François Lallemend

Om mig
Publikationer
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CV
Populärvetenskap och samverkan

Om mig

Francois Lallemend är professor i neurobiologi av sensoriska system vid institutionen för neurovetenskap, Karolinska Institutet sedan 1 december 2023.
För mer information om hans karriär och forskning, se
den engelska profilsidan.

Artiklar

Article: EMBO JOURNAL. 2022;41(17):e108780

Schwann cell precursors represent a neural crest-like state with biased multipotency.

Kastriti ME; Faure L; Von Ahsen D; Bouderlique TG; Boström J; Solovieva T; Jackson C; Bronner M; Meijer D; Hadjab S; Lallemend F; Erickson A; Kaucka M; Dyachuk V; Perlmann T; Lahti L; Krivanek J; Brunet J-F; Fried K; Adameyko I
Article: NATURE COMMUNICATIONS. 2022;13(1):3878

Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification.

Petitpré C; Faure L; Uhl P; Fontanet P; Filova I; Pavlinkova G; Adameyko I; Hadjab S; Lallemend F
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(6):1077-1091

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss.

Trpchevska N; Freidin MB; Broer L; Oosterloo BC; Yao S; Zhou Y; Vona B; Bishop C; Bizaki-Vallaskangas A; Canlon B; Castellana F; Chasman DI; Cherny S; Christensen K; Concas MP; Correa A; Elkon R; Estonian Biobank Research Team; Mengel-From J; Gao Y; Giersch ABS; Girotto G; Gudjonsson A; Gudnason V; Heard-Costa NL; Hertzano R; Hjelmborg JVB; Hjerling-Leffler J; Hoffman HJ; Kaprio J; Kettunen J; Krebs K; Kähler AK; Lallemend F; Launer LJ; Lee I-M; Leonard H; Li C-M; Lowenheim H; Magnusson PKE; van Meurs J; Milani L; Morton CC; Mäkitie A; Nalls MA; Nardone GG; Nygaard M; Palviainen T; Pratt S; Quaranta N; Rämö J; Saarentaus E; Sardone R; Satizabal CL; Schweinfurth JM; Seshadri S; Shiroma E; Shulman E; Simonsick E; Spankovich C; Tropitzsch A; Lauschke VM; Sullivan PF; Goedegebure A; Cederroth CR; Williams FMK; Nagtegaal AP
Article: NATURE COMMUNICATIONS. 2021;12(1):6830

Theory of branching morphogenesis by local interactions and global guidance.

Uçar MC; Kamenev D; Sunadome K; Fachet D; Lallemend F; Adameyko I; Hadjab S; Hannezo E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(24):e1922586118

Involvement of Scratch2 in GalR1-mediated depression-like behaviors in the rat ventral periaqueductal gray.

Yang Y; Li Y; Liu B; Li C; Liu Z; Deng J; Luo H; Li X; Wu J; Li H; Wang C-Y; Zhao M; Wu H; Lallemend F; Svenningsson P; Hökfelt TGM; Xu Z-QD
Article: NATURE COMMUNICATIONS. 2021;12(1):1026

Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice.

Wu H; Petitpré C; Fontanet P; Sharma A; Bellardita C; Quadros RM; Jannig PR; Wang Y; Heimel JA; Cheung KKY; Wanderoy S; Xuan Y; Meletis K; Ruas J; Gurumurthy CB; Kiehn O; Hadjab S; Lallemend F
Journal article: CURRENT OPINION IN PHYSIOLOGY. 2020;18:85-94

Genetic and functional diversity of primary auditory afferents

Petitpre C; Bourien J; Wu H; Diuba A; Puel J-L; Lallemend F
Article: NATURE COMMUNICATIONS. 2020;11(1):4175

Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates.

Faure L; Wang Y; Kastriti ME; Fontanet P; Cheung KKY; Petitpré C; Wu H; Sun LL; Runge K; Croci L; Landy MA; Lai HC; Consalez GG; de Chevigny A; Lallemend F; Adameyko I; Hadjab S
Article: NATURE. 2020;582(7811):246-252

Molecular design of hypothalamus development.

Romanov RA; Tretiakov EO; Kastriti ME; Zupancic M; Häring M; Korchynska S; Popadin K; Benevento M; Rebernik P; Lallemend F; Nishimori K; Clotman F; Andrews WD; Parnavelas JG; Farlik M; Bock C; Adameyko I; Hökfelt T; Keimpema E; Harkany T
Article: DEVELOPMENT. 2019;146(20):dev181750

Muscle-selective RUNX3 dependence of sensorimotor circuit development.

Wang Y; Wu H; Zelenin P; Fontanet P; Wanderoy S; Petitpré C; Comai G; Bellardita C; Xue-Franzén Y; Huettl R-E; Huber AB; Tajbakhsh S; Kiehn O; Ernfors P; Deliagina TG; Lallemend F; Hadjab S
Article: NATURE COMMUNICATIONS. 2019;10(1):4137

A cell fitness selection model for neuronal survival during development.

Wang Y; Wu H; Fontanet P; Codeluppi S; Akkuratova N; Petitpré C; Xue-Franzén Y; Niederreither K; Sharma A; Da Silva F; Comai G; Agirman G; Palumberi D; Linnarsson S; Adameyko I; Moqrich A; Schedl A; La Manno G; Hadjab S; Lallemend F
Article: CELL REPORTS. 2019;26(13):3484-3492.e4

PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis.

Bartesaghi L; Wang Y; Fontanet P; Wanderoy S; Berger F; Wu H; Akkuratova N; Bouçanova F; Médard J-J; Petitpré C; Landy MA; Zhang M-D; Harrer P; Stendel C; Stucka R; Dusl M; Kastriti ME; Croci L; Lai HC; Consalez GG; Pattyn A; Ernfors P; Senderek J; Adameyko I; Lallemend F; Hadjab S; Chrast R
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:6

Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia.

Kastriti ME; Kameneva P; Kamenev D; Dyachuk V; Furlan A; Hampl M; Memic F; Marklund U; Lallemend F; Hadjab S; Calvo-Enrique L; Ernfors P; Fried K; Adameyko I
Article: NATURE COMMUNICATIONS. 2018;9(1):3691

Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system.

Petitpré C; Wu H; Sharma A; Tokarska A; Fontanet P; Wang Y; Helmbacher F; Yackle K; Silberberg G; Hadjab S; Lallemend F
Article: SCIENCE. 2017;357(6346):eaal3753

Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla.

Furlan A; Dyachuk V; Kastriti ME; Calvo-Enrique L; Abdo H; Hadjab S; Chontorotzea T; Akkuratova N; Usoskin D; Kamenev D; Petersen J; Sunadome K; Memic F; Marklund U; Fried K; Topilko P; Lallemend F; Kharchenko PV; Ernfors P; Adameyko I
Article: SCIENCE. 2017;356(6343):1168-1171

miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes.

Peng C; Li L; Zhang M-D; Bengtsson Gonzales C; Parisien M; Belfer I; Usoskin D; Abdo H; Furlan A; Häring M; Lallemend F; Harkany T; Diatchenko L; Hökfelt T; Hjerling-Leffler J; Ernfors P
Article: PLOS ONE. 2017;12(7):e0177962

Human bone marrow harbors cells with neural crest-associated characteristics like human adipose and dermis tissues.

Coste C; Neirinckx V; Sharma A; Agirman G; Rogister B; Foguenne J; Lallemend F; Gothot A; Wislet S
Article: SCIENTIFIC REPORTS. 2016;6:18617

Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone.

Wang Y; Fisahn A; Sinha I; Nguyen DP; Sterzenbach U; Lallemend F; Hadjab S
Article: JOURNAL OF NEUROSCIENCE. 2013;33(45):17656-17666

A local source of FGF initiates development of the unmyelinated lineage of sensory neurons.

Hadjab S; Franck MCM; Wang Y; Sterzenbach U; Sharma A; Ernfors P; Lallemend F
Article: EMBO JOURNAL. 2013;32(11):1613-1625

The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification.

Furlan A; Lübke M; Adameyko I; Lallemend F; Ernfors P
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2013;7:242

A role for the canonical nuclear factor-κB pathway in coupling neurotrophin-induced differential survival of developing spiral ganglion neurons.

Vandenbosch R; Chocholova E; Robe PA; Wang Y; Lambert C; Moonen G; Lallemend F; Malgrange B; Hadjab S
Article: NATURE COMMUNICATIONS. 2013;4:1438

Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells.

Defourny J; Poirrier A-L; Lallemend F; Mateo Sánchez S; Neef J; Vanderhaeghen P; Soriano E; Peuckert C; Kullander K; Fritzsch B; Nguyen L; Moonen G; Moser T; Malgrange B
Article: EMBO JOURNAL. 2012;31(18):3718-3729

Positional differences of axon growth rates between sensory neurons encoded by Runx3.

Lallemend F; Sterzenbach U; Hadjab-Lallemend S; Aquino JB; Castelo-Branco G; Sinha I; Villaescusa JC; Levanon D; Wang Y; Franck MCM; Kharchenko O; Adameyko I; Linnarsson S; Groner Y; Turner E; Ernfors P
Article: DEVELOPMENT. 2012;139(2):397-410

Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest.

Adameyko I; Lallemend F; Furlan A; Zinin N; Aranda S; Kitambi SS; Blanchart A; Favaro R; Nicolis S; Lübke M; Müller T; Birchmeier C; Suter U; Zaitoun I; Takahashi Y; Ernfors P
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2011;34(10):1529-1541

Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch.

Abdo H; Li L; Lallemend F; Bachy I; Xu X-J; Rice FL; Ernfors P
Article: CELL. 2009;139(2):366-379

Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin.

Adameyko I; Lallemend F; Aquino JB; Pereira JA; Topilko P; Müller T; Fritz N; Beljajeva A; Mochii M; Liste I; Usoskin D; Suter U; Birchmeier C; Ernfors P
Article: NEUROSCIENCE. 2009;162(4):1106-1119

The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamics.

Aquino JB; Lallemend F; Marmigère F; Adameyko II; Golemis EA; Ernfors P
Article: GENE EXPRESSION PATTERNS. 2008;8(4):217-226

Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues.

Aquino JB; Marmigère F; Lallemend F; Lundgren TK; Villar MJ; Wegner M; Ernfors P
Article: NEUROSCIENCE. 2007;150(1):212-222

New insights into peripherin expression in cochlear neurons.

Lallemend F; Vandenbosch R; Hadjab S; Bodson M; Breuskin I; Moonen G; Lefebvre PP; Malgrange B
Article: JOURNAL OF CELL SCIENCE. 2005;118(Pt 19):4511-4525

Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons.

Lallemend F; Hadjab S; Hans G; Moonen G; Lefebvre PP; Malgrange B
Article: BIOCHEMICAL PHARMACOLOGY. 2005;69(5):819-830

Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression.

Hans G; Wislet-Gendebien S; Lallemend F; Robe P; Rogister B; Belachew S; Nguyen L; Malgrange B; Moonen G; Rigo J-M
Article: NEUROPHARMACOLOGY. 2005;48(1):105-117

Beta-carbolines induce apoptosis in cultured cerebellar granule neurons via the mitochondrial pathway.

Hans G; Malgrange B; Lallemend F; Crommen J; Wislet-Gendebien S; Belachew S; Robe P; Rogister B; Moonen G; Rigo J-M
Article: OTOLOGY & NEUROTOLOGY. 2004;25(4):627-632

Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells.

Van De Water TR; Lallemend F; Eshraghi AA; Ahsan S; He J; Guzman J; Polak M; Malgrange B; Lefebvre PP; Staecker H; Balkany TJ
Article: NEUROREPORT. 2004;15(4):583-587

Striatal PSA-NCAM(+) precursor cells from the newborn rat express functional glycine receptors.

Nguyen L; Malgrange B; Breuskin I; Lallemend F; Hans G; Moonen G; Belachew S; Rigo J-M
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Preprint: BIORXIV. 2023

Motor nerves direct the development of the sympathetic nervous system

Erickson A; Motta A; Kastriti ME; Edwards S; Lallemend F; Hadjab S; Ruhrberg C; Schwarz Q; Fried K; Bonanomi D; Adameyko I
Preprint: BIORXIV. 2021

Theory of branching morphogenesis by local interactions and global guidance

Uçar MC; Kamenev D; Sunadome K; Fachet D; Lallemend F; Adameyko I; Hadjab S; Hannezo E
Review: TRENDS IN NEUROSCIENCES. 2012;35(6):373-381

Molecular interactions underlying the specification of sensory neurons.

Lallemend F; Ernfors P
Review: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2011;301(4):C750-C761

Structure and development of cochlear afferent innervation in mammals.

Defourny J; Lallemend F; Malgrange B
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2010;67(18):3037-3055

Glial versus melanocyte cell fate choice: Schwann cell precursors as a cellular origin of melanocytes.

Adameyko I; Lallemend F
Review: CURRENT PHARMACEUTICAL DESIGN. 2005;11(17):2257-2275

Molecular pathways involved in apoptotic cell death in the injured cochlea: cues to novel therapeutic strategies.

Lallemend F; Lefebvre PP; Hans G; Moonen G; Malgrange B
Review: JOURNAL OF NEUROCHEMISTRY. 2003;87(2):508-521

Substance P protects spiral ganglion neurons from apoptosis via PKC-Ca2+-MAPK/ERK pathways.

Lallemend F; Lefebvre PP; Hans G; Rigo JM; Van de Water TR; Moonen G; Malgrange B
Published conference paper: AUDIOLOGY AND NEURO-OTOLOGY. 2002;7(3):165-170

Mechanisms of cell death in the injured auditory system: otoprotective strategies.

Lefebvre PP; Malgrange B; Lallemend F; Staecker H; Moonen G; Van De Water TR

Forskningsbidrag

KAW Project Grant

Knut and Alice Wallenberg Foundation

1 January 2023 - 1 January 2028
KI Consolidator Grant

Karolinska Institutet

1 January 2020 - 1 January 2024
Wallenberg Academy Fellow in Medicine, Prolongation

Knut and Alice Wallenberg Foundation

1 January 2019 - 1 January 2023
Neural circuits underlying sound levels processing

Swedish Research Council (Consolidator Grant)

1 January 2019 - 31 December 2024
Genetic control of neuronal survival: implications for new cancer therapies

Swedish Research Council

1 January 2016 - 31 December 2019
Wallenberg Academy Fellow in Medicine

Knut and Alice Wallenberg Foundation

1 January 2014 - 1 January 2018
MOLECULAR MECHANISMS CONTROLLING THE ASSEMBLY OF SENSORY-MOTOR CIRCUIT

Swedish Research Council

1 January 2013 - 31 December 2016
MOLECULAR MECHANISMS CONTROLLING SENSORY NEURON DIVERSIFICATION AND ASSOCIATED ASSEMBLY INTO SPINAL CIRCUITS

Ragnar Söderberg Foundation

1 January 2013 - 31 December 2017
Genetic control of neuronal identity and connectivity in the peripheral nervous system

Swedish Research Council

1 January 2011 - 31 December 2013
Genetic control of neuronal identity and connectivity in the peripheral nervous system

Swedish Research Council

1 January 2011 - 31 December 2013

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