Rakesh Kumar

Publications
CV
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Articles

Article: PROTEIN SCIENCE. 2024;33(8):e5091
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS
Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstal H; Otzen DE; Johansson J; Abelein A
Article: NATURE COMMUNICATIONS. 2024;15(1):965
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain
Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511
Molecular Mechanisms of Amyloid-? Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone
Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
Article: JACS AU. 2022;2(11):2571-2584
Molecular Structure of Cu(II)-Bound Amyloid-β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease
Abelein A; Ciofi-Baffoni S; Morman C; Kumar R; Giachetti A; Piccioli M; Biverstal H
Article: NANOSCALE. 2022;14(40):15021-15033
Charge and hydrophobicity of amyloidogenic protein/peptide templates regulate the growth and morphology of gold nanoparticles
Kadu P; Gadhe L; Navalkar A; Patel K; Kumar R; Sastry M; Maji SK
Article: JOURNAL OF MOLECULAR BIOLOGY. 2022;434(19):167761
a-Synuclein Aggregation Intermediates form Fibril Polymorphs with Distinct Prion-like Properties
Mehra S; Ahlawat S; Kumar H; Datta D; Navalkar A; Singh N; Patel K; Gadhe L; Kadu P; Kumar R; Jha NN; Sakunthala A; Sawner AS; Padinhateeri R; Udgaonkar JB; Agarwal V; Maji SK
Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211
Amyloid Fibril Formation of Arctic Amyloid-β 1-42 Peptide is Efficiently Inhibited by the BRICHOS Domain
Zhong X; Kumar R; Wang Y; Biverstal H; Jegerschoeld CI; Koeck PJB; Johansson J; Abelein A; Chen G
Article: NATURE COMMUNICATIONS. 2022;13(1):4695
Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform
Arndt T; Jaudzems K; Shilkova O; Francis J; Johansson M; Laity PR; Sahin C; Chatterjee U; Kronqvist N; Barajas-Ledesma E; Kumar R; Chen G; Stromberg R; Abelein A; Langton M; Landreh M; Barth A; Holland C; Johansson J; Rising A
Article: JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2022;13(28):6427-6438
Direct Demonstration of Seed Size-Dependent α-Synuclein Amyloid Amplification
Sakunthala A; Datta D; Navalkar A; Gadhe L; Kadu P; Patel K; Mehra S; Kumar R; Chatterjee D; Devi J; Sengupta K; Padinhateeri R; Maji SK
Article: EMBO REPORTS. 2022;23(7):e54405
Isotope-labeled amyloid-β does not transmit to the brain in a prion-like manner after peripheral administration
Brackhan M; Calza G; Lundgren K; Bascunana P; Bruning T; Soliymani R; Kumar R; Abelein A; Baumann M; Lalowski M; Pahnke J
Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:878303
Autophagy Impairment in App Knock-in Alzheimer's Model Mice
Jiang R; Shimozawa M; Mayer J; Tambaro S; Kumar R; Abelein A; Winblad B; Bogdanovic N; Nilsson P
Article: JOURNAL OF NEUROCHEMISTRY. 2021;156(6):1003-1019
Benzimidazole-based fluorophores for the detection of amyloid fibrils with higher sensitivity than Thioflavin-T
Pravin N; Kumar R; Tripathi S; Kumar P; Mohite GM; Navalkar A; Panigrahi R; Singh N; Gadhe LG; Manchanda S; Shimozawa M; Nilsson P; Johansson J; Kumar A; Maji SK; Shanmugam M
Article: JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2020;11(24):10489-10496
Machine-Free Polymerase Chain Reaction with Triangular Gold and Silver Nanoparticles
Kadu P; Pandey S; Neekhra S; Kumar R; Gadhe L; Srivastava R; Sastry M; Maji SK
Article: SCIENTIFIC REPORTS. 2020;10(1):21765
Functionalization of amyloid fibrils via the Bri2 BRICHOS domain
Biverstal H; Kumar R; Schellhaus AK; Sarr M; Dantuma NP; Abelein A; Johansson J
Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(18):2836-2848
Effect of Disease-Associated P123H and V70M Mutations on β-Synuclein Fibrillation
Sharma K; Mehra S; Sawner AS; Markam PS; Panigrahi R; Navalkar A; Chatterjee D; Kumar R; Kadu P; Patel K; Ray S; Kumar A; Maji SK
Article: NATURE CHEMISTRY. 2020;12(8):705-716
α-Synuclein aggregation nucleates through liquid-liquid phase separation
Ray S; Singh N; Kumar R; Patel K; Pandey S; Datta D; Mahato J; Panigrahi R; Navalkar A; Mehra S; Gadhe L; Chatterjee D; Sawner AS; Maiti S; Bhatia S; Gerez JA; Chowdhury A; Kumar A; Padinhateeri R; Riek R; Krishnamoorthy G; Maji SK
Article: ACS CHEMICAL NEUROSCIENCE. 2019;10(5):2229-2236
Lipopolysaccharide from Gut Microbiota Modulates α-Synuclein Aggregation and Alters Its Biological Function
Bhattacharyya D; Mohite GM; Krishnamoorthy J; Gayen N; Mehra S; Navalkar A; Kotler SA; Ratha BN; Ghosh A; Kumar R; Garai K; Mandal AK; Maji SK; Bhunia A
Article: JOURNAL OF MATERIALS CHEMISTRY A. 2019;7(9):4486-4493
Fabrication of an amyloid fibril-palladium nanocomposite: a sustainable catalyst for C-H activation and the electrooxidation of ethanol
Jayarajan R; Kumar R; Gupta J; Dev G; Kadu P; Chatterjee D; Bahadur D; Maiti D; Maji SK
Article: ACS BIOMATERIALS SCIENCE & ENGINEERING. 2019;5(1):126-138
Amyloid Fibrils with Positive Charge Enhance Retroviral Transduction in Mammalian Cells
Kirti S; Patel K; Das S; Shrimali P; Samanta S; Kumar R; Chatterjee D; Ghosh D; Kumar A; Tayalia P; Maji SK
Article: ACS CHEMICAL NEUROSCIENCE. 2018;9(11):2628-2638
Parkinson's Disease Associated α-Synuclein Familial Mutants Promote Dopaminergic Neuronal Death in Drosophila melanogaster
Mohite GM; Dwivedi S; Das S; Kumar R; Paluri S; Mehra S; Ruhela N; Arunima S; Jha NN; Maji SK
Article: ADVANCED MATERIALS INTERFACES. 2018;5(18)
Cell Alignment on Graphene-Amyloid Composites
Das S; Kumawat MK; Ranganathan S; Kumar R; Adamcik J; Kadu P; Padinhateeri R; Srivastava R; Mezzenga R; Maji SK
Article: BIOCHEMISTRY. 2018;57(35):5183-5187
Comparison of Kinetics, Toxicity, Oligomer Formation, and Membrane Binding Capacity of α-Synuclein Familial Mutations at the A53 Site, Including the Newly Discovered A53V Mutation
Mohite GM; Kumar R; Panigrahi R; Navalkar A; Singh N; Datta D; Mehra S; Ray S; Gadhe LG; Das S; Singh N; Chatterjee D; Kumar A; Maji SK
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2018;293(34):12975-12991
Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils
Mehra S; Ghoshn D; Kumar R; Mondal M; Gadhe LG; Das S; Anoop A; Jha NN; Jacob RS; Chatterjee D; Ray S; Singh N; Kumar A; Maji SK
Article: BIOCHEMISTRY. 2018;57(33):5014-5028
The Familial α-Synuclein A53E Mutation Enhances Cell Death in Response to Environmental Toxins Due to a Larger Population of Oligomers
Mohite GM; Navalkar A; Kumar R; Mehra S; Das S; Gadhe LG; Ghosh D; Alias B; Chandrawanshi V; Ramakrishnan A; Mehra S; Maji SK
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2018;57(19):5262-5266
Cytotoxic Oligomers and Fibrils Trapped in a Gel-like State of α-Synuclein Assemblies
Kumar R; Das S; Mohite GM; Rout SK; Halder S; Jha NN; Ray S; Mehra S; Agarwal V; Maji SK
Article: CHEMICAL COMMUNICATIONS. 2018;54(29):3605-3608
Multitude NMR studies of α-synuclein familial mutants: probing their differential aggregation propensities
Bhattacharyya D; Kumar R; Mehra S; Ghosh A; Maji SK; Bhunia A
Article: BIOCHEMISTRY. 2018;57(5):791-804
Complexation of NAC-Derived Peptide Ligands with the C-Terminus of α-Synuclein Accelerates Its Aggregation
Jha NN; Ranganathan S; Kumar R; Mehra S; Panigrahi R; Navalkar A; Ghosh D; Kumar A; Padinhateeri R; Maji SK
Article: ACS CHEMICAL NEUROSCIENCE. 2017;8(12):2722-2733
Comparison of α-Synuclein Fibril Inhibition by Four Different Amyloid Inhibitors
Jha NN; Kumar R; Panigrahi R; Navalkar A; Ghosh D; Sahay S; Mondal M; Kumar A; Maji SK
Article: CELL DEATH AND DIFFERENTIATION. 2017;24(10):1784-1798
p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis
Ghosh S; Salot S; Sengupta S; Navalkar A; Ghosh D; Jacob R; Das S; Kumar R; Jha NN; Sahay S; Mehra S; Mohite GM; Ghosh SK; Kombrabail M; Krishnamoorthy G; Chaudhari P; Maji SK
Article: ADVANCED HEALTHCARE MATERIALS. 2017;6(18)
Controlled Exposure of Bioactive Growth Factor in 3D Amyloid Hydrogel for Stem Cells Differentiation
Das S; Kumar R; Jha NN; Maji SK
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Review: FRONTIERS IN MOLECULAR BIOSCIENCES. 2023;10:1193458
Misfolded alpha-synuclein detection by RT-QuIC in dementia with lewy bodies: a systematic review and meta-analysis
Pena-Bautista C; Kumar R; Baquero M; Johansson J; Chafer-Pericas C; Abelein A; Ferreira D

Employments

Affiliated to Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2025-2026
Postdoctoral Researcher, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2024-2025

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