Sophia Schedin Weiss

Sophia Schedin Weiss

Researcher | Docent
Telephone: +46852483507
Mobile phone: +46730462626
Visiting address: BioClinicum, Akademiska Stråket 1, J9:20, 17164 Stockholm
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Neurogeriatrik Schedin Weiss, 171 77 Stockholm
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About me

  • We use innovative approaches to elucidate mechanisms behind Alzheimer disease
    and other neurodegenerative disorders. The overall goal is to develop novel
    diagnostic and treatment strategies.
    I am a Docent (Associate Professor) in medical biochemistry and have
    throughout my scientific career sought after biochemical and cellular
    pathways that are dysregulated and causative in human neurological and
    age-related diseases. Initially, as a PhD student, I investigated how
    biosynthesis and transport of lipids are affected in the neurological
    disorder Niemann-Pick type C disease, which displays a number of pathogenic
    pathways similar to those found in AD. These first studies in my career were
    published under my premarital name Sophia Schedin.
    I have further studied protein biochemistry and molecular interactions
    involved in the regulation of thrombosis, where I developed my expertise in
    proteolytic pathways, including the protein C pathway and the blood
    coagulation cascade.
    I devoted the past ten years of my career to study molecular mechanisms
    behind, and biomarkers involved in, AD.

Research

  • I am dedicated to study the molecular mechanisms behind and find biomarkers
    for Alzheimer disease (AD) and other neurodegenerative diseases. I have
    studied novel molecular interactions important for the regulation of
    gamma-secretase, the last one of two enzymes that process the amyloid
    precursor protein (APP) to generate the amyloid β-peptide (Aβ), which is
    known as a toxic agent in AD, and the component of amyloid plaques in the
    brains of AD patients. One of my main interests is to study the subcellular
    localization of the Aβ processing machinery in neurons. To this end I have
    set up super-resolution microscopy techniques and master and teach in the
    techniques stimulated emission depletion (STED) microscopy and stochastic
    optical reconstruction microscopy (STORM). By using these techniques we have
    determined the synaptic localization of gamma-secretase and Aβ in neurons at
    the nano-scale level.
    I also have a great interest in studying the roles of glycans in
    neurodegenerative diseases. We have in our research group shown that
    asparagine-linked glycans have altered structural pattern in cerebrospinal
    fluid and brain in AD and believe that understanding these alterations are
    important for new diagnotics and treatment strategies.

Articles

All other publications

Employments

  • Researcher, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2011-

Degrees and Education

  • Docent, Karolinska Institutet, 2024

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