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Skelett- och broskfysiologi

Gruppens forskning syftar till att förstå de molekylära mekanismer som ligger bakom den fysiologiska regleringen av homeostas i skelett och brosk hos människan.

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Andrei Chagins forskargrupp.

Gruppmedlemmar

Andrei Chagin – Forskare

Jussi Heinonen – Anknuten

Lei Li – Doktorand

Phillip Newton – Anknuten

Baoyi Zhou – Doktorand

Samarbetspartners

Björn Barenius, MD, PhD, Head of Section for Arthroplasty and Arthroscopy, Department of Orthopaedic Surgery, Södersjukhuset.

Alumni

  • Eva Lindgren (forskningsingenjör)
  • Giuseppe di Lernia (masterstudent, Karolinska Institutet)
  • Rinat Gizatulin (gästforskare)
  • Sima Rahbar Zare, (masterstudent 2012-2013, Högskolan i Skövde)
  • Oskar Ljungkvist (sommarstudent, Karolinska Summer School, 2012)
  • Frida Kozma (sommarstudent, Karolinska Summer School, 2012)
  • Amanda Demir (sommarstudent, Karolinska Summer School, 2013)
  • Klas Walldén (sommarstudent, Karolinska Summer School, 2013)
  • Savas Ay (läkarstudent vid Dicle University, Medical Faculty, Diyarbakir, Turkiet)

Projekt

Information om forskningsprojekt i gruppen finns på engelska.

Se också KI Nyheter: New findings explain why we stop growing at one point

Anslagsgivare

Senaste publikationer

A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, et al
Nature 2019 Mar;567(7747):234-238

Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis.
Bouderlique T, Vuppalapati KK, Newton PT, Li L, Barenius B, Chagin AS
Ann. Rheum. Dis. 2016 Mar;75(3):627-31

Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.
Newton PT, Vuppalapati KK, Bouderlique T, Chagin AS
Autophagy 2015 ;11(9):1594-607

Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation.
Vuppalapati KK, Bouderlique T, Newton PT, Kaminskyy VO, Wehtje H, Ohlsson C, et al
J. Bone Miner. Res. 2015 Dec;30(12):2249-61

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.
Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, et al
Nat Commun 2014 Apr;5():3673

Mice depleted of the coxsackievirus and adenovirus receptor display normal spermatogenesis and an intact blood-testis barrier.
Sultana T, Hou M, Stukenborg JB, Töhönen V, Inzunza J, Chagin AS, et al
Reproduction 2014 Jun;147(6):875-83

Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: role of pro-apoptotic Bid.
Zaman F, Chrysis D, Huntjens K, Chagin A, Takigawa M, Fadeel B, et al
Toxicol. Lett. 2014 Jan;224(2):196-200

Resveratrol treatment delays growth plate fusion and improves bone growth in female rabbits.
Karimian E, Tamm C, Chagin AS, Samuelsson K, Kjartansdóttir KR, Ohlsson C, et al
PLoS ONE 2013 ;8(6):e67859

Genetic regulation of the growth plate.
Karimian E, Chagin AS, Sävendahl L
Front Endocrinol (Lausanne) 2011 ;2():113

Mechanisms of growth plate maturation and epiphyseal fusion.
Emons J, Chagin AS, Sävendahl L, Karperien M, Wit JM
Horm Res Paediatr 2011 ;75(6):383-91

Insulin-like growth factor-1 restores dexamethasone-induced heart growth arrest in rats: the role of the ubiquitin pathway.
Chrysis D, Chagin A, Sävendahl L
Hormones (Athens) ;10(1):46-56

Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life.
Hirai T, Chagin AS, Kobayashi T, Mackem S, Kronenberg HM
Proc. Natl. Acad. Sci. U.S.A. 2011 Jan;108(1):191-6

Expression of vascular endothelial growth factor in the growth plate is stimulated by estradiol and increases during pubertal development.
Emons J, Chagin AS, Malmlöf T, Lekman M, Tivesten A, Ohlsson C, et al
J. Endocrinol. 2010 Apr;205(1):61-8

Catch-up growth after dexamethasone withdrawal occurs in cultured postnatal rat metatarsal bones.
Chagin AS, Karimian E, Sundström K, Eriksson E, Sävendahl L
J. Endocrinol. 2010 Jan;204(1):21-9

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