLOS ONE. 2014;9(7):e101467

Transcriptome analysis reveals signature of adaptation to landscape fragmentation.

Somervuo P; Kvist J; Ikonen S; Auvinen P; Paulin L; Koskinen P; Holm L; Taipale M; Duplouy A; Ruokolainen A; Saarnio S; Sirén J; Kohonen J; Corander J; Frilander MJ; Ahola V; Hanski I

Article: GASTROENTEROLOGY. 2013;145(3):540-3.e22

Identification of candidate oncogenes in human colorectal cancers with microsatellite instability.

Gylfe AE; Kondelin J; Turunen M; Ristolainen H; Katainen R; Pitkänen E; Kaasinen E; Rantanen V; Tanskanen T; Varjosalo M; Lehtonen H; Palin K; Taipale M; Taipale J; Renkonen-Sinisalo L; Järvinen H; Böhm J; Mecklin J-P; Ristimäki A; Kilpivaara O; Tuupanen S; Karhu A; Vahteristo P; Aaltonen LA

Article: CELL. 2013;154(4):801-813

Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites.

Yan J; Enge M; Whitington T; Dave K; Liu J; Sur I; Schmierer B; Jolma A; Kivioja T; Taipale M; Taipale J

Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2013;48(6):672-678

Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients.

Tanskanen T; Gylfe AE; Katainen R; Taipale M; Renkonen-Sinisalo L; Mecklin J-P; Järvinen H; Tuupanen S; Kilpivaara O; Vahteristo P; Aaltonen LA

Article: PLOS GENETICS. 2013;9(10):e1003876

Eleven candidate susceptibility genes for common familial colorectal cancer.

Gylfe AE; Katainen R; Kondelin J; Tanskanen T; Cajuso T; Hänninen U; Taipale J; Taipale M; Renkonen-Sinisalo L; Järvinen H; Mecklin J-P; Kilpivaara O; Pitkänen E; Vahteristo P; Tuupanen S; Karhu A; Aaltonen LA

Article: G3-GENES GENOMES GENETICS. 2013;3(1):75-90

Transcriptional networks controlling the cell cycle.

Bonke M; Turunen M; Sokolova M; Vähärautio A; Kivioja T; Taipale M; Björklund M; Taipale J

Article: SCIENCE. 2012;338(6112):1360-1363

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

Sur IK; Hallikas O; Vähärautio A; Yan J; Turunen M; Enge M; Taipale M; Karhu A; Aaltonen LA; Taipale J

Article: SCIENCE. 2011;334(6053):252-255

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.

Mäkinen N; Mehine M; Tolvanen J; Kaasinen E; Li Y; Lehtonen HJ; Gentile M; Yan J; Enge M; Taipale M; Aavikko M; Katainen R; Virolainen E; Böhling T; Koski TA; Launonen V; Sjöberg J; Taipale J; Vahteristo P; Aaltonen LA

Article: NATURE. 2006;439(7079):1009-1013

Identification of pathways regulating cell size and cell-cycle progression by RNAi.

Björklund M; Taipale M; Varjosalo M; Saharinen J; Lahdenperä J; Taipale J

Article: ONCOGENE. 2001;20(41):5888-5896

Ectopic expression of Cdk6 circumvents transforming growth factor-beta mediated growth inhibition.

Zhang F; Taipale M; Heiskanen A; Laiho M

Article: EXPERIMENTAL CELL RESEARCH. 2000;259(1):107-116

Accumulation of a form of p27(Kip1) not associated with Cdk-cyclin complexes in transforming growth factor-beta-arrested Mv1Lu cells.

Taipale M; Tiihonen E; Heiskanen A; Laiho M

Article: ONCOGENE. 1999;18(46):6252-6261

Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites.

Kivinen L; Tsubari M; Haapajärvi T; Datto MB; Wang XF; Laiho M

Article: MOLECULAR AND CELLULAR BIOLOGY. 1999;19(5):3654-3663

Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity.

Tsubari M; Taipale J; Tiihonen E; Keski-Oja J; Laiho M

Article: CANCER RESEARCH. 1997;57(14):2966-2973

Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor.

Tsubari M; Tiihonen E; Laiho M

Article: MOLECULAR AND CELLULAR BIOLOGY. 1997;17(6):3074-3080

p53 transactivation and protein accumulation are independently regulated by UV light in different phases of the cell cycle.

Haapajärvi T; Pitkänen K; Tsubari M; Laiho M

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