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Forskningsbeskrivning

Jag kombinerar beteendemetoder, beräkningsmodellering, farmakologiska manipuleringar och bildteknik som fMRI, PET och MEG. Mina forskningsintresse består numera av: att förstå den roll som neuromodulatorer dopamin har i motivationsprocessen och beslutsfattande; att förstå sambandet mellan försämringen av det dopaminerga systemet och kognitiv försämring vid normalt åldrandet; att förstå hippocampus roll vid alstring av adaptiva svar i samband med ångest eller nyheter. Dessutom planerar jag en ny studie för att utöka vår förståelse av kopplingen mellan kognitiva funktioner som ligger bakom beslutsfattande och depressionsrisk. 

Publikationer

Distinct phenotypes of spontaneous activity and induction of amphetamine sensitization in inbred Roman high- and low-avoidance rats: Vulnerability and protection
Giménez-llort L, Guitart-masip M, Tobeña A, Fernández-teruel A, Johansson B
Neuroscience letters 2018;673():92-98

Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations
Lövdén M, Karalija N, Andersson M, Wåhlin A, Axelsson J, Köhncke Y, et al
Cerebral cortex (New York, N.Y. : 1991) 2018;28(11):3894-3907

Attenuation of dopamine-modulated prefrontal value signals underlies probabilistic reward learning deficits in old age
De Boer L, Axelsson J, Riklund K, Nyberg L, Dayan P, Bäckman L, et al
eLife 2017;6():-

Parsing the Role of the Hippocampus in Approach-Avoidance Conflict
Loh E, Kurth-nelson Z, Berron D, Dayan P, Duzel E, Dolan R, et al
Cerebral cortex (New York, N.Y. : 1991) 2017;27(1):201-215

BOLD Variability is Related to Dopaminergic Neurotransmission and Cognitive Aging
Guitart-masip M, Salami A, Garrett D, Rieckmann A, Lindenberger U, Bäckman L
Cerebral cortex (New York, N.Y. : 1991) 2016;26(5):2074-2083

Arbitration between controlled and impulsive choices
Economides M, Guitart-masip M, Kurth-nelson Z, Dolan Rj
NeuroImage 2015;109():206-16

Basal Ganglia Activity Mirrors a Benefit of Action and Reward on Long-Lasting Event Memory
Koster R, Guitart-masip M, Dolan Rj, Düzel E
Cerebral cortex (New York, N.Y. : 1991) 2015;25(12):4908-17

Corrigendum: Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression
Richter A, Guitart-masip M, Barman A, Libeau C, Behnisch G, Czerney S, et al
Frontiers in systems neuroscience 2015;9():36-

Deep brain stimulation of the subthalamic nucleus modulates reward processing and action selection in Parkinson patients
Wagenbreth C, Zaehle T, Galazky I, Voges J, Guitart-masip M, Heinze Hj, et al
Journal of neurology 2015;262(6):1541-7

Dopamine, Salience, and Response Set Shifting in Prefrontal Cortex
Shiner T, Symmonds M, Guitart-masip M, Fleming Sm, Friston Kj, Dolan Rj
Cerebral cortex (New York, N.Y. : 1991) 2015;25(10):3629-39

Model-Based Reasoning in Humans Becomes Automatic with Training
Economides M, Kurth-nelson Z, Lübbert A, Guitart-masip M, Dolan Rj
PLoS computational biology 2015;11(9):e1004463-

Action versus valence in decision making
Guitart-masip M, Duzel E, Dolan R, Dayan P
Trends in cognitive sciences 2014;18(4):194-202

Anterior cingulate cortex instigates adaptive switches in choice by integrating immediate and delayed components of value in ventromedial prefrontal cortex
Economides M, Guitart-masip M, Kurth-nelson Z, Dolan Rj
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014;34(9):3340-9

Differential, but not opponent, effects of L -DOPA and citalopram on action learning with reward and punishment
Guitart-masip M, Economides M, Huys Qj, Frank Mj, Chowdhury R, Duzel E, et al
Psychopharmacology 2014;231(5):955-66

Dopamine restores reward prediction errors in old age (vol 16, pg 648, 2013)
Chowdhury R, Guitart-masip M, Lambert C, Dayan P, Huys Q, Duzel E, et al
NATURE NEUROSCIENCE 2014;17(12):1840-1840

Human hippocampus arbitrates approach-avoidance conflict
Bach Dr, Guitart-masip M, Packard Pa, Miró J, Falip M, Fuentemilla L, et al
Current biology : CB 2014;24(5):541-7

Human Hippocampus Arbitrates Approach-Avoidance Conflict (vol 24, pg 541, 2014)
Bach Dr, Guitart-masip M, Packard Pa, Miro J, Falip M, Fuentemilla L, et al
CURRENT BIOLOGY 2014;24(12):1435-

Pharmacological Dissociation of Novelty Responses in the Human Brain
Bunzeck N, Guitart-masip M, Dolan Rj, Duzel E
CEREBRAL CORTEX 2014;24(5):1351-60

Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression
Richter A, Guitart-masip M, Barman A, Libeau C, Behnisch G, Czerney S, et al
Frontiers in systems neuroscience 2014;8():140-

Dopamine Modulates Reward-Related Vigor
Beierholm U, Guitart-masip M, Economides M, Chowdhury R, Duzel E, Dolan R, et al
NEUROPSYCHOPHARMACOLOGY 2013;38(8):1495-503

Dopamine restores reward prediction errors in old age
Chowdhury R, Guitart-masip M, Lambert C, Dayan P, Huys Q, Düzel E, et al
Nature neuroscience 2013;16(5):648-53

Effort and valuation in the brain: the effects of anticipation and execution
Kurniawan It, Guitart-masip M, Dayan P, Dolan Rj
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(14):6160-9

Electrophysiological correlates of anticipating improbable but desired events
Fuentemilla L, Cucurell D, Marco-pallares J, Guitart-masip M, Moris J, Rodriguez-fornells A
NEUROIMAGE 2013;:135-44

Frontal Theta Overrides Pavlovian Learning Biases
Cavanagh Jf, Eisenberg I, Guitart-masip M, Huys Q, Frank Mj
JOURNAL OF NEUROSCIENCE 2013;33(19):8541-8

Manipulating the contribution of approach-avoidance to the perturbation of economic choice by valence
Wright Nd, Morris Ls, Guitart-masip M, Dolan Rj
Frontiers in neuroscience 2013;7():228-

Not so uncertain at last: locus coeruleus and decision making
Duzel E, Guitart-masip M
Neuron 2013;79(1):9-11

Preparing for Selective Inhibition within Frontostriatal Loops
Smittenaar P, Guitart-masip M, Lutti A, Dolan Rj
JOURNAL OF NEUROSCIENCE 2013;33(46):18087-97

Structural integrity of the substantia nigra and subthalamic nucleus predicts flexibility of instrumental learning in older-age individuals
Chowdhury R, Guitart-masip M, Lambert C, Dolan Rj, Duzel E
NEUROBIOLOGY OF AGING 2013;34(10):2261-70

Synchronization of Medial Temporal Lobe and Prefrontal Rhythms in Human Decision Making
Guitart-masip M, Barnes Gr, Horner A, Bauer M, Dolan Rj, Duzel E
JOURNAL OF NEUROSCIENCE 2013;33(2):442-51

Action controls dopaminergic enhancement of reward representations
Guitart-masip M, Chowdhury R, Sharot T, Dayan P, Duzel E, Dolan Rj
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012;109(19):7511-6

Dopamine Modulates Episodic Memory Persistence in Old Age
Chowdhury R, Guitart-masip M, Bunzeck N, Dolan Rj, Duzel E
JOURNAL OF NEUROSCIENCE 2012;32(41):14193-204

Go and no-go learning in reward and punishment: Interactions between affect and effect
Guitart-masip M, Nuys Qjm, Fuentemilla L, Dayan P, Duzel E, Dolan Rj
NEUROIMAGE 2012;62(1):154-66

How Dopamine Enhances an Optimism Bias in Humans
Sharot T, Guitart-masip M, Korn Cw, Chowdhury R, Dolan Rj
CURRENT BIOLOGY 2012;22(16):1477-81

Human responses to unfairness with primary rewards and their biological limits
Wright Nd, Hodgson K, Fleming Sm, Symmonds M, Guitart-masip M, Dolan Rj
SCIENTIFIC REPORTS 2012;:593-

Action Dominates Valence in Anticipatory Representations in the Human Striatum and Dopaminergic Midbrain
Guitart-masip M, Fuentemilla L, Bach Dr, Huys Qjm, Dayan P, Dolan Rj, et al
JOURNAL OF NEUROSCIENCE 2011;31(21):7867-75

Contextual Novelty Modulates the Neural Dynamics of Reward Anticipation
Bunzeck N, Guitart-masip M, Dolan Rj, Duzel E
JOURNAL OF NEUROSCIENCE 2011;31(36):12816-22

Dopamine and effort-based decision making
Kurniawan It, Guitart-masip M, Dolan Rj
Frontiers in neuroscience 2011;5():81-

Two-way avoidance acquisition is negatively related to conditioned freezing and positively associated with startle reactions: A dissection of anxiety and fear in genetically heterogeneous rats
Vicens-costa E, Martinez-membrives E, Lopez-aumatell R, Guitart-masip M, Canete T, Blazquez G, et al
PHYSIOLOGY & BEHAVIOR 2011;103(2):148-56

Vigor in the Face of Fluctuating Rates of Reward: An Experimental Examination
Guitart-masip M, Beierholm Ur, Dolan R, Duzel E, Dayan P
JOURNAL OF COGNITIVE NEUROSCIENCE 2011;23(12):3933-8

Conditioned associations and economic decision biases
Guitart-masip M, Talmi D, Dolan R
NEUROIMAGE 2010;53(1):206-14

Contextual Novelty Changes Reward Representations in the Striatum
Guitart-masip M, Bunzeck N, Stephan Ke, Dolan Rj, Duzel E
JOURNAL OF NEUROSCIENCE 2010;30(5):1721-6

NOvelty-related Motivation of Anticipation and exploration by Dopamine (NOMAD): Implications for healthy aging
Duzel E, Bunzeck N, Guitart-masip M, Duzel S
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 2010;34(5):660-9

A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock
Johannesson M, Lopez-aumatell R, Stridh P, Diez M, Tuncel J, Blazquez G, et al
GENOME RESEARCH 2009;19(1):150-8

Functional imaging of the human dopaminergic midbrain
Duzel E, Bunzeck N, Guitart-masip M, Wittmann B, Schott Bh, Tobler Pn
TRENDS IN NEUROSCIENCES 2009;32(6):321-8

Neural correlates of impaired emotional discrimination in borderline personality disorder: An fMRI study
Guitart-masip M, Pascual Jc, Carmona S, Hoekzema E, Berge D, Perez V, et al
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 2009;33(8):1537-45

Unlearned anxiety predicts learned fear: a comparison among heterogeneous rats and the Roman rat strains
López-aumatell R, Vicens-costa E, Guitart-masip M, Martínez-membrives E, Valdar W, Johannesson M, et al
Behavioural brain research 2009;202(1):92-101

Divergent effect of the selective D-3 receptor agonist pd-128,907 on locomotor activity in Roman high- and low-avoidance rats: relationship to NGFI-A gene expression in the Calleja islands
Guitart-masip M, Johansson B, Fernandez-teruel A, Tobena A, Gimenez-llort L
PSYCHOPHARMACOLOGY 2008;196(1):39-49

Effects of naltrexone and acamprosate on alcohol-induced NGFI-A expression in mouse brain
Lindholm J, Guitart-masip M, Hassankhali H, Landgren S, Nicoleau C, Giménez-llort L, et al
Neurochemical research 2008;33(10):2062-9

Fearfulness in a large N/Nih genetically heterogeneous rat stock: differential profiles of timidity and defensive flight in males and females
Lopez-aumatell R, Guitart-masip M, Vicens-costa E, Gimenez-llort L, Valdar W, Johannesson M, et al
Behavioural brain research 2008;188(1):41-55

Regional adaptations in PSD-95, NGFI-A and secretogranin gene transcripts related to vulnerability to behavioral sensitization to amphetamine in the Roman rat strains
Guitart-masip M, Johansson B, Canete T, Fernandez-teruel A, Tobena A, Terenius L, et al
NEUROSCIENCE 2008;151(1):195-208

Divergent anatomical pattern of D-1 and D-3 binding and dopamine- and cyclic AMP-regulated phosphoprotein of 32 kDa mRNA expression in the Roman rat strains: Implications for drug addiction
Guitart-masip M, Johansson B, Fernandez-teruel A, Canete T, Tobena A, Terenius L, et al
NEUROSCIENCE 2006;142(4):1231-43

Reduced ethanol response in the alcohol-preferring RHA rats and neuropeptide mRNAs in relevant structures
Guitart-masip M, Gimenez-llort L, Fernandez-teruel A, Canete T, Tobena A, Ogren So, et al
EUROPEAN JOURNAL OF NEUROSCIENCE 2006;23(2):531-40

Two distinctive apomorphine-induced phenotypes in the Roman high- and low-avoidance rats
Gimenez-llort L, Canete T, Guitart-masip M, Fernandez-teruel A, Tobena A
PHYSIOLOGY & BEHAVIOR 2005;86(4):458-66

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