Aline Pfefferle

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Journal article: NATURE IMMUNOLOGY. 2024;25(2):240-255

IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development.

Goh W; Sudholz H; Foroutan M; Scheer S; Pfefferle A; Delconte RB; Meng X; Shen Z; Hennessey R; Kong IY; Schuster IS; Andoniou CE; Davis MJ; Hediyeh-Zadeh S; Souza-Fonseca-Guimaraes F; Parish IA; Beavis P; Thiele D; Chopin M; Degli-Esposti MA; Cursons J; Kallies A; Rautela J; Nutt SL; Huntington ND
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2023;29(6):376.e1-376.e11

Effect of mTOR Inhibition with Sirolimus on Natural Killer Cell Reconstitution in Allogeneic Stem Cell Transplantation.

Haroun-Izquierdo A; Lanuza PM; Pfefferle A; Netskar H; Ask EH; Törlén J; Björklund A; Sohlberg E; Malmberg K-J
Article: BLOOD. 2022;139(5):704-716

Perturbed NK-cell homeostasis associated with disease severity in chronic neutropenia.

Sohlberg E; Pfefferle A; Heggernes Ask E; Tschan-Plessl A; Jacobs B; Netskar H; Lorenz S; Kanaya M; Kosugi-Kanaya M; Meinke S; Mörtberg A; Höglund P; Sundin M; Carlsson G; Palmblad J; Malmberg K-J
Article: CANCER IMMUNOLOGY RESEARCH. 2021;9(10):1125-1140

The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome.

Foroutan M; Molania R; Pfefferle A; Behrenbruch C; Scheer S; Kallies A; Speed TP; Cursons J; Huntington ND
Article: CELL REPORTS. 2019;29(8):2284-2294.e4

Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity.

Pfefferle A; Jacobs B; Netskar H; Ask EH; Lorenz S; Clancy T; Goodridge JP; Sohlberg E; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2019;202(3):736-746

Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal.

Jacobs B; Pfefferle A; Clement D; Berg-Larsen A; Saetersmoen ML; Lorenz S; Wiiger MT; Goodridge JP; Malmberg K-J
Article: NATURE COMMUNICATIONS. 2019;10(1):514

Remodeling of secretory lysosomes during education tunes functional potential in NK cells.

Goodridge JP; Jacobs B; Saetersmoen ML; Clement D; Hammer Q; Clancy T; Skarpen E; Brech A; Landskron J; Grimm C; Pfefferle A; Meza-Zepeda L; Lorenz S; Wiiger MT; Louch WE; Ask EH; Liu LL; Oei VYS; Kjällquist U; Linnarsson S; Patel S; Taskén K; Stenmark H; Malmberg K-J
Article: CANCER IMMUNOLOGY RESEARCH. 2017;5(8):654-665

Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells.

Liu LL; Béziat V; Oei VYS; Pfefferle A; Schaffer M; Lehmann S; Hellström-Lindberg E; Söderhäll S; Heyman M; Grandér D; Malmberg K-J
Article: ONCOTARGET. 2015;6(33):34178-34190

Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome.

Sohlberg E; Pfefferle A; Andersson S; Baumann BC; Hellström-Lindberg E; Malmberg K-J
Article: CLINICAL CANCER RESEARCH. 2014;20(22):5733-5744

Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.

Wennerberg E; Pfefferle A; Ekblad L; Yoshimoto Y; Kremer V; Kaminskyy VO; Juhlin CC; Höög A; Bodin I; Svjatoha V; Larsson C; Zedenius J; Wennerberg J; Lundqvist A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(3):1060-1065

Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.

Brenner D; Brüstle A; Lin GHY; Lang PA; Duncan GS; Knobbe-Thomsen CB; St Paul M; Reardon C; Tusche MW; Snow B; Hamilton SR; Pfefferle A; Gilani SO; Ohashi PS; Lang KS; Mak TW
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1833(1):80-89

Glutathionylation of UCP2 sensitizes drug resistant leukemia cells to chemotherapeutics.

Pfefferle A; Mailloux RJ; Adjeitey CN-K; Harper M-E

Alla övriga publikationer

Preprint: 2023;bioRxiv

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping

Netskar H; Pfefferle A; Goodridge J; Sohlberg E; Dufva O; Teichmann S; Clancy T; Horowitz A; Malmberg K-J
Review: CANCERS. 2020;12(3):E706-706

You Have Got a Fast CAR: Chimeric Antigen Receptor NK Cells in Cancer Therapy.

Pfefferle A; Huntington ND
Review: FRONTIERS IN IMMUNOLOGY. 2020;11:812

Deciphering Natural Killer Cell Homeostasis.

Pfefferle A; Jacobs B; Haroun-Izquierdo A; Kveberg L; Sohlberg E; Malmberg K-J
KI thesis / dissertation: 2019

Dynamics of natural killer cell homeostasis : implications for cell-based cancer immunotherapy

Pfefferle, Aline
Review: MOLECULAR ONCOLOGY. 2015;9(10):1904-1917

Harnessing adaptive natural killer cells in cancer immunotherapy.

Liu LL; Pfefferle A; Yi Sheng VO; Björklund AT; Béziat V; Goodridge JP; Malmberg K-J

Anställningar

Postdoktor, Medicin, Huddinge, Karolinska Institutet, 2022-2024
Research Fellow, Biomedicine Discovery Institute, Monash University, 2019-2022
Senior Scientist, oNKo-innate Pty Ltd, 2019-2022
Summer Research Student, The Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, 2011-2011
Summer Research Student, The Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, 2010-2010

Examina och utbildning

Medicine Doktorsexamen, Medical Science, Dynamics of Natural Killer Cell Homeostasis - Implications for Cell-Based Cancer Immunotherapy, Institutionen för medicin, Huddinge, Karolinska Institutet, 2019
Medicine Masterexamen, Biomedicine, The role of semaphorin 3A in re-educating macrophages and their cross-talk with natural killer cells, Karolinska Institutet, 2014
Bachelor of Science, Honours in Biopharmaceutical Sciences: Genomics Option, Manipulation of redox state and sensitization of drug resistant cancer cells to chemotherapeutics: role for UCP2?, Department of Biochemistry, Microbiology & Immunology, University of Ottawa, 2012

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

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