Jorge Ruas

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Professor och forskargruppsledare för Molekylär och cellulär arbetsfysiologi vid institutionen för fysiologi och farmakologi.

Artiklar

Article: MOLECULAR METABOLISM. 2024;82:101912

Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition.

Ducommun S; Jannig PR; Cervenka I; Murgia M; Mittenbühler MJ; Chernogubova E; Dias JM; Jude B; Correia JC; Van Vranken JG; Ocana-Santero G; Porsmyr-Palmertz M; McCann Haworth S; Martínez-Redondo V; Liu Z; Carlström M; Mann M; Lanner JT; Teixeira AI; Maegdefessel L; Spiegelman BM; Ruas JL
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2024;103(1):151377

Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration.

Nunes MJ; Carvalho AN; Sá-Lemos C; Colaço M; Cervenka I; Ciraci V; Santos SG; Ribeiro MM; Castanheira M; Jannig PR; Gama MJ; Castro-Caldas M; Rodrigues CMP; Rodrigues E; Ruas JL
Article: NATURE NANOTECHNOLOGY. 2024;19(2):237-245

Multivalent insulin receptor activation using insulin-DNA origami nanostructures.

Spratt J; Dias JM; Kolonelou C; Kiriako G; Engström E; Petrova E; Karampelias C; Cervenka I; Papanicolaou N; Lentini A; Reinius B; Andersson O; Ambrosetti E; Ruas JL; Teixeira AI
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(2):166980

NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease.

Caria I; Nunes MJ; Ciraci V; Carvalho AN; Ranito C; Santos SG; Gama MJ; Castro-Caldas M; Rodrigues CMP; Ruas JL; Rodrigues E
Journal article: TOXICOLOGY LETTERS. 2023;384(Front. Cell Dev. Biol. 9 2021):s188-S193

P16-19: The role of glucose homeostasis and glucocorticoid signalling for the development of relevant hepatic in vitro models for toxicology, drug metabolism and energy metabolism studies

Rodrigues JS; Faria-Pereira A; Camões SP; Serras AS; Morais VA; Ruas JL; Miranda JP
Article: CELL REPORTS. 2023;42(1):112021

Epiblast-like stem cells established by Wnt/β-catenin signaling manifest distinct features of formative pluripotency and germline competence.

Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Chen X; Petropoulos S; Ruas JL; Wu J; Deng Q
Journal article: NATURE NANOTECHNOLOGY. 2023

Multivalent insulin receptor activation using insulin-DNA origami nanostructures

Spratt J; Dias JM; Kolonelou C; Kiriako G; Engstrom E; Petrova E; Karampelias C; Cervenka I; Papanicolaou N; Lentini A; Reinius B; Andersson O; Ambrosetti E; Ruas JL; Teixeira AI
Article: CELLS. 2022;11(19):2944

PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes.

Tuomainen T; Naumenko N; Mutikainen M; Shakirzyanova A; Sczelecki S; Estall JL; Ruas JL; Tavi P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(9):102328

Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias.

Schihada H; Klompstra TM; Humphrys LJ; Cervenka I; Dadvar S; Kolb P; Ruas JL; Schulte G
Article: BMC BIOLOGY. 2022;20(1):169

Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity.

Oehler D; Spychala A; Gödecke A; Lang A; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
Article: NATURE METABOLISM. 2022;4(6):739-758

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.

Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sörensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: CARDIOVASCULAR RESEARCH. 2022;118(6):1520-1534

PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice.

Naumenko N; Mutikainen M; Holappa L; Ruas JL; Tuomainen T; Tavi P
Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(638):eaba9112

HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes.

Ilegems E; Bryzgalova G; Correia J; Yesildag B; Berra E; Ruas JL; Pereira TS; Berggren P-O
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2022;322(1):C49-C62

Changes in plasma concentration of kynurenine following intake of branched-chain amino acids are not caused by alterations in muscle kynurenine metabolism.

Jonsson WO; Ponette J; Horwath O; Rydenstam T; Söderlund K; Ekblom B; Azzolini M; Ruas JL; Blomstrand E
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:1043543

Improving human mesenchymal stem cell-derived hepatic cell energy metabolism by manipulating glucose homeostasis and glucocorticoid signaling.

Rodrigues JS; Faria-Pereira A; Camões SP; Serras AS; Morais VA; Ruas JL; Miranda JP
Article: FASEB JOURNAL. 2021;35(12):e22010

Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force.

Liu Z; Chaillou T; Santos Alves E; Mader T; Jude B; Ferreira DMS; Hynynen H; Cheng AJ; Jonsson WO; Pironti G; Andersson DC; Kenne E; Ruas JL; Tavi P; Lanner JT
Article: CELL METABOLISM. 2021;33(11):2215-2230.e8

Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity.

Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Shvaikovskaya D; Zhengye L; Cervenka I; Khan N; Stec M; Oliveira M; Nijssen J; Martínez-Redondo V; Ducommun S; Azzolini M; Lanner JT; Kleiner S; Hedlund E; Ruas JL
Article: NATURE COMMUNICATIONS. 2021;12(1):5948

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism.

Massart J; Sjögren RJO; Egan B; Garde C; Lindgren M; Gu W; Ferreira DMS; Katayama M; Ruas JL; Barrès R; O'Gorman DJ; Zierath JR; Krook A
Article: METABOLITES. 2021;11(8):508

Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans.

Valente-Silva P; Cervenka I; Ferreira DMS; Correia JC; Edman S; Horwath O; Heng B; Chow S; Jacobs KR; Guillemin GJ; Blomstrand E; Ruas JL
Article: BIOTECHNOLOGY AND BIOENGINEERING. 2021;118(6):2234-2242

Effects of topological constraints on the alignment and maturation of multinucleated myotubes.

Song K-Y; Correia JC; Ruas JL; Teixeira AI
Article: BMC BIOLOGY. 2021;19(1):57

Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling.

Naia L; Pinho CM; Dentoni G; Liu J; Leal NS; Ferreira DMS; Schreiner B; Filadi R; Fão L; Connolly NMC; Forsell P; Nordvall G; Shimozawa M; Greotti E; Basso E; Theurey P; Gioran A; Joselin A; Arsenian-Henriksson M; Nilsson P; Rego AC; Ruas JL; Park D; Bano D; Pizzo P; Prehn JHM; Ankarcrona M
Article: SCIENTIFIC REPORTS. 2021;11(1):6453

High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles.

Moberg M; Apró W; Cervenka I; Ekblom B; van Hall G; Holmberg H-C; Ruas JL; Blomstrand E
Article: NATURE COMMUNICATIONS. 2021;12(1):1026

Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice.

Wu H; Petitpré C; Fontanet P; Sharma A; Bellardita C; Quadros RM; Jannig PR; Wang Y; Heimel JA; Cheung KKY; Wanderoy S; Xuan Y; Meletis K; Ruas J; Gurumurthy CB; Kiehn O; Hadjab S; Lallemend F
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):541

Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes.

Hahn M; van Krieken PP; Nord C; Alanentalo T; Morini F; Xiong Y; Eriksson M; Mayer J; Kostromina E; Ruas JL; Sharpe J; Pereira T; Berggren P-O; Ilegems E; Ahlgren U
Article: MOLECULAR METABOLISM. 2020;39:101012

Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN.

Alves CRR; Neves WD; de Almeida NR; Eichelberger EJ; Jannig PR; Voltarelli VA; Tobias GC; Bechara LRG; de Paula Faria D; Alves MJN; Hagen L; Sharma A; Slupphaug G; Moreira JBN; Wisloff U; Hirshman MF; Negrão CE; de Castro G; Chammas R; Swoboda KJ; Ruas JL; Goodyear LJ; Brum PC
Article: NURSING OPEN. 2020;7(5):1446-1452

A qualitative study-Patient experience of tactile massage after stroke.

Seiger Cronfalk B; Åkesson E; Nygren J; Nyström A; Strandell A-M; Ruas J; von Euler M
Article: MOLECULAR METABOLISM. 2020;34:72-84

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments.

Léveillé M; Besse-Patin A; Jouvet N; Gunes A; Sczelecki S; Jeromson S; Khan NP; Baldwin C; Dumouchel A; Correia JC; Jannig PR; Boulais J; Ruas JL; Estall JL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):2978-2986

Modeling the transport of nuclear proteins along single skeletal muscle cells.

Taylor-Weiner H; Grigsby CL; Ferreira DMS; Dias JM; Stevens MM; Ruas JL; Teixeira AI
Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:591476

Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats.

Kelahmetoglu Y; Jannig PR; Cervenka I; Koch LG; Britton SL; Zhou J; Wang H; Robinson MM; Nair KS; Ruas JL
Article: REDOX BIOLOGY. 2020;28:101387

Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status.

Peleli M; Ferreira DMS; Tarnawski L; McCann Haworth S; Xuechen L; Zhuge Z; Newton PT; Massart J; Chagin AS; Olofsson PS; Ruas JL; Weitzberg E; Lundberg JO; Carlström M
Article: SKELETAL MUSCLE. 2019;9(1):26

LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force.

Ferreira DMS; Cheng AJ; Agudelo LZ; Cervenka I; Chaillou T; Correia JC; Porsmyr-Palmertz M; Izadi M; Hansson A; Martínez-Redondo V; Valente-Silva P; Pettersson-Klein AT; Estall JL; Robinson MM; Nair KS; Lanner JT; Ruas JL
Article: NATURE COMMUNICATIONS. 2019;10(1):2767

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.

Agudelo LZ; Ferreira DMS; Dadvar S; Cervenka I; Ketscher L; Izadi M; Zhengye L; Furrer R; Handschin C; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Ruas JL
Article: CARDIOVASCULAR RESEARCH. 2019;115(1):107-118

Heart specific PGC-1α deletion identifies metabolome of cardiac restricted metabolic heart failure.

Kärkkäinen O; Tuomainen T; Mutikainen M; Lehtonen M; Ruas JL; Hanhineva K; Tavi P
Journal article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13

Activation of the Unfolded Protein Response in Parkinson's disease

Carvalho A; Ranito C; Tavares C; Castro-Caldas M; Rodrigues E; Ruas J; Van Horssen J; Gama M
Journal article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13

Unanswered role of cholesterol homeostasis in Parkinson’s disease

Nunes M; Caria I; Carvalho A; Costa D; Castro-Caldas M; Gama M; Rodrigues E; Ruas J
Article: PHYSIOLOGICAL GENOMICS. 2018;50(12):1071-1082

Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice.

Blackwell TA; Cervenka I; Khatri B; Brown JL; Rosa-Caldwell ME; Lee DE; Perry RA; Brown LA; Haynie WS; Wiggs MP; Bottje WG; Washington TA; Kong BC; Ruas JL; Greene NP
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(5):519-533

The weight of nutrients: kynurenine metabolites in obesity and exercise.

Dadvar S; Ferreira DMS; Cervenka I; Ruas JL
Article: EMBO MOLECULAR MEDICINE. 2018;10(8):e8613

Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.

Bayindir-Buchhalter I; Wolff G; Lerch S; Sijmonsma T; Schuster M; Gronych J; Billeter AT; Babaei R; Krunic D; Ketscher L; Spielmann N; Hrabe de Angelis M; Ruas JL; Müller-Stich BP; Heikenwalder M; Lichter P; Herzig S; Vegiopoulos A
Journal article: IBJ PLUS. 2018

Exploring the regulation of frataxin expression by neurotrophic factors in the mouse cerebellum after physical exercise.

Agró M; Díaz Nido J; Giménez Cassina A; Katsu Jiménez Y; da Silva P; Ruas J
Article: MOLECULAR METABOLISM. 2018;9:28-42

Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration.

Pettersson-Klein AT; Izadi M; Ferreira DMS; Cervenka I; Correia JC; Martinez-Redondo V; Southern M; Cameron M; Kamenecka T; Agudelo LZ; Porsmyr-Palmertz M; Martens U; Lundgren B; Otrocka M; Jenmalm-Jensen A; Griffin PR; Ruas JL
Article: CELL METABOLISM. 2018;27(2):378-392.e5

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.

Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martínez-Redondo V; Ueland PM; Midttun Ø; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
Journal article: ANNALS OF RESEARCH IN SPORT AND PHYSICAL ACTIVITY. 2018;(ex2018):79-80

Effects of exercise training on kynurenines, metabolism, and mental health

Ruas JL
Article: MOLECULAR METABOLISM. 2018;7:12-22

Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation.

Mills R; Taylor-Weiner H; Correia JC; Agudelo LZ; Allodi I; Kolonelou C; Martinez-Redondo V; Ferreira DMS; Nichterwitz S; Comley LH; Lundin V; Hedlund E; Ruas JL; Teixeira AI
Journal article: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY. 2017;27(4):7218

Report and Abstracts of the 14th Meeting of IIM, the Interuniversity Institute of Myology, - Assisi (Italy), October 12-15, 2017

Gabellini D; Musarò A
Article: ARCHIVES OF TOXICOLOGY. 2017;91(6):2469-2489

The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells.

Cipriano M; Correia JC; Camões SP; Oliveira NG; Cruz P; Cruz H; Castro M; Ruas JL; Santos JM; Miranda JP
Article: CELL REPORTS. 2017;18(3):636-646

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.

Ruby MA; Massart J; Hunerdosse DM; Schönke M; Correia JC; Louie SM; Ruas JL; Näslund E; Nomura DK; Zierath JR
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(23):7049-7071

Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling.

Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Laidinen S; Kokki K; Hynynen H; Ylä-Herttuala S; Heinäniemi M; Ruas JL; Tavi P
Article: SCIENTIFIC REPORTS. 2016;6:30928

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.

Moutinho M; Nunes MJ; Correia JC; Gama MJ; Castro-Caldas M; Cedazo-Minguez A; Rodrigues CMP; Björkhem I; Ruas JL; Rodrigues E
Article: SCIENCE TRANSLATIONAL MEDICINE. 2016;8(350):350ra103

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction.

Salah H; Li M; Cacciani N; Gastaldello S; Ogilvie H; Akkad H; Namuduri AV; Morbidoni V; Artemenko KA; Balogh G; Martinez-Redondo V; Jannig P; Hedström Y; Dworkin B; Bergquist J; Ruas J; Vigh L; Salviati L; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(15):4371-4388

Mechano-signalling pathways in an experimental intensive critical illness myopathy model.

Corpeno Kalamgi R; Salah H; Gastaldello S; Martinez-Redondo V; Ruas JL; Fury W; Bai Y; Gromada J; Sartori R; Guttridge DC; Sandri M; Larsson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(29):15169-15184

Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes.

Martínez-Redondo V; Jannig PR; Correia JC; Ferreira DMS; Cervenka I; Lindvall JM; Sinha I; Izadi M; Pettersson-Klein AT; Agudelo LZ; Gimenez-Cassina A; Brum PC; Dahlman-Wright K; Ruas JL
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2016;310(10):C836-C840

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans.

Schlittler M; Goiny M; Agudelo LZ; Venckunas T; Brazaitis M; Skurvydas A; Kamandulis S; Ruas JL; Erhardt S; Westerblad H; Andersson DC
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(50):15492-15497

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise.

Place N; Ivarsson N; Venckunas T; Neyroud D; Brazaitis M; Cheng AJ; Ochala J; Kamandulis S; Girard S; Volungevičius G; Paužas H; Mekideche A; Kayser B; Martinez-Redondo V; Ruas JL; Bruton J; Truffert A; Lanner JT; Skurvydas A; Westerblad H
Article: MOLECULAR METABOLISM. 2015;4(12):891-902

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.

Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martínez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Björnholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(44):15756-15761

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.

White JP; Wrann CD; Rao RR; Nair SK; Jedrychowski MP; You J-S; Martínez-Redondo V; Gygi SP; Ruas JL; Hornberger TA; Wu Z; Glass DJ; Piao X; Spiegelman BM
Article: CELL. 2014;159(1):33-45

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.

Agudelo LZ; Femenía T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: CELL. 2014;157(6):1279-1291

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.

Rao RR; Long JZ; White JP; Svensson KJ; Lou J; Lokurkar I; Jedrychowski MP; Ruas JL; Wrann CD; Lo JC; Camera DM; Lachey J; Gygi S; Seehra J; Hawley JA; Spiegelman BM
Article: MOLECULAR CANCER. 2014;13:54

Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways.

Aesoy R; Gradin K; Aasrud KS; Hoivik EA; Ruas JL; Poellinger L; Bakke M
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(2):E157-E167

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.

Sczelecki S; Besse-Patin A; Abboud A; Kleiner S; Laznik-Bogoslavski D; Wrann CD; Ruas JL; Haibe-Kains B; Estall JL
Journal article: FASEB JOURNAL. 2013;27(S1):940.18

A novel PGC‐1á isoform induced by resistance training regulates skeletal muscle hypertrophy

White J; Ruas J; Rao R; Kleiner S; Wu J; Spiegelman B
Article: CELL. 2012;151(6):1319-1331

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.

Ruas JL; White JP; Rao RR; Kleiner S; Brannan KT; Harrison BC; Greene NP; Wu J; Estall JL; Irving BA; Lanza IR; Rasbach KA; Okutsu M; Nair KS; Yan Z; Leinwand LA; Spiegelman BM
Article: GENES & DEVELOPMENT. 2011;25(12):1232-1244

Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase.

Lustig Y; Ruas JL; Estall JL; Lo JC; Devarakonda S; Laznik D; Choi JH; Ono H; Olsen JV; Spiegelman BM
Article: CELL METABOLISM. 2011;13(2):160-169

The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex.

Wu J; Ruas JL; Estall JL; Rasbach KA; Choi JH; Ye L; Boström P; Tyra HM; Crawford RW; Campbell KP; Rutkowski DT; Kaufman RJ; Spiegelman BM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(50):21866-21871

PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.

Rasbach KA; Gupta RK; Ruas JL; Wu J; Naseri E; Estall JL; Spiegelman BM
Article: DEVELOPMENT. 2010;137(20):3489-3499

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons.

Chakkalakal JV; Nishimune H; Ruas JL; Spiegelman BM; Sanes JR
Article: NATURE. 2010;466(7305):451-456

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

Choi JH; Banks AS; Estall JL; Kajimura S; Boström P; Laznik D; Ruas JL; Chalmers MJ; Kamenecka TM; Blüher M; Griffin PR; Spiegelman BM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(4):2601-2609

Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.

Ruas JL; Berchner-Pfannschmidt U; Malik S; Gradin K; Fandrey J; Roeder RG; Pereira T; Poellinger L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(52):22510-22515

PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.

Estall JL; Ruas JL; Choi CS; Laznik D; Badman M; Maratos-Flier E; Shulman GI; Spiegelman BM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(50):21401-21406

The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle.

Chinsomboon J; Ruas J; Gupta RK; Thom R; Shoag J; Rowe GC; Sawada N; Raghuram S; Arany Z
Article: GENES & DEVELOPMENT. 2008;22(10):1397-1409

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.

Kajimura S; Seale P; Tomaru T; Erdjument-Bromage H; Cooper MP; Ruas JL; Chin S; Tempst P; Lazar MA; Spiegelman BM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3368-3373

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

Zheng X; Linke S; Dias JM; Zheng X; Gradin K; Wallis TP; Hamilton BR; Gustafsson M; Ruas JL; Wilkins S; Bilton RL; Brismar K; Whitelaw ML; Pereira T; Gorman JJ; Ericson J; Peet DJ; Lendahl U; Poellinger L
Article: NATURE. 2008;451(7181):1008-1012

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.

Arany Z; Foo S-Y; Ma Y; Ruas JL; Bommi-Reddy A; Girnun G; Cooper M; Laznik D; Chinsomboon J; Rangwala SM; Baek KH; Rosenzweig A; Spiegelman BM
Article: FASEB JOURNAL. 2007;21(8):1821-1830

Hypoxia inducible factor regulates the cardiac expression and secretion of apelin.

Ronkainen V-P; Ronkainen JJ; Hänninen SL; Leskinen H; Ruas JL; Pereira T; Poellinger L; Vuolteenaho O; Tavi P
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.

Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
Article: DEVELOPMENTAL CELL. 2005;9(5):617-628

Hypoxia requires notch signaling to maintain the undifferentiated cell state.

Gustafsson MV; Zheng X; Pereira T; Gradin K; Jin S; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
Article: JOURNAL OF CELL SCIENCE. 2005;118(Pt 2):301-311

Role of CBP in regulating HIF-1-mediated activation of transcription.

Ruas JL; Poellinger L; Pereira T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(9):6816-6823

Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.

Pereira T; Zheng X; Ruas JL; Tanimoto K; Poellinger L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(41):38723-38730

Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein.

Ruas JL; Poellinger L; Pereira T
Article: PHARMACOGENETICS AND GENOMICS. 1997;7(4):333-335

Allele frequency of CYP2C19 in a Portuguese population.

Ruas JL; Lechner MC
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Preprint: BIORXIV. 2023

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Pham TCP; Raun SH; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig PR; Andersen NR; Kruse R; Ali MS; Halling JF; Ringholm S; Needham EJ; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas JL; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
Preprint: BIORXIV. 2023

A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue

Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Preprint: BIORXIV. 2023;BIORXIV

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration.

Correia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Præstholm SM; Dumont K; Liu Z; Liang Q; Edsgärd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Yeo GW; Ruas JL
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:839.1-83839

SKELETAL MUSCLE PGC1.1 PREVENTS ARTHRITIS-INDUCED CAPILLARY RAREFACTION AND IMPAIRED GLUCOSE UPTAKE

Jude B; Chibalin A; Ducommun S; Zierath J; Von Walden F; Ruas J; Krook A; Lanner J
Conference publication: ACTA PHYSIOLOGICA. 2023;239

Can PGC-1α1 counteract skeletal muscle capillary rarefaction and reduced glucose uptake induced by chronic inflammation?

Jude B; Tagadirt L; Santos-Alves E; Mader T; Chibalin AV; Ducommun S; Zierath JR; Von Walden F; Krook A; Ruas JL; Lanner JT
Conference publication: TOXICOLOGY LETTERS. 2023;384:S188

The role of glucose homeostasis and glucocorticoid signalling for the development of relevant hepatic in vitro models for toxicology, drug metabolism and energy metabolism studies

Saraiva Rodrigues J; Faria-Pereira A; Camoes SP; Serras AS; Morais VA; Ruas JL; Miranda JP
Conference publication: ANNALS OF NUTRITION AND METABOLISM. 2023;79:85

The Tryptophan-Kynurenine pathway in the control of energy metabolism

Ruas JL
Conference publication: ACTA PHYSIOLOGICA. 2023;239

Control of cell-cell communication during muscle remodeling and regeneration by a novel RNA-binding protein

Ruas J
Corrigendum: NATURE METABOLISM. 2022;4(10):1421

Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.

Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sörensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Conference publication: FASEB JOURNAL. 2022;36

Ruxolitinib Prevents Ventilator Induced Diaphragm Dysfunction

Addinsall AB; Cacciani N; Akkad H; Moruzzi N; Maestri A; Shevchenko G; Bergquist J; Ruas J; Larsson L
Editorial comment: CELL. 2022;185(8):1444-1444.e1

SnapShot: Regulation and biology of PGC-1α.

Jannig PR; Dumesic PA; Spiegelman BM; Ruas JL
Preprint: BIORXIV. 2022

Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

Oehler D; Spychala A; Gödecke A; Lang A; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
Conference publication: FEBS OPEN BIO. 2022;12:34

Novel players in the regulation of muscle mass, strength, and regeneration

Ruas J
Preprint: SSRN ELECTRONIC JOURNAL. 2022

Epiblast-Like Stem Cells Established by Wnt/β-Catenin Signaling Manifest Distinct Features of Formative Pluripotency

Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Petropoulos S; Chen X; Ruas JL; Wu J; Deng Q
Review: TRENDS IN MOLECULAR MEDICINE. 2021;27(10):946-954

The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?

Joisten N; Ruas JL; Braidy N; Guillemin GJ; Zimmer P
Preprint: BIORXIV. 2021

Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Svaikovskaya D; Zhengye L; Cervenka I; Oliveira M; Nijssen J; Martínez-Redondo V; Stec M; Khan N; Lanner JT; Kleiner S; Hedlund E; Ruas JL
Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3582

Full-length-transcriptomic analysis in mice and human heart using Single-Molecule Real-time Sequencing (SMRT) identified 15 novel isoforms and a novel promoter region of PGC1-alpha

Oehler D; Goedecke A; Spychala A; Lai K; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
Editorial comment: SCIENCE. 2020;368(6490):470-471

Exercised cytokines promote endurance.

Correia JC; Ruas JL
Review: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2020;318(5):C818-C830

The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain.

Martin KS; Azzolini M; Lira Ruas J
Preprint: BIORXIV. 2019

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

Léveillé M; Besse-Patin A; Jouvet N; Gunes A; Jeromson S; Khan NP; Sczelecki S; Baldwin C; Dumouchel A; Correia J; Jannig P; Boulais J; Ruas JL; Estall JL
Conference publication: TOXICOLOGY LETTERS. 2019;314:S288

Hepatocyte-like cells in microfluidic devices: a new platform for disease modelling, drug screening and toxicology

Rodrigues JS; Cipriano M; Correia J; Camoes SP; Oliveira N; Castro M; Ruas J; Miranda J
Review: SCIENCE. 2017;357(6349):eaaf9794

Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.

Cervenka I; Agudelo LZ; Ruas JL
Editorial comment: ACTA PHYSIOLOGICA. 2017;219(1):14-16

Targeting mitochondrial mRNA translation to tackle obesity-induced insulin resistance: thumbs up for exercise.

Jannig PR; Ruas JL
Conference publication: ACTA PHYSIOLOGICA. 2017;219:16-17

The mitochondrial NDUFA4L2 protein: a novel modulator of skeletal muscle mass and force

Chaillou T; Hynynen H; Ferreira D; Pironti G; Andersson D; Ruas J; Tavi P; Lanner J
Conference publication: ACTA PHYSIOLOGICA. 2017;219:20

Moderate PGC-1α1 expression induces beneficial E-C coupling phenotype without metabolic remodelling

Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Hynynen H; Laidinen S; Yla-Herttuala S; Heinaniemi M; Ruas J; Tavi P
Book chapter: HORMONES, METABOLISM AND THE BENEFITS OF EXERCISE: RESEARCH AND PERSPECTIVES IN ENDOCRINE INTERACTIONS. 2017;p. 83-91

Tryptophan-Kynurenine Metabolites in Exercise and Mental Health

Valente-Silva P; Ruas JL
Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S186

NDUFA4L2-Connecting Metabolic Signals and Mitochondrial Function in Cardiac and Skeletal Muscle

Chaillou T; Hynynen H; Ferreira D; Pironti G; Kenne E; Andersson DC; Ruas JL; Tavi P; Lanner JT
Letter: ACTA NEUROPSYCHIATRICA. 2016;28(4):244-245

Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle.

Zepf FD; Stewart RM; Guillemin G; Ruas JL
Review: DIABETOLOGIA. 2015;58(9):1969-1977

The hitchhiker's guide to PGC-1α isoform structure and biological functions.

Martínez-Redondo V; Pettersson AT; Ruas JL
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2015;26(6):305-314

Intercellular: local and systemic actions of skeletal muscle PGC-1s.

Correia JC; Ferreira DMS; Ruas JL
Corrigendum: CELL. 2015;160(1-2):351

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression (vol 159, pg 33, 2014)

Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson A; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Conference publication: DIABETOLOGIA. 2015;58:S300

Acute exercise impacts kynurenine metabolism in type 2 diabetic and healthy people

Mudry JM; Ruas JL; Erhardt S; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009;29(7):E16-E17

HIF-Independent Regulation of Angiogenesis in Ischemia and Exercise

Arany ZP; Foo S-Y; Chinsomboon J; Girnun G; Cooper M; Ruas J; Bommi-Reddy A; Rangwala S; Baek KH; Rosenzweig A; Spiegelman B
Review: CURRENT OPINION IN LIPIDOLOGY. 2007;18(5):508-514

Modulation of vascular gene expression by hypoxia.

Ruas JL; Lendahl U; Poellinger L
Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2005;16(4-5):514-522

Hypoxia-dependent activation of HIF into a transcriptional regulator.

Ruas JL; Poellinger L
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Forskningsbidrag

Um outro olhar para a prescrição do exercício: Exercício a diferentes horas do dia e o ciclo circadiano em pessoas com diabetes tipo 2 e aqueles que se encontram em risco

Fundação para a Ciência e Tecnologia

1 March 2023 - 31 August 2024
New molecular targets and biomarkers for non-alcoholic fatty liver disease and steatohepatitis (NAFLD/NASH)

Swedish Research Council

1 January 2023 - 31 December 2026
PGC-1alpha Isoforms as novel Therapeutic targets in ParkinsON's Disease

Fundação para a Ciência e Tecnologia

1 August 2018 - 31 July 2022
Molecular Mechanisms Regulating Skeletal Muscle Function and their Systemic Impact

Novo Nordisk Foundation

1 January 2017 - 1 January 2020
Muscle Talks: Local and systemic effects of skeletal muscle mass regulation

Swedish Research Council

1 January 2017 - 31 December 2022
Bench to bedside research on the intensive care unit muscle wasting. Underlying mechanisms, diagnosis and specific interventions

Swedish Research Council

1 January 2016 - 31 December 2019
Novel Molecular Mechanisms and Therapies Regulating Skeletal Muscle Mass and Function.

Swedish Research Council

1 January 2015 - 31 December 2018
Mechanism of transcriptional regulation via skeletal muscle glucocorticoid receptor(Fostering Joint International Research)

Japan Society for the Promotion of Science

1 January 2015 - 31 December 2017
Modeling information flow between tissues during metabolic adaptation and dysfunction

International Human Frontier Science Program Organization

1 May 2014 - 30 April 2017
Mechanisms of Skeletal Muscle Adaptations to Exercise

Novo Nordisk Foundation

19 March 2012 - 18 March 2017
Mechanisms of skeletal muscle adaptation to exercise and their implications in health and disease

Swedish Research Council

1 January 2011 - 31 December 2014
Mechanisms of skeletal muscle adaptation to exercise and their implications in health and disease

Swedish Research Council

1 January 2011 - 31 December 2014
MECHANISM OF HYPOXIA DEPENDENT TRANSCRIPTION ACTIVATION MEDIATED BY THE HYPOXIA-INDUCIBLE FACTOR-1

Fundação para a Ciência e Tecnologia

1 July 1999 - 30 June 2003
STUDY OF THE POLYMORPHISM OF THE CYP2AG AND CYP2C19 GENES IN PORTUGUESE POPULATIONS.

Fundação para a Ciência e Tecnologia

1 August 1996 - 31 July 1998

Anställningar

Professor, Fysiologi och farmakologi, Karolinska Institutet, 2020-

Examina och utbildning

Docent, Molekylär fysiologi, Karolinska Institutet, 2016
MEDICINE DOKTORSEXAMEN, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2005
Pharm.D., Pharmaceutical Sciences, University of Lisbon, 1995

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