Dhanu Gupta

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE MICROBIOLOGY. 2024;9(4):905-921

Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens.

Groß R; Reßin H; von Maltitz P; Albers D; Schneider L; Bley H; Hoffmann M; Cortese M; Gupta D; Deniz M; Choi J-Y; Jansen J; Preußer C; Seehafer K; Pöhlmann S; Voelker DR; Goffinet C; Pogge-von Strandmann E; Bunz U; Bartenschlager R; El Andaloussi S; Sparrer KMJ; Herker E; Becker S; Kirchhoff F; Münch J; Müller JA
Article: CELLS. 2023;12(18):2285

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation.

Gupta D; Orehek S; Turunen J; O'Donovan L; Gait MJ; El-Andaloussi S; Wood MJA
Article: SCIENCE ADVANCES. 2023;9(35):eadh1168

The cellular response to extracellular vesicles is dependent on their cell source and dose.

Hagey DW; Ojansivu M; Bostancioglu BR; Saher O; Bost JP; Gustafsson MO; Gramignoli R; Svahn M; Gupta D; Stevens MM; Görgens A; El Andaloussi S
Article: NATURE COMMUNICATIONS. 2023;14(1):4734

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles.

Zheng W; Rädler J; Sork H; Niu Z; Roudi S; Bost JP; Görgens A; Zhao Y; Mamand DR; Liang X; Wiklander OPB; Lehto T; Gupta D; Nordin JZ; El Andaloussi S
Article: JOURNAL OF CONTROLLED RELEASE. 2023;357:630-640

Surface display of functional moieties on extracellular vesicles using lipid anchors.

Zheng W; Schürz M; Wiklander RJ; Gustafsson O; Gupta D; Slovak R; Traista A; Coluzzi A; Roudi S; Barone A; Farcas D; Kyriakopoulou E; Galli V; Sharma H; Meisner-Kober N; Honcharenko M; Andaloussi SEL
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(7):e12248

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models.

Liang X; Niu Z; Galli V; Howe N; Zhao Y; Wiklander OPB; Zheng W; Wiklander RJ; Corso G; Davies C; Hean J; Kyriakopoulou E; Mamand DR; Amin R; Nordin JZ; Gupta D; Andaloussi SE
Article: ADVANCED HEALTHCARE MATERIALS. 2022;11(5):e2101658

Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles.

Bost JP; Saher O; Hagey D; Mamand DR; Liang X; Zheng W; Corso G; Gustafsson O; Görgens A; Smith CE; Zain R; El Andaloussi S; Gupta D
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):185

Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides.

Bost JP; Ojansivu M; Munson MJ; Wesén E; Gallud A; Gupta D; Gustafsson O; Saher O; Rädler J; Higgins SG; Lehto T; Holme MN; Dahlén A; Engkvist O; Strömstedt P-E; Andersson S; Edvard Smith CI; Stevens MM; Esbjörner EK; Collén A; El Andaloussi S
Article: BIOMOLECULES. 2021;11(11):1606

Diagnostic and Prognostic Utility of the Extracellular Vesicles Subpopulations Present in Pleural Effusion.

Javadi J; Görgens A; Vanky H; Gupta D; Hjerpe A; El-Andaloussi S; Hagey D; Dobra K
Article: NATURE BIOMEDICAL ENGINEERING. 2021;5(9):1084-1098

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.

Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balusu S; Feldin U; Bostancioglu B; Jawad R; Mamand DR; Lee YXF; Hean J; Mäger I; Roberts TC; Gustafsson M; Mohammad DK; Sork H; Backlund A; Lundin P; de Fougerolles A; Smith CIE; Wood MJA; Vandenbroucke RE; Nordin JZ; El-Andaloussi S
Article: BIOMEDICINES. 2021;9(8):1046

Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo.

Bazaz S; Lehto T; Tops R; Gissberg O; Gupta D; Bestas B; Bost J; Wiklander OPB; Sork H; Zaghloul EM; Mamand DR; Hällbrink M; Sillard R; Saher O; Ezzat K; Smith CIE; Andaloussi SE; Lehto T
Article: PHARMACEUTICS. 2021;13(6):878

Efficient Peptide-Mediated In Vitro Delivery of Cas9 RNP.

Gustafsson O; Rädler J; Roudi S; Lehto T; Hällbrink M; Lehto T; Gupta D; Andaloussi SE; Nordin JZ
Article: SMALL. 2021;17(14):e2008155

Multiparametric Profiling of Single Nanoscale Extracellular Vesicles by Combined Atomic Force and Fluorescence Microscopy: Correlation and Heterogeneity in Their Molecular and Biophysical Features.

Cavallaro S; Pevere F; Stridfeldt F; Görgens A; Paba C; Sahu SS; Mamand DR; Gupta D; El Andaloussi S; Linnros J; Dev A
Article: BIOMATERIALS. 2021;266:120435

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle.

Conceição M; Forcina L; Wiklander OPB; Gupta D; Nordin JZ; Vrellaku B; McClorey G; Mäger I; Gӧrgens A; Lundin P; Musarò A; Wood MJA; Andaloussi SE; Roberts TC
Article: MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. 2020;18:880-892

Use of Nanovesicles from Orange Juice to Reverse Diet-Induced Gut Modifications in Diet-Induced Obese Mice.

Berger E; Colosetti P; Jalabert A; Meugnier E; Wiklander OPB; Jouhet J; Errazurig-Cerda E; Chanon S; Gupta D; Rautureau GJP; Geloen A; El-Andaloussi S; Panthu B; Rieusset J; Rome S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222

Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging.

Gupta D; Liang X; Pavlova S; Wiklander OPB; Corso G; Zhao Y; Saher O; Bost J; Zickler AM; Piffko A; Maire CL; Ricklefs FL; Gustafsson O; Llorente VC; Gustafsson MO; Bostancioglu RB; Mamand DR; Hagey DW; Görgens A; Nordin JZ; El Andaloussi S
Article: BLOOD ADVANCES. 2020;4(11):2439-2450

Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects.

Estupiñán HY; Bouderlique T; He C; Berglöf A; Gupta D; Saher O; Daza Cruz MÁ; Peña-Perez L; Yu L; Zain R; Karlsson MCI; Månsson R; Smith CIE
Article: NATURE COMMUNICATIONS. 2020;11(1):1113

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA.

de Jong OG; Murphy DE; Mäger I; Willms E; Garcia-Guerra A; Gitz-Francois JJ; Lefferts J; Gupta D; Steenbeek SC; van Rheenen J; El Andaloussi S; Schiffelers RM; Wood MJA; Vader P
Article: METHODS IN MOLECULAR BIOLOGY. 2020;2109:35-44

Isolation and Characterization of Extracellular Vesicles from Keratinocyte Cultures.

Sjöqvist S; Imafuku A; Gupta D; El Andaloussi S
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2020;78:106042

The kidney injury caused by the onset of acute graft-versus-host disease is associated with down-regulation of αKlotho.

Amin R; He R; Gupta D; Zheng W; Burmakin M; Mohammad DK; DePierre JW; Sadeghi B; Olauson H; Wernerson A; El-Andaloussi S; Hassan M; Abedi-Valugerdi M
Article: PHARMACEUTICS. 2019;11(12):E666-666

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations.

Saher O; Lehto T; Gissberg O; Gupta D; Gustafsson O; Andaloussi SE; Darbre T; Lundin KE; Smith CIE; Zain R
Article: ACS SENSORS. 2019;4(5):1399-1408

Label-Free Surface Protein Profiling of Extracellular Vesicles by an Electrokinetic Sensor.

Cavallaro S; Horak J; Hååg P; Gupta D; Stiller C; Sahu SS; Görgens A; Gatty HK; Viktorsson K; El Andaloussi S; Lewensohn R; Karlström AE; Linnros J; Dev A
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018;132:29-40

Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity.

Saher O; Rocha CSJ; Zaghloul EM; Wiklander OPB; Zamolo S; Heitz M; Ezzat K; Gupta D; Reymond J-L; Zain R; Hollfelder F; Darbre T; Lundin KE; El Andaloussi S; Smith CIE
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1326

Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures.

Wiklander OPB; Bostancioglu RB; Welsh JA; Zickler AM; Murke F; Corso G; Felldin U; Hagey DW; Evertsson B; Liang X-M; Gustafsson MO; Mohammad DK; Wiek C; Hanenberg H; Bremer M; Gupta D; Björnstedt M; Giebel B; Nordin JZ; Jones JC; El Andaloussi S; Görgens A
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Review: MOLECULAR THERAPY. 2023;31(5):1231-1250

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading.

Rädler J; Gupta D; Zickler A; Andaloussi SE
Thesis / dissertation: 2021

Engineered extracellular vesicles for biomedical applications

Gupta, Dhanu
Review: ADVANCED DRUG DELIVERY REVIEWS. 2021;178:113961

Dosing extracellular vesicles.

Gupta D; Zickler AM; El Andaloussi S
Review: ACS NANO. 2021;15(9):13993-14021

Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles.

Bost JP; Barriga H; Holme MN; Gallud A; Maugeri M; Gupta D; Lehto T; Valadi H; Esbjörner EK; Stevens MM; El-Andaloussi S
Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):1701

Publisher Correction: A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA.

de Jong OG; Murphy DE; Mäger I; Willms E; Garcia-Guerra A; Gitz-Francois JJ; Lefferts J; Gupta D; Steenbeek SC; van Rheenen J; El Andaloussi S; Schiffelers RM; Wood MJA; Vader P
Corrigendum: METHODS IN MOLECULAR BIOLOGY. 2020;2109:293

Correction to: Isolation and Characterization of Extracellular Vesicles from Keratinocyte Cultures.

Sjöqvist S; Imafuku A; Gupta D; El Andaloussi S

Anställningar

Anknuten till Forskning, Laboratoriemedicin, Karolinska Institutet, 2024-2025
Postdoktor, Laboratoriemedicin, Karolinska Institutet, 2022-2024

Examina och utbildning

Medicine Doktorsexamen, Institutionen för laboratoriemedicin, Karolinska Institutet, 2022

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