Sofia Frisk
Postdoctoral Researcher
E-mail: sofia.frisk@ki.se
Visiting address: Karolinska Institutet, BioClinicum J10:20, Visionsgatan 4, 17164 Solna
Postal address: K1 Molekylär medicin och kirurgi, K1 MMK Klinisk genetik, 171 76 Stockholm
About me
I work as a consultant at Department of Clinical Genetics, at Karolinska University Hospital, passionate about genetics in rare diseases, especially understanding mosaic mechanisms. I combine my research work with clinical work and strive to solve the unsolved.
Swedish Research Council has awarded me a grant to do a postdoctoral project in Brussels 2023-2026, focusing on finding genetic mechanisms in vascular anomalies.
Articles
- Journal article: PRESSE MEDICALE. 2025;54(3):104293Fransen J; Frisk S; Ghaffarpour N
- Journal article: JOURNAL OF VASCULAR ANOMALIES. 2025;6(1):e102Baselga E; Andersen R; Barea M; Bejarano Serrano M; Berger S; Bisdorff-Bresson A; Boccara O; Bom-Sucesso M; Boon LM; Borgards P; Diociaiuti A; Dompmartin A; Dvorakova V; El Hachem M; Frisk S; Gasparella P; Ghaffarpour N; Haxhija E; Hjuler T; Holm A; Kaltoft M; Kapp FG; Kyrklund K; Irvine AD; Madureira M; Palionis D; Rößler J; Salminen P; Tolonen J; Vaisnyte B; Van Den Bosch C; van der Vleuten C; Schultze Kool L; Vikkula M
- Article: ORPHANET JOURNAL OF RARE DISEASES. 2024;19(1):213Revencu N; Eijkelenboom A; Bracquemart C; Alhopuro P; Armstrong J; Baselga E; Cesario C; Dentici ML; Eyries M; Frisk S; Karstensen HG; Gene-Olaciregui N; Kivirikko S; Lavarino C; Mero I-L; Michiels R; Pisaneschi E; Schoenewolf-Greulich B; Wieland I; Zenker M; Vikkula M
- Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2022;10(4):e1880Frisk S; Wachtmeister A; Laurell T; Lindstrand A; Jantti N; Malmgren H; Lagerstedt-Robinson K; Tesi B; Taylan F; Nordgren A
- Article: JOURNAL OF MEDICAL GENETICS. 2022;59(2):141-146Ponten E; Frisk S; Taylan F; Vaz R; Wessman S; de Kock L; Pal N; Foulkes WD; Lagerstedt-Robinson K; Nordgren A
- Article: CLINICAL GENETICS. 2019;96(2):118-125Frisk S; Taylan F; Blaszczyk I; Nennesmo I; Anneren G; Herm B; Stattin E-L; Zachariadis V; Lindstrand A; Tesi B; Laurell T; Nordgren A
- Article: CLINICAL CASE REPORTS. 2018;6(11):2103-2110Frisk S; Grandpeix-Guyodo C; Silwerfeldt KP; Hjartarson HT; Chatzianastassiou D; Magnusson I; Laurell T; Nordgren A
- Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2012;22:s29Sahlholm K; Frisk S; Marcellino D; Nilsson J; Fuxe K; Århem P
- Article: INTERNATIONAL JOURNAL OF LEGAL MEDICINE. 2006;120(6):383-390Andreasson H; Nilsson M; Budowle B; Frisk S; Allen M
All other publications
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:1128Hammarsjo A; Sollander K; Frisk S
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:1128Hammarsjo A; Sollander K; Frisk S
- Corrigendum: ORPHANET JOURNAL OF RARE DISEASES. 2024;19(1):369Revencu N; Eijkelenboom A; Bracquemart C; Alhopuro P; Armstrong J; Baselga E; Cesario C; Dentici ML; Eyries M; Frisk S; Karstensen HG; Gene-Olaciregui N; Kivirikko S; Lavarino C; Mero I-L; Michiels R; Pisaneschi E; Schoenewolf-Greulich B; Wieland I; Zenker M; Vikkula M
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:444Frisk S; Wachtmeister A; Laurell T; Lindstrand A; Jantti N; Malmgren H; Lagerstedt-Robinson K; Tesi B; Taylan F; Nordgren A
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(SUPPL 1):462-463Frisk SA; Ponten E; Lagerstedt-Robinson K; Vaz R; Taylan F; Nordgren A
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1519-1520Taylan F; Frisk S; Blaszczyk I; Nennesmo I; Anneren G; Stattin E; Zachariadis V; Lindstrand A; Tesi B; Laurell T; Nordgren A
- Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):26ASahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Ogren SO; Arhem P
- Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:167Sahlholm K; Frisk S; Marcellino D; Nilsson J; Fuxe K; Arhem P
- Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):517ASahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Arhem P
- Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S511-S512Sahlholm K; Frisk S; Fuxe K; Arhem P
Grants
- Swedish Research Council1 July 2023 - 30 June 2026Vascular anomalies are rare diseases that may cause important life-long morbidity, including chronic pain, bleeding/ulceration and death. Lately, it has been shown that genetic mosaicism is a common underlying mechanism of vascular anomalies. Although many genes have been discovered, numerous subtypes are still unexplained. Our aim is to decipher underlying genetic mechanisms of vascular anomalies, improve clinical characterization and enable precision-based health care for the patients. The research will be carried out in Prof. Miikka Vikkula’s group because of access to his large biobank of tissue-derived DNA from vascular anomaly patients, user-friendly software sequencing data filtering tools, extensive research network and close clinical collaborations with on-going clinical trials within vascular anomalies. By using the biobank of Prof. Vikkula’s group (based on samples from over 4,000 families (~12,000 samples), and more than 1,700 fresh frozen tissues), we plan to search for low-level mosaic variants in patients without known genetic etiology. We plan to use deep exome sequencing data of tissued derived-DNA and in some cases run droplet digital PCR for verification and quantification of mosaic variants.The available treatments are commonly not curative, and often impossible and/or risky to perform. Hence, there is an important unmet medical need to develop novel treatments. To enable precision-based care, it is important to indetify underlying mechanisms.
Employments
- Postdoctoral Researcher, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2025-2026
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022