Xiao-Wei Zheng

About me
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About me

I am a trained cardiologist, and I got my Ph.D. degree at the Department of Cell and Molecular Biology of Karolinska Institutet. Now I am working as Senior Research Specialist at the Department of Molecular Medicine and Surgery, Karolinska Institutet.

Research

We investigate new pathogenic mechanisms of diabetes complications. The main focus of our research is how diabetes affects hypoxia, Notch and other signaling pathways and how this contributes to the development of diabetes complications including diabetic nephropathy, diabetic foot ulcer, infection and diabetic heart disease. We use clinical samples together with animal and cellular models of diabetes as well as genetically-modified mice to conduct mechanistical, translational, and clinical research.

Articles

Article: BRITISH JOURNAL OF PHARMACOLOGY. 2025;182(2):417-431
miR-210 as a therapeutic target in diabetes-associated endothelial dysfunction
Collado A; Jiao T; Kontidou E; Carvalho LRRA; Chernogubova E; Yang J; Zaccagnini G; Zhao A; Tengbom J; Zheng X; Rethi B; Alvarsson M; Catrina S-B; Mahdi A; Carlstroem M; Martelli F; Pernow J; Zhou Z
Article: EMBO REPORTS. 2024;25(4):1752-1772
Appropriate glycemic management protects the germline but not the uterine environment in hyperglycemia
Zhao A; Jiang H; Palomares AR; Larsson A; He W; Grunler J; Zheng X; Wallberg KAR; Catrina S-B; Deng Q
Article: EMBO MOLECULAR MEDICINE. 2024;16(3):596-615
Rare coding variants in NOX4 link high ROS levels to psoriatic arthritis mutilans
Wang S; Nikamo P; Laasonen L; Gudbjornsson B; Ejstrup L; Iversen L; Lindqvist U; Alm JJ; Eisfeldt J; Zheng X; Catrina S-B; Taylan F; Vaz R; Stahle M; Tapia-Paez I
Article: ANTIOXIDANTS. 2023;12(12):2043
Comparing the Blood Response to Hyperbaric Oxygen with High-Intensity Interval Training-A Crossover Study in Healthy Volunteers
Kjellberg A; Lindholm ME; Zheng X; Liwenborg L; Rodriguez-Wallberg KA; Catrina S-B; Lindholm P
Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(17):e167693
Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP
Yang J; Sundqvist ML; Zheng X; Jiao T; Collado A; Tratsiakovich Y; Mahdi A; Tengbom J; Mergia E; Catrina S-B; Zhou Z; Carlstroem M; Akaike T; Cortese-Krott MM; Weitzberg E; Lundberg JO; Pernow J
Article: JOURNAL OF AUTOIMMUNITY. 2022;133:102903
Autoantibodies targeting malondialdehyde-modifications in rheumatoid arthritis regulate osteoclasts via inducing glycolysis and lipid biosynthesis
Sakuraba K; Krishnamurthy A; Sun J; Zheng X; Xu C; Peng B; Engstrom M; Jakobsson P-J; Wermeling F; Catrina S; Gronwall C; Catrina AI; Rethi B
Article: BMJ OPEN. 2022;12(11):e061870
Hyperbaric oxygen for treatment of long COVID-19 syndrome (HOT-LoCO): protocol for a randomised, placebo-controlled, double-blind, phase II clinical trial
Kjellberg A; Abdel-Halim L; Hassler A; El Gharbi S; Al-Ezerjawi S; Bostrom E; Sundberg CJ; Pernow J; Medson K; Kowalski JH; Rodriguez-Wallberg KA; Zheng X; Catrina S; Runold M; Stahlberg M; Bruchfeld J; Nygren-Bonnier M; Lindholm P
Article: MBIO. 2022;13(5):e0108622-e01022
High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages
Teran G; Li H; Catrina S-B; Liu R; Brighenti S; Zheng X; Grunler J; Nylen S; Carow B; Rottenberg ME
Article: ELIFE. 2022;11:e70714
Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes
Zheng X; Narayanan S; Xu C; Eliasson Angelstig S; Grunler J; Zhao A; Di Toro A; Bernardi L; Mazzone M; Carmeliet P; Del Sole M; Solaini G; Forsberg EA; Zhang A; Brismar K; Schiffer TA; Rajamand Ekberg N; Botusan IR; Palm F; Catrina S-B
Article: DIABETES. 2022;71(2):285-297
Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes
Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
Article: BMJ OPEN. 2021;11(7):e046738
Randomised, controlled, open label, multicentre clinical trial to explore safety and efficacy of hyperbaric oxygen for preventing ICU admission, morbidity and mortality in adult patients with COVID-19
Kjellberg A; Douglas J; Pawlik MT; Kraus M; Oscarsson N; Zheng X; Bergman P; Franberg O; Kowalski JH; Nyren SP; Silvanius M; Skold M; Catrina S-B; Rodriguez-Wallberg KA; Lindholm P
Article: ANTIOXIDANTS. 2021;10(7):1070
Dehydro-Tocotrienol-β Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice
Dallner G; Bentinger M; Hussain S; Sinha I; Yang J; Schwank-Xu C; Zheng X; Swiezewska E; Brismar K; Valladolid-Acebes I; Tekle M
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(3):659-671
miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes
Li D; Peng H; Qu L; Sommar P; Wang A; Chu T; Li X; Bi X; Liu Q; Serezal IG; Rollman O; Lohcharoenkal W; Zheng X; Angelstig SE; Grunler J; Pivarcsi A; Sonkoly E; Catrina S-B; Xiao C; Stahle M; Mi Q-S; Zhou L; Landen NX
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):768
HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism
Narayanan S; Angelstig SE; Xu C; Grunler J; Zhao A; Zhu W; Landen NX; Stahle M; Zhang J; Ivan M; Maltesen RG; Botusan IR; Ekberg NR; Zheng X; Catrina S-B
Article: EBIOMEDICINE. 2019;44:489-501
Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation
Petrus P; Fernandez TL; Kwon MM; Huang JL; Lei V; Safikhan NS; Karunakaran S; O'Shannessy DJ; Zheng X; Catrina S-B; Albone E; Laine J; Virtanen K; Clee SM; Kieffer TJ; Noll C; Carpentier AC; Johnson JD; Ryden M; Conway EM
Article: JOURNAL OF DIABETES RESEARCH. 2019;2019:2936962-8
Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy
Ekberg NR; Eliasson S; Li YW; Zheng X; Chatzidionysiou K; Falhammar H; Gu HF; Catrina S-B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(14):6985-6994
Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes
Zheng X; Narayanan S; Sunkari VG; Eliasson S; Botusan IR; Grunler J; Catrina AI; Radtke F; Xu C; Zhao A; Ekberg NR; Lendahl U; Catrina S-B
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(138)
Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
Zheng X; Ho CQW; Zheng X; Lee KL; Gradin K; Pereira TS; Berggren P-O; Ali Y
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):450-463
Red Blood Cells in Type 2 Diabetes Impair Cardiac Post-Ischemic Recovery Through an Arginase-Dependent Modulation of Nitric Oxide Synthase and Reactive Oxygen Species
Yang J; Zheng X; Mahdi A; Zhou Z; Tratsiakovich Y; Jiao T; Kiss A; Kovamees O; Alvarsson M; Catrina S-B; Lundberg JO; Brismar K; Pernow J
Article: PLOS ONE. 2018;13(3):e0193084
Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate
Botusan IR; Zheng X; Narayanan S; Grunler J; Sunkari VG; Calissendorff FS; Ansurudeen I; Illies C; Svensson J; Jansson J-O; Ohlsson C; Brismar K; Catrina S-B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638
MicroRNA-132 with Therapeutic Potential in Chronic Wounds
Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grunler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrstrom M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Stahle M; Landen NX
Article: EXPERIMENTAL CELL RESEARCH. 2017;358(2):129-139
A Notch-independent mechanism contributes to the induction of Hes1 gene expression in response to hypoxia in P19 cells
Zheng X; Narayanan S; Zheng X; Luecke-Johansson S; Gradin K; Catrina S-B; Poellinger L; Pereira TS
Article: ACTA PHYSIOLOGICA. 2014;210(3):590-599
Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors
Yang J; Zheng X; Haugen F; Dare E; Lovdahl C; Schulte G; Fredholm BB; Valen G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):2560-2565
Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response
Zheng X; Zhou A-X; Rouhi P; Uramoto H; Boren J; Cao Y; Pereira T; Akyurek LM; Poellinger L
Article: DIABETES CARE. 2013;36(2):415-421
Impact of the Hypoxia-Inducible Factor-1 α (HIF1A) Pro582Ser Polymorphism on Diabetes Nephropathy
Gu HF; Zheng X; Abu Seman N; Gu T; Botusan IR; Sunkari VG; Lokman EF; Brismar K; Catrina S-B
Article: CELL DEATH & DISEASE. 2012;3(6):e322
Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP
Zheng X; Zheng X; Wang X; Ma Z; Sunkari VG; Botusan I; Takeda T; Bjorklund A; Inoue M; Catrina S-B; Brismar K; Poellinger L; Pereira TS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3368-3373
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
Zheng X; Linke S; Dias JM; Zheng X; Gradin K; Wallis TP; Hamilton BR; Gustafsson M; Ruas JL; Wilkins S; Bilton RL; Brismar K; Whitelaw ML; Pereira T; Gorman JJ; Ericson J; Peet DJ; Lendahl U; Poellinger L
Article: CELL CYCLE. 2006;5(23):2720-2722
Degradation of the hypoxia-inducible factor 1α -: Where does it happen?
Pereira T; Zheng X; Poellinger L
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1α:: Role of subcellular compartmentalization
Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
Article: DEVELOPMENTAL CELL. 2005;9(5):617-628
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
Gustafsson MV; Zheng XW; Pereira T; Gradin K; Jin SB; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(9):6816-6823
Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor gene product
Pereira T; Zheng XW; Ruas JL; Tanimoto K; Poellinger L
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All other publications

Corrigendum: JOURNAL OF DIABETES RESEARCH. 2021;2021:9827150-1
Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy (vol 2019, 2936962, 2019)
Ekberg NR; Eliasson S; Li YW; Zheng X; Chatzidionysiou K; Falhammar H; Gu HF; Catrina S-B
Review: DIABETOLOGIA. 2021;64(4):709-716
Hypoxia and hypoxia-inducible factors in diabetes and its complications
Catrina S-B; Zheng X
Letter: CLINICAL AND TRANSLATIONAL MEDICINE. 2021;11(1):e273
Repressed hypoxia inducible factor-1 in diabetes aggravates pulmonary aspergillus fumigatus infection through modulation of inflammatory responses
Ye Y; Chen Y; Sun J; Zhang H; Li W; Wang W; Zheng X; Catrina S-B
Published conference paper: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2016;32:179-185
Disturbed hypoxic responses as a pathogenic mechanism of diabetic foot ulcers
Catrina S-B; Zheng X
Editorial comment: ENDOCRINE. 2014;46(2):347-350
Selective blockade of estrogen receptor beta improves wound healing in diabetes
Sunkari VG; Botusan IR; Savu O; Grunler J; Zheng X; Gustafsson J-A; Brismar K; Catrina S-B

Employments

Senior Research Specialist, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2025
Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2009

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