John Inge Johnsen | Karolinska Institutet

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Artiklar

Article: NUCLEIC ACIDS RESEARCH. 2024;52(5):2648-2671

METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma.

Vaid R; Thombare K; Mendez A; Burgos-Panadero R; Djos A; Jachimowicz D; Lundberg KI; Bartenhagen C; Kumar N; Tümmler C; Sihlbom C; Fransson S; Johnsen JI; Kogner P; Martinsson T; Fischer M; Mondal T
Article: CANCERS. 2024;16(4):812

Recent Advances in Neuroblastoma Research.

Johnsen JI; Kogner P
Article: JCI INSIGHT. 2024;9(6):e173337

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.

Mei S; Alchahin AM; Embaie BT; Gavriliuc IM; Verhoeven BM; Zhao T; Li X; Jeffries NE; Pepich A; Sarkar H; Olsen TK; Wickström M; Stenman J; Reina-Bedoya O; Kharchenko PV; Saylor PJ; Johnsen JI; Sykes DB; Kogner P; Baryawno N
Article: GENOME MEDICINE. 2024;16(1):1

Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions.

Mei S; Alchahin AM; Tsea I; Kfoury Y; Hirz T; Jeffries NE; Zhao T; Xu Y; Zhang H; Sarkar H; Wu S; Subtelny AO; Johnsen JI; Zhang Y; Salari K; Wu C-L; Randolph MA; Scadden DT; Dahl DM; Shin J; Kharchenko PV; Saylor PJ; Sykes DB; Baryawno N
Article: CANCERS. 2023;15(18):4599

Target Genes of c-MYC and MYCN with Prognostic Power in Neuroblastoma Exhibit Different Expressions during Sympathoadrenal Development.

Yuan Y; Alzrigat M; Rodriguez-Garcia A; Wang X; Bexelius TS; Johnsen JI; Arsenian-Henriksson M; Liaño-Pons J; Bedoya-Reina OC
Article: BRITISH JOURNAL OF CANCER. 2022;127(11):2060-2071

Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246.

Zhou X; Santos GS; Zhan Y; Oliveira MMS; Rezaei S; Singh M; Peuget S; Westerberg LS; Johnsen JI; Selivanova G
Article: JCI INSIGHT. 2022;7(17):e153836

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma.

Olsen TK; Dyberg C; Embaie BT; Alchahin A; Milosevic J; Ding J; Otte J; Tümmler C; Hed Myrberg I; Westerhout EM; Koster J; Versteeg R; Ding H-F; Kogner P; Johnsen JI; Sykes DB; Baryawno N
Article: CELL REPORTS MEDICINE. 2022;3(6):100657

The immune cell atlas of human neuroblastoma.

Verhoeven BM; Mei S; Olsen TK; Gustafsson K; Valind A; Lindström A; Gisselsson D; Fard SS; Hagerling C; Kharchenko PV; Kogner P; Johnsen JI; Baryawno N
Journal article: CANCER RESEARCH. 2022;82(12_Supplement):1677

Abstract 1677: Transcriptomic landscape of medulloblastoma reveals pathways of tumor-stroma remodelling

Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N
Journal article: CANCER RESEARCH. 2022;82(12_Supplement):6215

Abstract 6215: The immune cell atlas of human neuroblastoma

Verhoeven BM; Mei S; Olsen TK; Gustafsson KK; Valind A; Lindström A; Nord DG; Fard SS; Hagerling C; Kharchenko PV; Kogner P; Johnsen JI; Baryawno N
Article: LIFE SCIENCES. 2022;295:120394

Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E2 and suppress tumor growth in medulloblastoma.

Ljungblad L; Bergqvist F; Tümmler C; Madawala S; Olsen TK; Andonova T; Jakobsson P-J; Johnsen JI; Pickova J; Strandvik B; Kogner P; Gleissman H; Wickström M
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(3):182-201

MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner.

Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickström M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(7):3702

The Merkel Cell Polyomavirus T-Antigens and IL-33/ST2-IL1RAcP Axis: Possible Role in Merkel Cell Carcinoma.

Rasheed K; Moens U; Policastro B; Johnsen JI; Koljonen V; Sihto H; Lui W-O; Sveinbjørnsson B
Article: NATURE COMMUNICATIONS. 2022;13(1):1537

GIT1 protects against breast cancer growth through negative regulation of Notch.

Zhang S; Miyakawa A; Wickström M; Dyberg C; Louhivuori L; Varas-Godoy M; Kemppainen K; Kanatani S; Kaczynska D; Ellström ID; Elfman L; Kronqvist P; Repo H; Mikoshiba K; Sahlgren C; Johnsen JI; Uhlén P
Article: BMC GENOMICS. 2022;23(1):149

TC-hunter: identification of the insertion site of a transgenic gene within the host genome.

Börjesson V; Martinez-Monleon A; Fransson S; Kogner P; Johnsen JI; Milosevic J; López MD
Article: JCO PRECISION ONCOLOGY. 2022;6:e2100271

Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation.

Treis D; Umapathy G; Fransson S; Guan J; Mendoza-García P; Siaw JT; Wessman S; Gordon Murkes L; Stenman JJE; Djos A; Elfman LHM; Johnsen JI; Hallberg B; Palmer RH; Martinsson T; Kogner P
Article: NEURO-ONCOLOGY ADVANCES. 2022;4(1):vdac028

Filamin A increases aggressiveness of human neuroblastoma.

Bandaru S; Prajapati B; Juvvuna PK; Dosa S; Kogner P; Johnsen JI; Kanduri C; Akyürek LM
Article: CANCER DISCOVERY. 2021;11(12):3090-3105

Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity.

Zhou X; Singh M; Sanz Santos G; Guerlavais V; Carvajal LA; Aivado M; Zhan Y; Oliveira MMS; Westerberg LS; Annis DA; Johnsen JI; Selivanova G
Article: CANCERS. 2021;13(23):6042

PPM1D Is a Therapeutic Target in Childhood Neural Tumors.

Milosevic J; Treis D; Fransson S; Gallo-Oller G; Sveinbjörnsson B; Eissler N; Tanino K; Sakaguchi K; Martinsson T; Wickström M; Kogner P; Johnsen JI
Article: CANCERS. 2021;13(21):5493

High Expression of PPM1D Induces Tumors Phenotypically Similar to TP53 Loss-of-Function Mutations in Mice.

Milosevic J; Fransson S; Gulyas M; Olsen TK; Gallo-Oller G; Treis D; Elfman LHM; Wilhelm M; Martinsson T; Baryawno N; Kogner P; Johnsen JI
Article: CELL DEATH & DISEASE. 2021;12(10):914

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound.

Giovannucci TA; Salomons FA; Haraldsson M; Elfman LHM; Wickström M; Young P; Lundbäck T; Eirich J; Altun M; Jafari R; Gustavsson A-L; Johnsen JI; Dantuma NP
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2021;169:102285

Body surface area-based omega-3 fatty acids supplementation strongly correlates to blood concentrations in children.

Ljungblad L; Gleissman H; Hedberg G; Wickström M; Eissler N; Pickova J; Johnsen JI; Tedroff K; Strandvik B; Kogner P
Article: CANCER RESEARCH. 2021;81(6):1457-1471

Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma.

Mitra S; Muralidharan SV; Di Marco M; Juvvuna PK; Kosalai ST; Reischl S; Jachimowicz D; Subhash S; Raimondi I; Kurian L; Huarte M; Kogner P; Fischer M; Johnsen JI; Mondal T; Kanduri C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(33):20127-20138

Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells.

Susanto E; Marin Navarro A; Zhou L; Sundström A; van Bree N; Stantic M; Moslem M; Tailor J; Rietdijk J; Zubillaga V; Hübner J-M; Weishaupt H; Wolfsberger J; Alafuzoff I; Nordgren A; Magnaldo T; Siesjö P; Johnsen JI; Kool M; Tammimies K; Darabi A; Swartling FJ; Falk A; Wilhelm M
Article: FASEB JOURNAL. 2020;34(8):11101-11114

Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting.

Kock A; Bergqvist F; Steinmetz J; Elfman LHM; Korotkova M; Johnsen JI; Jakobsson P-J; Kogner P; Larsson K
Article: FRONTIERS IN ONCOLOGY. 2020;10:598872

Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures.

Xia C; Olsen TK; Zirakzadeh AA; Almamoun R; Sjöholm LK; Dahlström J; Sjöberg J; Claesson H-E; Johnsen JI; Winqvist O; Xu D; Ekström TJ; Björkholm M; Strååt K
Article: CANCERS. 2019;12(1):E73-73

Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth.

Dyberg C; Andonova T; Olsen TK; Brodin B; Kool M; Kogner P; Johnsen JI; Wickström M
Article: ONCOGENE. 2019;38(15):2800-2813

Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma.

Hald ØH; Olsen L; Gallo-Oller G; Elfman LHM; Løkke C; Kogner P; Sveinbjörnsson B; Flægstad T; Johnsen JI; Einvik C
Article: CANCERS. 2019;11(2):E202-202

SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro.

Tümmler C; Dumitriu G; Wickström M; Coopman P; Valkov A; Kogner P; Johnsen JI; Moens U; Sveinbjörnsson B
Article: CANCER LETTERS. 2019;442:341-350

RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism.

Azatyan A; Gallo-Oller G; Diao Y; Selivanova G; Johnsen JI; Zaphiropoulos PG
Article: EBIOMEDICINE. 2018;32:84-92

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth.

Kock A; Larsson K; Bergqvist F; Eissler N; Elfman LHM; Raouf J; Korotkova M; Johnsen JI; Jakobsson P-J; Kogner P
Article: PHARMACOLOGICAL RESEARCH. 2018;131:164-176

Molecular mechanisms and therapeutic targets in neuroblastoma.

Johnsen JI; Dyberg C; Fransson S; Wickström M
Article: ONCOTARGET. 2017;8(56):95135-95151

Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo.

Tümmler C; Snapkov I; Wickström M; Moens U; Ljungblad L; Maria Elfman LH; Winberg J-O; Kogner P; Johnsen JI; Sveinbjørnsson B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(32):E6603-E6612

Rho-associated kinase is a therapeutic target in neuroblastoma.

Dyberg C; Fransson S; Andonova T; Sveinbjörnsson B; Lännerholm-Palm J; Olsen TK; Forsberg D; Herlenius E; Martinsson T; Brodin B; Kogner P; Johnsen JI; Wickström M
Journal article: CANCER RESEARCH. 2017;77:687

Targeting tumor-promoting neuroblastoma microenvironment: inhibiton of tumor development and progression by targeting mPGES-1 expressed by cancer associated fibroblasts

Kock A; Larsson K; Eissler N; Bergqvist F; Rauf J; Korotkova M; Johnsen J-I; Jakobsson P-J; Kogner P
Journal article: CANCER RESEARCH. 2017;77:1945

PPM1D/Wip1, promising new target in childhood cancers neuroblastoma and medulloblastoma

Milosevic J; Eissler N; Treis D; Wicktrom M; Fransson S; Sveinbjornsson B; Baryawno N; Kosalai S; Kanduri C; Sakaguchi K; Martinsson T; Johnsen JI; Kogner P
Article: SCIENTIFIC REPORTS. 2017;7:46366

Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation.

Sandén E; Dyberg C; Krona C; Gallo-Oller G; Olsen TK; Enríquez Pérez J; Wickström M; Estekizadeh A; Kool M; Visse E; Ekström TJ; Siesjö P; Johnsen JI; Darabi A
Article: CLINICAL CANCER RESEARCH. 2016;22(15):3849-3859

Targeting Suppressive Myeloid Cells Potentiates Checkpoint Inhibitors to Control Spontaneous Neuroblastoma.

Mao Y; Eissler N; Blanc KL; Johnsen JI; Kogner P; Kiessling R
Article: CELL REPORTS. 2016;16(4):979-993

Regulation of Nuclear Hormone Receptors by MYCN-Driven miRNAs Impacts Neural Differentiation and Survival in Neuroblastoma Patients.

Ribeiro D; Klarqvist MDR; Westermark UK; Oliynyk G; Dzieran J; Kock A; Savatier Banares C; Hertwig F; Johnsen JI; Fischer M; Kogner P; Lovén J; Arsenian Henriksson M
Article: BMC CANCER. 2016;16:490

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis.

Snapkov I; Öqvist CO; Figenschau Y; Kogner P; Johnsen JI; Sveinbjørnsson B
Journal article: CANCER RESEARCH. 2016;76:761

Specific inhibition of prostaglandin E2 production in medulloblastoma

Bergqvist F; Ljungblad L; Wickstrom M; Larsson K; Kock A; Korotkova M; Johnsen JI; Kogner P; Jakobsson P-J
Journal article: CANCER RESEARCH. 2016;76:2454

Omega-3 fatty acids DHA and EPA decrease oncogenic PGE2 in medulloblastoma in vitro and in vivo

Ljungblad L; Bergqvist F; Andonova T; Jakobsson P-J; Johnsen JI; Kogner P; Wickstrom M
Journal article: CANCER RESEARCH. 2016;76:2465

Spleen tyrosine kinase (SYK) in neuroblastoma tumorigenesis

Tuemmler C; Dumitriu G; Cserna J; Moens UL; Kogner P; Johnsen JI; Sveinbjornsson B
Journal article: NEURO-ONCOLOGY. 2016;18(suppl_3):iii116

MB-83OMEGA-3 FATTY ACIDS DHA AND EPA SUPPRESS ONCOGENIC PGE2 IN MEDULLOBLASTOMA

Ljungblad L; Bergqvist F; Andonova T; Jakobsson P-J; Johnsen JI; Gleissman H; Kogner P; Wickström M
Article: BMC CANCER. 2016;16:259

Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma.

Dyberg C; Papachristou P; Haug BH; Lagercrantz H; Kogner P; Ringstedt T; Wickström M; Johnsen JI
Article: MOLECULAR AND CELLULAR ONCOLOGY. 2016;3(2):e1131356

Wingless/β-catenin signaling as a modulator of chemoresistance in cancer.

Johnsen JI; Wickström M; Baryawno N
Article: DEVELOPMENTAL CELL. 2016;36(2):164-178

The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis.

Li S; Fell SM; Surova O; Smedler E; Wallis K; Chen ZX; Hellman U; Johnsen JI; Martinsson T; Kenchappa RS; Uhlén P; Kogner P; Schlisio S
Article: ONCOIMMUNOLOGY. 2016;5(12):e1232222

Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade.

Eissler N; Mao Y; Brodin D; Reuterswärd P; Andersson Svahn H; Johnsen JI; Kiessling R; Kogner P
Article: NATURE COMMUNICATIONS. 2015;6:8904

Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance.

Wickström M; Dyberg C; Milosevic J; Einvik C; Calero R; Sveinbjörnsson B; Sandén E; Darabi A; Siesjö P; Kool M; Kogner P; Baryawno N; Johnsen JI
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(26):8070-8075

COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset.

Larsson K; Kock A; Idborg H; Arsenian Henriksson M; Martinsson T; Johnsen JI; Korotkova M; Kogner P; Jakobsson P-J
Article: JOURNAL OF NEURO-ONCOLOGY. 2015;123(1):1-13

Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas.

Sandén E; Dyberg C; Krona C; Visse E; Carén H; Northcott PA; Kool M; Ståhl N; Persson A; Englund E; Johnsen JI; Siesjö P; Darabi A
Journal article: LINDBERGIA. 2015;38(1):30-38

Porella obtusata: distribution, ecology and threats at the west coast of Norway, the northern fringe of its European distribution

Hassel K; Johnsen JI; Jordal JB; Knutsen A
Article: BMC CANCER. 2014;14:600

The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling.

Diao Y; Rahman MF-U; Villegas VE; Wickström M; Johnsen JI; Zaphiropoulos PG
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;450(4):1600-1605

Effects of epigenetic modificators in combination with small molecule inhibitors of receptor tyrosine kinases on medulloblastoma growth.

Marino A-M; Frijhoff J; Calero R; Baryawno N; Ostman A; Johnsen JI
Article: CANCER DISCOVERY. 2014;4(4):434-451

RNA helicase A is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma.

Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramsköld D; Hellman U; Sandberg R; Kenchappa RS; Martinson T; Johnsen JI; Kogner P; Schlisio S
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2014;106(3):djt459

Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.

Eriksson E; Wickström M; Perup LS; Johnsen JI; Eksborg S; Kogner P; Sävendahl L
Article: PLOS ONE. 2014;9(4):e95628

Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis.

Calero R; Morchon E; Johnsen JI; Serrano R
Journal article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2014;2(Suppl 3):p203

Immune suppression by myeloid-derived suppressor cells, MDSCs, in MYCN-driven neuroblastoma provides a potential target for cancer immunotherapy

Eissler N; Sveinbjörnsson B; Kock A; Johnsen JI; Kogner P
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;133(10):2351-2361

Frequent detection of human cytomegalovirus in neuroblastoma: a novel therapeutic target?

Wolmer-Solberg N; Baryawno N; Rahbar A; Fuchs D; Odeberg J; Taher C; Wilhelmi V; Milosevic J; Mohammad A-A; Martinsson T; Sveinbjörnsson B; Johnsen JI; Kogner P; Söderberg-Nauclér C
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2013;43(3):831-838

Neuroblastoma cells injected into experimental mature teratoma reveal a tropism for embryonic loose mesenchyme.

Jamil S; Cedervall J; Hultman I; Ali R; Margaryan NV; Rasmuson A; Johnsen JI; Sveinbjörnsson B; Dalianis T; Kanter L; Orrego A; Strizzi L; Hendrix MJC; Sandstedt B; Kogner P; Ahrlund-Richter L
Journal article: CANCER RESEARCH. 2013;73(8_Supplement):2751

Abstract 2751: Wnt/β-catenin regulates the expression of MGMT through TCF/LEF transcription: new strategy for DNA alkylators in cancer therapy.

Wickström M; Baryawno N; Dyberg C; Milosevic J; Sveinbjörnsson B; Northcott PA; Taylor M; Kool M; Kogner P; Johnsen JI
Journal article: CANCER RESEARCH. 2013;73(8_Supplement):2746

Abstract 2746: Microsomal prostaglandin E2 synthase-1 may provide a novel specific therapeutic target in neuroblastoma.

Kock A; Rasmuson A; Korotkova M; Idborg H; Johnsen JI; Jakobsson P-J; Kogner P
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2013;42(4):1239-1248

Expression of TWEAK/Fn14 in neuroblastoma: implications in tumorigenesis.

Pettersen I; Baryawno N; Abel F; Bakkelund WH; Zykova SN; Winberg J-O; Moens U; Rasmuson A; Kogner P; Johnsen JI; Sveinbjörnsson B
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;132(7):1516-1524

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.

Wickström M; Dyberg C; Shimokawa T; Milosevic J; Baryawno N; Fuskevåg OM; Larsson R; Kogner P; Zaphiropoulos PG; Johnsen JI
Article: BMC MEDICAL GENETICS. 2012;13:83

Quantitative global and gene-specific promoter methylation in relation to biological properties of neuroblastomas.

Kiss NB; Kogner P; Johnsen JI; Martinsson T; Larsson C; Geli J
Article: BRITISH JOURNAL OF CANCER. 2012;106(11):1807-1815

Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase.

Hiyoshi H; Abdelhady S; Segerström L; Sveinbjörnsson B; Nuriya M; Lundgren TK; Desfrere L; Miyakawa A; Yasui M; Kogner P; Johnsen JI; Andäng M; Uhlén P
Article: PLOS ONE. 2012;7(12):e51297

Tumor development, growth characteristics and spectrum of genetic aberrations in the TH-MYCN mouse model of neuroblastoma.

Rasmuson A; Segerström L; Nethander M; Finnman J; Elfman LHM; Javanmardi N; Nilsson S; Johnsen JI; Martinsson T; Kogner P
Article: PLOS ONE. 2012;7(1):e29331

Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.

Rasmuson A; Kock A; Fuskevåg OM; Kruspig B; Simón-Santamaría J; Gogvadze V; Johnsen JI; Kogner P; Sveinbjörnsson B
Article: ONCOTARGET. 2011;2(12):1329-1338

Is human cytomegalovirus a target in cancer therapy?

Johnsen JI; Baryawno N; Söderberg-Nauclér C
Article: INTERNATIONAL JOURNAL OF CANCER. 2011;129(12):2958-2965

Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo.

Segerström L; Baryawno N; Sveinbjörnsson B; Wickström M; Elfman L; Kogner P; Johnsen JI
Article: CANCER LETTERS. 2011;310(2):222-231

Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+ cell compartment and the in vitro tumorigenic capability of neuroblastoma cells.

Schiapparelli P; Shahi MH; Enguita-Germán M; Johnsen JI; Kogner P; Lázcoz P; Castresana JS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(10):4043-4055

Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target.

Baryawno N; Rahbar A; Wolmer-Solberg N; Taher C; Odeberg J; Darabi A; Khan Z; Sveinbjörnsson B; FuskevÅg O-M; Segerström L; Nordenskjöld M; Siesjö P; Kogner P; Johnsen JI; Söderberg-Nauclér C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;411(1):208-212

Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models.

Marino A-M; Sofiadis A; Baryawno N; Johnsen JI; Larsson C; Vukojević V; Ekström TJ
Article: INTERNATIONAL JOURNAL OF CANCER. 2011;128(7):1703-1711

Omega-3 fatty acid supplementation delays the progression of neuroblastoma in vivo.

Gleissman H; Segerström L; Hamberg M; Ponthan F; Lindskog M; Johnsen JI; Kogner P
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;38(3):843-849

Differential forms of p53 in medulloblastoma primary tumors, cell lines and xenografts.

Philipova T; Baryawno N; Hartmann W; Pietsch T; Druid H; Johnsen JI; Ekström TJ
Article: CELL CYCLE. 2010;9(13):2548-2554

Medulloblastoma: a disease with disorganized developmental signaling cascades.

Baryawno N; Sveinbjörnsson B; Kogner P; Johnsen JI
Journal article: CANCER RESEARCH. 2010;70(8_Supplement):4354

Abstract 4354: Celecoxib reduces MGMT expression and potentiates the effect of temozolomide in childhood medulloblastoma

Baryawno N; Milosevic J; Wickström M; Sveinbjörnsson B; Eksborg S; Kogner P; Johnsen JI
Article: FASEB JOURNAL. 2010;24(3):906-915

Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.

Gleissman H; Yang R; Martinod K; Lindskog M; Serhan CN; Johnsen JI; Kogner P
Article: CANCER RESEARCH. 2010;70(1):266-276

Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth.

Baryawno N; Sveinbjörnsson B; Eksborg S; Chen C-S; Kogner P; Johnsen JI
Journal article: ECANCERMEDICALSCIENCE. 2010;4:156

Might salicylate exert benefits against childhood cancer?

Morgan G; Johnsen J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18757-18762

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.

Hanaka H; Pawelzik S-C; Johnsen JI; Rakonjac M; Terawaki K; Rasmuson A; Sveinbjörnsson B; Schumacher MC; Hamberg M; Samuelsson B; Jakobsson P-J; Kogner P; Rådmark O
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;124(5):1227-1234

Metronomic scheduling of imatinib abrogates clonogenicity of neuroblastoma cells and enhances their susceptibility to selected chemotherapeutic drugs in vitro and in vivo.

Palmberg E; Johnsen JI; Paulsson J; Gleissman H; Wickström M; Edgren M; Ostman A; Kogner P; Lindskog M
Article: FASEB JOURNAL. 2008;22(10):3525-3536

Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.

Sveinbjörnsson B; Rasmuson A; Baryawno N; Wan M; Pettersen I; Ponthan F; Orrego A; Haeggström JZ; Johnsen JI; Kogner P
Article: NEURO-ONCOLOGY. 2008;10(5):661-674

Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets.

Baryawno N; Sveinbjörnsson B; Eksborg S; Orrego A; Segerström L; Oqvist CO; Holm S; Gustavsson B; Kågedal B; Kogner P; Johnsen JI
Article: ONCOGENE. 2008;27(20):2910-2922

Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo.

Johnsen JI; Segerström L; Orrego A; Elfman L; Henriksson M; Kågedal B; Eksborg S; Sveinbjörnsson B; Kogner P
Article: MOLECULAR CANCER THERAPEUTICS. 2007;6(9):2409-2417

The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo.

Wickström M; Johnsen JI; Ponthan F; Segerström L; Sveinbjörnsson B; Lindskog M; Lövborg H; Viktorsson K; Lewensohn R; Kogner P; Larsson R; Gullbo J
Article: CLINICAL CANCER RESEARCH. 2007;13(3):1036-1044

Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.

Ponthan F; Wickström M; Gleissman H; Fuskevåg OM; Segerström L; Sveinbjörnsson B; Redfern CPF; Eksborg S; Kogner P; Johnsen JI
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;119(3):493-500

The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo.

Eliassen LT; Berge G; Leknessund A; Wikman M; Lindin I; Løkke C; Ponthan F; Johnsen JI; Sveinbjørnsson B; Kogner P; Flaegstad T; Rekdal Ø
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;118(10):2584-2593

Neuroblastoma cell death in response to docosahexaenoic acid: sensitization to chemotherapy and arsenic-induced oxidative stress.

Lindskog M; Gleissman H; Ponthan F; Castro J; Kogner P; Johnsen JI
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2004;25(6):1849-1857

Synergistic induction of apoptosis in neuroblastoma cells using a combination of cytostatic drugs with interferon-gamma and TRAIL.

Johnsen JI; Pettersen I; Ponthan F; Sveinbjørnsson B; Flaegstad T; Kogner P
Article: CANCER RESEARCH. 2004;64(20):7210-7215

Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo.

Johnsen JI; Lindskog M; Ponthan F; Pettersen I; Elfman L; Orrego A; Sveinbjörnsson B; Kogner P
Article: JOURNAL OF MEDICAL VIROLOGY. 2003;70(1):14-19

Identification of a unique BK virus variant in the CNS of a patient with AIDS.

Jørgensen GEK; Hammarin A-L; Bratt G; Grandien M; Flaegstad T; Johnsen JI
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;104(4):418-424

The synthetic retinoid RO 13-6307 induces neuroblastoma differentiation in vitro and inhibits neuroblastoma tumour growth in vivo.

Ponthan F; Johnsen JI; Klevenvall L; Castro J; Kogner P
Article: ANTICANCER RESEARCH. 2001;21(6A):3733-3738

Interferon-gamma modulates TRAIL-mediated apoptosis in human colon carcinoma cells.

Langaas V; Shahzidi S; Johnsen JI; Smedsrød B; Sveinbjørnsson B
Article: INTERNATIONAL JOURNAL OF CANCER. 2000;88(5):685-691

p53-mediated negative regulation of stathmin/Op18 expression is associated with G(2)/M cell-cycle arrest.

Johnsen JI; Aurelio ON; Kwaja Z; Jörgensen GE; Pellegata NS; Plattner R; Stanbridge EJ; Cajot JF
Article: CANCER RESEARCH. 1999;59(5):1160-1163

A possible contributory role of BK virus infection in neuroblastoma development.

Flaegstad T; Andresen PA; Johnsen JI; Asomani SK; Jørgensen GE; Vignarajan S; Kjuul A; Kogner P; Traavik T
Article: VIRUS RESEARCH. 1997;52(1):61-71

The human polyomavirus BK T antigen induces gene expression in human cytomegalovirus.

Kristoffersen AK; Johnsen JI; Seternes OM; Rollag H; Degré M; Traavik T
Article: NUCLEIC ACIDS RESEARCH. 1996;24(11):2158-2165

Isolation and characterization of the QM promoter.

Farmer AA; Johnsen JI; Loftus TM; Smith KP; Stanbridge EJ
Article: JOURNAL OF GENERAL VIROLOGY. 1995;76 ( Pt 7):1571-1581

Subpopulations of non-coding control region variants within a cell culture-passaged stock of BK virus: sequence comparisons and biological characteristics.

Johnsen JI; Seternes OM; Johansen T; Moens U; Mäntyjärvi R; Traavik T
Journal article: JOURNAL OF IMMUNOLOGICAL METHODS. 1994;173(2):149-156

A two fusion partner system for raising antibodies against small immunogens expressed in bacteria.

Hey AW; Johnsen JI; Johansen B; Traavik T
Visa fler

Alla övriga publikationer

Conference publication: NEURO-ONCOLOGY. 2023;25:i62

SINGLE-CELL TRANSCRIPTOMIC ANALYSIS REVEALS DISTINCT GENOMIC LANDSCAPES, CELL TRAJECTORIES, AND TUMOUR-MICROENVIRONMENT INTERACTIONS IN FOUR SUBTYPES OF MEDULLOBLASTOMA

Ruchiy Y; Tsea I; Verhoeven BM; Sinha I; Preka E; Olsen TK; Mei S; Blomgren K; Johnsen JI; Carlson L-M; Dyberg C; Baryawno N
Conference publication: CANCER SCIENCE. 2023;114:249

Pharmacological activation of p53 triggers viral mimicry response thereby promoting anti-tumor immunity

Selivanova G; Zhou X; Singh M; Sanz G; Guerlavais V; Carvajal LA; Aivado M; Annis A; Zhan Y; Oliveira M; Westerberg L; Johnsen JI
Preprint: BIORXIV. 2022

METTL3 drives telomere targeting of TERRA lncRNA through m⁶A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma

Vaid R; Thombare K; Mendez A; Burgos-Panadero R; Djos A; Jachimowicz D; Lundberg KI; Bartenhagen C; Kumar N; Tümmler C; Sihlbom C; Fransson S; Johnsen JI; Kogner P; Martinsson T; Fischer M; Mondal T
Review: CURRENT ONCOLOGY REPORTS. 2022;24(8):1053-1062

Neuroblastoma Heterogeneity, Plasticity, and Emerging Therapies.

Lundberg KI; Treis D; Johnsen JI
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S230

NOVEL DRUG COMBINATIONS FOR NEUROBLASTOMA THERAPY - EXPLORING THE FULL POTENTIAL OF THE ROCK2-SPECIFIC INHIBITOR KD025

Tummler C; Pepich A; Vellema Q; Abu Ajamieh S; Park SW; Ljungblad L; Seashore-Ludlow B; Karlsson K; Kogner P; Johnsen JI; Nasman MW
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S226

SCHWANN CELL PRECURSORS IS THE CELL-OF-ORIGIN IN HUMAN NEUROBLASTOMA

Otte J; Olsen T; Mei S; Kameneva P; Embaie BT; Bjorklund A; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Cheng H; Zachariadis V; Enge M; Johnsen JI; Kogner P; Adameyko I; Kharchenko P; Baryawno N
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69

THE IMMUNE CELL ATLAS OF HUMAN NEUROBLASTOMA

Verhoeven BM; Mei S; Olsen T; Gustafsson K; Valind A; Nord DG; Fard S; Hagerling C; Kharchenko P; Kogner P; Johnsen JI; Baryawno N
Conference publication: CANCER RESEARCH. 2022;82(12)

The immune cell atlas of human neuroblastoma

Verhoeven BM; Mei S; Olsen TK; Gustafsson KK; Valind A; Lindstrom A; Nord DG; Fard SS; Hagerling C; Kharchenko PV; Kogner P; Johnsen JI; Baryawno N
Conference publication: CANCER RESEARCH. 2022;82(12)

The immune cell atlas of human neuroblastoma.

Verhoeven BM; Mei S; Olsen TK; Gustafsson KK; Valind A; Lindstrom A; Nord DG; Fard SS; Hagerling C; Kharchenko PV; Kogner P; Johnsen JI; Baryawno N
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S229-S230

INVESTIGATING THE INTERACTIONS OF DISTINCT TUMOR SUBPOPULATIONS IN HUMAN NEUROBLASTOMA USING SINGLE-CELL RNASEQ AND NOVEL SPATIAL MULTI-OMICS

Tsea I; Olsen T; Otte J; Mei S; Embaie BT; Kogner P; Johnsen JI; Baryawno N; Fard S
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S229

SYNERGISTIC EFFECT OF WIP1 INHIBITOR SL-176 AND H3K27 DEMETHYLASE INHIBITOR GSK-J4 ON NEUROBLASTOMA CELLS AND SPHEROIDS

Treis D; Tummler C; Kogner P; Johnsen JI; Nasman MW
Conference publication: CANCER RESEARCH. 2022;82(12)

Transcriptomic landscape of medulloblastoma reveals pathways of tumor-stroma remodelling

Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S211

CHARACTERIZATION OF TENEURIN-4 AND ITS ROLE IN NEUROBLASTOMA TUMORIGENESIS

Abu Ajamieh S; Andonova T; Pepich A; Olsen T; Tummler C; Thankaswamy-Kosalai S; Kanduri C; Fransson S; Martinsson T; Baryawno N; Nasman A; Kogner P; Johnsen JI; Wickstrom M
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S227

COMBINATIONAL TREATMENT WITH ROCK INHIBITOR RKI-1447 AND BET INHIBITORS SYNERGISTICALLY IMPAIRS NEUROBLASTOMA GROWTH COMBINATIONAL TREATMENT WITH ROCK INHIBITOR RKI-1447 AND BET INHIBITORS SYNERGISTICALLY IMPAIRS NEUROBLASTOMA GROWTH

Pepich A; Tummler C; Abu Ajamieh S; Vellema Q; Akerlund E; Treis D; Seashore-Ludlow B; Kogner P; Johnsen JI; Wickstrom M
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S211-S212

SINGLE CELL ANALYSIS OF HUMAN BONE METASTATIC NEUROBLASTOMA UNRAVELS EMERGING IMMUNE CELL POPULATIONS IN THE BONE MARROW

Alchahin A; Embaie BT; Mei S; Verhoeven BM; Olsen T; Kharchenko P; Johnsen JI; Kogner P; Baryawno N
Preprint: BIORXIV. 2021

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

Olsen TK; Dyberg C; Embaie B; Alchahin A; Milosevic J; Otte J; Tümmler C; Myrberg IH; Westerhout E; Koster J; Versteeg R; Kogner P; Johnsen JI; Sykes D; Baryawno N
Preprint: BIORXIV. 2021

Inhibition of the ubiquitin-proteasome system by a bioactivatable compound

Giovannucci T; Salomons F; Haraldsson M; Elfman L; Wickström M; Young P; Lundbäck T; Eirich J; Altun M; Jafari R; Gustavsson A-L; Johnsen JI; Dantuma N
Preprint: BIORXIV. 2020

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors

Milosevic J; Fransson S; Gulyas M; Gallo-Oller G; Olsen T; Treis D; Wickström M; Elfman LHM; Sveinbjornsson B; Hertwig F; Bartenhagen C; Reinsbach S; Wilhelm M; Abel F; Javanmardi N; Thankaswamy-Kosalai S; Eissler N; Kock A; Shi Y; Tanino K; Hehir-Kwa J; Mensenkamp A; Tytgat GAM; Kanduri C; Holmberg J; Gisselsson D; Molenaar J; Jongmans M; Fischer M; Kool M; Sakaguchi K; Baryawno N; Martinsson T; Johnsen JI; Kogner P
Preprint: BIORXIV. 2020

Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma

Olsen T; Otte J; Mei S; Kameneva P; Björklund Å; Kryukov E; Hou Z; Johansson A; Sundström E; Martinsson T; Fransson S; Johnsen JI; Kogner P; Adameyko I; Kharchenko P; Baryawno N
Review: FRONTIERS IN ONCOLOGY. 2020;10:624079

MYCN Function in Neuroblastoma Development.

Otte J; Dyberg C; Pepich A; Johnsen JI
Conference publication: PEDIATRIC BLOOD & CANCER. 2020;67:S3

Malignant Schwann Cell Precursors Mediate Intratumoral Plasticity in Human Neuroblastoma

Olsen TK; Otte J; Mei S; Kameneva P; Bjorklund A; Kryukov E; Hou Z; Johansson A; Sundstrom E; Martinsson T; Fransson S; Johnsen JI; Kogner P; Adameyko I; Kharchenko P; Baryawno N
Preprint: SSRN ELECTRONIC JOURNAL. 2020

Inhibition of the Ubiquitin-Proteasome System by a Bioactivatable Prodrug

Giovannucci TA; Salomons FA; Martin Haraldsson M; Elfman LMH; Wickström M; Young P; Lundbäck T; Eirich J; Altun M; Jafari R; Gustavsson A-L; Johnsen JI; Dantuma N
Review: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:9

Neuroblastoma-A Neural Crest Derived Embryonal Malignancy.

Johnsen JI; Dyberg C; Wickström M
Conference publication: CANCER RESEARCH. 2018;78(13):4145

Characterization of the ODZ receptor family in neuroblastoma

Andonova T; Kogner P; Johnsen JI; Wickstrom M
Conference publication: CANCER RESEARCH. 2018;78(13):5092

Establishment of an induction protocol for medulloblastoma during prenatal stages of a floxed-cre inducible model

Gallo-Oller G; Azatyan A; Baryawno N; Kogner P; Johnsen JI
Review: EXPERT OPINION ON DRUG DISCOVERY. 2017;12(8):801-811

Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project.

Moreno L; Caron H; Geoerger B; Eggert A; Schleiermacher G; Brock P; Valteau-Couanet D; Chesler L; Schulte JH; De Preter K; Molenaar J; Schramm A; Eilers M; Van Maerken T; Johnsen JI; Garrett M; George SL; Tweddle DA; Kogner P; Berthold F; Koster J; Barone G; Tucker ER; Marshall L; Herold R; Sterba J; Norga K; Vassal G; Pearson AD
Conference publication: CANCER RESEARCH. 2017;77:5832

Rho-associated kinase is a therapeutic target in neuroblastoma

Dyberg CH; Fransson S; Andonova T; Sveinbjornsson B; Lannerholm-Palm J; Forsberg D; Herlenius E; Martinsson T; Kogner P; Johnsen JI; Wickstrom M
Conference publication: PEDIATRIC BLOOD & CANCER. 2017;64:S343

Omegachild - An Early Clinical Study Aiming at a Novel Approach to Treat Neural Tumors and Prevent Long-Term Side Effects

Ljungblad L; Wickstrom M; Eissler N; Pickova J; Johnsen JI; Tedroff K; Strandvik B; Gleissman H; Kogner P
Conference publication: PEDIATRIC BLOOD & CANCER. 2017;64:S232

Complete Clinical Response in High-Risk Neuroblastoma After ALK-Inhibitor Mono-Therapy Specifically Targeting the Novel Activating I1171T ALK Mutation

Kogner P; Treis D; Siaw J; Fransson S; Guan J; Svenberg P; Hansson M; Wessman S; Gordon L; Stenman J; Svensson PJ; Johnsen JI; Martinsson T; Palmer RH; Hallberg B
Conference publication: NEURO-ONCOLOGY. 2016;18:116

OMEGA-3 FATTY ACIDS DHA AND EPA SUPPRESS ONCOGENIC PGE2 IN MEDULLOBLASTOMA

Ljungblad L; Bergqvist F; Andonova T; Jakobsson P-J; Johnsen JI; Gleissman H; Kogner P; Wickstrom M
Conference publication: PEDIATRIC BLOOD & CANCER. 2016;63:S82-S83

Targeting the Benign to Kill the Malignant : Inhibition of Inflammatory Progression of Neuroblastoma by Targeting mPGES-1 in Cancer Associated Fibroblasts in the Tumour Microenvironment

Kock A; Larsson K; Eissler N; Bergqvist F; Elfman L; Raouf J; Korotkova M; Johnsen JI; Jakobsson PJ; Kogner P
Conference publication: PEDIATRIC BLOOD & CANCER. 2016;63:S82

The PPM1D-Encoded Wip1-Phosphatase is a Candidate Oncogene on 17q Contributing to Neuroblastoma Development and Providing a Novel Therapeutic Target

Milosevic J; Fransson S; Treis D; Tanino K; Wickstrom M; Sveinbjornsson B; Kosalai ST; Baryawno N; Johnsen JI; Sakaguchi K; Kanduri C; Martinsson T; Kogner P
Conference publication: PEDIATRIC BLOOD & CANCER. 2016;63:S28

Combination Therapy of Anti-PD-1 Antibody and CSF-1R Inhibitor Reverses Induction of Suppressive Myeloid Cells and Controls Spontaneous Neuroblastoma Progression

Eissler N; Mao Y; Brodin D; Reutersward P; Svahn HA; Johnsen JI; Kiessling R; Kogner P
Conference publication: CANCER RESEARCH. 2015;75:3275

A novel approach to treat medulloblastoma: The omega-3 fatty acids DHA and EPA reduce medulloblastoma tumor growth in vitro and in vivo

Ljungblad LM; Johnsen J-I; Wickstrom M; Kogner P; Gleissman H
Conference publication: CANCER RESEARCH. 2015;75:503

The PPM1D encoded phosphatase Wip1 is a novel oncogene and potential therapeutic target in neuroblastoma and medulloblastoma

Miloseyic J; Treis D; Wickstrom M; Fransson S; Eissler N; Syeinbjornsson B; Baryawno N; Tanino K; Selivanova G; Sakaguchi K; Martinsson T; Johnsen JI; Kogner P
Conference publication: CANCER RESEARCH. 2015;75:3279

Expression of chemerin and chemerin receptors in neuroblastoma: implications in tumorigenesis

Tuemmler C; Snapkov I; Moens UL; Kogner P; Johnsen JI; Sveinbjornsson B
Conference publication: CANCER RESEARCH. 2015;75:3283

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis

Snapkov I; Oqvist CO; Figenschau YA; Kogner P; Johnsen JI; Sveinbjornsson B
Conference publication: CANCER RESEARCH. 2015;75:1632

Microsomal prostaglandin E synthase 1: a novel therapeutic target of neuroblastoma

Kock A; Larsson K; Joan R; Korotkova M; Johnsen J-I; Jakobsson P-J; Kogner P
Conference publication: CANCER RESEARCH. 2015;75:3266

Inhibition of Rho-associated kinase 2 suppresses MYCN expression and induces differentiation of neuroblastoma

Dyberg C; Forsberg D; Fransson S; Palm JL; Haug BH; Sveinbjornsson B; Martinsson T; Kogner P; Johnsen JI; Wickstrom M
Review: WORLD JOURNAL OF EXPERIMENTAL MEDICINE. 2015;5(1):1-10

Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options.

Söderberg-Nauclér C; Johnsen JI
Conference publication: PEDIATRIC BLOOD & CANCER. 2015;62:S332

THE PPM1D ENCODED PHOSPHATASE WIP1 IS A NOVEL ONCOGENE AND POTENTIAL THERAPEUTIC TARGET IN NEUROBLASTOMA AND MEDULLOBLASTOMA

Milosevic J; Treis D; Malin M; Fransson S; Sveinbjornsson B; Eissler N; Baryawno N; Tanino K; Selivanova G; Sakaguchi K; Martinsson T; Johnsen JI; Kogner P
Conference publication: PEDIATRIC BLOOD & CANCER. 2015;62:S149

NEUROBLASTOMA IMMUNOTHERAPY TARGETING CSF-1R REVERSES INDUCTION OF SUPPRESSIVE MYELOID CELLS AND CONTROLS AGGRESSIVE TUMOR PROGRESSION

Eissler N; Mao Y; Johnsen JI; Kiessling R; Kogner P
Conference publication: PEDIATRIC BLOOD & CANCER. 2015;62:S328-S329

INHIBITION OF RHO-ASSOCIATED KINASE 2 INHIBITS MALIGNANT PROGRESSION IN NEUROBLASTOMA BY INDUCING DIFFERENTIATION AND MYCN DEGRADATION

Dyberg C; Forsberg D; Fransson S; Lannerholm-Palm J; Sveinbjornsson B; Martinsson T; Kogner P; Johnsen JI; Wickstrom M
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:135

RNA helicase A is essential for 1p36 gene KIF1 Bβ tumor suppression in neuroblastomas

Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramskold D; Choo Z; Hellman U; Sandberg R; Kenchappa RS; Martinsson T; Johnsen JI; Kogner P; Schlisio S
Conference publication: CANCER RESEARCH. 2014;74(20):a84

Stereotactic injections of primary medulloblastomas as a representative model of the different subgroups for preclinical drug screening

Krona C; Dyberg C; Sanden E; Darabi A; Wickstrom M; Northcott P; Johnsen JI; Siesjo P
Conference publication: CANCER RESEARCH. 2014;74(19):3988

The omega-3 fatty acids DHA and EPA inhibit medulloblastoma growth

Ljungblad LM; Wickstrom M; Johnsen J-I; Kogner P; Gleissman H
Conference publication: CANCER RESEARCH. 2014;74(19):3986

Characterization of prostaglandin signaling in primary neuroblastoma

Kock A; Larsson K; Ljungblad L; Idborg H; Korotkova M; Elfman L; Johnsen J-I; Jakobsson P-J; Kogner P
Conference publication: CANCER RESEARCH. 2014;74(19):3976

Expression of formyl peptide receptor 1 (FPR1) in neuroblastoma: Implications in tumorigenesis

Snapkov I; Kogner P; Johnsen J-I; Sveinbjornsson B
Conference publication: CANCER RESEARCH. 2014;74(19):3971

PPM1D/WIP1, a potential target in neuroblastoma

Milosevic J; Wickstrom M; Treis D; Nordegren HS; Elfman L; Baryawno N; Fransson S; Sveinbjornsson B; Martinsson T; Johnsen JI; Kogner P
Meeting abstract: CANCER RESEARCH. 2014;74(19):3110

Targeting the Wnt/PCP signaling through ROCK: A new neuroblastoma drug target

Dyberg C; Forsberg D; Papachristou P; Lannerholm-Palm J; Haug BH; Sveinbjoernsson B; Lagercrantz H; Kogner P; Johnsen JI; Wickstrom M
Letter: BRITISH JOURNAL OF CANCER. 2013;108(10):2191

Reply: Comment on 'Quiescence and yH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase': ouabain and cancer.

Hiyoshi H; Johnsen JI; Andäng M; Uhlén P
Meeting abstract: CANCER RESEARCH. 2013;73(8):3795

Vangl2 and Pricklel expression, interaction and regulation of Wnt/PCP signaling in medulloblastoma and neuroblastoma

Dyberg CH; Papachristou P; Lagercrantz H; Johnsen JI; Wickstrom M
Conference publication: CANCER RESEARCH. 2013;73(8):3817

The potential oncogenic significance of Wip1 in neuroblastoma

Milosevic J; Wickstrom M; Elfman L; Baryawno N; Sveinbjornsson B; Martinsson T; Johnsen JI; Kogner P
Conference publication: NEURO-ONCOLOGY. 2013;15:18

EXPERIMENTAL COMBINATION THERAPY: HISTONE DEACETYLASE AND DNA METHYL TRANSFERASE INHIBITORS IN BRAIN CANCER CELL MODEL

Marino A-M; Baryawno N; Johnsen J-I; Ostman A
Editorial comment: ONCOIMMUNOLOGY. 2012;1(5):739-740

Cytomegalovirus infection in brain tumors: A potential new target for therapy?

Söderberg-Nauclér C; Johnsen JI
Conference publication: CANCER RESEARCH. 2012;72:4725

Inhibition of the Hedgehog signaling pathway - a new target in treatment for children with neuroblastoma

Wickstrom M; Dyberg C; Shimokawa T; Baryawno N; Milosevic J; Fuskevag OM; Larsson R; Zaphiropoulos PG; Kogner P; Johnsen JI
Conference publication: CANCER RESEARCH. 2012;72:1420

Microsomal prostaglandin E2 synthase 1 (mPGES-1) is expressed in neuroblastoma and may represent a novel target for therapy

Kock A; Rasmuson A; Idborg H; Johnsen JI; Kogner P
Conference publication: CANCER RESEARCH. 2012;72:825

Wnt/beta-catenin signaling regulates the expression of O6-methylguanine DNA-methyltransferase in cancer cells: a new strategy to overcome resistance for DNA alkylators in cancer therapy

Dyberg CH; Baryawno N; Milosevic J; Wickstrom M; Sveinbjornsson B; Northcott PA; Taylor MD; Kool M; Kogner P; Johnsen JI
Conference publication: CANCER RESEARCH. 2012;72:2499

The significance of Wip1 in neuroblastoma and medulloblastoma

Milosevic J; Baryawno N; Syeinbjornsson B; Martinsson T; Johnsen JI; Kogner P
Conference publication: NEURO-ONCOLOGY. 2012;14:102

THE POTENTIAL ONCOGENIC SIGNIFICANCE OF WIP1 IN MEDULLOBLASTOMA

Milosevic J; Baryawno N; Sveinbjornsson B; Martinsson T; Grotzer M; Johnsen JI; Kogner P
Conference publication: NEURO-ONCOLOGY. 2012;14:99-100

ANTINEOPLASTIC ACTION OF 5-AZA-2′DEOXYCYTIDINE AND SODIUM 4-PHENYLBUTYRATE ON MEDULLOBLASTOMA CELL MODELS

Marino A-M; Baryawno N; Ekstrom TP; Ostman A; Johnsen J-I
Conference publication: CANCER RESEARCH. 2011;71:lb-209-lb-209

Expression of O6-methylguanine DNA-methyltransferase is regulated by Wnt/β-catenin signalling in cancer cells: A new strategy for DNA alkylators in cancer therapy

Milosevic J; Baryawno N; Dyberg C; Wickstrom M; Sveinbjornsson B; Northcott PA; Taylor MD; Kool M; Kogner P; Johnsen JI
Conference publication: NEURO-ONCOLOGY. 2011;13:I9

COMBINED EFFECTS OF 5-AZA-2′DEOXYCYTIDINE AND 4-PHENYLBUTYRATE ON MEDULLOBLASTOMA

Marino AM; Johnsen J-I; Ekstrom TJ; Zaphiropoulos P; Ostman A
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1365-1373

Omega-3 fatty acids in cancer, the protectors of good and the killers of evil?

Gleissman H; Johnsen JI; Kogner P
Corrigendum: CANCER RESEARCH. 2010;70(5):2138-2139

Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/β-Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth (vol 70, pg 266, 2010)

Baryawno N; Sveinbjornsson B; Eksborg S; Chen C-S; Kogner P; Johnsen JI
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2010;107:163-224

MYC in oncogenesis and as a target for cancer therapies.

Albihn A; Johnsen JI; Henriksson MA
Review: APOPTOSIS. 2009;14(4):424-438

Embryonal neural tumours and cell death.

Johnsen JI; Kogner P; Albihn A; Henriksson MA
Conference publication: PEDIATRIC BLOOD & CANCER. 2009;53(5):807

OMEGA-3 FATTY ACIDS IN CHILDHOOD CANCER: ELUCIDATION OF THE DOCOSAHEXAENOIC ACID METABOLIC PATHWAY IN NEUROBLASTOMA AND DEFINITION OF CYTOTOXIC INTERMEDIATES

Kogner P; Gleissman H; Serhan CN; Hamberg M; Segerstrom L; Lindskog M; Johnsen JI
Conference publication: CANCER RESEARCH. 2009;69

Novel tyrosine kinase inhibitors are effective in in vitro models of high risk neuroblastoma

Palmberg E; Rickardson L; Johnsen JI; Kogner P; Lindskog M
Conference publication: CANCER RESEARCH. 2009;69

Neuroblastoma cells produce PGE₂ and express all four PGE₂ receptors: Implications for tumorigenesis

Rasmuson A; Johnsen JI; Koshnevis M; Simon-SantaMaria J; Elfman L; Fuskevag OM; Orrego A; Kogner P; Sveinbjornsson B
Conference publication: CANCER RESEARCH. 2009;69

The cyclooxygenase-2 prostaglandin E2 pathway is expressed in childhood medulloblastoma providing novel therapeutic targets as indicated by promising response to Celecoxib-therapy in vitro, in vivo and pilot clinical experience

Milosevic J; Baryawno N; Sveinbjornsson B; Eksborg S; Holm S; Johnsen J-I; Kogner P
Conference publication: CANCER RESEARCH. 2009;69

Small molecule inhibitors of PI3K/Akt signaling inhibit WntA#946;-catenin pathway crosstalk and suppress medulloblastoma growth

Ninib B; Sveinbjornsson B; Eksborg S; Chen C-S; Kogner P; Johnsen J-I
Conference publication: NEURO-ONCOLOGY. 2008;10(3):515

The cyclooxygenase-2 prostaglandin E2 pathway is expressed in childhood medulloblastoma providing novel therapeutic targets as indicated by promising response to NSAID-therapy in vitro, in vivo and pilot clinical experience

Baryawno N; Sveinbjbornsson B; Eksborg S; Orrego A; Segerstrom L; Oqvist CO; Holm S; Gustavsson B; Kagedal B; Kogner P; Johnsen JI
Conference publication: NEURO-ONCOLOGY. 2008;10(3):506

A novel celecoxib derivate, OSU03012, suppresses medulloblastoma growth by inhibiting catenin function and MYC expression

Baryawno N; Sveinbjornsson B; Eksborg S; Kogner P; Johnsen JI
Meeting abstract: CYTOKINE. 2007;39(1):33

Expression of TWEAK and Fn-14 in neuroblastoma, and their implications in tumorigenesis

Pettersen I; Bakkelund WH; Winberg J-O; Johnsen JI; Kogner P; Sveinbjornsson B
Conference publication: NEURO-ONCOLOGY. 2007;9(2):197

Cyclooxygenase 2 is abundantly expressed in medulloblastoma tumors and cell lines:: Nonsteroidal anti-inflammatory drugs are potent inhibitors of medulloblastoma growth

Baryawno N; Sveinbjornsson B; Holm S; Orrego A; Gustavsson B; Johnsen JI; Kogner P
Conference publication: CANCER RESEARCH. 2006;66(8)

Omega-3 docosahexaenoic acid inhibits neuroblastoma cell growth in vivo

Gleissman H; Lindskog M; Ponthan F; Elfman L; Johnsen JI; Kogner P
Conference publication: CANCER RESEARCH. 2006;66(8)

Neuroblastoma cells express all four PGE₂ receptor subtypes and specific receptor antagonists may inhibit tumor growth

Rasmuson A; Johnsen JI; Orrego A; Kogner P; Sveinbjornsson B
Conference publication: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2006;79(1-2):185

Expression of 5-lipoxygenase in human neuroblastoma and effects of its inhibitors on neuroblastoma cell proliferation and apoptosis

Sveinbjörnsson B; Johnsen JI; Rasmuson A; Pettersen I; Orrego A; Phontan F; Elfnan L; Kogner P
Conference publication: CANCER RESEARCH. 2006;66(8)

COX inhibitors as a potential adjuvant therapy in childhood medulloblastoma

Baryawno N; Sveinbjornsson B; Holm S; Orrego A; Gustavsson B; Kogner P; Johnsen JI
Review: CANCER LETTERS. 2005;228(1-2):195-201

NSAIDs in neuroblastoma therapy.

Johnsen JI; Lindskog M; Ponthan F; Pettersen I; Elfman L; Orrego A; Sveinbjörnsson B; Kogner P
Review: CANCER LETTERS. 2005;228(1-2):247-255

Proton magnetic resonance spectroscopy in neuroblastoma: current status, prospects and limitations.

Lindskog M; Spenger C; Klason T; Jarvet J; Gräslund A; Johnsen JI; Ponthan F; Douglas L; Nordell B; Kogner P
Published conference paper: PEDIATRIC BLOOD & CANCER. 2000;35(6):593-596

Human polyomavirus BK (BKV) and neuroblastoma: mechanisms of oncogenic action and possible strategy for novel treatment.

Jørgensen GE; Johnsen JI; Ponthan F; Kogner P; Flaegstad T; Traavik T
Review: VIRUS GENES. 1995;10(3):261-275

Noncoding control region of naturally occurring BK virus variants: sequence comparison and functional analysis.

Moens U; Johansen T; Johnsen JI; Seternes OM; Traavik T
Visa fler

Forskningsbidrag

New therapy for medulloblastoma and neuroblastoma

Swedish Cancer Society

1 January 2018
New therapy for medulloblastoma and neuroblastoma

Swedish Cancer Society

1 January 2017
New therapy for medulloblastoma and neuroblastoma

Swedish Cancer Society

1 January 2016
Novel Neuroblastoma Biomarkers of Clinical Relevance

Swedish Foundation for Strategic Research

1 January 2015 - 31 December 2019
New therapy for medulloblastoma and neuroblastoma

Swedish Cancer Society

1 January 2015
Targeted therapy for children with medulloblastoma

Swedish Cancer Society

1 January 2014
Novel targeted therapy for childhood cancer with emphasis on Wip-1 in medulloblastoma and neuroblastoma

Swedish Research Council

1 January 2009 - 31 December 2011
BK virus and neuroblastoma

Dam Foundation

1 January 2001 - 1 August 2002

Anställningar

Senior Forskare, Kvinnors och barns hälsa, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Tumörbiologi, Karolinska Institutet, 2010

Nyheter från KI

Kalenderhändelser från KI