Lars-Arne Haldosen

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: CANCER LETTERS. 2021;506:23-34

Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor.

Song D; He H; Sinha I; Hases L; Yan F; Archer A; Haldosen L-A; Zhao C; Williams C
Article: ONCOGENE. 2019;38(28):5725-5738

Endogenous interaction profiling identifies DDX5 as an oncogenic coactivator of transcription factor Fra-1.

He H; Song D; Sinha I; Hessling B; Li X; Haldosen L-A; Zhao C
Article: ONCOGENE. 2018;37(19):2586-2600

c-Jun/AP-1 overexpression reprograms ERα signaling related to tamoxifen response in ERα-positive breast cancer.

He H; Sinha I; Fan R; Haldosen L-A; Yan F; Zhao C; Dahlman-Wright K
Article: PLOS ONE. 2018;13(5):e0197183

Expression of the three components of linear ubiquitin assembly complex in breast cancer.

Kharman-Biz A; Gao H; Ghiasvand R; Haldosen L-A; Zendehdel K
Article: ONCOTARGET. 2017;8(44):76622-76633

Estrogen receptor β2 induces proliferation and invasiveness of triple negative breast cancer cells: association with regulation of PHD3 and HIF-1α.

Bialesova L; Xu L; Gustafsson J-Å; Haldosen L-A; Zhao C; Dahlman-Wright K
Article: CANCER RESEARCH. 2016;76(19):5634-5646

Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism.

Jia M; Andreassen T; Jensen L; Bathen TF; Sinha I; Gao H; Zhao C; Haldosen L-A; Cao Y; Girnita L; Moestue SA; Dahlman-Wright K
Article: ADVANCED FUNCTIONAL MATERIALS. 2015;25(42):6596-6605

Linear Dendritic Block Copolymers as Promising Biomaterials for the Manufacturing of Soft Tissue Adhesive Patches Using Visible Light Initiated Thiol-Ene Coupling Chemistry

Granskog V; Andren OCJ; Cai Y; Gonzalez-Granillo M; Fellander-Tsai L; von Holst H; Haldosen L-A; Malkoch M
Article: ONCOTARGET. 2015;6(32):33623-33635

Induction of USP17 by combining BET and HDAC inhibitors in breast cancer cells.

Borbely G; Haldosen L-A; Dahlman-Wright K; Zhao C
Article: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH. 2013;8:30

Diclofenac and triamcinolone acetonide impair tenocytic differentiation and promote adipocytic differentiation of mesenchymal stem cells.

Fredriksson M; Li Y; Stålman A; Haldosén L-A; Felländer-Tsai L
Article: CARCINOGENESIS. 2012;33(8):1502-1511

MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer.

Aydoğdu E; Katchy A; Tsouko E; Lin C-Y; Haldosén L-A; Helguero L; Williams C
Article: BREAST CANCER RESEARCH. 2011;13(2):R43

Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity.

Lindberg K; Helguero LA; Omoto Y; Gustafsson J-Å; Haldosén L-A
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2010;222(1):156-167

Expression of estrogen receptor beta increases integrin alpha1 and integrin beta1 levels and enhances adhesion of breast cancer cells.

Lindberg K; Ström A; Lock JG; Gustafsson J-A; Haldosén L-A; Helguero LA
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2009;609(1-3):13-18

Resveratrol inhibits proliferation and promotes apoptosis of osteosarcoma cells.

Li Y; Bäckesjö C-M; Haldosén L-A; Lindgren U
Article: BREAST CANCER RESEARCH. 2009;11(3):R26

Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression.

Williams C; Helguero L; Edvardsson K; Haldosén L-A; Gustafsson J-A
Article: CANCER RESEARCH. 2008;68(21):8695-8704

Different roles of estrogen receptors alpha and beta in the regulation of E-cadherin protein levels in a mouse mammary epithelial cell line.

Helguero LA; Lindberg K; Gardmo C; Schwend T; Gustafsson J-A; Haldosén L-A
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2008;112(1-3):110-116

Species difference exists in the effects of 1alpha,25(OH)(2)D(3) and its analogue 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D(3) (2MD) on osteoblastic cells.

Li Y; Bäckesjö C-M; Haldosén L-A; Lindgren U
Article: CYTOKINE. 2008;43(2):165-173

IL-6 receptor expression and IL-6 effects change during osteoblast differentiation.

Li Y; Bäckesjö C-M; Haldosén L-A; Lindgren U
Article: BIOCHEMICAL JOURNAL. 2007;406(2):343-353

Co-planar 3,3',4,4',5-pentachlorinated biphenyl and non-co-planar 2,2',4,6,6'-pentachlorinated biphenyl differentially induce recruitment of oestrogen receptor alpha to aryl hydrocarbon receptor target genes.

Matthews J; Wihlén B; Heldring N; MacPherson L; Helguero L; Treuter E; Haldosén L-A; Gustafsson J-A
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21(7):993-1002

Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells.

Bäckesjö C-M; Li Y; Lindgren U; Haldosén L-A
Article: ENDOCRINOLOGY. 2006;147(7):3249-3259

DAX-1 expression is regulated during mammary epithelial cell differentiation.

Helguero LA; Hedengran Faulds M; Förster C; Gustafsson J-A; Haldosén L-A
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(8):1371-1380

Peroxisome proliferator-activated receptor gamma regulates expression of signal transducer and activator of transcription 5A.

Olsen H; Haldosén L-A
Article: ONCOGENE. 2005;24(44):6605-6616

Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11.

Helguero LA; Faulds MH; Gustafsson J-A; Haldosén L-A
Article: MOLECULAR ENDOCRINOLOGY. 2004;18(2):412-421

Estrogen receptor functional activity changes during differentiation of mammary epithelial cells.

Faulds MH; Olsen H; Helguero LA; Gustafsson J-A; Haldosén L-A
Article: ENDOCRINOLOGY. 2004;145(1):87-94

Effects of 1alpha,25-dihydroxyvitamin D3 and growth hormone on apoptosis and proliferation in UMR 106 osteoblast-like cells.

Morales O; Samuelsson MKR; Lindgren U; Haldosén L-A
Article: MOLECULAR ENDOCRINOLOGY. 2002;16(11):2571-2581

Transcriptional synergism on the pS2 gene promoter between a p160 coactivator and estrogen receptor-alpha depends on the coactivator subtype, the type of estrogen response element, and the promoter context.

Barkhem T; Haldosén L-A; Gustafsson J-A; Nilsson S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(38):34879-34884

1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells.

Morales O; Faulds MH; Lindgren UJ; Haldosén L-A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;296(1):139-144

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells.

Olsen H; Hedengran Faulds MA; Saharinen P; Silvennoinen O; Haldosén LA
Article: MOLECULAR PHARMACOLOGY. 2002;61(6):1273-1283

pS2 Gene expression in HepG2 cells: complex regulation through crosstalk between the estrogen receptor alpha, an estrogen-responsive element, and the activator protein 1 response element.

Barkhem T; Haldosén L-A; Gustafsson J-A; Nilsson S
Article: MOLECULAR ENDOCRINOLOGY. 2001;15(11):1929-1940

Cross-talk between ERs and signal transducer and activator of transcription 5 is E2 dependent and involves two functionally separate mechanisms.

Faulds MH; Pettersson K; Gustafsson JA; Haldosén LA
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2000;15(11):2284-2290

Growth hormone-regulated intracellular signaling in UMR 106 osteosarcoma cells.

Morales O; Lindgren U; Haldosén LA
Article: MOLECULAR ENDOCRINOLOGY. 1999;13(4):555-565

Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a.

Pircher TJ; Petersen H; Gustafsson JA; Haldosén LA
Article: EXPERIMENTAL CELL RESEARCH. 1998;243(2):347-358

EGF modulates expression of STAT5 in mammary epithelial cells.

Petersen H; Haldosén LA
Article: ENDOCRINOLOGY. 1998;139(4):1815-1824

Desensitization of the growth hormone-induced Janus kinase 2 (Jak 2)/signal transducer and activator of transcription 5 (Stat5)-signaling pathway requires protein synthesis and phospholipase C.

Fernández L; Flores-Morales A; Lahuna O; Sliva D; Norstedt G; Haldosén LA; Mode A; Gustafsson JA
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 1998;138(1-2):1-10

In vitro interaction between STAT 5 and JAK 2; dependence upon phosphorylation status of STAT 5 and JAK 2.

Flores-Morales A; Pircher TJ; Silvennoinen O; Gustafsson JA; Sanchez-Gomez M; Norstedt G; Haldosén LA; Wood TJ
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 1997;133(2):169-176

Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5.

Pircher TJ; Flores-Morales A; Mui AL; Saltiel AR; Norstedt G; Gustafsson JA; Haldosén LA
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 1997;130(1-2):69-81

Specificity of transcription enhancement via the STAT responsive element in the serine protease inhibitor 2.1 promoter.

Wood TJ; Sliva D; Lobie PE; Goullieux F; Mui AL; Groner B; Norstedt G; Haldosén LA
Article: ENDOCRINOLOGY. 1996;137(9):4037-4045

Constitutive nuclear localization of Janus kinases 1 and 2.

Lobie PE; Ronsin B; Silvennoinen O; Haldosén LA; Norstedt G; Morel G
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;225(2):562-569

STAT-like DNA-binding activity in Spodoptera frugiperda cells.

Sliva D; Haldosén LA
Article: EMBO JOURNAL. 1995;14(9):2005-2013

Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity.

Gouilleux F; Pallard C; Dusanter-Fourt I; Wakao H; Haldosen LA; Norstedt G; Levy D; Groner B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(16):9448-9453

Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/Stat 5.

Wood TJ; Sliva D; Lobie PE; Pircher TJ; Gouilleux F; Wakao H; Gustafsson JA; Groner B; Norstedt G; Haldosén LA
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Review: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2014;382(1):665-672

Estrogen receptor beta in breast cancer.

Haldosén L-A; Zhao C; Dahlman-Wright K
Published conference paper: CELLS TISSUES ORGANS. 2009;189(1-4):93-97

Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells.

Bäckesjö C-M; Li Y; Lindgren U; Haldosén L-A
Review: ENDOCRINE REVIEWS. 2005;26(3):465-478

Reflections on the discovery and significance of estrogen receptor beta.

Koehler KF; Helguero LA; Haldosén L-A; Warner M; Gustafsson J-A
Review: PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY. 1997;57:73-94

Stimulation of kinase cascades by growth hormone: a paradigm for cytokine signaling.

Wood TJ; Haldosén LA; Sliva D; Sundsthöm M; Norstedt G

Anställningar

Anknuten till Undervisning/Handledning, Medicin, Solna, Karolinska Institutet, 2024-2024

Examina och utbildning

Docent, molekylär endokrinologi, Karolinska institutet, 1998
Läkarexamen, Karolinska Institutet, 1991

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