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Research description

Current projects

Regulation of immunoglobulin class switch recombination in human B cells

The project is aimed at understanding the complex molecular mechanisms involved in DNA editing, repair and recombination during immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) and their involvement in the pathophysiological processes leading to immunodeficiency, genome instability and cancer development in humans.

Induced pluripotent stems cells a platform for personalized diagnosis and therapy in patients with primary immunodeficiency

The project is aimed at reprogramming the fibroblasts or peripheral blood B cells derived from IgA deficient (IgAD) patients into pluripotent stem (iPS) cells and to re-differentiate these iPS cells into antibody-producing B cells. If successful, this study may provide a potentially curative treatment in patients with IgA deficiency. They will also provide a methodological platform for studies aimed at replacing cells in patients with a variety of other primary immunodeficiency diseases as well as autoimmune and neurological disorders associated with these diseases.

Discovery of therapeutic targets in B cell lymphoma by next generation sequencing

The project is aimed at identifying potentially treatable molecular targets in mature B cell lymphomas (with focus on diffuse large B cell lymphomas and mantle cell lymphomas) by high-throughput, next generation-sequencing omic- technologies such as whole genome and exome sequencing and RNA-seq.

Our research is supported by the Swedish Research Council (VR), the Swedish Cancer Society (Cancerfonden) and the European Research Council (ERC).

Selected publications

Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis.
Du L, Peng R, Björkman A, Filipe de Miranda N, Rosner C, Kotnis A, et al
J. Exp. Med. 2012 Feb;209(2):291-305

Nurture your scientific curiosity early in your research career.
Jagodic M, Stridh P, Gad A, Paine A, Udekwu K, Sjöholm L, et al
Nat. Genet. 2013 Feb;45(2):116-8

DNA repair genes are selectively mutated in diffuse large B cell lymphomas.
de Miranda N, Peng R, Georgiou K, Wu C, Falk Sörqvist E, Berglund M, et al
J. Exp. Med. 2013 Aug;210(9):1729-42

New facets of antibody deficiencies.
Liadaki K, Sun J, Hammarström L, Pan-Hammarström Q
Curr. Opin. Immunol. 2013 Oct;25(5):629-38

A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.
Enervald E, Du L, Visnes T, Björkman A, Lindgren E, Wincent J, et al
J. Exp. Med. 2013 Nov;210(12):2503-13

Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.
de Miranda N, Georgiou K, Chen L, Wu C, Gao Z, Zaravinos A, et al
Blood 2014 Oct;124(16):2544-53

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.
Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon K, Resch W, et al
Cell 2014 Dec;159(7):1524-37


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