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About me

I am Assistant Professor and co-group leader in Angel Cedazo Minguez group. I have defended my PhD at the University of Bologna in 2011 and did my  postdoc at KI. I have been working within the neuroscience field in relation to Alzheimer’s Disease (AD) since my PhD and my work is based on investigating the mechanisms for risk factors for Alzheimer's Disease with special focus on ApoE, cholesterol metabolism and oxysterols. I have extensive knowledge in the field of mouse behavior and mouse models of neurodegenerative disease and I am Facility Coordinator for the Animal Behavior Core Facility (ABCF) at KI. In addition, I have deep knowledge on a large variety of molecular biology techniques. This makes possible to combine my studies in the most translational way, from in vitro to in vivo models and finally in human samples. 

Research description

My research is focused on understanding the biological mechanisms behind  risk factors for Alzheimer's Disease (AD) and aging. 

Cholesterol metabolism and oxysterols

I work on cholesterol metabolism and its role in neurodegenerative processes. Specifically, I study the effects and functions of oxidized metabolites of cholesterol such as 24-S-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol in brain by using in vitro models, mouse models and human samples. I study behavior of mouse models for cholesterol metabolism, i.e. mice overexpressing Cyp46A1, Cyp27A1 and Cyp27 Knock Out mice. Until now we have shown key-roles of oxysterols in cognitive functions: while increased levels of 24-hydroxycholesterol show beneficial effects on memory and synaptic plasticity, accumulation of 27-hydroxycholesterol in brain leads to cognitive decline. 

Polypharmacy

Polypharmacy (the concurrent use of 5 or more drugs) and inappropriate drug use are very common in old age and they have been associated with hospitalization and mortality. Particularly vulnerable are dementia patients who are especially sensitive to adverse effects of drugs. With our research we aim to discover mechanisms and biomarkers of adverse events to multiple medication use in mouse models for aging and AD. 

Publications

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons
Merino-serrais P, Loera-valencia R, Rodriguez-rodriguez P, Parrado-fernandez C, Ismail Ma, Maioli S, et al
Cerebral cortex (New York, N.Y. : 1991) 2019;29(1):429-446

The composition of polypharmacy: A register-based study of Swedes aged 75 years and older
Wastesson Jw, Cedazo Minguez A, Fastbom J, Maioli S, Johnell K
PloS one 2018;13(3):e0194892-

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation
Ismail Ma, Mateos L, Maioli S, Merino-serrais P, Ali Z, Lodeiro M, et al
The Journal of experimental medicine 2017;214(3):699-717

Aggregation of the Inflammatory S100A8 Precedes Aβ Plaque Formation in Transgenic APP Mice: Positive Feedback for S100A8 and Aβ Productions
Lodeiro M, Puerta E, Ismail Ma, Rodriguez-rodriguez P, Rönnbäck A, Codita A, et al
The journals of gerontology. Series A, Biological sciences and medical sciences 2017;72(3):319-328

Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis
Persson T, Lattanzio F, Calvo-garrido J, Rimondini R, Rubio-rodrigo M, Sundström E, et al
Journal of Alzheimer's disease : JAD 2017;56(2):601-617

Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease
Tajeddinn W, Persson T, Calvo-garrido J, Seed Ahmed M, Maioli S, Vijayaraghavan S, et al
Journal of Alzheimer's disease : JAD 2016;53(1):349-61

27-Hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice
Heverin M, Maioli S, Pham T, Mateos L, Camporesi E, Ali Z, et al
BEHAVIOURAL BRAIN RESEARCH 2015;:356-9

5-HT1B and other related serotonergic proteins are altered in APPswe mutation
Tajeddinn W, Persson T, Maioli S, Calvo-garrido J, Parrado-fernandez C, Yoshitake T, et al
Neuroscience letters 2015;594():137-43

Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease
Alzheimer's Disease Neuroimaging Initiative, Maioli S, Lodeiro M, Merino-serrais P, Falahati F, Khan W, et al
Aging cell 2015;14(1):122-9

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations
Wanngren J, Lara P, Ojemalm K, Maioli S, Moradi N, Chen L, et al
FEBS open bio 2014;4():393-406

Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?
Maioli S, Båvner A, Ali Z, Heverin M, Ismail Ma, Puerta E, et al
PloS one 2013;8(7):e68534-

Combination of apolipoprotein E4 and high carbohydrate diet reduces hippocampal BDNF and arc levels and impairs memory in young mice
Maioli S, Puerta E, Merino-serrais P, Fusari L, Gil-bea F, Rimondini R, et al
Journal of Alzheimer's disease : JAD 2012;32(2):341-55

Excitotoxic lesion of the perirhinal cortex impairs spatial working memory in a delayed-alternation task
Maioli S, Gangarossa G, Locchi F, Andrioli A, Bertini G, Rimondini R
BEHAVIOURAL BRAIN RESEARCH 2012;230(2):349-54

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Akademiska Stråket 1
Stockholm