Konstantinos Meletis

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Forskningsbidrag
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Populärvetenskap och samverkan

Om mig

Konstantinos Meletis är professor i systemneurovetenskap vid institutionen för neurovetenskap. Utvalda akademiska priser och utmärkelser 2024 – Arvid Carlsson Fondens pris 2015 – William K. Bowes Jr. Foundation Associate Professor Award 2013 – Framtidens Forskningsledare, FFL5, Stiftelsen för Strategisk Forskning 2011 – William K. Bowes Jr. Foundation Assistant Professor Award 2010 – Marie Curie Reintegration Grant FP7 (EU) 2010 – NARSAD Young Investigator Award (USA)

Utvalda publikationer

Review: ANNUAL REVIEW OF NEUROSCIENCE. 2021;44:547-562

Spatial Transcriptomics: Molecular Maps of the Mammalian Brain.

Ortiz C; Carlén M; Meletis K
Article: SCIENCE ADVANCES. 2020;6(26):eabb3446

Molecular atlas of the adult mouse brain.

Ortiz C; Navarro JF; Jurek A; Märtin A; Lundeberg J; Meletis K
Article: CELL REPORTS. 2019;29(13):4320-4333.e5

A Spatiomolecular Map of the Striatum.

Märtin A; Calvigioni D; Tzortzi O; Fuzik J; Wärnberg E; Meletis K
Article: MOLECULAR PSYCHIATRY. 2019;24(9):1351-1368

A hypothalamus-habenula circuit controls aversion.

Lazaridis I; Tzortzi O; Weglage M; Märtin A; Xuan Y; Parent M; Johansson Y; Fuzik J; Fürth D; Fenno LE; Ramakrishnan C; Silberberg G; Deisseroth K; Carlén M; Meletis K
Article: NATURE NEUROSCIENCE. 2018;21(1):139-149

An interactive framework for whole-brain maps at cellular resolution.

Fürth D; Vaissière T; Tzortzi O; Xuan Y; Märtin A; Lazaridis I; Spigolon G; Fisone G; Tomer R; Deisseroth K; Carlén M; Miller CA; Rumbaugh G; Meletis K
Article: NEURON. 2014;83(3):663-678

A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei.

Pollak Dorocic I; Fürth D; Xuan Y; Johansson Y; Pozzi L; Silberberg G; Carlén M; Meletis K
Article: PLOS ONE. 2014;9(1):e83879

Mice lacking NMDA receptors in parvalbumin neurons display normal depression-related behavior and response to antidepressant action of NMDAR antagonists.

Pozzi L; Pollak Dorocic I; Wang X; Carlén M; Meletis K
Article: JOURNAL OF NEUROSCIENCE. 2013;33(4):1678-1683

Target selectivity of feedforward inhibition by striatal fast-spiking interneurons.

Szydlowski SN; Pollak Dorocic I; Planert H; Carlén M; Meletis K; Silberberg G

Artiklar

Journal article: BIORXIV. 2023;:2023.09.27.559787

Sensorimotor Integration Supporting Perception Requires Syngap1 Expression in Cortex.

Vaissiere T; Michaelson S; Creson T; Goins J; Fürth D; Balazsfi D; Rojas C; Golovin R; Meletis K; Miller CA; O'Connor D; Rumbaugh G
Article: NATURE NEUROSCIENCE. 2023;26(7):1245-1255

Esr1+ hypothalamic-habenula neurons shape aversive states.

Calvigioni D; Fuzik J; Le Merre P; Slashcheva M; Jung F; Ortiz C; Lentini A; Csillag V; Graziano M; Nikolakopoulou I; Weglage M; Lazaridis I; Kim H; Lenzi I; Park H; Reinius B; Carlén M; Meletis K
Journal article: ENEURO. 2023;10(7):1-20

A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.

Kondabolu K; Doig NM; Ayeko O; Khan B; Torres A; Calvigioni D; Meletis K; Koós T; Magill PJ
Article: NUCLEIC ACIDS RESEARCH. 2023;51(8):e47

The spatial landscape of gene expression isoforms in tissue sections.

Lebrigand K; Bergenstråhle J; Thrane K; Mollbrink A; Meletis K; Barbry P; Waldmann R; Lundeberg J
Article: CELL REPORTS. 2021;36(4):109437

Complete representation of action space and value in all dorsal striatal pathways.

Weglage M; Wärnberg E; Lazaridis I; Calvigioni D; Tzortzi O; Meletis K
Article: PLOS BIOLOGY. 2021;19(7):e3001341

Assessing the replicability of spatial gene expression using atlas data from the adult mouse brain.

Lu S; Ortiz C; Fürth D; Fischer S; Meletis K; Zador A; Gillis J
Article: JOURNAL OF NEUROSCIENCE. 2021;41(14):3120-3141

Adult trkB Signaling in Parvalbumin Interneurons is Essential to Prefrontal Network Dynamics.

Guyon N; Zacharias LR; van Lunteren JA; Immenschuh J; Fuzik J; Märtin A; Xuan Y; Zilberter M; Kim H; Meletis K; Lopes-Aguiar C; Carlén M
Article: NATURE COMMUNICATIONS. 2021;12(1):1026

Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice.

Wu H; Petitpré C; Fontanet P; Sharma A; Bellardita C; Quadros RM; Jannig PR; Wang Y; Heimel JA; Cheung KKY; Wanderoy S; Xuan Y; Meletis K; Ruas J; Gurumurthy CB; Kiehn O; Hadjab S; Lallemend F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(51):25958-25967

Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants.

Fuzik J; Rehman S; Girach F; Miklosi AG; Korchynska S; Arque G; Romanov RA; Hanics J; Wagner L; Meletis K; Yanagawa Y; Kovacs GG; Alpár A; Hökfelt TGM; Harkany T
Article: NATURE NEUROSCIENCE. 2019;22(4):657-668

A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.

Ährlund-Richter S; Xuan Y; van Lunteren JA; Kim H; Ortiz C; Pollak Dorocic I; Meletis K; Carlén M
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2017;525(15):3227-3250

Monosynaptic retrograde tracing of neurons expressing the G-protein coupled receptor Gpr151 in the mouse brain.

Broms J; Grahm M; Haugegaard L; Blom T; Meletis K; Tingström A
Article: CELL RESEARCH. 2016;26(9):1033-1047

Cortical neurons gradually attain a post-mitotic state.

Anda FCD; Madabhushi R; Rei D; Meng J; Gräff J; Durak O; Meletis K; Richter M; Schwanke B; Mungenast A; Tsai L-H
Article: NATURE. 2012;489(7414):150-154

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision.

Song J; Zhong C; Bonaguidi MA; Sun GJ; Hsu D; Gu Y; Meletis K; Huang ZJ; Ge S; Enikolopov G; Deisseroth K; Luscher B; Christian KM; Ming G-L; Song H
Article: NATURE NEUROSCIENCE. 2012;15(7):1022-1031

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.

de Anda FC; Rosario AL; Durak O; Tran T; Gräff J; Meletis K; Rei D; Soda T; Madabhushi R; Ginty DD; Kolodkin AL; Tsai L-H
Article: MOLECULAR PSYCHIATRY. 2012;17(5):537-548

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior.

Carlén M; Meletis K; Siegle JH; Cardin JA; Futai K; Vierling-Claassen D; Rühlmann C; Jones SR; Deisseroth K; Sheng M; Moore CI; Tsai L-H
Article: ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. ANNUAL INTERNATIONAL CONFERENCE. 2011;2011:7529-7532

Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice.

Siegle JH; Carlen M; Meletis K; Tsai L-H; Moore CI; Ritt J
Article: CELL STEM CELL. 2010;7(4):470-482

Origin of new glial cells in intact and injured adult spinal cord.

Barnabé-Heider F; Göritz C; Sabelström H; Takebayashi H; Pfrieger FW; Meletis K; Frisén J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(33):14657-14661

Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene.

Forsberg M; Carlén M; Meletis K; Yeung MSY; Barnabé-Heider F; Persson MAA; Aarum J; Frisén J
Article: JOURNAL OF NEUROSCIENCE. 2010;30(31):10391-10406

Centrosome motility is essential for initial axon formation in the neocortex.

de Anda FC; Meletis K; Ge X; Rei D; Tsai L-H
Article: NEURON. 2010;67(1):33-48

Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.

Singh KK; Ge X; Mao Y; Drane L; Meletis K; Samuels BA; Tsai L-H
Article: BRAIN. 2010;133(Pt 4):983-995

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha.

Seidel S; Garvalov BK; Wirta V; von Stechow L; Schänzer A; Meletis K; Wolter M; Sommerlad D; Henze A-T; Nistér M; Reifenberger G; Lundeberg J; Frisén J; Acker T
Article: NATURE PROTOCOLS. 2010;5(2):247-254

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2.

Cardin JA; Carlén M; Meletis K; Knoblich U; Zhang F; Deisseroth K; Tsai L-H; Moore CI
Article: NATURE. 2009;459(7247):663-U63

Driving fast-spiking cells induces gamma rhythm and controls sensory responses.

Cardin JA; Carlén M; Meletis K; Knoblich U; Zhang F; Deisseroth K; Tsai L-H; Moore CI
Article: NATURE NEUROSCIENCE. 2009;12(3):259-267

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.

Carlén M; Meletis K; Göritz C; Darsalia V; Evergren E; Tanigaki K; Amendola M; Barnabé-Heider F; Yeung MSY; Naldini L; Honjo T; Kokaia Z; Shupliakov O; Cassidy RM; Lindvall O; Frisén J
Article: PLOS BIOLOGY. 2008;6(7):e182-1507

Spinal cord injury reveals multilineage differentiation of ependymal cells.

Meletis K; Barnabé-Heider F; Carlén M; Evergren E; Tomilin N; Shupliakov O; Frisén J
Article: NATURE METHODS. 2008;5(2):189-196

Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation.

Barnabé-Heider F; Meletis K; Eriksson M; Bergmann O; Sabelström H; Harvey MA; Mikkers H; Frisén J
Article: DEVELOPMENTAL DYNAMICS. 2007;236(6):1663-1676

Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan.

Nguyen S; Meletis K; Fu D; Jhaveri S; Jaenisch R
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(15):2851-2859

Genetic visualization of neurogenesis.

Carlén M; Meletis K; Barnabé-Heider F; Frisén J
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(10):1798-1812

Catalog of gene expression in adult neural stem cells and their in vivo microenvironment.

Williams C; Wirta V; Meletis K; Wikström L; Carlsson L; Frisén J; Lundeberg J
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(8):2976-2983

Suppression of intestinal neoplasia by deletion of Dnmt3b.

Lin H; Yamada Y; Nguyen S; Linhart H; Jackson-Grusby L; Meissner A; Meletis K; Lo G; Jaenisch R
Article: DEVELOPMENT. 2006;133(2):363-369

p53 suppresses the self-renewal of adult neural stem cells.

Meletis K; Wirta V; Hede S-M; Nistér M; Lundeberg J; Frisén J
Article: DEVELOPMENTAL NEUROSCIENCE. 2006;28(1-2):118-127

Recording Notch signaling in real time.

Hansson EM; Teixeira AI; Gustafsson MV; Dohda T; Chapman G; Meletis K; Muhr J; Lendahl U
Article: BMC NEUROSCIENCE. 2005;6:28

Transcriptome analysis in primary neural stem cells using a tag cDNA amplification method.

Sievertzon M; Wirta V; Mercer A; Meletis K; Erlandsson R; Wikström L; Frisén J; Lundeberg J
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Alla övriga publikationer

Preprint: 2023;bioRxiv

Cell type-specific representation of spatial context in the rat prefrontal cortex

Brünner H; Kim H; Ährlund-Richter S; van Lunteren J; Crestani A; Meletis K; Carlén M
Preprint: 2023;bioRxiv

Recurrent circuits encode visual center-surround computations in the mouse superior colliculus

Cui P; Song K; Mariatos Metaxas D; Isla A; Femenia T; Lazaridis I; Meletis K; Kumar A; Kardamakis A
Preprint: 2022;bioRxiv

Esr1+ hypothalamic-habenula neurons shape aversive states

Calvigioni D; Fuzik J; Le Merre P; Slashcheva M; Jung F; Ortiz C; Lentini A; Csillag V; Graziano M; Nikolakopoulou I; Weglage M; Lazaridis I; Kim H; Lenzi I; Park H; Reinius B; Carlén M; Meletis K
Preprint: 2022;bioRxiv

Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility

Weglage M; Ährlund-Richter S; Fuzik J; Skara V; Lazaridis I; Meletis K
Preprint: 2020;bioRxiv

A selective projection from the subthalamic nucleus to parvalbumin-expressing interneurons of the striatum

Kondabolu K; Doig N; Ayeko O; Khan B; Torres A; Calvigioni D; Meletis K; Magill P; Koós T
Preprint: 2020;bioRxiv

Replicability of spatial gene expression atlas data from the adult mouse brain

Lu S; Ortiz C; Fürth D; Fischer S; Meletis K; Zador A; Gillis J
Preprint: 2020;bioRxiv

The spatial landscape of gene expression isoforms in tissue sections

Lebrigand K; Bergenstråhle J; Thrane K; Mollbrink A; Meletis K; Meletis K; Barbry P; Waldmann R; Lundeberg J
Preprint: 2020;bioRxiv

A critical role for trkB signaling in the adult function of parvalbumin interneurons and prefrontal network dynamics

Guyon N; Zacharias LR; van Lunteren JA; Immenschuh J; Fuzik J; Märtin A; Xuan Y; Zilberter M; Kim H; Meletis K; Lopes-Aguiar C; Carlén M
Preprint: 2020;bioRxiv

Complete representation of action space and value in all striatal pathways

Weglage M; Wärnberg E; Lazaridis I; Tzortzi O; Meletis K
Preprint: 2019;bioRxiv

Molecular Atlas of the Adult Mouse Brain

Ortiz C; Navarro JF; Jurek A; Märtin A; Lundeberg J; Meletis K
Preprint: 2019;bioRxiv

Brain-wide genetic mapping identifies the indusium griseum as a prenatal and shared target of pharmacologically-unrelated psychostimulants

Fuzik J; Rehman S; Girach F; Miklosi A; Korchynska S; Arque G; Romanov R; Hanics J; Wagner L; Meletis K; Yanagawa Y; Kovacs G; Alpár A; Hökfelt TGM; Harkany T
Corrigendum: NATURE NEUROSCIENCE. 2019;22(6):1037

Publisher Correction: A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.

Ährlund-Richter S; Xuan Y; van Lunteren JA; Kim H; Ortiz C; Dorocic IP; Meletis K; Carlén M
Preprint: 2019;bioRxiv

A Spatiomolecular Map of the Striatum

Märtin A; Calvigioni D; Tzortzi O; Fuzik J; Wärnberg E; Meletis K
Corrigendum: NATURE NEUROSCIENCE. 2018;21(6):895

Publisher Correction: An interactive framework for whole-brain maps at cellular resolution.

Fürth D; Vaissière T; Tzortzi O; Xuan Y; Märtin A; Lazaridis I; Spigolon G; Fisone G; Tomer R; Deisseroth K; Carlén M; Miller CA; Rumbaugh G; Meletis K
Corrigendum: NATURE NEUROSCIENCE. 2014;17(12):1840

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex (vol 15, pg 1022, 2012)

de Anda FC; Rosario AL; Durak O; Tran T; Graeff J; Meletis K; Rei D; Soda T; Madabhushi R; Ginty DD; Kolodkin AL; Tsai L-H
Corrigendum: PLOS ONE. 2014;9(2):e91486

Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists (vol 9, e83879, 2014)

Pozzi L; Dorocic PI; Wang X; Carlen M; Meletis K
Editorial comment: TRENDS IN NEUROSCIENCES. 2003;26(6):292-296

Blood on the tracks: a simple twist of fate?

Meletis K; Frisén J
Editorial comment: JOURNAL OF CELL BIOLOGY. 2001;155(5):699-702

Have the bloody cells gone to our heads?

Meletis K; Frisen J

Forskningsbidrag

Brain circuits in decision-making

Knut and Alice Wallenberg Foundation

1 January 2020 - 1 January 2025
The organization and function of striatal circuits.

Swedish Research Council

1 January 2019 - 31 December 2024
Brain circuits regulating reward, anhedonia and addiction.

Swedish Research Council

1 January 2018 - 31 December 2021
Development of a whole-brain cellular mapping approach in a genetic model of autism and intellectual disability

National Institute of Mental Health

15 April 2016 - 31 March 2018
Optogenetic dissection of limbic circuits

Swedish Foundation for Strategic Research

1 January 2014 - 31 December 2018
ERA-NET NEURON Mental Disorders RDmaria aDBS

Swedish Research Council

1 January 2014 - 31 December 2016
Optogenetic characterization of limbic circuits for reward and addiction.

Swedish Research Council

1 January 2013 - 31 December 2017

Anställningar

Professor, Neurovetenskap, Karolinska Institutet, 2021-

Examina och utbildning

Docent, Neurovetenskap, Karolinska Institutet, 2015
MEDICINE DOKTORSEXAMEN, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2006
Medicine Magisterexamen, Karolinska Institutet, 2000

Om mig

Utvalda publikationer

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Forskningsbidrag

Anställningar

Examina och utbildning

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