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About me

I am a professor of clinical immunology at the Department of Biosciences and Nutrition, Karolinska Institutet.

I was trained as a medical doctor and graduated from Sun Yat-Sen Medical University in China in 1993. During 1993 and 1994, I worked as a physician at the Guangzhou Respiratory Disease Research Institute. I obtained my PhD degree in Clinical Immunology / Immunology at the Karolinska Institutet in 1999 and carried out postdoc training at Harvard Medical School in 2000. In 2001 I came back to the Karolinska Institutet where I became an associate professor and group leader in 2004. I was appointed professor of clinical immunology at the Karolinska Institutet in 2011.

I have extensive international experience. I was a guest professor at Beijing University from 2005 to 2009, a visiting scientist in Harvard Medical School in 2012, a visiting professor at Rockefeller University from 2013 to 2015, a visiting scientist in the Broad Institute at Harvard and MIT from 2016 to 2017. Currently I am a visiting professor at Sun Yat-Sen University Cancer Centre and Tianjin Medical University Cancer Institute in China.

I have supervised 10 PhD students and trained 16 postdocs. I have published altogether 114 papers in areas of immunoglobulin gene diversifications, primary immunodeficiencies, genome instability, B cell malignancies and cancer genetics. 

Education

Bachelor degree in Medicine, Sun Yat-Sen Medical University, China, 1993

PhD degree in Clinical Immunology/Immunology, Department of    Laboratory Medicine, Karolinska Institutet, Sweden, 1999

Executive education program of leadership development, Harvard Business School, USA, 2018    

Research description

Current projects

Regulation of immunoglobulin class switch recombination in human B cells

The project is aimed at understanding the complex molecular mechanisms involved in DNA editing, repair and recombination during immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) and their involvement in the pathophysiological processes leading to immunodeficiency, genome instability and cancer development in humans.

Induced pluripotent stems cells a platform for personalized diagnosis and therapy in patients with primary immunodeficiency

The project is aimed at reprogramming the fibroblasts or peripheral blood B cells derived from IgA deficient (IgAD) patients into pluripotent stem (iPS) cells and to re-differentiate these iPS cells into antibody-producing B cells. If successful, this study may provide a potentially curative treatment in patients with IgA deficiency. They will also provide a methodological platform for studies aimed at replacing cells in patients with a variety of other primary immunodeficiency diseases as well as autoimmune and neurological disorders associated with these diseases.

Discovery of therapeutic targets in B cell lymphoma by next generation sequencing

The project is aimed at identifying potentially treatable molecular targets in mature B cell lymphomas (with focus on diffuse large B cell lymphomas and mantle cell lymphomas) by high-throughput, next generation-sequencing omic- technologies such as whole genome and exome sequencing and RNA-seq.

Our research is funded by the Swedish Research Council (VR), Swedish Cancer Society (Cancerfonden), Swedish Childhood Cancer Foundation (Barncancerfonden), European Research Council (ERC), Stockholm Cancer Society, the Swedish Foundation for International Cooperation in Research and Higher Education (STINT), and Center for innovative Medicine (CIMED).

Selected publications

Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma.
Ren W, Ye X, Su H, Li W, Liu D, Pirmoradian M, et al
Blood 2018 Jun;131(24):2670-2681

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.
Abolhassani H, Edwards E, Ikinciogullari A, Jing H, Borte S, Buggert M, et al
J. Exp. Med. 2017 01;214(1):91-106

Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.
Bronson P, Chang D, Bhangale T, Seldin M, Ortmann W, Ferreira R, et al
Nat. Genet. 2016 11;48(11):1425-1429

Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas.
Georgiou K, Chen L, Berglund M, Ren W, de Miranda N, Lisboa S, et al
Blood 2016 06;127(24):3026-34

Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas.
Wu K, Zhang X, Li F, Xiao D, Hou Y, Zhu S, et al
Nat Commun 2015 Dec;6():10131

Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Björkman A, Qvist P, Du L, Bartish M, Zaravinos A, Georgiou K, et al
Proc. Natl. Acad. Sci. U.S.A. 2015 Feb;112(7):2157-62

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.
Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon K, Resch W, et al
Cell 2014 Dec;159(7):1524-37

Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.
de Miranda N, Georgiou K, Chen L, Wu C, Gao Z, Zaravinos A, et al
Blood 2014 Oct;124(16):2544-53

A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.
Enervald E, Du L, Visnes T, Björkman A, Lindgren E, Wincent J, et al
J. Exp. Med. 2013 Nov;210(12):2503-13

New facets of antibody deficiencies.
Liadaki K, Sun J, Hammarström L, Pan-Hammarström Q
Curr. Opin. Immunol. 2013 Oct;25(5):629-38

DNA repair genes are selectively mutated in diffuse large B cell lymphomas.
de Miranda N, Peng R, Georgiou K, Wu C, Falk Sörqvist E, Berglund M, et al
J. Exp. Med. 2013 Aug;210(9):1729-42

Nurture your scientific curiosity early in your research career.
Jagodic M, Stridh P, Gad A, Paine A, Udekwu K, Sjöholm L, et al
Nat. Genet. 2013 Feb;45(2):116-8

Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis.
Du L, Peng R, Björkman A, Filipe de Miranda N, Rosner C, Kotnis A, et al
J. Exp. Med. 2012 Feb;209(2):291-305

Academic honours, awards and prizes

Scholarship for postdoctoral medical research, Swedish Society for Medical Research, 2003

Assistant Professor position, 4 years, awarded by the Swedish Research Council, 2003

Young investigator prize, awarded by the Swedish Society of Medicine, 2007

ERC Starting Grant, awarded by the European Research Council, 2009

Senior researcher position, 6 years, awarded by the Swedish Research Council, 2010

Distinguished Alumni, Faculty of Medical Sciences, Sun Yat-Sen University, 2011

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