Therese Andersson
Senior Lecturer
| Docent
E-mail: therese.m-l.andersson@ki.se
Visiting address: ,
Postal address: C8 Medicinsk epidemiologi och biostatistik, C8 MEB II Andersson, 171 77 Stockholm
About me
- I am a biostatistician, working with statistical methods for cancer
epidemiology. My main research interest is cancer patient survival and I have
published studies on cancer patient survival for a range of cancer sites. I
have also worked on international benchmarking of cancer patient survival,
for example the International Cancer Benchmarking Partnership SURVMARK-2, run
by the International Agency for Research on Cancer (IARC) and in a Nordic
collaborative project. I develop statistical methods as well as apply the
methods to register-based data to answer important epidemiological and
clinical research questions. I’m currently
working in several projects, a description of two projects I'm heavily
involved with currently are described below.
Research
- *Loss in life expectancy due to cancer*
One useful summary measure for survival data is the life expectancy, which is
calculated by obtaining the area under a survival curve. Life expectancy is a
well-established, easily understood concept that quantifies the expected
number of life years remaining. In comparison to many other measures, it
takes the whole time scale into account instead of at particular points
during follow-up (such as the 1- or 5-year survival). Another statistic,
closely related to the life expectancy, is the loss in life expectancy (LLE),
a measure of how much a patient's life expectancy is reduced due to a cancer
diagnosis. The LLE is defined as the difference in life expectancy between
the cancer patients and a comparable group in the general population. The
LLE can be used to address a wide range of research questions on both
individual and population levels, and to quantify survival differences
between groups. Another use of LLE is to quantify the burden of cancer on
society as the total number of life years lost in the population - in this
way, it can be useful for measuring cancer control progress and to provide
guidance for resource allocation. I have developed methods for estimating the
LLE for cancer patients, and further extend and evaluate the methodology to
enable use of the measure in different contexts.
*Survival after hematological cancers, with a focus on MPN*
Compared to many other hematological
malignancies MPNs are rather indolent diseases. Despite efforts to optimize
treatment and prophylactic measures, patients with MPNs have a shorter
survival than the general population and experience complications, such as
thromboembolism and bleedings, due to their MPN. There are few
population-based studies on MPNs, and most studies are small with short
follow-up time and do not include population controls. It is therefore of
great importance to gain a further understanding of the disease trajectory
and risk of complications for this group of patients. By taking advantage of
the Swedish health registers and novel statistical methods, we will improve
the understanding of the clinical course and prognosis among MPN patients.
Teaching
- I have been involved in teaching and/or course organising of:
* Development of a MSc programme in Biostatistics and Data Science given within the Stockholm Trio, i.e. Karolinska Institutet, KTH Royal Institute of Technology and Stockholm University.
* Survival analysis (biostat III), within the Doctoral Programme in
Epidemiology
* Data Management within epidemiological research, including lectures on
laws and regulations concerning the use of personal data in research
* Competing risks and multistate models
* IARC summer school on cancer epidemiology, module 1, cancer survival
methods for cancer registries.
* Summer school on modern methods in biostatistics and epidemiology.
Survival analysis using Stata (a 1-day course) and Statistical Methods for
Population-based Cancer Survival (a 1-week course). Treviso, Italy.
* Workshops on epidemiological designs and cancer survival analysis
* Pre-conference courses on Statistical Methods for Population-based Cancer
Survival
* Biostatistics/evidence based medicine within the medical program at KI
Articles
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Article: HEMASPHERE. 2024;8(7):e121
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Article: LUNG CANCER. 2024;192:107826
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Article: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2024;78(6):402-408
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Article: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2024;90(5):963-969
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Article: EUROPEAN JOURNAL OF CANCER. 2024;202:113980
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Article: LEUKEMIA. 2024;38(5):1081-1085
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Article: SCIENTIFIC REPORTS. 2024;14(1):8577
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Article: ACTA ONCOLOGICA. 2024;63:179-191
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Article: EUROPEAN JOURNAL OF CANCER. 2024;199:113572
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Article: COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION. 2024;53(2):993-1006
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2023;23(1):291
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Article: BRITISH JOURNAL OF CANCER. 2023;129(5):819-828
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Article: JNCI CANCER SPECTRUM. 2023;7(3):pkad038
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2023;23(1):87
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Article: ACTA ONCOLOGICA. 2023;62(2):103-109
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Article: BRITISH JOURNAL OF DERMATOLOGY. 2023;188(1):32-40
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Article: ACTA ONCOLOGICA. 2022;61(12):1481-1489
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2022;22(1):290
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Article: BRITISH JOURNAL OF CANCER. 2022;127(10):1808-1815
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Article: ACTA ONCOLOGICA. 2022;61(11):1377-1385
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Article: BRITISH JOURNAL OF CANCER. 2022;127(6):1061-1068
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Article: LEUKEMIA. 2022;36(10):2461-2467
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Article: BIOMETRICAL JOURNAL. 2022;64(7):1161-1177
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Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2022;31(9):1720-1726
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Article: STATA JOURNAL. 2022;22(3):679-701
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Article: EUROPEAN JOURNAL OF CANCER. 2022;172:76-84
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Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2022;31(6):1168-1175
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Article: CANCERS. 2022;14(10):2349
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Article: BRITISH JOURNAL OF CANCER. 2022;126(8):1224-1228
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2022;22(1):130
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Article: BREAST CANCER RESEARCH. 2022;24(1):15
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Article: CANCER EPIDEMIOLOGY. 2022;76:102085
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2022;22(1):2
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2021;21(1):262
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Article: BREAST CANCER RESEARCH. 2021;23(1):109
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Article: COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION. 2021;50(11):3777-3793
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Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2021;137:92-103
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Article: SCANDINAVIAN JOURNAL OF UROLOGY. 2021;55(4):299-306
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Article: ARCHIVES OF SUICIDE RESEARCH. 2021;25(3):424-438
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Article: CANCERS. 2021;13(10):2456
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Article: STATISTICS IN MEDICINE. 2021;40(9):2139-2154
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Article: CANCER EPIDEMIOLOGY. 2021;71(Pt A):101881
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Article: BRITISH JOURNAL OF CANCER. 2021;124(5):1026-1032
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Article: LEUKEMIA. 2021;35(2):476-484
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Article: THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY. 2021;11:20451253211006508-204512532110065
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Article: BIOMETRICS. 2020;76(4):1053-1063
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Article: ACTA ONCOLOGICA. 2020;59(11):1266-1274
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Article: ACTA ONCOLOGICA. 2020;59(11):1322-1328
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Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2020;49(5):1614-1623
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Article: CANCER RESEARCH. 2020;80(16):3436-3442
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Article: CANCER EPIDEMIOLOGY. 2020;67:101759
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Article: AMERICAN JOURNAL OF HEMATOLOGY. 2020;95(7):740-748
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Journal article: INVESTIGATIVE UROLOGY. 2020;203(Supplement 4)
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Article: CANCER EPIDEMIOLOGY. 2020;65:101686
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Article: JOURNAL OF INTERNAL MEDICINE. 2020;287(4):448-454
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2020;20(1):71
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Article: SCANDINAVIAN JOURNAL OF UROLOGY. 2020;54(2):115-121
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Article: WORLD JOURNAL OF SURGERY. 2020;44(2):436-441
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Article: CLINICAL EPIDEMIOLOGY. 2020;12:737-744
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Article: STATISTICAL METHODS IN MEDICAL RESEARCH. 2019;28(12):3822-3842
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Article: LANCET ONCOLOGY. 2019;20(11):1493-1505
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Article: INTERNATIONAL JOURNAL OF CANCER. 2019;145(5):1200-1208
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2019;19(1):145
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Article: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(9):703-713
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Article: PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE. 2019;35(2):78-86
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Article: EUROPEAN JOURNAL OF CANCER. 2019;110:42-48
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2019;19(1):23
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Article: CLINICAL EPIDEMIOLOGY. 2019;11:1025-1034
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Article: EUROPEAN JOURNAL OF CANCER. 2018;103:299-307
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Article: EUROPEAN JOURNAL OF CANCER. 2018;103:288-298
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Article: JOURNAL OF AFFECTIVE DISORDERS. 2018;238:674-679
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Article: LEUKEMIA. 2018;32(10):2203-2210
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Article: MEDICINE. 2018;97(41):e12738
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Article: BMJ OPEN. 2018;8(8):e022094
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Article: CANCER EPIDEMIOLOGY. 2018;55:1-7
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Article: AMERICAN JOURNAL OF HEMATOLOGY. 2018;93(8):1020-1028
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Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2018;187(4):828-836
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Article: INTERNATIONAL JOURNAL OF CANCER. 2018;142(7):1343-1354
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Article: ANNALS OF INTERNAL MEDICINE. 2018;168(5):317-325
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Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2017;186(9):1065-1073
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Article: BRITISH JOURNAL OF CANCER. 2017;117(9):1419-1426
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Article: EUROPEAN JOURNAL OF CANCER. 2017;79:106-118
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Article: CANCER EPIDEMIOLOGY. 2017;46:50-56
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Article: INTERNATIONAL JOURNAL OF CANCER. 2017;140(1):34-40
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Article: JAMA ONCOLOGY. 2016;2(9):1188-1196
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Article: CANCER CAUSES & CONTROL. 2016;27(8):955-964
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Article: INTERNATIONAL JOURNAL OF CANCER. 2016;138(12):2829-2836
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Article: BLOOD CANCER JOURNAL. 2016;6(2):e390
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Article: AMERICAN JOURNAL OF HEMATOLOGY. 2015;90(12):1128-1134
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Article: JOURNAL OF CLINICAL ONCOLOGY. 2015;33(20):2288-2295
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Article: CANCER. 2015;121(12):2072-2077
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Article: BMC CANCER. 2015;15:412
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Article: BREAST CANCER RESEARCH AND TREATMENT. 2015;151(1):209-217
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Article: BMJ OPEN. 2015;5(4):e006740
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Article: NEUROBIOLOGY OF AGING. 2015;36(4):1751-1756
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Article: CANCER EPIDEMIOLOGY. 2015;39(1):118-125
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Article: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2014;71(6):1093-1101
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Article: EPIDEMIOLOGY. 2014;25(5):742-748
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Article: BMC CANCER. 2014;14:391
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Article: CANCER EPIDEMIOLOGY. 2014;38(1):93-99
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Article: STATISTICS IN MEDICINE. 2013;32(30):5286-5300
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Article: CANCER EPIDEMIOLOGY. 2013;37(6):836-842
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Article: BRITISH JOURNAL OF HAEMATOLOGY. 2013;162(4):509-516
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Article: BREAST CANCER RESEARCH AND TREATMENT. 2013;139(1):183-192
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Article: JOURNAL OF CLINICAL ONCOLOGY. 2013;31(11):1435-1441
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Article: CANCER CAUSES & CONTROL. 2013;24(3):505-515
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Article: LAKARTIDNINGEN. 2013;110(8):416-419
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Article: JOURNAL OF NUTRITIONAL SCIENCE. 2013;2:e15
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Article: AMERICAN JOURNAL OF HEMATOLOGY. 2013;88(1):60-65
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Article: INTERNATIONAL JOURNAL OF CANCER. 2013;132(1):155-161
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Article: STATA JOURNAL. 2012;12(4):623-638
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Article: PUBLIC HEALTH NUTRITION. 2012;15(10):1897-1908
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Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(24):2995-3001
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2012;12:86
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Article: JOURNAL OF TRAUMA AND ACUTE CARE SURGERY. 2012;72(4):954-960
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Article: BMJ-BRITISH MEDICAL JOURNAL. 2012;344:e900
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Journal article: BMJ-BRITISH MEDICAL JOURNAL. 2012;344
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Journal article: BLOOD. 2011;118(21):3855
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Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2011;20(9):1865-1872
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Article: BMC MEDICAL RESEARCH METHODOLOGY. 2011;11:96
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Article: JOURNAL OF CLINICAL ONCOLOGY. 2011;29(18):2514-2520
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Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2011;20(2):308-317
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Journal article: BLOOD. 2010;116(21):205
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Article: EUROPEAN JOURNAL OF CANCER. 2010;46(16):2965-2972
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Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS. 2010;153B(6):1160-1166
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Article: TRANSFUSION. 2010;50(6):1249-1256
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Article: BRITISH JOURNAL OF HAEMATOLOGY. 2010;148(6):918-924
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Article: HAEMATOLOGICA. 2009;94(12):1714-1720
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Journal article: BLOOD. 2009;114(22):1378
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Article: OBSTETRICS AND GYNECOLOGY. 2009;114(3):568-572
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Article: VOX SANGUINIS. 2009;96(4):316-323
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Article: BLOOD. 2009;113(16):3666-3672
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Article: INTERNATIONAL JOURNAL OF CANCER. 2007;121(9):2052-2059
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All other publications
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Corrigendum: EUROPEAN JOURNAL OF CANCER. 2024;201:113940
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Conference publication: EUROPEAN UROLOGY. 2024;85:s52
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Conference publication: ANNALS OF ONCOLOGY. 2023;34:s948
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Conference publication: BLOOD. 2022;140:6856-6857
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Preprint: RESEARCH SQUARE. 2022
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Preprint: RESEARCH SQUARE. 2021
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Preprint: RESEARCH SQUARE. 2021
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Review: JOURNAL OF INTERNAL MEDICINE. 2021;289(1):12-28
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Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2020;29:70
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Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2020;29:84-85
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Conference publication: JOURNAL OF UROLOGY. 2020;203:E247-E248
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Review: CANCER EPIDEMIOLOGY. 2019;60:168-173
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Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(15):e16555
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Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2019;28:99
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Conference publication: BLOOD. 2018;132:930
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Letter: ANNALS OF INTERNAL MEDICINE. 2018;169(4):268
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Corrigendum: EUROPEAN JOURNAL OF CANCER. 2017;87:219-220
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Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S852
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Letter: JOURNAL OF CLINICAL ONCOLOGY. 2017;35(6):696-697
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Meeting abstract: BLOOD. 2016;128(22):946
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Published conference paper: JOURNAL OF CLINICAL ONCOLOGY. 2016;34(24):2851-2857
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Published conference paper: STATISTICS IN MEDICINE. 2016;35(7):1193-1209
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Conference publication: CANCER RESEARCH. 2016;76:p6-10-07-p6-10-07
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Conference publication: HAEMATOLOGICA. 2016;101:6-7
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Conference publication: BLOOD. 2015;126(23):1605
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Conference publication: BLOOD. 2015;126(23):2779
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Meeting abstract: PSYCHONEUROENDOCRINOLOGY. 2015;61:50
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Conference publication: HAEMATOLOGICA. 2015;100:260-261
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Conference publication: HAEMATOLOGICA. 2015;100:193
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Meeting abstract: BLOOD. 2014;124(21):632
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Thesis / dissertation: 2013
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Conference publication: HAEMATOLOGICA. 2013;98:219
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Conference publication: CANCER RESEARCH. 2011;71:p1-08-09-p1-08-09
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Conference publication: PEDIATRIC BLOOD & CANCER. 2011;57(5):823
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Conference publication: BLOOD. 2011;118(21):1648-1649
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Meeting abstract: BLOOD. 2010;116(21):1266-1267
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Conference publication: BLOOD. 2010;116(21):93-94
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Conference publication: HAEMATOLOGICA. 2010;95:470
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Conference publication: BLOOD. 2009;114(22):561
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Conference publication: HAEMATOLOGICA. 2009;94:157
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Scholarly edition:Estimating and modeling cure within the framework of flexible parametric survival models
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Selected grants
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Swedish Research Council1 January 2020 - 31 December 2023
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Development of flexible parametric survival models with multiple time-scales – with applications to Myeloproliferative Neoplasm (MPN)Swedish Cancer Society1 January 2019
Grants
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Swedish Research Council1 January 2024 - 31 December 2026
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Extensions and applications of loss in life expectancy for cancer patientsCancerfonden1 January 2023 - 31 December 2025
Employments
- Senior Lecturer, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2020-
- Postdoctoral Researcher, Danish Cancer Society, 2015-2016
Degrees and Education
- Docent, Karolinska Institutet, 2020
- Degree Of Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2013
- MSc, Mathematical Statistics, Uppsala University, 2007
Supervisor
- Anna Oksanen, Loss of life expectancy for patients with malignant melanoma, by socioeconomic groups and sex, 2023
- Nurgul Betyrbekova, Modeling multiple time-scales with flexible parametric survival models – with applications to Myeloproliferative Neoplasm (MPN), 2019
- Yuliya Leontyeva, Development, extensions and applications of statistical models in population-based studies to estimate loss in expectation of life (LEL) due to cancer., 2019
- Hannah Bower, Flexible parametric models for cancer patient survival: loss in expectation of life and further developments, https://openarchive.ki.se/xmlui/bitstream/handle/10616/46179/Thesis_Hannah_Bower.pdf?sequence=1&isAllowed=y