Angel Cedazo Minguez

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Min forskning är inriktad på den molekylära mekanismen bakom riskfaktorer för neurodegenerativa sjukdomar. Från 2017, kombinerar jag min professur på KI med chefstjänsten Head av Neuroforskning i Sanofi (Frankrike). Hittills har jag publicerat 100+ artiklar och handlett 10 doktorsavhandlingar.

Befattningar

Från 2017- Professor. Molekylär Neurogeriatrik. KI

Från 2017-Head av Neuroforskning. Sanofi (Frankrike).

Från 2006-17 Biträdande chef för KI-Alzheimers sjukdom forskningscentrum/Neurogeriatrik.

Från 2014- 17 Vicedirektör i Swedish Brain Power: Ett nationellt nätverk av forskning i neurodegenerativa sjukdomar.

Från 2014- Sft-prefekt. Institution NVS

För mer information se min sida på engelska

Utvalda publikationer

Article: MOLECULAR PSYCHIATRY. 2021;26(4):1410-1423

Thioredoxin-80 protects against amyloid-beta pathology through autophagic-lysosomal pathway regulation.

Gerenu G; Persson T; Goikolea J; Calvo-Garrido J; Loera-Valencia R; Pottmeier P; Santiago C; Poska H; Presto J; Cedazo-Minguez A
Article: ALZHEIMERS RESEARCH & THERAPY. 2021;13(1):56

27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial.

Sandebring-Matton A; Goikolea J; Björkhem I; Paternain L; Kemppainen N; Laatikainen T; Ngandu T; Rinne J; Soininen H; Cedazo-Minguez A; Solomon A; Kivipelto M
Article: SCIENTIFIC REPORTS. 2021;11(1):3736

High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus.

Loera-Valencia R; Vazquez-Juarez E; Muñoz A; Gerenu G; Gómez-Galán M; Lindskog M; DeFelipe J; Cedazo-Minguez A; Merino-Serrais P
Article: MOLECULAR PSYCHIATRY. 2021;26(1):322-340

Lithium treatment reverses irradiation-induced changes in rodent neural progenitors and rescues cognition.

Zanni G; Goto S; Fragopoulou AF; Gaudenzi G; Naidoo V; Di Martino E; Levy G; Dominguez CA; Dethlefsen O; Cedazo-Minguez A; Merino-Serrais P; Stamatakis A; Hermanson O; Blomgren K
Article: CEREBRAL CORTEX. 2019;29(1):429-446

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons.

Merino-Serrais P; Loera-Valencia R; Rodriguez-Rodriguez P; Parrado-Fernandez C; Ismail MA; Maioli S; Matute E; Jimenez-Mateos EM; Björkhem I; DeFelipe J; Cedazo-Minguez A
Article: BRAIN. 2017;140(12):3269-3285

Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons.

Rodriguez-Rodriguez P; Sandebring-Matton A; Merino-Serrais P; Parrado-Fernandez C; Rabano A; Winblad B; Ávila J; Ferrer I; Cedazo-Minguez A
Article: LANCET NEUROLOGY. 2016;15(5):455-532

Defeating Alzheimer's disease and other dementias: a priority for European science and society.

Winblad B; Amouyel P; Andrieu S; Ballard C; Brayne C; Brodaty H; Cedazo-Minguez A; Dubois B; Edvardsson D; Feldman H; Fratiglioni L; Frisoni GB; Gauthier S; Georges J; Graff C; Iqbal K; Jessen F; Johansson G; Jönsson L; Kivipelto M; Knapp M; Mangialasche F; Melis R; Nordberg A; Rikkert MO; Qiu C; Sakmar TP; Scheltens P; Schneider LS; Sperling R; Tjernberg LO; Waldemar G; Wimo A; Zetterberg H
Article: AGING CELL. 2015;14(1):122-129

Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease.

Maioli S; Lodeiro M; Merino-Serrais P; Falahati F; Khan W; Puerta E; Codita A; Rimondini R; Ramirez MJ; Simmons A; Gil-Bea F; Westman E; Cedazo-Minguez A; Alzheimer's Disease Neuroimaging Initiative
Article: ANALYTICAL CHEMISTRY. 2012;84(20):8532-8540

Toward a predictive model of Alzheimer's disease progression using capillary electrophoresis-mass spectrometry metabolomics.

Ibáñez C; Simó C; Martín-Álvarez PJ; Kivipelto M; Winblad B; Cedazo-Mínguez A; Cifuentes A
Article: EMBO MOLECULAR MEDICINE. 2012;4(10):1097-1111

Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain.

Gil-Bea F; Akterin S; Persson T; Mateos L; Sandebring A; Avila-Cariño J; Gutierrez-Rodriguez A; Sundström E; Holmgren A; Winblad B; Cedazo-Minguez A

Artiklar

Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2023;234:106387

Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison.

Goikolea J; Latorre-Leal M; Tsagkogianni C; Pikkupeura S; Gulyas B; Cedazo-Minguez A; Loera-Valencia R; Björkhem I; Rodriguez Rodriguez P; Maioli S
Article: BRAIN COMMUNICATIONS. 2023;5(5):fcad228

Alzheimer's disease biomarker profiling in a memory clinic cohort without common comorbidities.

Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths WJ; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Matton A
Article: GLIA. 2023;71(6):1414-1428

27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changes.

Alanko V; Gaminde-Blasco A; Quintela-López T; Loera-Valencia R; Solomon A; Björkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Sandebring-Matton A
Article: ALZHEIMERS RESEARCH & THERAPY. 2022;14(1):37

Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer's disease: a potential early sign of AD.

Goikolea J; Gerenu G; Daniilidou M; Mangialasche F; Mecocci P; Ngandu T; Rinne J; Solomon A; Kivipelto M; Cedazo-Minguez A; Sandebring-Matton A; Maioli S
Article: MOLECULAR NEUROBIOLOGY. 2021;58(12):6063-6076

Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration.

Loera-Valencia R; Ismail M-A; Goikolea J; Lodeiro M; Mateos L; Björkhem I; Puerta E; Romão MA; Gomes CM; Merino-Serrais P; Maioli S; Cedazo-Minguez A
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(16):3194-3204

Sex difference in flux of 27-hydroxycholesterol into the brain.

Parrado-Fernandez C; Leoni V; Saeed A; Rodriguez-Rodriguez P; Sandebring-Matton A; Córdoba-Beldad CM; Bueno P; Gali CC; Panzenboeck U; Cedazo-Minguez A; Björkhem I
Article: AGING-US. 2021;13(11):14729-14744

Long-term exposure to polypharmacy impairs cognitive functions in young adult female mice.

Eroli F; Johnell K; Latorre-Leal M; Hilmer S; Wastesson J; Cedazo-Minguez A; Maioli S
Journal article: MOLECULAR PSYCHIATRY. 2021;26(1):1-2

Irradiation-induced changes in neural progenitor cells are reversed by lithium: Immature newborn dentate granule neurons display dendritic processes that are either tangential or parallel to the granule cell layer of the dentate gyrus of the hippocampus

Zanni G; Goto S; Fragopoulou AF; Gaudenzi G; Naidoo V; Di Martino E; Levy G; Dominguez CA; Dethlefsen O; Cedazo-Minguez A; Merino-Serrais P; Stamatakis A; Hermanson O; Blomgren K
Article: NEUROSCIENCE. 2020;448:14-27

Chronic Airway Allergy Induces Pro-Inflammatory Responses in the Brain of Wildtype Mice but Not 3xTgAD Mice.

Sarlus H; Codita A; Wang X; Cedazo-Minguez A; Schultzberg M; Oprica M
Article: AGING-US. 2020;12(11):10147-10161

Chronic polypharmacy impairs explorative behavior and reduces synaptic functions in young adult mice.

Eroli F; Johnell K; Latorre Leal M; Adamo C; Hilmer S; Wastesson JW; Cedazo-Minguez A; Maioli S
Article: NEUROBIOLOGY OF DISEASE. 2020;134:104645

Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration.

Höglund K; Schussler N; Kvartsberg H; Smailovic U; Brinkmalm G; Liman V; Becker B; Zetterberg H; Cedazo-Minguez A; Janelidze S; Lefevre IA; Eyquem S; Hansson O; Blennow K
Article: FRONTIERS IN GENETICS. 2020;11:1022

Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL.

Panahi M; Rodriguez PR; Fereshtehnejad S-M; Arafa D; Bogdanovic N; Winblad B; Cedazo-Minguez A; Rinne J; Darreh-Shori T; Hase Y; Kalaria RN; Viitanen M; Behbahani H
Article: CELL DEATH AND DIFFERENTIATION. 2019;26(9):1545-1565

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.

Guerrero-Gómez D; Mora-Lorca JA; Sáenz-Narciso B; Naranjo-Galindo FJ; Muñoz-Lobato F; Parrado-Fernández C; Goikolea J; Cedazo-Minguez Á; Link CD; Neri C; Sequedo MD; Vázquez-Manrique RP; Fernández-Suárez E; Goder V; Pané R; Cabiscol E; Askjaer P; Cabello J; Miranda-Vizuete A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(11):4169-4176

24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo.

Theofilopoulos S; Abreu de Oliveira WA; Yang S; Yutuc E; Saeed A; Abdel-Khalik J; Ullgren A; Cedazo-Minguez A; Björkhem I; Wang Y; Griffiths WJ; Arenas E
Article: SCIENTIFIC REPORTS. 2019;9(1):3965

Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases.

Caberlotto L; Nguyen T-P; Lauria M; Priami C; Rimondini R; Maioli S; Cedazo-Minguez A; Sita G; Morroni F; Corsi M; Carboni L
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018;22(11):5439-5449

Reduction of PINK1 or DJ-1 impair mitochondrial motility in neurites and alter ER-mitochondria contacts.

Parrado-Fernández C; Schneider B; Ankarcrona M; Conti MM; Cookson MR; Kivipelto M; Cedazo-Mínguez Á; Sandebring-Matton A
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018;22(10):5151-5154

Evidence for sex difference in the CSF/plasma albumin ratio in ~20 000 patients and 335 healthy volunteers.

Parrado-Fernández C; Blennow K; Hansson M; Leoni V; Cedazo-Minguez A; Björkhem I
Article: PHARMACOLOGICAL REPORTS. 2018;70(4):677-683

Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes.

Kazkayasi I; Burul-Bozkurt N; Ismail M-A; Merino-Serrais P; Pekiner C; Cedazo-Minguez A; Uma S
Article: PLOS ONE. 2018;13(3):e0194892

The composition of polypharmacy: A register-based study of Swedes aged 75 years and older.

Wastesson JW; Cedazo Minguez A; Fastbom J; Maioli S; Johnell K
Journal article: INNOVATION IN AGING. 2017;1(suppl_1):1040

ARE ANIMAL MODELS VALUABLE FOR AGING RESEARCH? LESSONS FROM ALZHEIMER’S DISEASE

Cedazo-Minguez A
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(3):699-717

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation.

Ismail M-A; Mateos L; Maioli S; Merino-Serrais P; Ali Z; Lodeiro M; Westman E; Leitersdorf E; Gulyás B; Olof-Wahlund L; Winblad B; Savitcheva I; Björkhem I; Cedazo-Mínguez A
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(3):319-328

Aggregation of the Inflammatory S100A8 Precedes Aβ Plaque Formation in Transgenic APP Mice: Positive Feedback for S100A8 and Aβ Productions.

Lodeiro M; Puerta E; Ismail M-A; Rodriguez-Rodriguez P; Rönnbäck A; Codita A; Parrado-Fernandez C; Maioli S; Gil-Bea F; Merino-Serrais P; Cedazo-Minguez A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;56(2):601-617

Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis.

Persson T; Lattanzio F; Calvo-Garrido J; Rimondini R; Rubio-Rodrigo M; Sundström E; Maioli S; Sandebring-Matton A; Cedazo-Mínguez Á
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1862(11):2110-2118

Anthocyanins protect from complex I inhibition and APPswe mutation through modulation of the mitochondrial fission/fusion pathways.

Parrado-Fernández C; Sandebring-Matton A; Rodriguez-Rodriguez P; Aarsland D; Cedazo-Mínguez A
Article: ALZHEIMERS & DEMENTIA. 2016;12(11):1149-1158

Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.

Bereczki E; Francis PT; Howlett D; Pereira JB; Höglund K; Bogstedt A; Cedazo-Minguez A; Baek J-H; Hortobágyi T; Attems J; Ballard C; Aarsland D
Article: NEUROSCIENCE LETTERS. 2016;633:174-181

Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats.

Kazkayasi I; Ismail M-A; Parrado-Fernandez C; Björkhem I; Pekiner C; Uma S; Cedazo-Minguez A; Burul-Bozkurt N
Article: SCIENTIFIC REPORTS. 2016;6:30928

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.

Moutinho M; Nunes MJ; Correia JC; Gama MJ; Castro-Caldas M; Cedazo-Minguez A; Rodrigues CMP; Björkhem I; Ruas JL; Rodrigues E
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;53(1):349-361

Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.

Tajeddinn W; Persson T; Calvo-Garrido J; Seed Ahmed M; Maioli S; Vijayaraghavan S; Kazokoglu MS; Parrado-Fernández C; Yoshitake T; Kehr J; Francis P; Winblad B; Höglund K; Cedazo-Minguez A; Aarsland D
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;53(2):621-630

Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers.

Tajeddinn W; Fereshtehnejad S-M; Seed Ahmed M; Yoshitake T; Kehr J; Shahnaz T; Milovanovic M; Behbahani H; Höglund K; Winblad B; Cedazo-Minguez A; Jelic V; Järemo P; Aarsland D
Article: JOURNAL OF ALZHEIMERS DISEASE. 2015;47(2):523-529

Autoantibodies Toward the Angiotensin 2 Type 1 Receptor: A Novel Autoantibody in Alzheimer's Disease.

Giil LM; Kristoffersen EK; Vedeler CA; Aarsland D; Nordrehaug JE; Winblad B; Cedazo-Minguez A; Lund A; Reksten TR
Article: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 2015;41(4):471-482

Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease.

Ugarte A; Gil-Bea F; García-Barroso C; Cedazo-Minguez Á; Ramírez MJ; Franco R; García-Osta A; Oyarzabal J; Cuadrado-Tejedor M
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2015;70(6):675-685

Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse.

Orejana L; Barros-Miñones L; Jordan J; Cedazo-Minguez A; Tordera RM; Aguirre N; Puerta E
Article: NEUROSCIENCE LETTERS. 2015;594:137-143

5-HT1B and other related serotonergic proteins are altered in APPswe mutation.

Tajeddinn W; Persson T; Maioli S; Calvo-Garrido J; Parrado-Fernandez C; Yoshitake T; Kehr J; Francis P; Winblad B; Höglund K; Cedazo-Minguez A; Aarsland D
Article: BEHAVIOURAL BRAIN RESEARCH. 2015;278:356-359

27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice.

Heverin M; Maioli S; Pham T; Mateos L; Camporesi E; Ali Z; Winblad B; Cedazo-Minguez A; Björkhem I
Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2015;55(2):396-405

Insufficient resolution response in the hippocampus of a senescence-accelerated mouse model--SAMP8.

Wang X; Puerta E; Cedazo-Minguez A; Hjorth E; Schultzberg M
Article: MOLECULAR NEUROBIOLOGY. 2015;51(3):1489-1503

Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.

Moutinho M; Nunes MJ; Gomes AQ; Gama MJ; Cedazo-Minguez A; Rodrigues CMP; Björkhem I; Rodrigues E
Article: INTERNATIONAL JOURNAL OF SPORTS MEDICINE. 2015;36(1):54-60

Resistance training does not have an effect on cognition or related serum biomarkers in nonagenarians: a randomized controlled trial.

Ruiz JR; Gil-Bea F; Bustamante-Ara N; Rodríguez-Romo G; Fiuza-Luces C; Serra-Rexach JA; Cedazo-Minguez A; Lucia A
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2014;69(9):1132-1138

Vitamin D in relation to cognitive impairment, cerebrospinal fluid biomarkers, and brain volumes.

Hooshmand B; Lökk J; Solomon A; Mangialasche F; Miralbell J; Spulber G; Annerbo S; Andreasen N; Winblad B; Cedazo-Minguez A; Wahlund L-O; Kivipelto M
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_13):p516

P2‐123: BIOMARKERS FOR COGNITIVE DECLINE OF EARLY PARKINSON's DISEASE

Bereczki E; Hoglund K; Svenningsson P; Cedazo‐Minguez A; Francis P; Ballard CG; Aarsland D
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_17):p639-p640

P3‐033: 5HT1B‐RECEPTOR AND RELATED SEROTONERGIC CHANGES IN ALZHEIMER'S DISEASE MODELS

Abderhim WT; Höglund K; Cedazo‐Minguez A; Aarsland D
Article: JOURNAL OF ALZHEIMERS DISEASE. 2014;41(1):223-232

Decreased cerebrospinal fluid levels of L-carnitine in non-apolipoprotein E4 carriers at early stages of Alzheimer's disease.

Lodeiro M; Ibáñez C; Cifuentes A; Simó C; Cedazo-Mínguez Á
Article: JOURNAL OF INTERNAL MEDICINE. 2014;275(3):296-303

Pathways to Alzheimer's disease.

Hardy J; Bogdanovic N; Winblad B; Portelius E; Andreasen N; Cedazo-Minguez A; Zetterberg H
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;37(4):713-733

Intracellular localization of amyloid-β peptide in SH-SY5Y neuroblastoma cells.

Zheng L; Calvo-Garrido J; Hallbeck M; Hultenby K; Marcusson J; Cedazo-Minguez A; Terman A
Article: JOURNAL OF CHROMATOGRAPHY A. 2013;1302:65-71

A new metabolomic workflow for early detection of Alzheimer's disease.

Ibáñez C; Simó C; Barupal DK; Fiehn O; Kivipelto M; Cedazo-Mínguez A; Cifuentes A
Article: JOURNAL OF NEUROINFLAMMATION. 2013;10:99

Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses.

Sarlus H; Wang X; Cedazo-Minguez A; Schultzberg M; Oprica M
Article: PLOS ONE. 2013;8(7):e68534

Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?

Maioli S; Båvner A; Ali Z; Heverin M; Ismail M-A; Puerta E; Olin M; Saeed A; Shafaati M; Parini P; Cedazo-Minguez A; Björkhem I
Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;32(2):341-355

Combination of apolipoprotein E4 and high carbohydrate diet reduces hippocampal BDNF and arc levels and impairs memory in young mice.

Maioli S; Puerta E; Merino-Serrais P; Fusari L; Gil-Bea F; Rimondini R; Cedazo-Minguez A
Article: TRANSLATIONAL NEURODEGENERATION. 2012;1(1):19

Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system.

Zheng L; Cedazo-Minguez A; Hallbeck M; Jerhammar F; Marcusson J; Terman A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;29(4):741-749

Grey matter and cognitive patterns in cognitive impaired subjects using CSF biomarker cut-offs.

Miralbell J; Spulber G; Hooshmand B; Besga A; Mataró M; Cedazo-Minguez A; Kivipelto M; Wahlund L-O
Article: NEUROSCIENCE LETTERS. 2012;510(2):121-126

Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms.

Besga A; Cedazo-Minguez A; Kåreholt I; Solomon A; Björkhem I; Winblad B; Leoni V; Hooshmand B; Spulber G; Gonzalez-Pinto A; Kivipelto M; Wahlund LO
Article: NEUROSCIENCE LETTERS. 2012;506(2):245-250

Estrogen protects against amyloid-β toxicity by estrogen receptor α-mediated inhibition of Daxx translocation.

Mateos L; Persson T; Katoozi S; Gil-Bea FJ; Cedazo-Minguez A
Article: AUTOPHAGY. 2011;7(12):1528-1545

Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells.

Zheng L; Terman A; Hallbeck M; Dehvari N; Cowburn RF; Benedikz E; Kågedal K; Cedazo-Minguez A; Marcusson J
Article: ELECTROPHORESIS. 2011;32(19):2757-2764

Analysis of chiral amino acids in cerebrospinal fluid samples linked to different stages of Alzheimer disease.

Samakashvili S; Ibáñez C; Simó C; Gil-Bea FJ; Winblad B; Cedazo-Mínguez A; Cifuentes A
Article: HIPPOCAMPUS. 2011;21(9):999-1009

Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation.

Gil-Bea FJ; Solas M; Mateos L; Winblad B; Ramírez MJ; Cedazo-Mínguez A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(29):25574-25585

Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism.

Mateos L; Ismail M-A; Gil-Bea F-J; Schüle R; Schöls L; Heverin M; Folkesson R; Björkhem I; Cedazo-Mínguez A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2011;24(4):669-679

Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease.

Mateos L; Ismail M-A; Gil-Bea F-J; Leoni V; Winblad B; Björkhem I; Cedazo-Mínguez A
Article: HUMAN MOLECULAR GENETICS. 2011;20(1):40-50

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.

Thomas KJ; McCoy MK; Blackinton J; Beilina A; van der Brug M; Sandebring A; Miller D; Maric D; Cedazo-Minguez A; Cookson MR
Article: JOURNAL OF ALZHEIMERS DISEASE. 2010;22(3):829-838

HPA axis dysregulation associated to apolipoprotein E4 genotype in Alzheimer's disease.

Gil-Bea FJ; Aisa B; Solomon A; Solas M; del Carmen Mugueta M; Winblad B; Kivipelto M; Cedazo-Mínguez A; Ramírez MJ
Article: JOURNAL OF ALZHEIMERS DISEASE. 2010;22(2):405-413

Insulin levels are decreased in the cerebrospinal fluid of women with prodomal Alzheimer's disease.

Gil-Bea FJ; Solas M; Solomon A; Mugueta C; Winblad B; Kivipelto M; Ramirez MJ; Cedazo-Mínguez A
Journal article: ALZHEIMERS & DEMENTIA. 2010;6(4S_Part_20):e32

P4‐042: The Role of Oxidative Stress and Autophagy in Amyloid Beta‐protein Toxicity to Cultured Neuroblastoma Cells

Zheng L; Dehvari N; Benedikz E; Cowburn R; Terman A; Cedazo-Minguez A; Marcusson J
Article: ONCOGENE. 2010;29(10):1531-1542

Ezrin mediates c-Myc actions in prostate cancer cell invasion.

Chuan Y-C; Iglesias-Gato D; Fernandez-Perez L; Cedazo-Minguez A; Pang S-T; Norstedt G; Pousette A; Flores-Morales A
Article: FEBS JOURNAL. 2009;276(18):5041-5052

Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.

Sandebring A; Dehvari N; Perez-Manso M; Thomas KJ; Karpilovski E; Cookson MR; Cowburn RF; Cedazo-Mínguez A
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2009;13(9B):3061-3068

Parkin-mediated ubiquitination regulates phospholipase C-gamma1.

Dehvari N; Sandebring A; Flores-Morales A; Mateos L; Chuan Y-C; Goldberg MS; Cookson MR; Cowburn RF; Cedazo-Mínguez A
Article: BIOPHYSICAL JOURNAL. 2009;97(1):277-285

Influence of residue 22 on the folding, aggregation profile, and toxicity of the Alzheimer's amyloid beta peptide.

Perálvarez-Marín A; Mateos L; Zhang C; Singh S; Cedazo-Mínguez A; Visa N; Morozova-Roche L; Gräslund A; Barth A
Article: PLOS ONE. 2009;4(5):e5701

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

Sandebring A; Thomas KJ; Beilina A; van der Brug M; Cleland MM; Ahmad R; Miller DW; Zambrano I; Cowburn RF; Behbahani H; Cedazo-Mínguez A; Cookson MR
Article: JOURNAL OF NEUROIMMUNOLOGY. 2009;208(1-2):46-53

Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain.

Spulber S; Mateos L; Oprica M; Cedazo-Minguez A; Bartfai T; Winblad B; Schultzberg M
Article: BRAIN PATHOLOGY. 2009;19(1):69-80

Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro.

Mateos L; Akterin S; Gil-Bea F-J; Spulber S; Rahman A; Björkhem I; Schultzberg M; Flores-Morales A; Cedazo-Mínguez A
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2008;12(6B):2762-2771

Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study.

Kivipelto M; Rovio S; Ngandu T; Kåreholt I; Eskelinen M; Winblad B; Hachinski V; Cedazo-Minguez A; Soininen H; Tuomilehto J; Nissinen A
Article: PHARMACOLOGICAL RESEARCH. 2008;58(1):32-37

Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain.

Sallam H; Jimenez P; Song H; Vita M; Cedazo-Minguez A; Hassan M
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_20):t643

P3‐414: Activity‐regulated cytoskeleton‐associated protein in rodent brain is down‐regulated by high fat diet in vivo and by 27‐hydroxycholesterol in vitro

Mateos L; Akterin S; Gil-Bea F-J; Spulber S; Rahman A; Björkhem I; Schultzberg M; Flores-Morales A; Cedazo-Minguez A
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_23):t752

P4‐276: Characterization of Thioredoxin‐80 in the brain and its relevance in Alzheimer′s disease

Gil-Bea FJ; Akterin S; Mateos-Montejo L; Avila-Carino J; Holmgren A; Winblad B; Cedazo-Minguez A
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_20):t639-t640

P3‐403: Parkin ubiquitylates phospholipase C–γ1 and protects against dopamine induced cell death

Dehvari N; Sandebring A; Flores-Morales A; Mateos L; Karpilovski E; Cookson MR; Goldberg MS; Cowburn RF; Cedazo-Minguez A
Article: PEDIATRIC TRANSPLANTATION. 2008;12(4):412-419

Prospective analysis of carotid arterial wall structure in pediatric renal transplants with ambulatory normotension and in treated hypertensive recipients.

Krmar RT; Balzano R; Jogestrand T; Cedazo-Minguez A; Englund MS; Berg UB
Article: NEUROSCIENCE LETTERS. 2008;436(1):77-80

Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism.

Dehvari N; Isacsson O; Winblad B; Cedazo-Minguez A; Cowburn RF
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):93-97

Presenilin-mediated signal transduction.

Cowburn RF; Popescu BO; Ankarcrona M; Dehvari N; Cedazo-Minguez A
Article: JOURNAL OF NEUROCHEMISTRY. 2007;102(3):848-857

Presenilin dependence of phospholipase C and protein kinase C signaling.

Dehvari N; Cedazo-Minguez A; Isacsson O; Nilsson T; Winblad B; Karlström H; Benedikz E; Cowburn RF
Journal article: ALZHEIMERS & DEMENTIA. 2007;3(3S_Part_3):s166-s167

O1–01–03: Healthy lifestyle reduces the risk of dementia especially among the apolipoprotein E e4 carriers

Rovio S; Ngandu T; Kåreholt I; Laitinen M; Winblad B; Haschinski V; Soininen H; Tuomilehto J; Cedazo-Minguez A; Nissinen A; Kivipelto M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(40):29938-29948

Androgen induction of prostate cancer cell invasion is mediated by ezrin.

Chuan Y-C; Pang S-T; Cedazo-Minguez A; Norstedt G; Pousette A; Flores-Morales A
Article: CELL DEATH AND DIFFERENTIATION. 2006;13(9):1454-1465

Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's disease.

Akterin S; Cowburn RF; Miranda-Vizuete A; Jiménez A; Bogdanovic N; Winblad B; Cedazo-Minguez A
Journal article: ALZHEIMERS & DEMENTIA. 2006;2(3S_Part_16):s495-s496

P3–407: Presenilin dependence of phospholipase C and associated signalling

Dehvari N; Cedazo-Minguez A; Isacsson O; Nilsson T; Winblad B; Benedikz E; Cowburn RF
Journal article: ALZHEIMERS & DEMENTIA. 2006;2(3S_Part_2):s47-s48

S3–02–04: Exploring the mechanisms behind risk factors for Alzheimer's disease

Cedazo-Minguez A
Article: JOURNAL OF NEUROCHEMISTRY. 2006;97(2):356-364

Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.

Hansson CA; Popescu BO; Laudon H; Cedazo-Minguez A; Popescu LM; Winblad B; Ankarcrona M
Article: FEBS LETTERS. 2005;579(28):6411-6416

High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice.

Rahman A; Akterin S; Flores-Morales A; Crisby M; Kivipelto M; Schultzberg M; Cedazo-Mínguez A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(8):6455-6464

Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction.

Popescu BO; Cedazo-Minguez A; Benedikz E; Nishimura T; Winblad B; Ankarcrona M; Cowburn RF
Article: JOURNAL OF NEUROCHEMISTRY. 2003;87(5):1152-1164

Apolipoprotein E and beta-amyloid (1-42) regulation of glycogen synthase kinase-3beta.

Cedazo-Mínguez A; Popescu BO; Blanco-Millán JM; Akterin S; Pei J-J; Winblad B; Cowburn RF
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(39):36646-36655

The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations.

Cedazo-Minguez A; Popescu BO; Ankarcrona M; Nishimura T; Cowburn RF
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2001;66(1):122-134

Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells.

Popescu BO; Cedazo-Minguez A; Popescu LM; Winblad B; Cowburn RF; Ankarcrona M
Article: FEBS LETTERS. 2001;504(1-2):45-49

Apolipoprotein E isoform-specific disruption of phosphoinositide hydrolysis: protection by estrogen and glutathione.

Cedazo-Mínguez A; Cowburn RF
Article: NEUROCHEMISTRY INTERNATIONAL. 2001;38(7):615-625

Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts.

Cedazo-Mínguez A; Wiehager B; Winblad B; Hüttinger M; Cowburn RF
Article: NEUROREPORT. 2001;12(2):201-206

Beta-VLDL protects against A beta(1-42) and apoE toxicity in human SH-SY5Y neuroblastoma cells.

Cedazo-Mínguez A; Hüttinger M; Cowburn RF
Article: NEUROSCIENCE. 2001;105(3):651-661

Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures.

Cedazo-Mínguez A; Hamker U; Meske V; Veh RW; Hellweg R; Jacobi C; Albert F; Cowburn RF; Ohm TG
Journal article: NEUROBIOLOGY OF AGING. 2000;21:252

Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures

Cedazo-Minguez A; Hamker U; Veh R; Meske V; Albert F; Cowburn RF; Ohm TG
Article: NEUROCHEMISTRY INTERNATIONAL. 1999;35(4):307-315

Nicergoline stimulates protein kinase C mediated alpha-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells.

Cedazo-Minguez A; Bonecchi L; Winblad B; Post C; Wong EH; Cowburn RF; Benatti L
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1999;1453(3):341-350

Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases.

Vestling M; Cedazo-Mínguez A; Adem A; Wiehager B; Racchi M; Lannfelt L; Cowburn RF
Journal article: NEUROBIOLOGY OF AGING. 1996;17(4):s57

226 Effect of fibroblast growth factor and insulin on β-amyloid production in normal and familial Alzheimer's disease fibroblasts

Vigo-Pelfrey C; Cedazo-Minguez A; Cowburn RF; Jensen M; Lannfelt L; Johnston JA
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Alla övriga publikationer

Preprint: BIORXIV. 2022

Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities

Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths W; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Sandebring-Matton A
Preprint: BIORXIV. 2022

The proto-oncogene DEK regulates neuronal excitability and tau accumulation in Alzheimer’s disease vulnerable neurons

Rodriguez-Rodriguez P; Arroyo-Garcia LE; Li L; Tsagkogianni C; Wang W; Salas-Allende I; Plautz Z; Cedazo-Minguez A; Sinha S; Troyanskaya O; Flajolet M; Yao V; Roussarie J-P
Preprint: BIORXIV. 2022

Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia

Goikolea J; Roussarie J-P; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
Conference publication: 2022;:219-227

Integrated Label Transfer for Oligodendrocyte Subpopulation Profiling in Parkinson’s Disease and Multiple System Atrophy

Teeple E; Joshi P; Pande R; Huang Y; Karambe A; Latta-Mahieu M; Sardi S; Cedazo-Minguez A; Klinger K; Flores-Morales A; Madden S; Rajpal D; Kumar D
Preprint: BIORXIV. 2021

Single Nuclei Sequencing of Human Putamen Oligodendrocytes Reveals Altered Heterogeneity and Disease-Associated Changes in Parkinson’s Disease and Multiple System Atrophy

Teeple E; Joshi P; Pande R; Huang Y; Karambe A; Latta-Mahieu M; Sardi SP; Cedazo-Minguez A; Klinger KW; Flores-Morales A; Madden SL; Rajpal D; Kumar D
Preprint: BIORXIV. 2021

Single Cell Atlas of Human Putamen Reveals Disease Specific Changes in Synucleinopathies: Parkinson’s Disease and Multiple System Atrophy

Pande R; Huang Y; Teeple E; Joshi P; Flores-Morales A; Latta-Mahieu M; Sardi SP; Cedazo-Minguez A; Klinger KW; Madden SL; Rajpal D; Kumar D
Preprint: RESEARCH SQUARE. 2021

27-Hydroxycholesterol Promotes Oligodendrocyte Maturation – Implications for Hypercholesterolemia Associated Brain White Matter Changes

Alanko V; Quintela-López T; Gaminde-Blasco A; Loera-Valencia R; Solomon A; Björkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Matton A
Preprint: BIORXIV. 2021

Sex-dependent effects of CYP46A1 overexpression on cognitive function during aging

Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Daniilidou M; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths W; Björkhem I; Sandebring Matton A; Merino-Serrais P; Cedazo-Minguez A; Maioli S
Review: JOURNAL OF INTERNAL MEDICINE. 2019;286(4):398-437

Current and emerging avenues for Alzheimer's disease drug targets.

Loera-Valencia R; Cedazo-Minguez A; Kenigsberg PA; Page G; Duarte AI; Giusti P; Zusso M; Robert P; Frisoni GB; Cattaneo A; Zille M; Boltze J; Cartier N; Buee L; Johansson G; Winblad B
Corrigendum: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019;23(6):4489

Corrigendum.
Preprint: BIORXIV. 2019

Lithium treatment reverses irradiation-induced changes in rodent neural progenitors

Giulia Z; Shinobu G; Giulia G; Vinogran N; Gabriel L; Elena DM; Olga D; Angel C-M; Paula M-S; Ola H; Klas B
Preprint: BIORXIV. 2018

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

Guerrero-Gómez D; Mora-Lorca JA; Sáenz-Narciso B; Naranjo-Galindo FJ; Muñoz-Lobato F; Parrado-Fernández C; Cedazo-Minguez Á; Link C; Neri C; Sequedo MD; Vázquez-Manrique R; Fernández-Suárez E; Goder V; Pané R; Cabiscol E; Askjaer P; Cabello J; Miranda-Vizuete A
Corrigendum: BRAIN. 2018;141(5):e43

Corrigendum.
Review: ALZHEIMER'S AND DEMENTIA: TRANSLATIONAL RESEARCH AND CLINICAL INTERVENTIONS. 2017;3(4):571-578

Toward common mechanisms for risk factors in Alzheimer's syndrome.

Medina M; Khachaturian ZS; Rossor M; Avila J; Cedazo-Minguez A
Review: JOURNAL OF INTERNAL MEDICINE. 2017;281(6):534-553

Can LDL cholesterol be too low? Possible risks of extremely low levels.

Olsson AG; Angelin B; Assmann G; Binder CJ; Björkhem I; Cedazo-Minguez A; Cohen J; von Eckardstein A; Farinaro E; Müller-Wieland D; Parhofer KG; Parini P; Rosenson RS; Starup-Linde J; Tikkanen MJ; Yvan-Charvet L
Review: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2014;2014:427318-11

Oxidative stress in Alzheimer's disease: why did antioxidant therapy fail?

Persson T; Popescu BO; Cedazo-Minguez A
Review: FRONTIERS IN PHARMACOLOGY. 2014;5:146

Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?

Franco R; Cedazo-Minguez A
Corrigendum: NEUROSCIENCE LETTERS. 2012;514(2):219

Estrogen protects against amyloid-β toxicity by estrogen receptor α-mediated inhibition of Daxx translocation (vol 506, pg 245, 2011)

Mateos L; Persson T; Katoozi S; Gil-Bea FJ; Cedazo-Minguez A
Published conference paper: NEURODEGENERATIVE DISEASES. 2012;10(1-4):313-316

side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons.

Mateos L; Ismail M-A; Winblad B; Cedazo-Mínguez A
Corrigendum: JOURNAL OF ALZHEIMERS DISEASE. 2011;25(4):763

Upregulation of Brain Renin Angiotensin System by 27-Hydroxycholesterol in Alzheimer's Disease (vol 24, pg 669, 2011)

Mateos L; Ismail M-A; Gil-Bea F-J; Leoni V; Winblad B; Bjoerkhem I; Cedazo-Minguez A
Review: EXPERT REVIEW OF NEUROTHERAPEUTICS. 2011;11(4):495-498

Plasma cholesterol and risk for late-onset Alzheimer's disease.

Cedazo-Mínguez A; Ismail M-A; Mateos L
Review: EXPERIMENTAL GERONTOLOGY. 2010;45(1):5-14

Biomarkers for Alzheimer's disease and other forms of dementia: clinical needs, limitations and future aspects.

Cedazo-Minguez A; Winblad B
Review: MOLECULAR ASPECTS OF MEDICINE. 2009;30(3):171-179

Oxysterols and neurodegenerative diseases.

Björkhem I; Cedazo-Minguez A; Leoni V; Meaney S
Meeting abstract: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2008;1777:S55

Altered mitochondrial dynamics caused by loss of PTEN-induced kinase 1 function, associated with recessive parkinsonism, are reversed by downregulation of Dynamin-related protein 1

Thomas KJ; Sandebring A; Beilina A; van der Brug M; Cleland MM; Zambrano I; Miller DW; Unger C; Cowburn R; Youle R; Behbahani H; Cedazo-Minguez A; Cookson MR
Conference publication: HAEMATOLOGICA. 2008;93:497

AGE DEPENDANT PHARMACOKINETICS OF ROSCOVITINE ANT ITS EFFECT ON BRAIN CDK5 AND ERK 1/2 IN RAT PUPS

Sallam H; Jimenez P; Vita M; Cedazo-Minguez A; Moustapha H
Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2007;11(6):1227-1238

Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities.

Cedazo-Mínguez A
Conference publication: PEDIATRIC TRANSPLANTATION. 2007;11:108

Prospective analysis of carotid intima-media thickness (IMT) in normotensive paediatric renal transplants and in recipients with newly diagnosed ambulatory hypertension.

Krmar RT; Balzano R; Jogestrand T; Cedazo-Minguez A; Englund M; Berg UB
Conference publication: FEBS JOURNAL. 2007;274:167

Role of presenilins in signal transduction pathways and cell death in Alzheimer's disease

Popescu BO; Ankarcrona M; Cedazo-Minguez A; Hansson CA; Popescu LM; Cowburn RF; Winblad B
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15:S350

Apolipoprotein E and presenilin regulation of cellular signalling

Cowburn R; Cedazo-Minguez A
Conference publication: INTERNATIONAL PSYCHOGERIATRICS. 2005;17:204-205

Presenilin dependence of phospholipase C regulation

Dehvari N; Cedazo-Minguez A; Winblad B; Cowburn R
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S525

The proteasome regulates presenilin 1 levels during apoptosis

Ankarcrona M; Cedazo-Minguez A; Winblad B; Popescu BO
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S541-S542

Beta-amyloid oxidation of thioredoxin and glutaredoxin.: A possible link between oxidative stress and apoptosis in Alzheimer's disease

Akterin S; Miranda-Vizuete A; Winblad B; Cowburn RF; Cedazo-Mínguez A
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S401-S402

Apolipoprotein E and beta amyloid peptide regulation of glycogen synthase kinase-3 beta

Cedazo-Minguez A; Wiehager B; Pei JJ; Cowburn RF
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2002;12:S56

Mutated presenilin 1 alters cholinergic signaling in neuroblastoma cells

Popescu BO; Cedazo-Mínguez A; Ankarcrona M; Cowburn RF
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S215

The presenilin-1 δE9 mutation gives enhanced phospholipase C activity and a resultant increase in intracellular calcium concentrations

Popescu BO; Cedazo-Minguez A; Ankarcrona M; Nishimura T; Cowburn RF
Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2001;5(3):254-266

Apolipoprotein E: a major piece in the Alzheimer's disease puzzle.

Cedazo-Mínguez A; Cowburn RF
Published conference paper: BIOCHEMICAL SOCIETY SYMPOSIUM. 2001;(67):121-129

Apolipoprotein E and beta A4-amyloid: signals and effects.

Ohm TG; Hamker U; Cedazo-Minguez A; Röckl W; Scharnagl H; März W; Cowburn R; Müller W; Meske V
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Professor, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2017-

Examina och utbildning

Docent, Neurovetenskap, Karolinska Institutet, 2010
MEDICINE DOKTORSEXAMEN, Institutionen för neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2002

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