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John Axelsson och hans forskarteam på Karolinska Institutet vill med sin forskning öka kunskapen och medvetenheten om hur sömn och sjukdom i det moderna samhället påverkar vår biologi, kognition och hälsa. De frågor som John just nu är mest intresserad av att besvara är: Kan vår kropp och hjärna anpassa sig till långvarig sömnbrist? Kan mer sömn snabba upp återhämtning när vi är sjuka? Hur påverkar sjukdom vår hjärna och våra beteenden? Har människan ett varningssystem som gör att vi undviker personer som kan smitta oss och hur fungerar det? Hur snabbt vaknar hjärnan upp från sömn?



Effect of sleep deprivation on emotional working memory
Gerhardsson A, Åkerstedt T, Axelsson J, Fischer H, Lekander M, Schwarz J
Journal of sleep research 2019;28(1):e12744-

Emotional expressions of the sick face
Sarolidou G, Axelsson J, Sundelin T, Lasselin J, Regenbogen C, Sorjonen K, et al
Brain, behavior, and immunity 2019;():-

Positivity Effect and Working Memory Performance Remains Intact in Older Adults After Sleep Deprivation
Gerhardsson A, Fischer H, Lekander M, Kecklund G, Axelsson J, Åkerstedt T, et al
Frontiers in psychology 2019;10():605-

Sleep deprivation and its effects on communication during individual and collaborative tasks
Holding Bc, Sundelin T, Lekander M, Axelsson J
Scientific reports 2019;9(1):3131-

Sleep during naturally occurring respiratory infections: A pilot study
Lasselin J, Ingre M, Regenbogen C, Olsson Mj, Garke M, Brytting M, et al
Brain, behavior, and immunity 2019;():-

The effect of a transient immune activation on subjective health perception in two placebo controlled randomised experiments
Andreasson A, Karshikoff B, Lidberg L, Åkerstedt T, Ingvar M, Olgart Höglund C, et al
PloS one 2019;14(3):e0212313-

The effect of sleep deprivation on objective and subjective measures of facial appearance
Holding Bc, Sundelin T, Cairns P, Perrett Di, Axelsson J
Journal of sleep research 2019;():e12860-

A global measure of sickness behaviour: Development of the Sickness Questionnaire
Andreasson A, Wicksell Rk, Lodin K, Karshikoff B, Axelsson J, Lekander M
Journal of health psychology 2018;23(11):1452-1463

Communication of health in experimentally sick men and women: A pilot study
Lasselin J, Lekander M, Paues-göranson S, Olsson Mj, Axelsson J
Psychoneuroendocrinology 2018;87():188-195

Detection of Inflammation via Volatile Cues in Human Urine
Gordon Ar, Kimball Ba, Sorjonen K, Karshikoff B, Axelsson J, Lekander M, et al
Chemical senses 2018;43(9):711-719

Identification of acutely sick people and facial cues of sickness
Axelsson J, Sundelin T, Olsson Mj, Sorjonen K, Axelsson C, Lasselin J, et al
Proceedings. Biological sciences 2018;285(1870):-

Man flu is related to health communication rather than symptoms and suffering
Axelsson J, Lasselin J, Lekander M
BMJ (Clinical research ed.) 2018;360():k450-

Mood impairment is stronger in young than in older adults after sleep deprivation
Schwarz J, Axelsson J, Gerhardsson A, Tamm S, Fischer H, Kecklund G, et al
Journal of sleep research 2018;():e12801-

Sex differences in how inflammation affects behavior: What we can learn from experimental inflammatory models in humans
Lasselin J, Lekander M, Axelsson J, Karshikoff B
Frontiers in neuroendocrinology 2018;50():91-106

Sickness behavior is not all about the immune response: Possible roles of expectations and prediction errors in the worry of being sick
Lasselin J, Petrovic P, Olsson Mj, Paues Göranson S, Lekander M, Jensen Kb, et al
Brain, behavior, and immunity 2018;74():213-221

Behavioral and neural correlates to multisensory detection of sick humans
Regenbogen C, Axelsson J, Lasselin J, Porada Dk, Sundelin T, Peter Mg, et al
Proceedings of the National Academy of Sciences of the United States of America 2017;114(24):6400-6405

Circadian Entrainment to the Natural Light-Dark Cycle across Seasons and the Weekend
Stothard Er, Mchill Aw, Depner Cm, Birks Br, Moehlman Tm, Ritchie Hk, et al
Current biology : CB 2017;27(4):508-513

Impact of sleep inertia on visual selective attention for rare targets and the influence of chronotype
Ritchie Hk, Burke Tm, Dear Tb, Mchill Aw, Axelsson J, Wright Kp
Journal of sleep research 2017;26(5):551-558

Lipopolysaccharide Alters Motivated Behavior in a Monetary Reward Task: a Randomized Trial
Lasselin J, Treadway Mt, Lacourt Te, Soop A, Olsson Mj, Karshikoff B, et al
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2017;42(4):801-810

Multimodal Emotion Recognition Is Resilient to Insufficient Sleep: Results From Cross-Sectional and Experimental Studies
Holding Bc, Laukka P, Fischer H, Bänziger T, Axelsson J, Sundelin T
Sleep 2017;40(11):-

Negative effects of restricted sleep on facial appearance and social appeal
Sundelin T, Lekander M, Sorjonen K, Axelsson J
Royal Society open science 2017;4(5):160918-

Skin colour changes during experimentally-induced sickness
Henderson Aj, Lasselin J, Lekander M, Olsson Mj, Powis Sj, Axelsson J, et al
Brain, behavior, and immunity 2017;60():312-318

Thank god it's Friday - sleep improved
Petersen H, Kecklund G, D'onofrio P, Axelsson J, Åkerstedt T
Journal of sleep research 2017;26(5):567-571

Yawning, a thermoregulatory mechanism during fever? A study of yawning frequency and its predictors during experimentally induced sickness
Marraffa A, Lekander M, Solsjö P, Olsson Mj, Lasselin J, Axelsson J
Physiology & behavior 2017;182():27-33

Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis
Nilsonne G, Lekander M, Åkerstedt T, Axelsson J, Ingre M
PloS one 2016;11(11):e0165799-

Eyelid-openness and mouth curvature influence perceived intelligence beyond attractiveness
Talamas Sn, Mavor Ki, Axelsson J, Sundelin T, Perrett Di
Journal of experimental psychology. General 2016;145(5):603-620

Health anxiety in a disease-avoidance framework: Investigation of anxiety, disgust and disease perception in response to sickness cues
Hedman E, Lekander M, Karshikoff B, Ljótsson B, Axelsson E, Axelsson J
Journal of abnormal psychology 2016;125(7):868-878

Health consequences of shift work and insufficient sleep
Kecklund G, Axelsson J
BMJ (Clinical research ed.) 2016;355():i5210-

Intrinsic functional connectivity of insular cortex and symptoms of sickness during acute experimental inflammation
Lekander M, Karshikoff B, Johansson E, Soop A, Fransson P, Lundström Jn, et al
Brain, behavior, and immunity 2016;56():34-41

Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults
Lasselin J, Kemani Mk, Kanstrup M, Olsson Gl, Axelsson J, Andreasson A, et al
Journal of behavioral medicine 2016;39(5):916-24

Mood disturbance during experimental endotoxemia: Predictors of state anxiety as a psychological component of sickness behavior
Lasselin J, Elsenbruch S, Lekander M, Axelsson J, Karshikoff B, Grigoleit Js, et al
Brain, behavior, and immunity 2016;57():30-37

Relationships Between Questionnaire Ratings of Sleep Quality and Polysomnography in Healthy Adults
Westerlund A, Lagerros Yt, Kecklund G, Axelsson J, Åkerstedt T
Behavioral sleep medicine 2016;14(2):185-99

Why sickness hurts: A central mechanism for pain induced by peripheral inflammation
Karshikoff B, Jensen Kb, Kosek E, Kalpouzos G, Soop A, Ingvar M, et al
Brain, behavior, and immunity 2016;57():38-46

Effect of long-term sleep restriction and subsequent recovery sleep on the diurnal rhythms of white blood cell subpopulations
Lasselin J, Rehman Ju, Åkerstedt T, Lekander M, Axelsson J
Brain, behavior, and immunity 2015;47():93-9

Modality and sex differences in pain sensitivity during human endotoxemia
Karshikoff B, Lekander M, Soop A, Lindstedt F, Ingvar M, Kosek E, et al
Brain, behavior, and immunity 2015;46():35-43

Sick man walking: Perception of health status from body motion
Sundelin T, Karshikoff B, Axelsson E, Höglund Co, Lekander M, Axelsson J
Brain, behavior, and immunity 2015;48():53-6

Do sleep, stress, and illness explain daily variations in fatigue? A prospective study
Akerstedt T, Axelsson J, Lekander M, Orsini N, Kecklund G
Journal of psychosomatic research 2014;76(4):280-5

Sleep polysomnography and reported stress across 6 weeks
Åkerstedt T, Lekander M, Petersén H, Kecklund G, Axelsson J
Industrial health 2014;52(1):36-42

Subjective sleepiness is a sensitive indicator of insufficient sleep and impaired waking function
Akerstedt T, Anund A, Axelsson J, Kecklund G
Journal of sleep research 2014;23(3):240-52

The scent of disease: human body odor contains an early chemosensory cue of sickness
Olsson Mj, Lundström Jn, Kimball Ba, Gordon Ar, Karshikoff B, Hosseini N, et al
Psychological science 2014;25(3):817-23

Cues of fatigue: effects of sleep deprivation on facial appearance
Sundelin T, Lekander M, Kecklund G, Van Someren Ej, Olsson A, Axelsson J
Sleep 2013;36(9):1355-60

Development of atopic disease and disturbed sleep in childhood and adolescence--a longitudinal population-based study
Jernelöv S, Lekander M, Almqvist C, Axelsson J, Larsson H
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2013;43(5):552-9

Effects of sustained sleep restriction on mitogen-stimulated cytokines, chemokines and T helper 1/ T helper 2 balance in humans
Axelsson J, Rehman Ju, Akerstedt T, Ekman R, Miller Ge, Höglund Co, et al
PloS one 2013;8(12):e82291-

Subjective health perception in healthy young men changes in response to experimentally restricted sleep and subsequent recovery sleep
Lekander M, Andreasson An, Kecklund G, Ekman R, Ingre M, Akerstedt T, et al
Brain, behavior, and immunity 2013;34():43-6

The daily variation in sleepiness and its relation to the preceding sleep episode--a prospective study across 42 days of normal living
Akerstedt T, Axelsson J, Lekander M, Orsini N, Kecklund G
Journal of sleep research 2013;22(3):258-65

20th International Symposium on Shiftwork and Working Time: biological mechanisms, recovery, and risk management in the 24-h society
Kecklund G, Di Milia L, Axelsson J, Lowden A, Åkerstedt T
Chronobiology international 2012;29(5):531-6

Diurnal variability of total calcium during normal sleep and after an acute shift of sleep
Ridefelt P, Axelsson J, Larsson A

Efficacy of a behavioral self-help treatment with or without therapist guidance for co-morbid and primary insomnia -a randomized controlled trial
Jernelov S, Lekander M, Blom K, Rydh S, Ljotsson B, Axelsson J, et al

Predicting sleep quality from stress and prior sleep - A study of day-to-day covariation across six weeks
Akerstedt T, Orsini N, Petersen H, Axelsson J, Lekander M, Kecklund G
SLEEP MEDICINE 2012;13(6):674-9

Screening for Sleep Disorders in Pediatric Primary Care: Are We There Yet?
Erichsen D, Godoy C, Granse F, Axelsson J, Rubin D, Gozal D
CLINICAL PEDIATRICS 2012;51(12):1125-9

Learning in a simple biological system: a pilot study of classical conditioning of human macrophages in vitro
Nilsonne G, Appelgren A, Axelsson J, Fredrikson M, Lekander M

Short natural sleep is associated with higher T cell and lower NK cell activities
Fondell E, Axelsson J, Franck K, Ploner A, Lekander M, Balter K, et al

Influences of sleep and the circadian rhythm on iron-status indices
Ridefelt P, Larsson A, Rehman Ju, Axelsson J
CLINICAL BIOCHEMISTRY 2010;43(16-17):1323-8

Naps, cognition and performance
Ficca G, Axelsson J, Mollicone Dj, Muto V, Vitiello Mv
SLEEP MEDICINE REVIEWS 2010;14(4):249-58

Sleeping during the day: effects on the 24-h patterns of IGF-binding protein 1, insulin, glucose, cortisol, and growth hormone
Rehman Ju, Brismar K, Holmback U, Akerstedt T, Axelsson J

Larsson A, Hassan M, Ridefelt P, Axelsson J

Effects of Examination Stress on Psychological Responses, Sleep and Allergic Symptoms in Atopic and Non-Atopic Students
Jernelov S, Hoglund Co, Axelsson J, Axen J, Gronneberg R, Grunewald J, et al

Sleep Homeostasis During Repeated Sleep Restriction and Recovery: Support from EEG Dynamics
Akerstedt T, Kecklund G, Ingre M, Lekander M, Axelsson J
SLEEP 2009;32(2):217-22

Accounting for partial sleep deprivation and cumulative sleepiness in the Three-Process Model of alertness regulation
Akerstedt T, Ingre M, Kecklund G, Folkard S, Axelsson J

Circadian Variability of Cystatin C, Creatinine, and Glomerular Filtration Rate (GFR) in Healthy Men during Normal Sleep and after an Acute Shift of Sleep
Larsson A, Akerstedt T, Hansson Lo, Axelsson J

Effects of context on sleepiness self-ratings during repeated partial sleep deprivation
Akerstedt T, Kecklund G, Axelsson J

Low diurnal variability of apolipoprotein A1, apolipoprotein B and apolipoprotein B/apolipoprotein A1 ratio during normal sleep and after an acute shift of sleep
Larsson A, Carlsson L, Axelsson J
CLINICAL BIOCHEMISTRY 2008;41(10-11):859-62

Sleepiness and performance in response to repeated sleep restriction and subsequent recovery during semi-laboratory conditions
Axelsson J, Kecklund G, Akerstedt T, Donofrio P, Lekander M, Ingre M

Impaired sleep after bedtime stress and worries
Akerstedt T, Kecklund G, Axelsson J

The effects of asking for verbal ratings of sleepiness on sleepiness and its masking effects on performance
Kaida K, Akerstedt T, Kecklund G, Nilsson Jp, Axelsson J

Use of subjective and physiological indicators of sleepiness to predict performance during a vigilance task
Kaida K, Akerstedt T, Kecklund G, Nilsson Jp, Axelsson J
INDUSTRIAL HEALTH 2007;45(4):520-6

Recovery after shift work: Relation to coronary risk factors in women
Axelsson J, Lowden A, Kecklund G

Effects of acutely displaced sleep on testosterone
Axelsson J, Ingre M, Akerstedt T, Holmback U

Less effective executive functioning after one night's sleep deprivation
Nilsson Jp, Soderstrom M, Karlsson Au, Lekander M, Akerstedt T, Lindroth Ne, et al

Sleep and sleepiness in young individuals with high burnout scores
Soderstrom M, Ekstedt M, Akerstedt T, Nilsson J, Axelsson J
SLEEP 2004;27(7):1369-77

Tolerance to shift work-how does it relate to sleep and wakefulness?
Axelsson J, Akerstedt T, Kecklund G, Lowden A

Hormonal changes in satisfied and dissatisfied shift workers across a shift cycle
Axelsson J, Akerstedt T, Kecklund G, Lindqvist A, Attefors R

Change from an 8-hour shift to a 12-hour shift, attitudes, sleep, sleepiness and performance
Lowden A, Kecklund G, Axelsson J, Akerstedt T

Effects of alternating 8- and 12-hour shifts on sleep, sleepiness, physical effort and performance
Axelsson J, Kecklund G, Akerstedt T, Lowden A

The effects of a short daytime nap after restricted night sleep
Gillberg M, Kecklund G, Axelsson J, Akerstedt T
SLEEP 1996;19(7):570-5

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