Robert Harris
About me
Professor of Immunotherapy in Neurological Diseases 2013-present
Academic Vice-President of Doctoral Education 2019-present
Chairperson International Advisory Council 2020-2023
President of ORPHEUS doctoral education organization 2014-2022
Professor Robert A. Harris (Bob) was born in Harpenden in Southern UK in 1966. He conducted a Bsc.Hons undergraduate degree at Portsmouth Polytechnic, majoring in Parasitology in 1987. PhD studies at University College London studying innate immune agglutinins in Schistosoma host snail species with Terry Preston and Vaughan Southgate as supervisors culminated with a thesis defence in early 1991. A 2.5 year postdoc at the London School of Hygiene & Tropical Medicine in Paul Kaye’s research group ensued, with focus on understanding the intracellular fate of Leishmania spp. protozoans in macrophages. Bob was awarded a Wellcome Trust postdoctoral fellowship that permitted his relocation to the Karolinska Institutet (Stockholm, Sweden) in the spring of 1994. A postdoc period was spent split between the labs of Anders Örn and Tomas Olsson, in which he studied Trypanosoma cruzi and Trypanosoma bruceii protozoan proteins. Bob became an Associate Professor at the Karolinska Institute in 1999, heralding his establishment as a PI. Bob started to work with autoimmune diseases in 1996 and began study of therapy using live parasite infections or parasite molecules. His research group has developed autoantigen-specific vaccines, defined the effects of post-translational biochemical molecules on autoantigenicity and developed a macrophage adoptive transfer therapy that prevents pathogenesis in several experimental disease models. He became Professor of Immunotherapy in Neurological Diseases in 2013.
Education
University Education
BSc (Hons) Biology - Upper Second Class Portsmouth Polytechnic, UK 1987
PhD Training
’Haemolymph proteins and the snail immune response’ University College London, UK 1991Karolinska Institutet's pedagogy prize 2014
FEBS Education Award 2024
Research
- We are primarily interested in understanding the pathogenesis of incurable, chronic disease states of the Central Nervous System, including ALS, MS, Alzheimer's disease and glioma brain tumors.
HOW CAN WE TREAT OR CURE THE DISEASES? There is currently no cure for the diseases we study, and existing medications are only partly effective.
Our main interest is thus on developing new strategies to reduce or abrogate disease symptoms.
We focus on using the body’s own myeloid cells as a means of treating the same individual through ‘personalised cell therapy’ or by targeting these cells for immunomodulation.
Teaching
- Central Director of Doctoral studies at Karolinska Institutet 2008-2018
Director of Doctoral studies at Department of Clinical Neurosciences, Karolinska Institutet 2005-2018
Awarded Karolinska Institutet’s Pedagogy Prize 2014
131 publications and 6 reviews – Web of Science h index = 45 Google Scholar H index = 39, i index = 95 (as of 27th April 2021)
Currently receives research funding from Swedish Medical research Council, CancerFonden, Alltid Litt Sterkere, Ulla Carin Lindquist Stiftelse and Karolinska Institutet
Currently supervises 1 PhD student, co-supervises 5 PhD students, 2 Postdoctoral Fellows and one undergraduate student
Courses taught at a postgraduate level:
- High Performance Chromatography Methods - Applications in Analysis of Biologically Significant Molecules (Chile)
- Trypanosomiasis and Lesihmanisasis protozoan infection biology (Stockholm University)
- I IUIS Course “Infections & Immunology: Views Towards the XXI Century” (Chile)
- Molecular Immunology (KI)
- Cellular and Molecular Infection Biology (KI)
- Winter Immunology School (KI)
- Summer School in Immunology, “Translational Medicine in the field of Autoimmunity” (KI)
- New Vaccines – advances in current vaccinology (KI)
- Clinical and Experimental Neuroimmunology (KI)
- Cytokines in inflammation (KI)
- Basic Immunology (KI)
- Neurovirology (KI)
- Immune, Gene and Cell therapy (KI)
- Translational Medicine (Germany)
Courses taught at an undergraduate level:
- Medical Microbiology and Immunology
- Experimental and Clinical Neuroimmunology
- Immunological mechanisms in autoimmune diseases
- Tropiska parasiter och svenska
- Eukaryot mikrobiologi
- Basic Immunology - Macrophages
Leadership courses for faculty:
- Introduction course for PhD students at KI
- Basic course for supervisors at KI
- Advance course in pedagogy for supervisors at KI
- Future Academic Leaders at KI
Workshops:
-Conflict prevention, management and resolution
- Intended Learning Outcomes - formulation and examination
- Professional responsbility as a PhD supervisor
These teaching activities are primarily conducted at locally at KI, but also both nationally in Swedish universities as well as internationally.
Articles
- Article: DEVELOPMENTAL CELL. 2025;60(2):320-336.e9Grommisch D; Lund H; Eenjes E; Julien A; Goritz C; Harris RA; Sandberg R; Hagemann-Jensen M; Genander M
- Article: FEBS OPEN BIO. 2025;15(1):48-55Harris RA; Kazdagli H
- Article: SCIENTIFIC REPORTS. 2024;14(1):24846Min J-H; Sarlus H; Oasa S; Harris RA
- Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;121:43-55Spielbauer J; Glotfelty EJ; Sarlus H; Harris RA; Heijtz RD; Karlsson TE
- Article: NATURE NANOTECHNOLOGY. 2024;19(9):1366-1374Wang Y; Baars I; Berzina I; Rocamonde-Lago I; Shen B; Yang Y; Lolaico M; Waldvogel J; Smyrlaki I; Zhu K; Harris RA; Hogberg B
- Article: METALLOMICS. 2024;16(5):mfae019Min J-H; Sarlus H; Harris RA
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20230675Lund H; Hunt MA; Kurtovic Z; Sandor K; Kagy PB; Fereydouni N; Julien A; Goritz C; Vazquez-Liebanas E; Andaloussi Mae M; Jurczak A; Han J; Zhu K; Harris RA; Lampa J; Graversen JH; Etzerodt A; Haglund L; Yaksh TL; Svensson CI
- Journal article: TRANSPLANTATION. 2023;107(10):49Sarlus H; Zhu K; Guo Y; Balasingh VJ; Min J-H; Cuesta IB; Bencina S; Harris R; Gramignoli R
- Article: JCI INSIGHT. 2023;8(17):e167656Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
- Article: ACTA PHARMACOLOGICA SINICA. 2023;44(4):766-779Sun J-X; Zhu K-Y; Wang Y-M; Wang D-J; Zhang M-Z; Sarlus H; Benito-Cuesta I; Zhao X-Q; Zou Z-F; Zhong Q-Y; Feng Y; Wu S; Wang Y-Q; Harris RA; Wang J
- Article: CELL TRANSPLANTATION. 2023;32:9636897231212780Friberger I; Gontu V; Harris RA; Tran TA; Lundberg J; Holmin S
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:911744Hildenborg M; Kahlin J; Granath F; Schening A; Granstrom A; Ebberyd A; Klevenvall L; Zetterberg H; Han J; Schlegel TT; Harris R; Harris HE; Eriksson LI
- Article: EMBO REPORTS. 2022;23(7):e54499Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Min J-H; Benito-Cuesta I; Lund H; Amor S; Wang J; Zhang X-M; Kutter C; Guerreiro-Cacais AO; Hogberg B; Harris RA
- Article: CHILD PSYCHIATRY & HUMAN DEVELOPMENT. 2022;53(2):354-364Gromark C; Hesselmark E; Djupedal IG; Silverberg M; Horne A; Harris RA; Serlachius E; Mataix-Cols D
- Article: ACTA BIOMATERIALIA. 2022;142:36-48Samanta S; Rangasami VK; Sarlus H; Samal JRK; Evans AD; Parihar VS; Varghese OP; Harris RA; Oommen OP
- Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20Zhou K; Han J; Lund H; Boggavarapu NR; Lauschke VM; Goto S; Cheng H; Wang Y; Tachi A; Xie C; Zhu K; Sun Y; Osman AM; Liang D; Han W; Gemzell-Danielsson K; Betsholtz C; Zhang X-M; Zhu C; Enge M; Joseph B; Harris RA; Blomgren K
- Article: CELL DEATH AND DIFFERENTIATION. 2022;29(1):246-261Karsten S; Fiskesund R; Zhang X-M; Marttila P; Sanjiv K; Pham T; Rasti A; Bräutigam L; Almlöf I; Marcusson-Ståhl M; Sandman C; Platzack B; Harris RA; Kalderén C; Cederbrant K; Helleday T; Warpman Berglund U
- Article: MOLECULAR IMAGING AND BIOLOGY. 2021;23(6):952-962Friberger I; Jussing E; Han J; Goos JACM; Siikanen J; Kaipe H; Lambert M; Harris RA; Samen E; Carlsten M; Holmin S; Tran TA
- Article: JOURNAL OF NEUROSCIENCE. 2021;41(40):8441-8459Hakim R; Zachariadis V; Sankavaram SR; Han J; Harris RA; Brundin L; Enge M; Svensson M
- Article: CANCER DISCOVERY. 2021;11(10):2456-2473Venkatesan S; Angelova M; Puttick C; Zhai H; Caswell DR; Lu W-T; Dietzen M; Galanos P; Evangelou K; Bellelli R; Lim EL; Watkins TBK; Rowan A; Teixeira VH; Zhao Y; Chen H; Ngo B; Zalmas L-P; Al Bakir M; Hobor S; Gronroos E; Pennycuick A; Nigro E; Campbell BB; Brown WL; Akarca AU; Marafioti T; Wu MY; Howell M; Boulton SJ; Bertoli C; Fenton TR; de Bruin RAM; Maya-Mendoza A; Santoni-Rugiu E; Hynds RE; Gorgoulis VG; Jamal-Hanjani M; McGranahan N; Harris RS; Janes SM; Bartkova J; Bakhoum SF; Bartek J; Kanu N; Swanton C
- Article: ONCOGENE. 2021;40(32):5066-5080Guo M; Goudarzi KM; Abedi S; Pieber M; Sjoberg E; Behnan J; Zhang X-M; Harris RA; Bartek J; Lindstrom MS; Nister M; Hagerstrand D
- Journal article: NEUROLOGY. 2021;96(15_supplement)Mickeviciute GC; Smertinaite L; Han J; Ntzouni M; Guttmann P; Harris R; Sandell A; Mohseni S; Karrenbauer V
- Article: NATURE MEDICINE. 2021;27(4):640-646Manberg A; Skene N; Sanders F; Trusohamn M; Remnestal J; Szczepinska A; Aksoylu IS; Lonnerberg P; Ebarasi L; Wouters S; Lehmann M; Olofsson J; von Gohren Antequera I; Domaniku A; De Schaepdryver M; De Vocht J; Poesen K; Uhlen M; Anink J; Mijnsbergen C; Vergunst-Bosch H; Hubers A; Klappe U; Rodriguez-Vieitez E; Gilthorpe JD; Hedlund E; Harris RA; Aronica E; Van Damme P; Ludolph A; Veldink J; Ingre C; Nilsson P; Lewandowski SA
- Article: CARBOHYDRATE POLYMERS. 2021;254:117291Rangasami VK; Samanta S; Parihar VS; Asawa K; Zhu K; Varghese OP; Teramura Y; Nilsson B; Hilborn J; Harris RA; Oommen OP
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(22):E8603-8603Han J; Fan Y; Zhou K; Zhu K; Blomgren K; Lund H; Zhang X-M; Harris RA
- Article: SCIENCE IMMUNOLOGY. 2020;5(52):eabb5077Berglund R; Guerreiro-Cacais AO; Adzemovic MZ; Zeitelhofer M; Lund H; Ewing E; Ruhrmann S; Nutma E; Parsa R; Thessen-Hedreul M; Amor S; Harris RA; Olsson T; Jagodic M
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(18):E6824-6824Han J; Zhu K; Zhou K; Hakim R; Sankavaram SR; Blomgren K; Lund H; Zhang X-M; Harris RA
- Article: NATURE COMMUNICATIONS. 2020;11(1):4071Carlstrom KE; Zhu K; Ewing E; Krabbendam IE; Harris RA; Falcao AM; Jagodic M; Castelo-Branco G; Piehl F
- Article: GLIA. 2020;68(7):1466-1478Zhu K; Pieber M; Han J; Blomgren K; Zhang X-M; Harris RA; Lund H
- Article: MOLECULAR NEUROBIOLOGY. 2020;57(5):2194-2205Di Martino E; Bocchetta E; Tsuji S; Mukai T; Harris RA; Blomgren K; Aden U
- Article: JOURNAL OF NEUROINFLAMMATION. 2020;17(1):111Tsuji S; Di Martino E; Mukai T; Tsuji S; Murakami T; Harris RA; Blomgren K; Aden U
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(2):838-852N'diaye M; Brauner S; Flytzani S; Kular L; Warnecke A; Adzemovic MZ; Piket E; Min J-H; Edwards W; Mela F; Choi HY; Magg V; James T; Linden M; Reichardt HM; Daws MR; van Horssen J; Kockum I; Harris RA; Olsson T; Guerreiro-Cacais AO; Jagodic M
- Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2020;38(1):42-49Tang Q; Gheorghe KR; Zhang X-M; Lindroos E; Alexanderson H; Wick C; Bruton M; Fernandes-Cerqueira C; Harris RA; Nennesmo I; Lundberg IE
- Article: JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY. 2019;29(8):625-633Gromark C; Harris RA; Wickstrom R; Horne A; Silverberg-Morse M; Serlachius E; Mataix-Cols D
- Article: FEBS OPEN BIO. 2019;9(5):830-839Williams A; Jones MG; Jonsson R; Harris RA; Mulvany MJ
- Article: BRAIN RESEARCH. 2019;1710:33-42Zhu K; Sun J; Kang Z; Zou Z; Wu X; Wang Y; Wu G; Harris RA; Wang J
- Article: BRITISH JOURNAL OF ANAESTHESIA. 2019;122(3):350-360Yang T; Xu G; Newton PT; Chagin AS; Mkrtchian S; Carlstrom M; Zhang X-M; Harris RA; Cooter M; Berger M; Maddipati KR; Akassoglou K; Terrando N
- Article: ISCIENCE. 2018;9:71-83Wallmann T; Zhang X-M; Wallerius M; Bolin S; Joly A-L; Sobocki C; Leiss L; Jiang Y; Bergh J; Holland EC; Enger PO; Andersson J; Swartling FJ; Miletic H; Uhrbom L; Harris RA; Rolny C
- Article: NATURE COMMUNICATIONS. 2018;9(1):4845Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Overby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
- Article: CANCER MANAGEMENT AND RESEARCH. 2018;10:2653-2661Al Obeed OA; Vaali-Mohamed M-A; Alkhayal KA; Bin Traiki TA; Zubaidi AM; Arafah M; Harris RA; Khan Z; Abdulla M-H
- Article: NATURE IMMUNOLOGY. 2018;19(5):1-7Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Kular L; Han J; Zhu K; Nijssen J; Hedlund E; Needhamsen M; Ruhrmann S; Guerreiro-Cacais AO; Berglund R; Forteza MJ; Ketelhuth DFJ; Butovsky O; Jagodic M; Zhang X-M; Harris RA
- Article: NEUROBIOLOGY OF AGING. 2017;60:173-182Sackmann V; Ansell A; Sackmann C; Lund H; Harris RA; Hallbeck M; Nilsberth C
- Article: NEUROMOLECULAR MEDICINE. 2017;19(4):463-479Warnecke A; Abele S; Musunuri S; Bergquist J; Harris RA
- Article: BMC BIOINFORMATICS. 2017;18(1):486Needhamsen M; Ewing E; Lund H; Gomez-Cabrero D; Harris RA; Kular L; Jagodic M
- Article: FEBS OPEN BIO. 2017;7(10):1444-1452Barnett JV; Harris RA; Mulvany MJ
- Article: REDOX BIOLOGY. 2017;13:320-330Yang T; Zhang X-M; Tarnawski L; Peleli M; Zhuge Z; Terrando N; Harris RA; Olofsson PS; Larsson E; Persson AEG; Lundberg JO; Weitzberg E; Carlstrom M
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2017;303:1-12Warnecke A; Musunuri S; N'diaye M; Sandalova T; Achour A; Bergquist J; Harris RA
- Article: ONCOTARGET. 2016;7(50):82305-82323Han W; Umekawa T; Zhou K; Zhang X-M; Ohshima M; Dominguez CA; Harris RA; Zhu C; Blomgren K
- Article: NATURE IMMUNOLOGY. 2016;17(12):1407-1414Hagglof T; Sedimbi SK; Yates JL; Parsa R; Salas BH; Harris RA; Leadbetter EA; Karlsson MCI
- Article: GLIA. 2016;64(11):1925-1937Parsa R; Lund H; Tosevski I; Zhang X-M; Malipiero U; Beckervordersandforth J; Merkler D; Prinz M; Gyllenberg A; James T; Warnecke A; Hillert J; Alfredsson L; Kockum I; Olsson T; Fontana A; Suter T; Harris RA
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2016;186(1):46-56Radenkovic M; Silver C; Arvastsson J; Lynch K; Lernmark A; Harris RA; Agardh C-D; Cilio CM
- Article: IMMUNOLOGY AND CELL BIOLOGY. 2016;94(8):747-762Schmidt A; Zhang X-M; Joshi RN; Iqbal S; Wahlund C; Gabrielsson S; Harris RA; Tegner J
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2016;213(8):1537-1553Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Guerreiro-Cacais AO; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(7):e003868Yang T; Zollbrecht C; Winerdal ME; Zhuge Z; Zhang X-M; Terrando N; Checa A; Sallstrom J; Wheelock CE; Winqvist O; Harris RA; Larsson E; Persson AEG; Fredholm BB; Carlstrom M
- Article: JOURNAL OF PROTEOME RESEARCH. 2016;15(7):2337-2345Tarasova NK; Ytterberg AJ; Lundberg K; Zhang X-M; Harris RA; Zubarev RA
- Article: CELL REPORTS. 2016;15(9):2000-2011Georgoudaki A-M; Prokopec KE; Boura VF; Hellqvist E; Sohn S; Ostling J; Dahan R; Harris RA; Rantalainen M; Klevebring D; Sund M; Brage SE; Fuxe J; Rolny C; Li F; Ravetch JV; Karlsson MCI
- Article: NEUROSCIENCE LETTERS. 2016;620:1-7Yao G; Wang P; Luo X-D; Yu T-M; Harris RA; Zhang X-M
- Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;99(3):437-446N'diaye M; Warnecke A; Flytzani S; Abdelmagid N; Ruhrmann S; Olsson T; Jagodic M; Harris RA; Guerreiro-Cacais AO
- Article: J CLIN CELL IMMUNOL. 2015;6(5):364Mills CD; Harris RA; Ley K
- Article: JOURNAL OF PROTEOME RESEARCH. 2015;14(9):3940-3947Tarasova NK; Ytterberg AJ; Lundberg K; Zhang X-M; Harris RA; Zubarev RA
- Article: DIABETOLOGIA. 2015;58(7):1610-1620Yang T; Gao X; Sandberg M; Zollbrecht C; Zhang X-M; Hezel M; Liu M; Peleli M; Lai E-Y; Harris RA; Persson AEG; Fredholm BB; Jansson L; Carlstrom M
- Article: CANCER RESEARCH. 2015;75(2):306-315Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor DevelopmentWang J; Cao Z; Zhang X-M; Nakamura M; Sun M; Hartman J; Harris RA; Sun Y; Cao Y
- Article: BMC BIOINFORMATICS. 2014;15(1):370Warnecke A; Sandalova T; Achour A; Harris RA
- Article: IMMUNOLOGY. 2014;142(3):431-441Fransson M; Piras E; Wang H; Burman J; Duprez I; Harris RA; LeBlanc K; Magnusson PU; Brittebo E; Loskog ASI
- Article: GLIA. 2014;62(5):804-817Zhang X-M; Lund H; Mia S; Parsa R; Harris RA
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(5):305-314Mia S; Warnecke A; Zhang X-M; Malmstrom V; Harris RA
- Article: PLOS ONE. 2013;8(11):e79281Abdulla M-H; Bakhiet M; Lejon V; Andersson J; McKerrow J; Al-Obeed O; Harris RA
- Article: PLOS ONE. 2013;8(5):e63172Khademi M; Dring AM; Gilthorpe JD; Wuolikainen A; Al Nimer F; Harris RA; Andersson M; Brundin L; Piehl F; Olsson T; Svenningsson A
- Article: GLIA. 2012;60(12):1930-1943Scheffel J; Regen T; Van Rossum D; Seifert S; Ribes S; Nau R; Parsa R; Harris RA; Boddeke HWGM; Chuang H-N; Pukrop T; Wessels JT; Juergens T; Merkler D; Brueck W; Schnaars M; Simons M; Kettenmann H; Hanisch U-K
- Article: DIABETES. 2012;61(11):2881-2892Parsa R; Andresen P; Gillett A; Mia S; Zhang X-M; Mayans S; Holmberg D; Harris RA
- Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:112Fransson M; Piras E; Burman J; Nilsson B; Essand M; Lu B; Harris RA; Magnusson PU; Brittebo E; Loskog ASI
- Article: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS. 2011;10(1):82-107Harris RA; Amor S
- Article: JOURNAL OF IMMUNOLOGY. 2010;185(11):6883-6890Beyeen AD; Adzemovic MZ; Ockinger J; Stridh P; Becanovic K; Laaksonen H; Lassmann H; Harris RA; Hillert J; Alfredsson L; Celius EG; Harbo HF; Kockum I; Jagodic M; Olsson T
- Article: MULTIPLE SCLEROSIS JOURNAL. 2010;16(9):1056-1065Gillett A; Hedreul MT; Khademi M; Espinosa A; Beyeen AD; Jagodic M; Kockum I; Harris RA; Olsson T
- Article: JOURNAL OF IMMUNOLOGY. 2010;185(1):442-450Gillett A; Marta M; Jin T; Tuncel J; Leclerc P; Nohra R; Lange S; Holmdahl R; Olsson T; Harris RA; Jagodic M
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2010;161(1):48-56Akesson C; Uvebrant K; Oderup C; Lynch K; Harris RA; Lernmark A; Agardh C-D; Cilio CM
- Article: PLOS ONE. 2009;4(11):e7773Gillett A; Maratou K; Fewings C; Harris RA; Jagodic M; Aitman T; Olsson T
- Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 7):705-708Uchtenhagen H; Sourial S; Friemann R; Ehnlund M; Spetz A-L; Harris RA; Madhurantakam C; Achour A
- Article: JOURNAL OF IMMUNOLOGY. 2009;182(11):6889-6895Covacu R; Arvidsson L; Andersson A; Khademi M; Erlandsson-Harris H; Harris RA; Svensson MA; Olsson T; Brundin L
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2009;210(1-2):30-39Hedreul MT; Gillett A; Olsson T; Jagodic M; Harris RA
- Article: GENES AND IMMUNITY. 2009;10(3):227-236Guo JP; Verdrengh M; Tarkowski A; Lange S; Jennische E; Lorentzen JC; Harris RA
- Article: JOURNAL OF IMMUNOLOGY. 2009;182(5):3105-3111Eriksson F; Tsagozis P; Lundberg K; Parsa R; Mangsbo SM; Persson MAA; Harris RA; Pisa P
- Article: JOURNAL OF PROTEOMICS. 2009;71(6):670-681Gonzalez H; Ottervald J; Nilsson KC; Sjogren N; Miliotis T; Von Bahr H; Khademi M; Eriksson B; Kjellstrom S; Vegvari A; Harris R; Marko-Varga G; Borg K; Nilsson J; Laurell T; Olsson T; Franzen B
- Article: PLOS ONE. 2008;3(11):e3682Andersson A; Isaksson M; Wefer J; Norling A; Flores-Morales A; Rorsman F; Kampe O; Harris RA; Lobell A
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;334(1-2):114-121Steed J; Gilliam LK; Harris RA; Lernmark A; Hampe CS
- Article: NATURE MEDICINE. 2008;14(3):337-342Stromnes IM; Cerretti LM; Liggitt D; Harris RA; Goverman JM
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2007;37(7):1986-1995Wallberg M; Bergquist J; Achour A; Breij E; Harris RA
- Article: CURRENT HIV RESEARCH. 2006;4(2):229-237Sourial S; Nilsson C; Wärnmark A; Achour A; Harris RA
- Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;356(2):382-396Achour A; Michaëlsson T; Harris RA; Ljunggren HG; Kärre M; Schneider G; Sandalova T
- Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 12):1090-1093Sandalova T; Michaëlsson J; Harris RA; Ljunggren HG; Kärre K; Schneider G; Achour A
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27069-27075Sandalova T; Michaëlsson J; Harris RA; Odeberg J; Schneider G; Kärres K; Achour A
- Article: JOURNAL OF DIABETES AND ITS COMPLICATIONS. 2005;19(4):238-246Agardh CD; Cilio CM; Lethagen Å; Lynch K; Leslie RDG; Palmér M; Harris RA; Robertson JA; Lernmark Å
- Article: MOLECULAR BIOTECHNOLOGY. 2005;30(2):155-162Sourial S; Wärnmark A; Nilsson C; Björling E; Achour A; Harris RA
- Article: INTERNATIONAL IMMUNOLOGY. 2005;17(6):721-728Wållberg M; Harris RA
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2005;61(1):1-9Kokkola R; Andersson Å; Mullins G; Östberg T; Treutiger CJ; Arnold B; Nawroth P; Andersson U; Harris RA; Harris HE
- Article: ACTA PROTOZOOLOGICA. 2004;43(4):373-377Sharafeldin A; Bittorf T; Harris RA; Mix E; Bakhiet M
- Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2004;76(6):1118-1124Andersson Å; Kokkola R; Wefer J; Erlandsson-Harris H; Harris RA
- Article: JOURNAL OF IMMUNOLOGY. 2004;172(11):7169-7176Khademi M; Illés Z; Gielen AW; Marta M; Takazawa N; Baecher-Allan C; Brundin L; Hannerz J; Martin C; Harris RA; Hafler DA; Kuchroo VK; Olsson T; Piehl F; Wallström E
- Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;59(6):613Wefer J; Harris RA; Lobell A
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2004;149(1-2):66-76Wefer J; Harris RA; Lobell A
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2003;141(1-2):10-19Abdul-Majid KB; Wefer J; Stadelmann C; Stefferl A; Lassmann H; Olsson T; Harris RA
- Article: ARCHIVES OF VIROLOGY. 2003;149(10):1985-2000Hindersson M; Örn A; Harris RA; Frisk G
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(6):1539-1547Wållberg M; Wefer J; Harris RA
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(3):579-587Wing K; Lindgren S; Kollberg G; Lundgren A; Harris RA; Rudin A; Lundin S; Suri-Payer E
- Article: JOURNAL OF IMMUNOLOGY. 2003;170(4):2064-2073Djerbi M; Abdul-Majid KB; Abedi-Valugerdi M; Olsson T; Harris RA; Grandien A
- Article: IMMUNITY. 2002;17(6):757-768Achour A; Michaëlsson J; Harris RA; Odeberg J; Grufman P; Sandberg JK; Levitsky V; Kärre K; Sandalova T; Schneider G
- Journal article: JOURNAL OF PARASITOLOGY. 2002;88(4):697Saldana A; Harris RA; Orn A; Monroy C; Ortega-Barria E; Sousa OE
- Article: JOURNAL OF PARASITOLOGY. 2002;88(4):697-701Saldaña A; Harris RA; Örn A; Monroy C; Ortega-Barria E; Sousa OE
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2002;32(7):1939-1946Svensson L; Abdul-Majid KB; Bauer J; Lassmann H; Harris RA; Holmdahl R
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(1):70-81Abdul-Majid KB; Stefferl A; Bourquin C; Lassmann H; Linington C; Olsson T; Kleinau S; Harris RA
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;114(3):398-402Bakhiet M; Mustafa M; Zhu J; Harris R; Lindquist L; Link H; Diab A
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;112(1):52-62Batoni G; Esin S; Harris RA; Källenius G; Svenson SB; Andersson R; Campa M; Wigzell H
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;122(3):477-483Mattsson L; Larsson P; Erlandsson-Harris H; Klareskog L; Harris RA
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;121(3):499-505Une C; Andersson J; Eloranta ML; Sunnemark D; Harris RA; Örn A
- Article: ATHEROSCLEROSIS. 2000;153(2):273-282Sunnemark D; Harris RA; Frostegård J; Örn A
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2000;111(1-2):23-33Abdul-Majid KB; Jirholt J; Stadelmann C; Stefferl A; Kjellén P; Wallström E; Holmdahl R; Lassmann H; Olsson T; Harris RA
- Article: PARASITOLOGY. 2000;120:281-287Hamadien M; Bakhiet M; Harris RA
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(1):300-307Michaëlsson J; Achour A; Salcedo M; Kåse-Sjöström A; Sundbäck J; Harris RA; Kärre K
- Article: INFECTION AND IMMUNITY. 1999;67(8):3800-3809Esin S; Batoni G; Saruhan-Direskeneli G; Harris RA; Grunewald J; Pardini M; Svenson SB; Campa M; Wigzell H
- Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1999;55(Pt 1):260-262Achour A; Harris RA; Persson K; Sundbäck J; Sentman CL; Schneider G; Lindqvist Y; Kärre K
- Article: AUTOIMMUNITY. 1999;30(2):71-80Xiang M; Zaccone P; Di Marco R; Harris R; Magro G; Di Mauro M; Meroni PL; Garotta G; Nicoletti F
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1998;48(5):480-484Sunnemark D; Frostegård J; Örn A; Harris RA
- Article: IMMUNITY. 1998;9(2):199-208Achour A; Persson K; Harris RA; Sundbäck J; Sentman CL; Lindqvist Y; Schneider G; Kärre K
- Article: ACTA TROPICA. 1998;70(1):87-99Saldaña A; Sousa OE; Örn A; Harris RA
- Article: JOURNAL OF PARASITOLOGY. 1998;84(1):67-73Saldaña A; Harris RA; Örn A; Sousa OE
- Article: IMMUNOLOGY LETTERS. 1998;60(2-3):171-177Sunnemark D; Andersson R; Harris RA; Jeddi-Tehrani M; Örn A
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1997;27(4):1005-1013Garcia MR; Graham S; Harris RA; Beverley SM; Kaye PM
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1997;45(3):322-330Vasquez JE; Krusnell J; Orn A; Sousa OE; Harris RA
- Article: ACTA TROPICA. 1997;63(2-3):159-166Aguillon JC; Harris R; Molina MC; Colombo A; Cortes C; Hermosilla T; Carreno P; Orn A; Ferreira A
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1996;44(5):421-429Sunnemark D; Ulfgren AK; Orn A; Harris RA
- Article: JOURNAL OF IMMUNOLOGY. 1996;156(12):4691-4696Culley FJ; Harris RA; Kaye PM; McAdam KPWJ; Raynes JG
- Article: IMMUNOLOGY LETTERS. 1996;50(1-2):71-80Bakhiet M; Buscher P; Harris RA; Kristensson K; Wigzell H; Olsson T
- Journal article: PARASITOLOGY. 1993;106:127-135HARRIS RA; PRESTON TM; SOUTHGATE VR
- Journal article: COMPARATIVE CLINICAL PATHOLOGY. 1992;2(1):30-34Harris RA; Adema CM; van Deutekom-Mulder EC
- Journal article: JOURNAL OF INVERTEBRATE PATHOLOGY. 1992;59(1):24-32ADEMA CM; HARRIS RA; VANDEUTEKOMMULDER EC
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All other publications
- Corrigendum: SCIENTIFIC REPORTS. 2024;14(1):30574Min J-H; Sarlus H; Oasa S; Harris RA
- Review: FRONTIERS IN NEUROSCIENCE. 2024;18:1467333Min J-H; Sarlus H; Harris RA
- Review: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2024;17:1408159Min J-H; Sarlus H; Harris RA
- Preprint: BIORXIV. 2024Grommisch D; Lund H; Eenjes E; Julien A; Göritz C; Harris R; Sandberg R; Hagemann-Jensen M; Genander M
- Preprint: BIORXIV. 2023Zhu K; Min J-H; Joshua V; Liu Y; Pieber M; Suerth V; Sarlus H; Harris R; Lund H
- Preprint: BIORXIV. 2023Lund H; Hunt M; Kurtovic Z; Sandor K; Fereydouni N; Julien A; Göritz C; Han J; Zhu K; Harris R; Lampa J; Haglund L; Yaksh T; Svensson C
- Preprint: BIORXIV. 2022Kritikou JS; Sánchez-Pascual I; Muñoz-Miranda JP; Vashist N; Wagner AK; Zhang X-M; Assarsson E; Dominguez-Villar M; Yagita H; Garcia-Cozar F; Riese P; Harris RA; Ljunggren H-G; Chambers BJ
- Corrigendum: MOLECULAR IMAGING AND BIOLOGY. 2022;24(3):510Friberger I; Jussing E; Han J; Goos JACM; Siikanen J; Kaipe H; Lambert M; Harris RA; Samen E; Carlsten M; Holmin S; Tran TA
- Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(4):219Han J; Chitu V; Stanley ER; Wszolek ZK; Karrenbauer VD; Harris RA
- Editorial comment: FRONTIERS IN CELLULAR NEUROSCIENCE. 2022;16:877567Zhou K; Harris RA; Shen X
- Preprint: MEDRXIV. 2021Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward D; Teifel S; Liu Y; Harris R; Murrell B; Mcinerney G; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam G; Dopico XC; Rorbach J
- Preprint: BIORXIV. 2021Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Lund H; Amor S; Wang J; Zhang X; Kutter C; Guerreiro Cacais AO; Högberg B; Harris R
- Corrigendum: ONCOGENE. 2021;40(32):5153Guo M; Goudarzi KM; Abedi S; Pieber M; Sjoberg E; Behnan J; Zhang X-M; Harris RA; Bartek J; Lindstrom MS; Nister M; Hagerstrand D
- Corrigendum: NATURE MEDICINE. 2021;27(7):1308Manberg A; Skene N; Sanders F; Trusohamn M; Remnestal J; Szczepinska A; Aksoylu IS; Lonnerberg P; Ebarasi L; Wouters S; Lehmann M; Olofsson J; von Gohren Antequera I; Domaniku A; De Schaepdryver M; De Vocht J; Poesen K; Uhlen M; Anink J; Mijnsbergen C; Vergunst-Bosch H; Hubers A; Klappe U; Rodriguez-Vieitez E; Gilthorpe JD; Hedlund E; Harris RA; Aronica E; Van Damme P; Ludolph A; Veldink J; Ingre C; Nilsson P; Lewandowski SA
- Conference publication: FEBS OPEN BIO. 2021;11:75Harris R
- Letter: MOVEMENT DISORDERS. 2021;36(6):1470-1471Han J; Harris RA; Karrenbauer VD
- Conference publication: NEUROLOGY. 2021;96(15)Mickeviciute GC; Smertinaite L; Han J; Ntzouni M; Guttmann P; Harris R; Sandell A; Mohseni S; Karrenbauer V
- Review: JOURNAL OF NEUROINFLAMMATION. 2021;18(1):74Han J; Fan Y; Zhou K; Blomgren K; Harris RA
- Preprint: SSRN ELECTRONIC JOURNAL. 2021Samanta S; Rangasami VK; Sarlus H; Samal JRK; Evans AD; Parihar VS; Varghese OP; Harris RA; Oommen OP
- Review: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2020;8(1):217Han J; Sarlus H; Wszolek ZK; Karrenbauer VD; Harris RA
- Preprint: BIORXIV. 2020Carlström K; Zhu K; Ewing E; Krabbendam I; Harris R; Falcão AM; Jagodic M; Castelo-Branco G; Piehl F
- Preprint: RESEARCH SQUARE. 2020Han J; Zhu K; Zhou K; Hakim R; Sankavaram SR; Blomgren K; Lund H; Zhang X-M; Harris RA
- Preprint: RESEARCH SQUARE. 2020Tsuji S; Martino ED; Mukai T; Tsuji S; Murakami T; Harris R; Blomgren K; Aden U
- Preprint: RESEARCH SQUARE. 2020Tsuji S; Martino ED; Mukai T; Tsuji S; Murakami T; Harris R; Blomgren K; Aden U
- Preprint: RESEARCH SQUARE. 2019Tsuji S; Martino ED; Mukai T; Tsuji S; Murakami T; Harris R; Blomgren K; Aden U
- Review: RADIOTHERAPY AND ONCOLOGY. 2019;140:116-124Lippitz BE; Harris RA
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49:1445-1446Zhu K; Han J; Sun J; Guerreiro-Cacais AO; Zhang X; Wang J; Harris R
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2019;25:211Han J; Zhu K; Harris RA; Zhang X-M
- Conference publication: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2019;62:S551-S552Jonsson I; Jussing E; Zhang X-M; Lu L; Samen E; Harris R; Holmin S; Thuy T
- Review: GLIA. 2019;67(2):217-231Han J; Zhu K; Zhang X-M; Harris RA
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):297Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Needhamsen M; Ruhrmann S; Kular L; Ortlieb A; Cacais G; Butovsky O; Jagodic M; Zhang X; Harris RA
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):328Han J; Lund H; Pieber M; Harris RA; Zhang X-M
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):306Pieber M; Lund H; Parsa R; Harris R; Zhang X
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):270Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Guerreiro-Cacais AO; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
- Review: FRONTIERS IN AGING NEUROSCIENCE. 2017;9:234Lund H; Pieber M; Harris RA
- Review: MOLECULAR BRAIN. 2017;10(1):25Han J; Harris RA; Zhang X-M
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43:S615Toth M; Harald L; Haggkvist J; Forsberg A; Varrone A; Halldin C; Harris R; Farde L
- Review: ONCOIMMUNOLOGY. 2016;5(5):e1093722Lippitz BE; Harris RA
- Review: CANCER RESEARCH. 2016;76(3):513-516Mills CD; Lenz LL; Harris RA
- Editorial comment: FRONTIERS IN IMMUNOLOGY. 2014;5:612Mills CD
- Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2014;275(1-2):87-88Lund H; Zhang X; Harris R
- Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2014;275(1-2):73-74Warnecke A; Sandalova T; Achour A; Harris RA
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):435Lund H; Harris R
- Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2012;253(1-2):100Khademi M; Dring A; Gilthorpe J; Wuolikainen A; Al Nimer F; Harris R; Andersson M; Brundin L; Piehl F; Olsson T; Svenningsson A
- Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2010;228(1-2):94Roham P; Pernilla A; Harris RA
- Published conference paper: JOURNAL OF PROTEOMICS. 2010;73(6):1117-1132Ottervald J; Franzen B; Nilsson K; Andersson LI; Khademi M; Eriksson B; Kjellstrom S; Marko-Varga G; Vegvari A; Harris RA; Laurell T; Miliotis T; Matusevicius D; Salter H; Ferm M; Olsson T
- Meeting abstract: CYTOKINE. 2009;48(1-2):134-135Mia MS; Parsa R; Harris RA
- Conference publication: JOURNAL OF IMMUNOLOGY. 2009;182:136.5Gillett AM; Marta M; Olsson T; Harris R; Jagodic M
- Review: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;84(5):1248-1255Andersson A; Covacu R; Sunnemark D; Danilov AI; Dal Bianco A; Khademi M; Wallstrom E; Lobell A; Brundin L; Lassmann H; Harris RA
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):255Guo JP; Verdrengh M; Tarkowski A; Lange S; Harris RA; Lorentzen JC
- Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2004;154(1-2):60Wållberg M; Bergquist J; Harris R
- Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2003;6(10):949-950Erlandsson-Harris H; Harris R
- Conference publication: BIOCHEMICAL SOCIETY TRANSACTIONS. 1994;22(1):S3RAYNES JG; CURRY A; HARRIS RA
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Grants
- Swedish Research Council1 January 2022 - 31 December 2024
- Swedish Research Council1 December 2021 - 30 November 2026The origin and progression of many neurodegenerative diseases is not clearly understood, and basic research is required to provide a platform for development of effective therapies. Amyotrophic Lateral Sclerosis (ALS) is an incurable progressive disease of motor neurons in the spinal cord and brain, being associated with dysfunctional microglia. The purpose of this research proposal is to address this unmet need using a dual therapeutic platform approach aiming to modulate the activity of disease-associated microglia. Based on several years of our research into microglial biology and development of immunotherapies, the aim of our research programme is to develop novel immunotherapies including (i) enforced cellular repopulation of the CNS, in which we will replace microglia with transplanted healthy cells, and (ii) cuttimg-edge nanobiologics delivering specific immunomodulatory drugs that will specifically modify microglial function. We will develop protocols for such therapies and investigate the immunomodulatory effects at molecular and functional levels in both in vitro brain organoid cell culture systems and in vivo in experimental models of ALS. We envisage that these therapeutic platforms will be applicable to a range of neurodegenerative diseases. Not only will these platforms provide potential personalised immunotherapies for translation into the clinic but will also greatly increase our understanding of the molecular cues governing microglial colonization of the CNS.
- Swedish Research Council1 January 2019 - 31 December 2021
- Nanoparticle immunotherapy for the treatment of brain tumorsSwedish Cancer Society1 January 2019Tumors suppress the host's immune system. Breaking this immunosuppression is important for effective tumor therapy. Nanoparticles that contain softening molecules or tumor-killing chemicals are a new form of specific therapy that can be used to achieve immunosuppression. We have previously identified some of the most important molecules and genes that need to be silenced to prevent the development of immunosuppression and to prevent the growth of brain tumors. We will develop new gene-silencing molecules, so-called RNAi, nanoparticles for the treatment of brain tumors. The technology for this development is already established and patented. A number of molecules in the brain tumor will be blocked while delivery of a tumor-killing substance is delivered. We will try different combinations of these different agents to develop an effective protocol for the treatment of brain tumors. The technique will also be tested in melanoma and could be used with various cancers. People with GBM die on average within 2.5 years after diagnosis. We strive to improve survival by combining new therapeutic options for inhibition of immunosuppression in parallel with tumor-killing treatment. Nanoparticles will be used to deliver specific immunomodulatory agents, and different types of nanoparticles will be tested so that an optimal variant can be selected. We will first explore this concept in animal models with the long-term goal of translating the therapy to the clinic and thereby dramatically increase the life expectancy of people with brain tumors.
- Swedish Research Council1 January 2018 - 31 December 2020
- Breaking brain tumor-associated immunosuppression by macrophage cell therapySwedish Cancer Society1 January 2015During inflammation the balance/imbalance of pro- and anti-inflammatory cellular activities will decide outcome – disease progression or healing. In patients with chronic inflammatory diseases there is an imbalance. Injecting pre-activated macrophages will restore this immunological imbalance. We have demonstrated that transfer of immunosuppressive macrophages modulates autoimmune diseases and have recently extended the myeloid cell therapy platform to include use of adult microglia. In cancer settings transfer of immunoactivated macrophages will reduce immunosuppression associated with the tumor environment and enable effective tumor killing Our goal is to provide proof-of-concept in an experimental model of glioblastoma brain tumors that effective therapy can be conducted using adoptive transfer of myeloid cells. Combined transfer of pre-activated, pro-inflammatory cells directly into the brain as well as peripherally will serve to enable mounting of an efficient anti-tumor immune response that will be not be suppressed by the tumor. We will study the immunological mechanisms involved in vitro by studying macrophage and TAMs. This project not only give us to better understanding of fundamental tumor immunobiological processes, but will also be directly translatable to the clinic Individuals with GBM are usaully dead with 2.5 years of diagnosis - we aim to increase that life expectancy dramatically through establishment of a clinical protocol that is repeatable due to use of an individual's own blood cells.
- NOVEL IMMUNOTHERAPIES IN CHRONIC NEUROLOGICAL DISEASES - REDUCING PATHOGENESIS AND IMPROVING HEALINGSwedish Research Council1 January 2015 - 31 December 2018
- Breaking brain tumor-associated immunosuppression by macrophage cell therapySwedish Cancer Society1 January 2014During inflammation the balance/imbalance of pro- and anti-inflammatory cellular activities will decide outcome – disease progression or healing. In patients with chronic inflammatory diseases there is an imbalance. Injecting pre-activated macrophages will restore this immunological imbalance. We have demonstrated that transfer of immunosuppressive macrophages modulates autoimmune diseases and have recently extended the myeloid cell therapy platform to include use of adult microglia. In cancer settings transfer of immunoactivated macrophages will reduce immunosuppression associated with the tumor environment and enable effective tumor killing Our goal is to provide proof-of-concept in an experimental model of glioblastoma brain tumors that effective therapy can be conducted using adoptive transfer of myeloid cells. Combined transfer of pre-activated, pro-inflammatory cells directly into the brain as well as peripherally will serve to enable mounting of an efficient anti-tumor immune response that will be not be suppressed by the tumor. We will study the immunological mechanisms involved in vitro by studying macrophage and TAMs. This project not only give us to better understanding of fundamental tumor immunobiological processes, but will also be directly translatable to the clinic Individuals with GBM are usaully dead with 2.5 years of diagnosis - we aim to increase that life expectancy dramatically through establishment of a clinical protocol that is repeatable due to use of an individual's own blood cells.
- Swedish Research Council1 January 2012 - 31 December 2012
- Swedish Research Council1 January 2012 - 31 December 2014
- Swedish Research Council1 January 2009 - 31 December 2011
- Alternatively activated macrophages as a novel innate immune T1D therapyJuvenile Diabetes Research Foundation1 September 2008 - 31 August 2009
Employments
- Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2013-
Degrees and Education
- Docent, Karolinska Institutet, 1999
Leadership and responsibility assignments
- Academic vice president, Academic Vice-President of Doctoral Education, Karolinska Institutet, 2019-
Distinction and awards
- FEBS Education Award, Federation of European Biochemical Societies, https://news.ki.se/bob-harris-receives-newly-established-education-award, 2024
- The Pedagogical Prize, Karolinska Institutet, 2014
- British Council Visiting Professor Award, British Council, 1996
- Wellcome Trust Travel Fellow recipient, 1994