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Dr Giovanna Zinzalla

Publikationer

A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex
Zinzalla G
Chembiochem : a European journal of chemical biology 2016;17(8):677-82

Targeting MYC: is it getting any easier?
Zinzalla G
FUTURE MEDICINAL CHEMISTRY 2016;8(16):1899-1902

Paving the way to targeting HECT ubiquitin ligases
Zinzalla G
Future medicinal chemistry 2015;7(16):2107-11

Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs)
Sammak S, Zinzalla G
Progress in biophysics and molecular biology 2015;119(1):41-6

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis
Allen Md, Freund Sm, Zinzalla G, Bycroft M
Structure (London, England : 1993) 2015;23(7):1344-9

Tetracycline analogues with a selective inhibitory effect on HIF-1 alpha
Bendiabdellah Y, Rahman Km, Uranchimeg B, Nahar Ks, Antonow D, Shoemaker Rh, et al
MEDCHEMCOMM 2014;5(7):923-926

Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry
Heidelberger S, Zinzalla G, Antonow D, Essex S, Basu Bp, Palmer J, et al
Bioorganic & medicinal chemistry letters 2013;23(16):4719-22

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography
Nkansah E, Shah R, Collie Gw, Parkinson Gn, Palmer J, Rahman Km, et al
FEBS LETTERS 2013;587(7):833-9

Molecular Dynamics Studies of the STAT3 Homodimer:DNA Complex: Relationships between STAT3 Mutations and Protein-DNA Recognition
Husby J, Todd Ak, Haider Sm, Zinzalla G, Thurston De, Neidle S
JOURNAL OF CHEMICAL INFORMATION AND MODELING 2012;52(5):1179-92

Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry
Harvey Sr, Porrini M, Stachl C, Macmillan D, Zinzalla G, Barran Pe
Journal of the American Chemical Society 2012;134(47):19384-92

One-Pot Synthesis of Fused-Tetracyclic Scaffolds Employing a Lewis Acid Promoted Domino Reaction of Naphthoquinones
Bendiabdellah Y, Villanueva-margalef I, Misale A, Nahar Ks, Haque Mr, Thurston De, et al
SYNTHESIS-STUTTGART 2011;:2321-2333

A novel small-molecule inhibitor of IL-6 signalling
Zinzalla G, Haque Mr, Basu Bp, Anderson J, Kaye Sl, Haider S, et al
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2010;20(23):7029-32

Facile nucleophilic substitution at the C3a tertiary carbon of the 3a-bromohexahydropyrrolo[2,3-b]indole scaffold
Villanueva-margalef I, Thurston De, Zinzalla G
ORGANIC & BIOMOLECULAR CHEMISTRY 2010;8(23):5294-303

Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5
Antonow D, Marrafa T, Dawood I, Ahmed T, Haque Mr, Thurston De, et al
CHEMICAL COMMUNICATIONS 2010;46(13):2289-91

Novel small-molecule inhibitors of Interleukin-6 (IL-6) signalling
Haque M, Zinzalla G, Basu Bp, Anderson J, Haider S, Hasan F, et al
EJC SUPPLEMENTS 2010;8(7):43-43

Total synthesis of YM-181741 for the preparation of natural product-like STAT3:STAT3 inhibitors
Misale A, Antonow D, Thurston De, Zinzalla G
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2010;:-

Targeting protein-protein interactions for therapeutic intervention: a challenge for the future
Zinzalla G, Thurston De
FUTURE MEDICINAL CHEMISTRY 2009;1(1):65-93

Natural-Product-Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B-Cell Chronic Lymphocytic Leukaemia
Milroy Lg, Zinzalla G, Loiseau F, Qian Zz, Prencipe G, Pepper C, et al
CHEMMEDCHEM 2008;3(12):1922-35

Chemical variation of natural-product-like scaffolds: Design, synthesis, and biological activity of fused bicyclic acetal derivatives
Milroy Lg, Zinzalla G, Prencipe G, Michel P, Ley Sv, Gunaratnam M, et al
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2007;46(14):2493-6

A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties (vol 689, pg 4791, 2004)
Baldoli C, Falciola L, Licandro E, Maiorana S, Mussini P, Ramani P, et al
JOURNAL OF ORGANOMETALLIC CHEMISTRY 2006;691(3):539-539

Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives
Zinzalla G, Milroy Lg, Ley Sv
ORGANIC & BIOMOLECULAR CHEMISTRY 2006;4(10):1977-2002

A new ferrocene conjugate of a tyrosine PNA monomer: synthesis and electrochemical properties
Baldoli C, Falciola L, Licandro E, Maiorana S, Mussini P, Ramani P, et al
JOURNAL OF ORGANOMETALLIC CHEMISTRY 2004;689(25):4791-4802

A thymine-PNA monomer as new isocyanide component in the Ugi reaction: A direct entry to PNA dimers
Baldoli C, Giannini C, Licandro E, Maiorana S, Zinzalla G
SYNLETT 2004;:1044-1048

Polymer-supported haloarene chromium dicarbonyl isonitrile complexes: A study of their synthesis and reactivity
Baldoli C, Maiorana S, Licandro E, Casiraghi L, Zinzalla G, Seneci P, et al
JOURNAL OF COMBINATORIAL CHEMISTRY 2003;5(6):809-13

Synthesis of chiral chromium tricarbonyl labeled thymine PNA monomers via the Ugi reaction
Baldoli C, Maiorana S, Licandro E, Zinzalla G, Perdicchia D
ORGANIC LETTERS 2002;4(24):4341-4

Stereoselective hetero Diels-Alder reactions of chiral tricarbonyl (eta(6)-benzaldehyde)chromium complexes
Baldoli C, Maiorana S, Licandro E, Zinzalla G, Lanfranchi M, Tiripicchio A
TETRAHEDRON-ASYMMETRY 2001;12(15):2159-2167

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