Robert Harris
About me
Professor of Immunotherapy in Neurological Diseases 2013-present
Academic Vice-President of Doctoral Education 2019-present
Chairperson International Advisory Council 2020-2023
President of ORPHEUS doctoral education organization 2014-2022
Professor Robert A. Harris (Bob) was born in Harpenden in Southern UK in 1966. He conducted a Bsc.Hons undergraduate degree at Portsmouth Polytechnic, majoring in Parasitology in 1987. PhD studies at University College London studying innate immune agglutinins in Schistosoma host snail species with Terry Preston and Vaughan Southgate as supervisors culminated with a thesis defence in early 1991. A 2.5 year postdoc at the London School of Hygiene &- Tropical Medicine in Paul Kaye’s research group ensued, with focus on understanding the intracellular fate of Leishmania spp. protozoans in macrophages. Bob was awarded a Wellcome Trust postdoctoral fellowship that permitted his relocation to the Karolinska Institutet (Stockholm, Sweden) in the spring of 1994. A postdoc period was spent split between the labs of Anders Örn and Tomas Olsson, in which he studied Trypanosoma cruzi and Trypanosoma bruceii protozoan proteins. Bob became an Associate Professor at the Karolinska Institute in 1999, heralding his establishment as a PI. Bob started to work with autoimmune diseases in 1996 and began study of therapy using live parasite infections or parasite molecules. His research group has developed autoantigen-specific vaccines, defined the effects of post-translational biochemical molecules on autoantigenicity and developed a macrophage adoptive transfer therapy that prevents pathogenesis in several experimental disease models. He became Professor of Immunotherapy in Neurological Diseases in 2013.
Education
University Education
BSc (Hons) Biology - Upper Second Class Portsmouth Polytechnic, UK 1987
PhD Training
’Haemolymph proteins and the snail immune response’ University College London, UK 1991 Karolinska Institutet's pedagogy prize 2014
FEBS Education Award 2024
Research
- We are primarily interested in understanding the pathogenesis of incurable, chronic disease states of the Central Nervous System, including ALS, MS, Alzheimer's disease and glioma brain tumors.
HOW CAN WE TREAT OR CURE THE DISEASES? There is currently no cure for the diseases we study, and existing medications are only partly effective.
Our main interest is thus on developing new strategies to reduce or abrogate disease symptoms.
We focus on using the body’s own myeloid cells as a means of treating the same individual through ‘personalised cell therapy’ or by targeting these cells for immunomodulation.
Teaching
- Central Director of Doctoral studies at Karolinska Institutet 2008-2018
Director of Doctoral studies at Department of Clinical Neurosciences, Karolinska Institutet 2005-2018
Awarded Karolinska Institutet’s Pedagogy Prize 2014
131 publications and 6 reviews – Web of Science h index = 45 Google Scholar H index = 39, i index = 95 (as of 27th April 2021)
Currently receives research funding from Swedish Medical research Council, CancerFonden, Alltid Litt Sterkere, Ulla Carin Lindquist Stiftelse and Karolinska Institutet
Currently supervises 1 PhD student, co-supervises 5 PhD students, 2 Postdoctoral Fellows and one undergraduate student
Courses taught at a postgraduate level:
- High Performance Chromatography Methods - Applications in Analysis of Biologically Significant Molecules (Chile)
- Trypanosomiasis and Lesihmanisasis protozoan infection biology (Stockholm University)
- I IUIS Course “Infections & - Immunology: Views Towards the XXI Century” (Chile)
- Molecular Immunology (KI)
- Cellular and Molecular Infection Biology (KI)
- Winter Immunology School (KI)
- Summer School in Immunology, “Translational Medicine in the field of Autoimmunity” (KI)
- New Vaccines – advances in current vaccinology (KI)
- Clinical and Experimental Neuroimmunology (KI)
- Cytokines in inflammation (KI)
- Basic Immunology (KI)
- Neurovirology (KI)
- Immune, Gene and Cell therapy (KI)
- Translational Medicine (Germany)
Courses taught at an undergraduate level:
- Medical Microbiology and Immunology
- Experimental and Clinical Neuroimmunology
- Immunological mechanisms in autoimmune diseases
- Tropiska parasiter och svenska
- Eukaryot mikrobiologi
- Basic Immunology - Macrophages
Leadership courses for faculty:
- Introduction course for PhD students at KI
- Basic course for supervisors at KI
- Advance course in pedagogy for supervisors at KI
- Future Academic Leaders at KI
Workshops:
-Conflict prevention, management and resolution
- Intended Learning Outcomes - formulation and examination
- Professional responsbility as a PhD supervisor
These teaching activities are primarily conducted at locally at KI, but also both nationally in Swedish universities as well as internationally.
Articles
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2024;121:43-55
- Article: NATURE NANOTECHNOLOGY. 2024;19(9):1366-1374
- Article: METALLOMICS. 2024;16(5):mfae019
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2024;221(2):e20230675
- Journal article: TRANSPLANTATION. 2023;107(10):49
- Article: JCI INSIGHT. 2023;8(17):e167656
- Article: ACTA PHARMACOLOGICA SINICA. 2023;44(4):766-779
- Article: CELL TRANSPLANTATION. 2023;32:9636897231212780
- Article: EMBO REPORTS. 2022;23(7):e54499
- Article: ACTA BIOMATERIALIA. 2022;142:36-48
- Article: CHILD PSYCHIATRY AND HUMAN DEVELOPMENT. 2022;53(2):354-364
- Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:911744
- Article: CELL DEATH AND DIFFERENTIATION. 2022;29(1):246-261
- Article: MOLECULAR IMAGING AND BIOLOGY. 2021;23(6):952-962
- Article: JOURNAL OF NEUROSCIENCE. 2021;41(40):8441-8459
- Article: CANCER DISCOVERY. 2021;11(10):2456-2473
- Article: ONCOGENE. 2021;40(32):5066-5080
- Journal article: NEUROLOGY. 2021;96(15_supplement)
- Article: NATURE MEDICINE. 2021;27(4):640-646
- Article: CARBOHYDRATE POLYMERS. 2021;254:117291
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(22):E8603-8603
- Article: SCIENCE IMMUNOLOGY. 2020;5(52):eabb5077
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(18):E6824-6824
- Article: NATURE COMMUNICATIONS. 2020;11(1):4071
- Article: GLIA. 2020;68(7):1466-1478
- Article: MOLECULAR NEUROBIOLOGY. 2020;57(5):2194-2205
- Article: JOURNAL OF NEUROINFLAMMATION. 2020;17(1):111
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(2):838-852
- Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2020;38(1):42-49
- Article: JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY. 2019;29(8):625-633
- Article: FEBS OPEN BIO. 2019;9(5):830-839
- Article: BRAIN RESEARCH. 2019;1710:33-42
- Article: BRITISH JOURNAL OF ANAESTHESIA. 2019;122(3):350-360
- Article: ISCIENCE. 2018;9:71-83
- Article: NATURE COMMUNICATIONS. 2018;9(1):4845
- Article: NATURE IMMUNOLOGY. 2018;19(5):1-7
- Article: CANCER MANAGEMENT AND RESEARCH. 2018;10:2653-2661
- Article: NEUROMOLECULAR MEDICINE. 2017;19(4):463-479
- Article: NEUROBIOLOGY OF AGING. 2017;60:173-182
- Article: BMC BIOINFORMATICS. 2017;18(1):486
- Article: FEBS OPEN BIO. 2017;7(10):1444-1452
- Article: REDOX BIOLOGY. 2017;13:320-330
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2017;303:1-12
- Article: ONCOTARGET. 2016;7(50):82305-82323
- Article: NATURE IMMUNOLOGY. 2016;17(12):1407-1414
- Article: GLIA. 2016;64(11):1925-1937
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2016;186(1):46-56
- Article: IMMUNOLOGY AND CELL BIOLOGY. 2016;94(8):747-762
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2016;213(8):1537-1553
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(7):e003868
- Article: JOURNAL OF PROTEOME RESEARCH. 2016;15(7):2337-2345
- Article: CELL REPORTS. 2016;15(9):2000-2011
- Article: NEUROSCIENCE LETTERS. 2016;620:1-7
- Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;99(3):437-446
- Article: J CLIN CELL IMMUNOL. 2015;6(5):364
- Article: JOURNAL OF PROTEOME RESEARCH. 2015;14(9):3940-3947
- Article: DIABETOLOGIA. 2015;58(7):1610-1620
- Article: CANCER RESEARCH. 2015;75(2):306-315
- Article: BMC BIOINFORMATICS. 2014;15(1):370
- Article: IMMUNOLOGY. 2014;142(3):431-441
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(5):305-314
- Article: PLOS ONE. 2013;8(5):e63172
- Article: PLOS ONE. 2013;8(11):e79281
- Article: GLIA. 2012;60(12):1930-1943
- Article: DIABETES. 2012;61(11):2881-2892
- Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:112
- Article: CNS AND NEUROLOGICAL DISORDERS - DRUG TARGETS. 2011;10(1):82-107
- Article: JOURNAL OF IMMUNOLOGY. 2010;185(11):6883-6890
- Article: MULTIPLE SCLEROSIS JOURNAL. 2010;16(9):1056-1065
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2010;161(1):48-56
- Article: JOURNAL OF IMMUNOLOGY. 2010;185(1):442-450
- Article: PLOS ONE. 2009;4(11):e7773
- Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 7):705-708
- Article: JOURNAL OF IMMUNOLOGY. 2009;182(11):6889-6895
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2009;210(1-2):30-39
- Article: GENES AND IMMUNITY. 2009;10(3):227-236
- Article: JOURNAL OF IMMUNOLOGY. 2009;182(5):3105-3111
- Article: JOURNAL OF PROTEOMICS. 2009;71(6):670-681
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;334(1-2):114-121
- Article: NATURE MEDICINE. 2008;14(3):337-342
- Article: PLOS ONE. 2008;3(11):e3682
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2007;37(7):1986-1995
- Article: CURRENT HIV RESEARCH. 2006;4(2):229-237
- Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;356(2):382-396
- Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 12):1090-1093
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27069-27075
- Article: JOURNAL OF DIABETES AND ITS COMPLICATIONS. 2005;19(4):238-246
- Article: MOLECULAR BIOTECHNOLOGY. 2005;30(2):155-162
- Article: INTERNATIONAL IMMUNOLOGY. 2005;17(6):721-728
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2005;61(1):1-9
- Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2004;76(6):1118-1124
- Article: JOURNAL OF IMMUNOLOGY. 2004;172(11):7169-7176
- Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;59(6):613
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2004;149(1-2):66-76
- Article: ACTA PROTOZOOLOGICA. 2004;43(4):373-377
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2003;141(1-2):10-19
- Article: ARCHIVES OF VIROLOGY. 2003;149(10):1985-2000
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(6):1539-1547
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(3):579-587
- Article: JOURNAL OF IMMUNOLOGY. 2003;170(4):2064-2073
- Article: IMMUNITY. 2002;17(6):757-768
- Journal article: JOURNAL OF PARASITOLOGY. 2002;88(4):697
- Article: JOURNAL OF PARASITOLOGY. 2002;88(4):697-701
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2002;32(7):1939-1946
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(1):70-81
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;114(3):398-402
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;112(1):52-62
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;121(3):499-505
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;122(3):477-483
- Article: ATHEROSCLEROSIS. 2000;153(2):273-282
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2000;111(1-2):23-33
- Article: PARASITOLOGY. 2000;120:281-287
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(1):300-307
- Article: INFECTION AND IMMUNITY. 1999;67(8):3800-3809
- Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1999;55(Pt 1):260-262
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1998;48(5):480-484
- Article: ACTA TROPICA. 1998;70(1):87-99
- Article: IMMUNOLOGY LETTERS. 1998;60(2-3):171-177
- Article: JOURNAL OF PARASITOLOGY. 1998;84(1):67
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1997;27(4):1005-1013
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1997;45(3):322-330
- Article: ACTA TROPICA. 1997;63(2-3):159-166
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1996;44(5):421-429
- Article: JOURNAL OF IMMUNOLOGY. 1996;156(12):4691-4696
- Article: IMMUNOLOGY LETTERS. 1996;50(1-2):71-80
- Journal article: PARASITOLOGY. 1993;106:127-135
- Journal article: COMPARATIVE CLINICAL PATHOLOGY. 1992;2(1):30-34
- Journal article: JOURNAL OF INVERTEBRATE PATHOLOGY. 1992;59(1):24-32
- Show more
All other publications
- Preprint: BIORXIV. 2024
- Review: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2024;17:1408159
- Preprint: BIORXIV. 2023
- Preprint: BIORXIV. 2022
- Corrigendum: MOLECULAR IMAGING AND BIOLOGY. 2022;24(3):510
- Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(4):219
- Editorial comment: FRONTIERS IN CELLULAR NEUROSCIENCE. 2022;16:877567
- Corrigendum: ONCOGENE. 2021;40(32):5153
- Corrigendum: NATURE MEDICINE. 2021;27(7):1308
- Letter: MOVEMENT DISORDERS. 2021;36(6):1470-1471
- Review: JOURNAL OF NEUROINFLAMMATION. 2021;18(1):74
- Conference publication: NEUROLOGY. 2021;96(15)
- Conference publication: FEBS OPEN BIO. 2021;11:75
- Preprint: SSRN ELECTRONIC JOURNAL. 2021
- Review: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2020;8(1):217
- Preprint: RESEARCH SQUARE. 2020
- Preprint: RESEARCH SQUARE. 2020
- Preprint: RESEARCH SQUARE. 2020
- Preprint: RESEARCH SQUARE. 2019
- Review: RADIOTHERAPY AND ONCOLOGY. 2019;140:116-124
- Review: GLIA. 2019;67(2):217-231
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2019;25:211
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49:1445-1446
- Conference publication: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2019;62:S551-S552
- Review: MOLECULAR BRAIN. 2017;10(1):25
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):297
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):328
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):306
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):270
- Review: FRONTIERS IN AGING NEUROSCIENCE. 2017;9:234
- Review: ONCOIMMUNOLOGY. 2016;5(5):e1093722
- Review: CANCER RESEARCH. 2016;76(3):513-516
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43:S615
- Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2014;275(1-2):87-88
- Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2014;275(1-2):73-74
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):435
- Editorial comment: FRONTIERS IN IMMUNOLOGY. 2014;5:612
- Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2012;253(1-2):100
- Published conference paper: JOURNAL OF PROTEOMICS. 2010;73(6):1117-1132
- Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2010;228(1-2):94
- Meeting abstract: CYTOKINE. 2009;48(1-2):134-135
- Conference publication: JOURNAL OF IMMUNOLOGY. 2009;182:136.5
- Review: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;84(5):1248-1255
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):255
- Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2004;154(1-2):60
- Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2003;6(10):949-950
- Conference publication: BIOCHEMICAL SOCIETY TRANSACTIONS. 1994;22(1):S3
- Show more
Grants
- Swedish Research Council1 January 2022 - 31 December 2024
- Swedish Research Council1 December 2021 - 30 November 2026
- Swedish Research Council1 January 2019 - 31 December 2021
- Nanoparticle immunotherapy for the treatment of brain tumorsSwedish Cancer Society1 January 2019
- Swedish Research Council1 January 2018 - 31 December 2020
- NOVEL IMMUNOTHERAPIES IN CHRONIC NEUROLOGICAL DISEASES - REDUCING PATHOGENESIS AND IMPROVING HEALINGSwedish Research Council1 January 2015 - 31 December 2018
- Breaking brain tumor-associated immunosuppression by macrophage cell therapySwedish Cancer Society1 January 2015
- Breaking brain tumor-associated immunosuppression by macrophage cell therapySwedish Cancer Society1 January 2014
- Swedish Research Council1 January 2012 - 31 December 2012
- Swedish Research Council1 January 2012 - 31 December 2014
- Swedish Research Council1 January 2009 - 31 December 2011
- Alternatively activated macrophages as a novel innate immune T1D therapyJuvenile Diabetes Research Foundation1 September 2008 - 31 August 2009
Employments
- Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2013-
Degrees and Education
- Docent, Karolinska Institutet, 1999
Leadership and responsibility assignments
- Academic vice president, Academic Vice-President of Doctoral Education, Karolinska Institute, 2019-
Distinction and awards
- The Pedagogical Prize, Karolinska Institute, 2014
- British Council Visiting Professor Award, British Council, 1996
- Wellcome Trust Travel Fellow recipient, 1994