Martin Enge

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(26):e2201267119

Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development.

Duvall E; Benitez CM; Tellez K; Enge M; Pauerstein PT; Li L; Baek S; Quake SR; Smith JP; Sheffield NC; Kim SK; Arda HE
Article: NATURE COMMUNICATIONS. 2022;13(1):1854

Elastic dosage compensation by X-chromosome upregulation.

Lentini A; Cheng H; Noble JC; Papanicolaou N; Coucoravas C; Andrews N; Deng Q; Enge M; Reinius B
Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20

An overlooked subset of Cx3cr1wt/wt microglia in the Cx3cr1CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1CreER-Eyfp/wt microglia following microglial depletion.

Zhou K; Han J; Lund H; Boggavarapu NR; Lauschke VM; Goto S; Cheng H; Wang Y; Tachi A; Xie C; Zhu K; Sun Y; Osman AM; Liang D; Han W; Gemzell-Danielsson K; Betsholtz C; Zhang X-M; Zhu C; Enge M; Joseph B; Harris RA; Blomgren K
Article: JOURNAL OF NEUROSCIENCE. 2021;41(40):8441-8459

Spinal Cord Injury Induces Permanent Reprogramming of Microglia into a Disease-Associated State Which Contributes to Functional Recovery.

Hakim R; Zachariadis V; Sankavaram SR; Han J; Harris RA; Brundin L; Enge M; Svensson M
Article: NATURE METHODS. 2021;18(8):912-920

An unsupervised method for physical cell interaction profiling of complex tissues.

Andrews N; Serviss JT; Geyer N; Andersson AB; Dzwonkowska E; Šutevski I; Heijboer R; Baryawno N; Gerling M; Enge M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(2):e2017849118

Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.

Cui L; Moraga I; Lerbs T; Van Neste C; Wilmes S; Tsutsumi N; Trotman-Grant AC; Gakovic M; Andrews S; Gotlib J; Darmanis S; Enge M; Quake S; Hitchcock IS; Piehler J; Garcia KC; Wernig G
Article: MOLECULAR CELL. 2020;80(3):541-553.e5

A Highly Scalable Method for Joint Whole-Genome Sequencing and Gene-Expression Profiling of Single Cells.

Zachariadis V; Cheng H; Andrews N; Enge M
Article: SCIENTIFIC REPORTS. 2019;9(1):5592

Modeling Spatial Correlation of Transcripts with Application to Developing Pancreas.

Liu R; Mignardi M; Jones R; Enge M; Kim SK; Quake SR; Zou J
Article: CELL. 2017;171(2):321-330.e14

Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns.

Enge M; Arda HE; Mignardi M; Beausang J; Bottino R; Kim SK; Quake SR
Article: CELL METABOLISM. 2017;25(3):622-634

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

Chakravarthy H; Gu X; Enge M; Dai X; Wang Y; Damond N; Downie C; Liu K; Wang J; Xing Y; Chera S; Thorel F; Quake S; Oberholzer J; MacDonald PE; Herrera PL; Kim SK
Article: NATURE. 2015;527(7578):384-388

DNA-dependent formation of transcription factor pairs alters their binding specificity.

Jolma A; Yin Y; Nitta KR; Dave K; Popov A; Taipale M; Enge M; Kivioja T; Morgunova E; Taipale J
Article: NATURE GENETICS. 2015;47(7):818-821

CTCF/cohesin-binding sites are frequently mutated in cancer.

Katainen R; Dave K; Pitkänen E; Palin K; Kivioja T; Välimäki N; Gylfe AE; Ristolainen H; Hänninen UA; Cajuso T; Kondelin J; Tanskanen T; Mecklin J-P; Järvinen H; Renkonen-Sinisalo L; Lepistö A; Kaasinen E; Kilpivaara O; Tuupanen S; Enge M; Taipale J; Aaltonen LA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(23):7285-7290

A survey of human brain transcriptome diversity at the single cell level.

Darmanis S; Sloan SA; Zhang Y; Enge M; Caneda C; Shuer LM; Hayden Gephart MG; Barres BA; Quake SR
Article: NATURE COMMUNICATIONS. 2015;6:6178

Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.

Jäger R; Migliorini G; Henrion M; Kandaswamy R; Speedy HE; Heindl A; Whiffin N; Carnicer MJ; Broome L; Dryden N; Nagano T; Schoenfelder S; Enge M; Yuan Y; Taipale J; Fraser P; Fletcher O; Houlston RS
Article: CELL. 2013;154(4):801-813

Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites.

Yan J; Enge M; Whitington T; Dave K; Liu J; Sur I; Schmierer B; Jolma A; Kivioja T; Taipale M; Taipale J
Article: CELL. 2013;152(1-2):327-339

DNA-binding specificities of human transcription factors.

Jolma A; Yan J; Whitington T; Toivonen J; Nitta KR; Rastas P; Morgunova E; Enge M; Taipale M; Wei G; Palin K; Vaquerizas JM; Vincentelli R; Luscombe NM; Hughes TR; Lemaire P; Ukkonen E; Kivioja T; Taipale J
Article: SCIENCE. 2012;338(6112):1360-1363

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

Sur IK; Hallikas O; Vähärautio A; Yan J; Turunen M; Enge M; Taipale M; Karhu A; Aaltonen LA; Taipale J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(35):29336-29347

Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo.

Smith SD; Enge M; Bao W; Thullberg M; Costa TDF; Olofsson H; Gashi B; Selivanova G; Strömblad S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(48):41600-41615

Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer.

Zawacka-Pankau J; Grinkevich VV; Hünten S; Nikulenkov F; Gluch A; Li H; Enge M; Kel A; Selivanova G
Article: NATURE METHODS. 2011;9(1):72-74

Counting absolute numbers of molecules using unique molecular identifiers.

Kivioja T; Vähärautio A; Karlsson K; Bonke M; Enge M; Linnarsson S; Taipale J
Article: SCIENCE. 2011;334(6053):252-255

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.

Mäkinen N; Mehine M; Tolvanen J; Kaasinen E; Li Y; Lehtonen HJ; Gentile M; Yan J; Enge M; Taipale M; Aavikko M; Katainen R; Virolainen E; Böhling T; Koski TA; Launonen V; Sjöberg J; Taipale J; Vahteristo P; Aaltonen LA
Article: CELL CYCLE. 2011;10(19):3346-3358

Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2.

Li H; Lakshmikanth T; Garofalo C; Enge M; Spinnler C; Anichini A; Szekely L; Kärre K; Carbone E; Selivanova G
Article: EMBO JOURNAL. 2010;29(13):2147-2160

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo.

Wei G-H; Badis G; Berger MF; Kivioja T; Palin K; Enge M; Bonke M; Jolma A; Varjosalo M; Gehrke AR; Yan J; Talukder S; Turunen M; Taipale M; Stunnenberg HG; Ukkonen E; Hughes TR; Bulyk ML; Taipale J
Article: GENOME RESEARCH. 2010;20(6):861-873

Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities.

Jolma A; Kivioja T; Toivonen J; Cheng L; Wei G; Enge M; Taipale M; Vaquerizas JM; Yan J; Sillanpää MJ; Bonke M; Palin K; Talukder S; Hughes TR; Luscombe NM; Ukkonen E; Taipale J
Article: CANCER CELL. 2009;15(5):441-453

Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis.

Grinkevich VV; Nikulenkov F; Shi Y; Enge M; Bao W; Maljukova A; Gluch A; Kel A; Sangfelt O; Selivanova G
Article: CANCER CELL. 2009;15(3):171-183

MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53.

Enge M; Bao W; Hedström E; Jackson SP; Moumen A; Selivanova G
Article: EXPERIMENTAL CELL RESEARCH. 2009;315(3):451-461

Tumor-specific induction of apoptosis by a p53-reactivating compound.

Hedström E; Issaeva N; Enge M; Selivanova G
Article: NATURE MEDICINE. 2004;10(12):1321-1328

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

Issaeva N; Bozko P; Enge M; Protopopova M; Verhoef LGGC; Masucci M; Pramanik A; Selivanova G
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Anställningar

Senior Forskare, Onkologi-Patologi, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Experimentell onkologi, Karolinska Institutet, 2023
Medicine Doktorsexamen, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2009

Artiklar

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI