Nils Lindefors

About me
Publications
Public outreach and news

About me

Nils Lindefors received his MD 1982 and PhD in pharmacology 1987, both at
Karolinska Institutet (KI). He was appointed associate professor (docent) in
pharmacology at KI 1990 and in psychiatry 1999
Nils Lindefors has been PI or investigator for several clinical trials, both
for pharmacotherapy of ADHD or schizophrenia as well as for internet-based
CBT (ICBT). NL started his research on ICBT in 2002 and founded the ICBT
clinic internetpsykiatri.se in Stockholm 2007. NL served as director for the
University Clinic of Psychiatry at Karolinska Southern Campus between 2006
and 2019, in which the ICBT clinic was included. From 2006 to 2018 NL was
appointed professor in psychiatry (adjunct) at Karolinska Institutet.

Articles

Article: BMJ OPEN. 2023;13(10):e069427
Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH)
Boberg J; Kaldo V; Mataix-Cols D; Crowley JJ; Roelstraete B; Halvorsen M; Forsell E; Isacsson NH; Sullivan PF; Svanborg C; Andersson EH; Lindefors N; Kravchenko O; Mattheisen M; Danielsdottir HB; Ivanova E; Boman M; Fernandez de la Cruz L; Wallert J; Ruck C
Article: INTERNET INTERVENTIONS. 2023;33:100636
Internet delivered cognitive behavioral therapy for adults with ADHD - A randomized controlled trial
Nasri B; Cassel M; Enharje J; Larsson M; Hirvikoski T; Ginsberg Y; Lindefors N; Kaldo V
Article: JOURNAL OF SLEEP RESEARCH. 2023;32(2):e13759
Treatment feasibility of a digital tool for brief self-help behavioural therapy for insomnia (FastAsleep)
Jernelov S; Forsell E; Westman H; Dufva YE; Lindefors N; Kaldo V; Kraepelien M
Article: JMIR DERMATOLOGY. 2023;6:e42360
A Digital Self-help Intervention for Atopic Dermatitis: Analysis of Secondary Outcomes From a Feasibility Study.
Kern D; Ljótsson B; Lönndahl L; Hedman-Lagerlöf E; Bradley M; Lindefors N; Kraepelien M
Article: BMJ OPEN. 2023;13(2):e068908
Brief self-guided digital intervention versus a comprehensive therapist-guided online cognitive behavioural therapy for atopic dermatitis: a trial protocol for a randomised non-inferiority trial
Kern D; Ljotsson B; Lonndahl L; Hedman-Lagerlof E; Bradley M; Lindefors N; Kraepelien M
Article: BMC PSYCHIATRY. 2022;22(1):701
The 14-item short health anxiety inventory (SHAI-14) used as a screening tool: appropriate interpretation and diagnostic accuracy of the Swedish version
Osterman S; Axelsson E; Lindefors N; Hedman-Lagerlof E; Hedman-Lagerlof M; Kern D; Svanborg C; Ivanov VZ
Article: JMIR FORMATIVE RESEARCH. 2022;6(7):e32950
Online Guided Self-help Cognitive Behavioral Therapy With Exposure to Anxiety and Problem Solving in Type 1 Diabetes Mellitus: Case Study
Kern D; Ljotsson B; Bonnert M; Lindefors N; Kraepelien M
Article: BJPSYCH OPEN. 2022;8(2):e43
A self-guided and monitored digital problem-solving intervention for patients with symptoms of depression or anxiety on the waiting list for treatment in routine psychiatric care: feasibility study
Hentati A; Forsell E; Ljotsson B; Lindefors N; Kraepelien M
Article: INTERNET INTERVENTIONS. 2021;26:100448
The effect of user interface on treatment engagement in a self-guided digital problem-solving intervention: A randomized controlled trial
Hentati A; Forsell E; Ljotsson B; Kaldo V; Lindefors N; Kraepelien M
Article: MOLECULAR PSYCHIATRY. 2021;26(8):4179-4190
Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression
Forstner AJ; Awasthi S; Wolf C; Maron E; Erhardt A; Czamara D; Eriksson E; Lavebratt C; Allgulander C; Friedrich N; Becker J; Hecker J; Rambau S; Conrad R; Geiser F; McMahon FJ; Moebus S; Hess T; Buerfent BC; Hoffmann P; Herms S; Heilmann-Heimbach S; Kockum I; Olsson T; Alfredsson L; Weber H; Alpers GW; Arolt V; Fehm L; Fydrich T; Gerlach AL; Hamm A; Kircher T; Pane-Farre CA; Pauli P; Rief W; Strohle A; Plag J; Lang T; Wittchen H-U; Mattheisen M; Meier S; Metspalu A; Domschke K; Reif A; Hovatta I; Lindefors N; Andersson E; Schalling M; Mbarek H; Milaneschi Y; de Geus EJC; Boomsma DI; Penninx BWJH; Thorgeirsson TE; Steinberg S; Stefansson K; Stefansson H; Muller-Myhsok B; Hansen TF; Borglum AD; Werge T; Mortensen PB; Nordentoft M; Hougaard DM; Hultman CM; Sullivan PF; Nothen MM; Woldbye DPD; Mors O; Binder EB; Rueck C; Ripke S; Deckert J; Schumacher J
Article: BMC GASTROENTEROLOGY. 2021;21(1):289
Return on investment of internet delivered exposure therapy for irritable bowel syndrome: a randomized controlled trial
Wallen H; Lindfors P; Andersson E; Hedman-Lagerlof E; Hesser H; Lindefors N; Svanborg C; Ljotsson B
Article: JAMA DERMATOLOGY. 2021;157(7):796-804
Internet-Delivered Cognitive Behavior Therapy for Atopic Dermatitis A Randomized Clinical Trial
Hedman-Lagerlof E; Fust J; Axelsson E; Bonnert M; Lalouni M; Molander O; Agrell P; Bergman A; Lindefors N; Bradley M
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2021;44:105-120
Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: A meta-analysis
Schiele MA; Reif A; Lin J; Alpers GW; Andersson E; Andersson G; Arolt V; Bergstrom J; Carlbring P; Eley TC; Esquivel G; Furmark T; Gerlach AL; Hamm A; Helbig-Lang S; Hudson JL; Lang T; Lester KJ; Lindefors N; Lonsdorf TB; Pauli P; Richter J; Rief W; Roberts S; Rueck C; Schruers KRJ; Thiel C; Wittchen H-U; Domschke K; Weber H; Lueken U
Article: JOURNAL OF PARKINSON’S DISEASE. 2020;10(2):653-664
Individually Tailored Internet -Based Cognitive -Behavioral Therapy for Daily Functioning in Patients with Parkinsons Disease: A Randomized Controlled Trial
Kraepelien M; Schibbye R; Mansson K; Sundstrom C; Riggare S; Andersson G; Lindefors N; Svenningsson P; Kaldo V
Article: JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY. 2020;88(4):311-321
Predicting Treatment Failure in Regular Care Internet-Delivered Cognitive Behavior Therapy for Depression and Anxiety Using Only Weekly Symptom Measures
Forsell E; Isacsson N; Blom K; Jernelov S; Ben Abdesslem F; Lindefors N; Boman M; Kaldo V
Article: JOURNAL OF ATTENTION DISORDERS. 2020;24(6):904-917
Group Treatment for Adults With ADHD Based on a Novel Combination of Cognitive and Dialectical Behavior Interventions: A Feasibility Study
Nasri B; Castenfors M; Fredlund P; Ginsberg Y; Lindefors N; Kaldo V
Article: COGNITIVE BEHAVIOUR THERAPY. 2019;48(4):300-310
Exposure-based cognitive behavior therapy for atopic dermatitis: an open trial
Hedman-Lagerlof E; Bergman A; Lindefors N; Bradley M
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):150
A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders
Rayner C; Coleman JRI; Purves KL; Hodsoll J; Goldsmith K; Alpers GW; Andersson E; Arolt V; Boberg J; Bogels S; Creswell C; Cooper P; Curtis C; Deckert J; Domschke K; El Alaoui S; Fehm L; Fydrich T; Gerlach AL; Grocholewski A; Hahlweg K; Hamm A; Hedman E; Heiervang ER; Hudson JL; Joehren P; Keers R; Kircher T; Lang T; Lavebratt C; Lee S-H; Lester KJ; Lindefors N; Margraf J; Nauta M; Pane-Farre CA; Pauli P; Rapee RM; Reif A; Rief W; Roberts S; Schalling M; Schneider S; Silverman WK; Stroehle A; Teismann T; Thastum M; Wannemueller A; Weber H; Wittchen H-U; Wolf C; Ruck C; Breen G; Eley TC
Article: CLINICAL PSYCHOLOGY AND PSYCHOTHERAPY. 2019;26(3):298-308
The effects of component-specific treatment compliance in individually tailored internet-based treatment
Kraepelien M; Blom K; Lindefors N; Johansson R; Kaldo V
Journal article: MOLECULAR PSYCHIATRY. 2019;24(4):484-490
Genetics of response to cognitive behavior therapy in adults with major depression: a preliminary report.
Andersson E; Crowley JJ; Lindefors N; Ljótsson B; Hedman-Lagerlöf E; Boberg J; El Alaoui S; Karlsson R; Lu Y; Mattheisen M; Kähler AK; Svanborg C; Mataix-Cols D; Mattsson S; Forsell E; Kaldo V; Schalling M; Lavebratt C; Sullivan PF; Rück C
Article: AMERICAN JOURNAL OF PSYCHIATRY. 2019;176(4):315-323
Proof of Concept for an Adaptive Treatment Strategy to Prevent Failures in Internet-Delivered CBT: A Single-Blind Randomized Clinical Trial With Insomnia Patients
Forsell E; Jernelov S; Blom K; Kraepelien M; Svanborg C; Andersson G; Lindefors N; Kaldo V
Article: COMPLEX PSYCHIATRY. 2019;4(4):196-203
Exercise Reduces Salivary Morning Cortisol Levels in Patients with Depression.
Rahman MS; Zhao X; Liu JJ; Torres EQ; Tibert B; Kumar P; Kaldo V; Lindefors N; Forsell Y; Lavebratt C
Article: LAKARTIDNINGEN. 2018;115:E9ES
[A Swedish example of integrated perinatal mental health care].
Blomdahl Wetterholm M; Bendix M; Pettersson K; Lindefors N
Article: BJPSYCH OPEN. 2018;4(4):282-284
Comparing individually tailored to disorder-specific internet-based cognitive-behavioural therapy: benchmarking study
Kraepelien M; Forsell E; Karin E; Johansson R; Lindefors N; Kaldo V
Article: BJPSYCH OPEN. 2018;4(4):265-273
Cost-effectiveness of internet-based cognitive-behavioural therapy and physical exercise for depression
Kraepelien M; Mattsson S; Hedman-Lagerlof E; Petersson IF; Forsell Y; Lindefors N; Kaldo V
Article: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2018;75(1):52-58
Effects of internet-based cognitive behavioural therapy and physical exercise on sick leave and employment in primary care patients with depression: two subgroup analyses
Kaldo V; Lundin A; Hallgren M; Kraepelien M; Strid C; Ekblom O; Lavebratt C; Lindefors N; Ojehagen A; Forsell Y
Article: PSYCHIATRY RESEARCH - NEUROIMAGING. 2017;267:15-21
Associations between cognition and serotonin receptor 1B binding in patients with major depressive disorder - A pilot study.
Tangen Ä; Borg J; Tiger M; Varnäs K; Sorjonen K; Lindefors N; Halldin C; Lundberg J
Article: BMJ OPEN. 2017;7(9):e017053
Does internet-based cognitive behaviour therapy reduce healthcare costs and resource use in treatment of social anxiety disorder? A cost-minimisation analysis conducted alongside a randomised controlled trial
El Alaoui S; Hedman-Lagerlof E; Ljotsson B; Lindefors N
Article: SLEEP. 2017;40(8):zsx108
Three-Year Follow-Up Comparing Cognitive Behavioral Therapy for Depression to Cognitive Behavioral Therapy for Insomnia, for Patients With Both Diagnoses
Blom K; Jernelov S; Ruck C; Lindefors N; Kaldo V
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27(5):462-469
Extrastriatal dopamine D2-receptor availability in social anxiety disorder
Plaven-Sigray P; Hedman E; Victorsson P; Matheson GJ; Forsberg A; Djurfeldt DR; Ruck C; Halldin C; Lindefors N; Cervenka S
Article: COGNITIVE BEHAVIOUR THERAPY. 2017;46(2):114-128
Group acceptance and commitment therapy (ACT) for bipolar disorder and co-existing anxiety - an open pilot study
Pankowski S; Adler M; Andersson G; Lindefors N; Svanborg C
Article: LAKARTIDNINGEN. 2017;114:D77R
[Internet CBT provides effective treatment].
Lindefors N; El Alaoui S; Svanborg C
Article: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2016;209(5):414-420
Exercise and internet-based cognitive-behavioural therapy for depression: multicentre randomised controlled trial with 12-month follow-up
Hallgren M; Helgadottir B; Herring MP; Zeebari Z; Lindefors N; Kaldo V; Ojehagen A; Forsell Y
Article: PSYCHIATRY RESEARCH - NEUROIMAGING. 2016;253:36-42
Low serotonin_1B receptor binding potential in the anterior cingulate cortex in drug-free patients with recurrent major depressive disorder
Tiger M; Farde L; Ruck C; Varrone A; Forsberg A; Lindefors N; Halldin C; Lundberg J
Article: SLEEP. 2016;39(6):1267-1274
Three-Year Follow-Up of Insomnia and Hypnotics after Controlled Internet Treatment for Insomnia
Blom K; Jernelov S; Ruck C; Lindefors N; Kaldo V
Article: INTERNET INTERVENTIONS. 2016;4:51-60
Facilitating and hindering factors in Internet-delivered treatment for insomnia and depression.
Blom K; Jernelöv S; Lindefors N; Kaldo V
Article: PLOS ONE. 2016;11(10):e0165389
Combining Time-Driven Activity-Based Costing with Clinical Outcome in Cost-Effectiveness Analysis to Measure Value in Treatment of Depression
El Alaoui S; Lindefors N
Article: PLOS ONE. 2016;11(9):e0161191
Predicting Outcome in Internet-Based Cognitive Behaviour Therapy for Major Depression: A Large Cohort Study of Adult Patients in Routine Psychiatric Care
El Alaoui S; Ljotsson B; Hedman E; Svanborg C; Kaldo V; Lindefors N
Article: CLINICAL PSYCHOLOGY AND PSYCHOTHERAPY. 2015;22(6):722-732
Testing the Mediating Effects of Obsessive Beliefs in Internet-Based Cognitive Behaviour Therapy for Obsessive-Compulsive Disorder: Results from a Randomized Controlled Trial
Andersson E; Ljotsson B; Hedman E; Hesser H; Enander J; Kaldo V; Andersson G; Lindefors N; Ruck C
Article: JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY. 2015;83(5):902-914
Effectiveness of Internet-Based Cognitive-Behavior Therapy for Social Anxiety Disorder in Clinical Psychiatry
El Alaoui S; Hedman E; Kaldo V; Hesser H; Kraepelien M; Andersson E; Ruck C; Andersson G; Ljotsson B; Lindefors N
Article: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 2015;35(5):535-543
Long-Term Treatment Outcome in Adult Male Prisoners With Attention-Deficit/ Hyperactivity Disorder Three-Year Naturalistic Follow-Up of a 52-Week Methylphenidate Trial
Ginsberg Y; Langstrom N; Larsson H; Lindefors N
Article: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2015;207(3):227-234
Physical exercise and internet-based cognitive-behavioural therapy in the treatment of depression: randomised controlled trial
Hallgren M; Kraepelien M; Ojehagen A; Lindefors N; Zeebari Z; Kaldo V; Forsell Y
Article: BEHAVIOUR RESEARCH AND THERAPY. 2015;71:90-100
Guided internet cognitive behavioral therapy for insomnia compared to a control treatment - A randomized trial
Kaldo V; Jernelov S; Blom K; Ljotsson B; Brodin M; Jorgensen M; Kraepelien M; Ruck C; Lindefors N
Article: JAMA PSYCHIATRY. 2015;72(7):659-667
D-Cycloserine vs Placebo as Adjunct to Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder and Interaction With Antidepressants A Randomized Clinical Trial
Andersson E; Hedman E; Enander J; Djurfeldt DR; Ljotsson B; Cervenka S; Isung J; Svanborg C; Mataix-Cols D; Kaldo V; Andersson G; Lindefors N; Ruck C
Article: BEHAVIOUR RESEARCH AND THERAPY. 2015;70:47-55
Internet-vs. group-delivered cognitive behavior therapy for insomnia: A randomized controlled non-inferiority trial
Blom K; Tillgren HT; Wiklund T; Danlycke E; Forssen M; Soderstrom A; Johansson R; Hesser H; Jernelov S; Lindefors N; Andersson G; Kaldo V
Article: BMJ OPEN. 2015;5(6):e007902
Long-term effectiveness and outcome predictors of therapist-guided internet-based cognitive-behavioural therapy for social anxiety disorder in routine psychiatric care
El Alaoui S; Hedman E; Ljotsson B; Lindefors N
Article: JOURNAL OF ANXIETY DISORDERS. 2015;31:32-37
Psychometric properties of Internet-administered measures of health anxiety: An investigation of the Health Anxiety Inventory, the Illness Attitude Scales, and the Whiteley Index
Hedman E; Ljotsson B; Andersson E; Andersson G; Lindefors N; Ruck C; Axelsson E; Lekander M
Article: SLEEP. 2015;38(2):267-277
Internet Treatment Addressing either Insomnia or Depression, for Patients with both Diagnoses: A Randomized Trial
Blom K; Jerneov S; Kraepelien M; Bergdahl MO; Jungmarker K; Ankartjarn L; Lindefors N; Kaldo V
Article: PLOS ONE. 2015;10(4):e0124258
Predictors of Symptomatic Change and Adherence in Internet-Based Cognitive Behaviour Therapy for Social Anxiety Disorder in Routine Psychiatric Care
El Alaoui S; Ljotsson B; Hedman E; Kaldo V; Andersson E; Ruck C; Andersson G; Lindefors N
Article: JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS. 2015;4:47-53
Cost-effectiveness of internet-based cognitive behavior therapy for obsessive-compulsive disorder: results from a randomized controlled trial
Andersson E; Hedman E; Ljotsson B; Wikstrom M; Elveling E; Lindefors N; Andersson G; Kaldo V; Ruck C
Article: JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS. 2015;4:1-7
Predictors and moderators of Internet-based cognitive behavior therapy for obsessive-compulsive disorder: Results from a randomized trial
Andersson E; Ljotsson B; Hedman E; Enander J; Kaldo V; Andersson G; Lindefors N; Ruck C
Article: JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS. 2015;4:14-19
Cost-effectiveness of an internet-based booster program for patients with obsessive-compulsive disorder: Results from a randomized controlled trial
Andersson E; Ljotsson B; Hedman E; Mattson S; Enander J; Andersson G; Kaldo V; Lindefors N; Ruck C
Article: PLOS ONE. 2015;10(4):e0123412
Optimal Cut-Off Points on the Health Anxiety Inventory, Illness Attitude Scales and Whiteley Index to Identify Severe Health Anxiety
Hedman E; Lekander M; Ljotsson B; Lindefors N; Ruck C; Andersson G; Andersson E
Article: PSYCHOLOGICAL MEDICINE. 2014;44(13):2877-2887
Long-term efficacy of Internet-based cognitive behavior therapy for obsessive-compulsive disorder with or without booster: a randomized controlled trial
Andersson E; Steneby S; Karlsson K; Ljotsson B; Hedman E; Enander J; Kaldo V; Andersson G; Lindefors N; Ruck C
Article: PSYCHIATRY RESEARCH. 2014;223(2):164-170
Reduced 5-HT_1B receptor binding in the dorsal brain stem after cognitive behavioural therapy of major depressive disorder
Tiger M; Ruck C; Forsberg A; Varrone A; Lindefors N; Halldin C; Farde L; Lundberg J
Article: BEHAVIOUR RESEARCH AND THERAPY. 2014;59:20-29
Clinical effectiveness and cost-effectiveness of Internet- vs. group-based cognitive behavior therapy for social anxiety disorder: 4-Year follow-up of a randomized trial
Hedman E; El Alaoui S; Lindefors N; Andersson E; Ruck C; Ghaderi A; Kaldo V; Lekander M; Andersson G; Ljotsson B
Article: BEHAVIOUR RESEARCH AND THERAPY. 2014;54:22-29
Sudden gains in internet-based cognitive behaviour therapy for severe health anxiety
Hedman E; Lekander M; Ljotsson B; Lindefors N; Ruck C; Hofmann SG; Andersson E; Andersson G; Schulz SM
Article: JOURNAL OF AFFECTIVE DISORDERS. 2014;155:49-58
Effectiveness of Internet-based cognitive behaviour therapy for depression in routine psychiatric care
Hedman E; Ljotsson B; Kaldo V; Hesser H; El Alaoui S; Kraepelien M; Andersson E; Ruck C; Svanborg C; Andersson G; Lindefors N
Article: PLOS ONE. 2014;9(6):e100614
Using Early Change to Predict Outcome in Cognitive Behaviour Therapy: Exploring Timeframe, Calculation Method, and Differences of Disorder-Specific versus General Measures
Schibbye P; Ghaderi A; Ljotsson B; Hedman E; Lindefors N; Ruck C; Kaldo V
Article: PLOS ONE. 2014;9(8):e104615
Effects of Baseline Problematic Alcohol and Drug Use on Internet-Based Cognitive Behavioral Therapy Outcomes for Depression, Panic Disorder and Social Anxiety Disorder
Gajecki M; Berman AH; Sinadinovic K; Andersson C; Ljotsson B; Hedman E; Ruck C; Lindefors N
Article: PLOS ONE. 2014;9(12):e113871
Personality Change following Internet-Based Cognitive Behavior Therapy for Severe Health Anxiety
Hedman E; Andersson G; Lindefors N; Gustavsson P; Lekander M; Rueck C; Andersson E; Ljotsson B
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2013;128(6):457-467
Effectiveness of Internet-based cognitive behaviour therapy for panic disorder in routine psychiatric care
Hedman E; Ljotsson B; Ruck C; Bergstrom J; Andersson G; Kaldo V; Jansson L; Andersson E; Andersson E; Blom K; El Alaoui S; Falk L; Ivarsson J; Nasri B; Rydh S; Lindefors N
Article: JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY. 2013;81(6):1113-1126
Mechanisms of Change in an Exposure-Based Treatment for Irritable Bowel Syndrome
Ljotsson B; Hesser H; Andersson E; Lindfors P; Hursti T; Ruck C; Lindefors N; Andersson G; Hedman E
Article: JOURNAL OF MEDICAL INTERNET RESEARCH. 2013;15(10):e229-138
Telephone Versus Internet Administration of Self-Report Measures of Social Anxiety, Depressive Symptoms, and Insomnia: Psychometric Evaluation of a Method to Reduce the Impact of Missing Data
Hedman E; Ljotsson B; Blom K; El Alaoui S; Kraepelien M; Ruck C; Andersson G; Svanborg C; Lindefors N; Kaldo V
Article: BEHAVIOUR RESEARCH AND THERAPY. 2013;51(10):711-717
Predictors of outcome in Internet-based cognitive behavior therapy for severe health anxiety
Hedman E; Lindefors N; Andersson G; Andersson E; Lekander M; Ruck C; Ljotsson B
Article: PSYCHOLOGICAL MEDICINE. 2013;43(2):363-374
Cost-effectiveness and long-term effectiveness of Internet-based cognitive behaviour therapy for severe health anxiety
Hedman E; Andersson E; Lindefors N; Andersson G; Ruck C; Ljotsson B
Article: PLOS ONE. 2013;8(10):e77752
Mediators in Internet-Based Cognitive Behavior Therapy for Severe Health Anxiety
Hedman E; Andersson E; Andersson G; Lindefors N; Lekander M; Ruck C; Ljotsson B
Article: PLOS ONE. 2013;8(11):e79015
Genetic Polymorphisms in Monoamine Systems and Outcome of Cognitive Behavior Therapy for Social Anxiety Disorder
Andersson E; Ruck C; Lavebratt C; Hedman E; Schalling M; Lindefors N; Eriksson E; Carlbring P; Andersson G; Furmark T
Article: COGNITIVE BEHAVIOUR THERAPY. 2013;42(4):303-314
Internet-Delivered CBT for Children with Specific Phobia: A Pilot Study
Vigerland S; Thulin U; Ljotsson B; Svirsky L; Ost L-G; Lindefors N; Andersson G; Serlachius E
Article: PLOS ONE. 2013;8(11):e79024
Predictors and Moderators of Internet- and Group-Based Cognitive Behaviour Therapy for Panic Disorder
El Alaoui S; Hedman E; Ljotsson B; Bergstrom J; Andersson E; Ruck C; Andersson G; Lindefors N
Article: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2012;262(8):705-724
Long-term functional outcome in adult prison inmates with ADHD receiving OROS-methylphenidate
Ginsberg Y; Hirvikoski T; Grann M; Lindefors N
Article: JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS. 2012;1(4):325-330
Internet administration of the Dimensional Obsessive-Compulsive Scale: a psychometric evaluation
Enander J; Andersson E; Kaldo V; Lindefors N; Andersson G; Ruck C
Article: PSYCHOLOGICAL MEDICINE. 2012;42(10):2193-2203
Internet-based cognitive behaviour therapy for obsessive-compulsive disorder: a randomized controlled trial
Andersson E; Enander J; Andren P; Hedman E; Ljotsson B; Hursti T; Bergstrom J; Kaldo V; Lindefors N; Andersson G; Ruck C
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2012;126(2):126-136
Clinical and genetic outcome determinants of Internet- and group-based cognitive behavior therapy for social anxiety disorder
Hedman E; Andersson E; Ljotsson B; Andersson G; Andersson E; Schalling M; Lindefors N; Ruck C
Article: TRANSLATIONAL PSYCHIATRY. 2012;2(5):e120
Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder
Cervenka S; Hedman E; Ikoma Y; Djurfeldt DR; Ruck C; Halldin C; Lindefors N
Article: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2012;200(1):68-73
Methylphenidate treatment of adult male prison inmates with attention-deficit hyperactivity disorder: randomised double-blind placebo-controlled trial with open-label extension
Ginsberg Y; Lindefors N
Article: BEHAVIOUR RESEARCH AND THERAPY. 2011;49(11):729-736
Cost-effectiveness of Internet-based cognitive behavior therapy vs. cognitive behavioral group therapy for social anxiety disorder: Results from a randomized controlled trial
Hedman E; Andersson E; Ljotsson B; Andersson G; Ruck C; Lindefors N
Article: BMC GASTROENTEROLOGY. 2011;11:110
Acceptability, effectiveness, and cost-effectiveness of internet-based exposure treatment for irritable bowel syndrome in a clinical sample: a randomized controlled trial
Ljotsson B; Andersson G; Andersson E; Hedman E; Lindfors P; Andreewitch S; Ruck C; Lindefors N
Article: BMC PSYCHIATRY. 2011;11:125
Internet-based cognitive behavior therapy for obsessive compulsive disorder: A pilot study
Andersson E; Ljotsson B; Hedman E; Kaldo V; Paxling B; Andersson G; Lindefors N; Ruck C
Article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2011;106(8):1481-1491
Internet-Delivered Exposure-Based Treatment vs. Stress Management for Irritable Bowel Syndrome: A Randomized Trial
Ljotsson B; Hedman E; Andersson E; Hesser H; Lindfors P; Hursti T; Rydh S; Ruck C; Lindefors N; Andersson G
Article: JOURNAL OF MEDICAL INTERNET RESEARCH. 2011;13(2):e39
A 5-Year Follow-up of Internet-Based Cognitive Behavior Therapy for Social Anxiety Disorder
Hedman E; Furmark T; Carlbring P; Ljotsson B; Ruck C; Lindefors N; Andersson G
Article: BMC PUBLIC HEALTH. 2011;11:215
Cost-effectiveness of internet-based cognitive behavior therapy for irritable bowel syndrome: results from a randomized controlled trial
Andersson E; Ljotsson B; Smit F; Paxling B; Hedman E; Lindefors N; Andersson G; Ruck C
Article: LAKARTIDNINGEN. 2011;108(14):785
[Anxiety is our heritage and we should administer it well].
Lindefors N; Andersson G
Article: PLOS ONE. 2011;6(3):e18001
Internet-Based Cognitive Behavior Therapy vs. Cognitive Behavioral Group Therapy for Social Anxiety Disorder: A Randomized Controlled Non-inferiority Trial
Hedman E; Andersson G; Ljotsson B; Andersson E; Ruck C; Mortberg E; Lindefors N
Article: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2011;198(3):230-236
Internet-based cognitive-behavioural therapy for severe health anxiety: randomised controlled trial
Hedman E; Andersson G; Andersson E; Ljotsson B; Ruck C; Asmundson GJG; Lindefors N
Article: BEHAVIOUR RESEARCH AND THERAPY. 2011;49(1):58-61
Long-term follow-up of internet-delivered exposure and mindfulness based treatment for irritable bowel syndrome
Ljotsson B; Hedman E; Lindfors P; Hursti T; Lindefors N; Andersson G; Ruck C
Article: BMC PSYCHIATRY. 2010;10:112
Attention Deficit Hyperactivity Disorder (ADHD) among longer-term prison inmates is a prevalent, persistent and disabling disorder
Ginsberg Y; Hirvikoski T; Lindefors N
Article: BMC PSYCHIATRY. 2010;10:99
The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder
Lonsdorf TB; Ruck C; Bergstrom J; Andersson G; Ohman A; Lindefors N; Schalling M
Article: JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY. 2010;41(3):185-190
Exposure and mindfulness based therapy for irritable bowel syndrome - An open pilot study
Ljotsson B; Andreewitch S; Hedman E; Ruck C; Andersson G; Lindefors N
Article: BMC PSYCHIATRY. 2010;10:54
Internet-versus group-administered cognitive behaviour therapy for panic disorder in a psychiatric setting: a randomised trial
Bergstrom J; Andersson G; Ljotsson B; Ruck C; Andreewitch S; Karlsson A; Carlbring P; Andersson E; Lindefors N
Article: COMPUTERS IN HUMAN BEHAVIOR. 2010;26(4):736-740
Internet administration of self-report measures commonly used in research on social anxiety disorder: A psychometric evaluation
Hedman E; Ljotsson B; Ruck C; Furmark T; Carlbring P; Lindefors N; Andersson G
Article: BEHAVIOUR RESEARCH AND THERAPY. 2010;48(6):531-539
Internet-delivered exposure and mindfulness based therapy for irritable bowel syndrome - A randomized controlled trial
Ljotsson B; Falk L; Vesterlund AW; Hedman E; Lindfors P; Ruck C; Hursti T; Andreewitch S; Jansson L; Lindefors N; Andersson G
Article: COGNITIVE BEHAVIOUR THERAPY. 2010;39(4):239-250
Effectiveness and cost offset analysis of group CBT for hypochondriasis delivered in a psychiatric setting: an open trial.
Hedman E; Ljótsson B; Andersson E; Rück C; Andersson G; Lindefors N
Article: AMERICAN JOURNAL OF PSYCHIATRY. 2009;166(6):675-682
Cognitive Effects of Antipsychotic Drugs in First-Episode Schizophrenia and Schizophreniform Disorder: A Randomized, Open-Label Clinical Trial (EUFEST)
Davidson M; Galderisi S; Weiser M; Werbeloff N; Fleischhacker WW; Keefe RS; Boter H; Keet IPM; Prelipceanu D; Rybakowski JK; Libiger J; Hummer M; Dollfus S; Lopez-Ibor JJ; Hranov LG; Gaebel W; Peuskens J; Lindefors N; Riecher-Roessler A; Kahn RS
Article: NORDIC JOURNAL OF PSYCHIATRY. 2009;63(1):44-50
An open study of the effectiveness of Internet treatment for panic disorder delivered in a psychiatric setting
Bergstrom J; Andersson G; Karlsson A; Andreewitch S; Ruck C; Carlbring P; Lindefors N
Article: PSYCHOPHARMACOLOGY. 2008;197(2):295-307
Emotional perception modulated by an opioid and a cholecystokinin agonist
Gospic K; Gunnarsson T; Fransson P; Ingvar M; Lindefors N; Petrovic P
Article: THE LANCET. 2008;371(9618):1085-1097
Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder:: an open randomised clinical trial
Kahn RS; Fleischhacker WW; Boter H; Davidson M; Vergouwe Y; Keet IPM; Gheorghe MD; Rybakowski JK; Galderisi S; Libiger J; Hummer M; Dollfus S; Lopez-Ibor JJ; Hranov LG; Gaebel W; Peuskens J; Lindefors N; Riecher-Roessler A; Grobbee DE
Article: BRAIN RESEARCH. 2006;1104(1):175-182
Overlapping regional distribution of CCK and TPPII mRNAs in Cynomolgus monkey brain and correlated levels in human cerebral cortex (BA 10)
Radu D; Tomkinson B; Zachrisson O; Weber G; de Belleroche J; Hirsch S; Lindefors N
Article: CURRENT OPINION IN PSYCHIATRY. 2005;18(1):73-77
The use of the Internet in the treatment of anxiety disorders
Andersson G; Bergström J; Carlbring P; Lindefors N
Article: PSYCHOPHARMACOLOGY. 2003;166(2):139-145
Pentagastrin test for anxiety -: psychophysiology and personality
Radu D; Åhlin A; Svanborg P; Lindefors N
Article: PSYCHOPHARMACOLOGY. 2002;161(4):396-403
Anxiogenic effects of the CCK_B agonist pentagastrin in humans and dose-dependent increase in plasma C-peptide levels
Radu D; Åhlin A; Svanborg P; Lindefors N
Article: BRAIN RESEARCH. 2001;908(2):197-203
Delayed stress-induced increase in tissue level of cholecystokinin in rat prefrontal cortex: modulation by microdialysis probe implantation and systemic ketamine
Radu D; Brodin E; Weber G; Lindefors N
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2000;10(5):355-363
Effects of antipsychotic drugs on cholecystokinin and preprotachykinin (substance P) mRNA expression in the rat hippocampal formation
Zachrisson O; Nomikos GG; Marcus MM; Svensson TH; Lindefors N
Article: NEUROREPORT. 1999;10(16):3265-3268
Cholecystokinin CCK_B receptor mRNA isoforms:: expression in schizophrenic brains
Zachrisson O; de Belleroche J; Wendt KR; Hirsch S; Lindefors N
Article: BRAIN RESEARCH. 1998;60(2):291-295
A tachykinin NK₁ receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity
Zachrisson O; Lindefors N; Brené S
Article: BRAIN RESEARCH. 1997;48(2):413-416
GABA release and GAD(67) mRNA expression in rat hippocampus following entorhinal cortex activation
Falkenberg T; Lindefors N; OConnor WT; Zachrisson O; Camilli F; Ungerstedt U
Article: BRAIN RESEARCH. 1997;759(2):205-212
Differential effects of single and repeated ketamine administration on dopamine, serotonin and GABA transmission in rat medial prefrontal cortex
Lindefors N; Barati S; OConnor WT
Article: BRAIN RESEARCH. 1997;45(2):275-282
Effect of chronic antipsychotic drug treatment on preprosomatostatin and preprotachykinin A mRNA levels in the medial prefrontal cortex, the nucleus accumbens and the caudate putamen of the rat
Marcus MM; Nomikos GG; Malmerfelt A; Zachrisson O; Lindefors N; Svensson TH
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1997;319(2-3):191-195
Decreased levels of preprotachykinin-A and tachykinin NK1 receptor mRNA in specific regions of the rat striatum after electroconvulsive stimuli
Zachrisson O; Mathe AA; Lindefors N
Article: BRAIN RESEARCH. 1996;43(1-2):347-350
Effects of chronic lithium and electroconvulsive stimuli on cholecystokinin mRNA expression in the rat brain
Zachrisson O; Mathe AA; Lindefors N
Article: BRAIN RESEARCH. 1996;42(2):317-327
Glutamate release correlates with brain-derived neurotrophic factor and trkB mRNA expression in the CA1 region of rat hippocampus
Falkenberg T; Lindefors N; Camilli F; Metsis M; Ungerstedt U
Article: BRAIN RESEARCH. 1996;36(1):169-173
Neuronal coexistence of trkB and glutamic acid decarboxylase(67) mRNAs in rat hippocampus
Zachrisson O; Falkenberg T; Lindefors N
Article: PSYCHOPHARMACOLOGY. 1995;120(3):333-340
ELECTROCONVULSIVE SHOCK INCREASES DOPAMINE D-1 AND D-2 RECEPTOR MESSENGER-RNA IN THE NUCLEUS-ACCUMBENS OF THE RAT
SMITH S; LINDEFORS N; HURD Y; SHARP T
Article: NEUROSCIENCE LETTERS. 1995;194(1-2):89-92
REGION-SPECIFIC EFFECTS OF CHRONIC LITHIUM ADMINISTRATION ON NEUROPEPTIDE-Y AND SOMATOSTATIN MESSENGER-RNA EXPRESSION IN THE RAT-BRAIN
ZACHRISSON O; MATHE AA; STENFORS C; LINDEFORS N
Article: NEUROSCIENCE. 1995;67(1):37-48
DISTRIBUTION OF MESSENGER-RNAS FOR D-1 DOPAMINE-RECEPTORS AND DARPP-32 IN STRIATUM AND CEREBRAL-CORTEX OF THE CYNOMOLGUS MONKEY - RELATIONSHIP TO D-1 DOPAMINE-RECEPTORS
BRENE S; HALL H; LINDEFORS N; KARLSSON P; HALLDIN C; SEDVALL G
Article: BRAIN RESEARCH. 1995;31(1-2):71-85
LIMBIC EFFECTS OF REPEATED ELECTROCONVULSIVE STIMULATION ON NEUROPEPTIDE-Y AND SOMATOSTATIN MESSENGER-RNA EXPRESSION IN THE RAT-BRAIN
ZACHRISSON O; MATHE AA; STENFORS C; LINDEFORS N
Article: NEUROSCIENCE. 1995;65(3):661-670
SPATIOTEMPORAL SELECTIVE EFFECTS ON BRAIN-DERIVED NEUROTROPHIC FACTOR AND TRKB MESSENGER-RNA IN RAT HIPPOCAMPUS BY ELECTROCONVULSIVE SHOCK
LINDEFORS N; BRODIN E; METSIS M
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Letter: JAMA DERMATOLOGY. 2022;158(11):1325-1327
Optimized User Experience, Efficiency, and Resource Use in Online Self-Management of Atopic Dermatitis
Kern D; Ljotsson B; Lonndahl L; Hedman-Lagerlof E; Bradley M; Lindefors N; Kraepelien M
Corrigendum: INTERNET INTERVENTIONS. 2022;29:100550
The effect of user interface on treatment engagement in a self-guided digital problem-solving intervention: A randomized controlled trial (vol 26, 100448, 2021)
Hentati A; Forsell E; Ljotsson B; Kaldo V; Lindefors N; Kraepelien M
Review: JAMA PSYCHIATRY. 2021;78(4):361-371
Internet-Based Cognitive Behavioral Therapy for Depression A Systematic Review and Individual Patient Data Network Meta-analysis
Karyotaki E; Efthimiou O; Miguel C; Bermpohl FMG; Furukawa TA; Cuijpers P
Published conference paper: INTERNET INTERVENTIONS. 2019;18:100263
Individually tailored internet treatment in routine care: A feasibility study
Kraepelien M; Svanborg C; Lallerstedt L; Sennerstam V; Lindefors N; Kaldo V
Review: CANADIAN JOURNAL OF PSYCHIATRY. 2019;64(7):465-470
Internet Interventions for Adults with Anxiety and Mood Disorders: A Narrative Umbrella Review of Recent Meta-Analyses
Andersson G; Carlbring P; Titov N; Lindefors N
Review: INTERNET INTERVENTIONS. 2018;13:108-115
ICBT in routine care: A descriptive analysis of successful clinics in five countries
Titov N; Dear B; Nielssen O; Staples L; Hadjistavropoulos H; Nugent M; Adlam K; Nordgreen T; Bruvik KH; Hovland A; Repal A; Mathiasen K; Kraepelien M; Blom K; Svanborg C; Lindefors N; Kaldo V
Review: CLINICAL PSYCHOLOGY REVIEW. 2018;63:80-92
Do guided internet-based interventions result in clinically relevant changes for patients with depression? An individual participant data meta-analysis
Karyotaki E; Ebert DD; Donkin L; Riper H; Twisk J; Burger S; Rozental A; Lange A; Williams AD; Zarski AC; Geraedts A; van Straten A; Kleiboer A; Meyer B; Ince BBU; Buntrock C; Lehr D; Snoek FJ; Andrews G; Andersson G; Choi I; Ruwaard J; Klein JP; Newby JM; Schroder J; Laferton JAC; Van Bastelaar K; Imamura K; Vernmark K; Boss L; Sheeber LB; Kivi M; Berking M; Tito N; Carlbring P; Johansson R; Kenter R; Perini S; Moritz S; Nobis S; Berger T; Kaldo V; Forsell Y; Lindefors N; Kraepelien M; Bjorkelund C; Kawakami N; Cuijpers P
Review: EXPERT REVIEW OF PHARMACOECONOMICS AND OUTCOMES RESEARCH. 2012;12(6):745-764
Cognitive behavior therapy via the Internet: a systematic review of applications, clinical efficacy and cost-effectiveness
Hedman E; Ljotsson B; Lindefors N
Corrigendum: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY AND BIOLOGICAL PSYCHIATRY. 2011;35(1):312
The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism (vol 33, pg 1479, 2009)
Lonsdorf TB; Ruck C; Bergstrom J; Andersson G; Ohman A; Schalling M; Lindefors N
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY AND BIOLOGICAL PSYCHIATRY. 2009;33(8):1479-1483
The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism
Lonsdorf TB; Ruck C; Bergstrom J; Andersson G; Ohman A; Schalling M; Lindefors N
Meeting abstract: EUROPEAN PSYCHIATRY. 2008;23:S355-S356
Effectiveness of internet treatment for panic disorder delivered in a psychiatric setting
Bergstroem J; Ljotsson B; Andersson G; Andreewitch S; Ruck C; Carlbring P; Lindefors N
Meeting abstract: EUROPEAN PSYCHIATRY. 2007;22:S61-S62
Can we benefit from internet to increase accessibility to an effective non-pharmacological treatment for major depression and anxiety disorders?
Lindefors N
Meeting abstract: SCHIZOPHRENIA RESEARCH. 2000;41(1):254-255
Cholecystokinin in CCK_B receptor mRNA isoforms:: Expression in post-mortem monkey and human brain -: Alterations following schizophrenia
Radu D; Zachrisson O; de Belleroche J; Wendt KR; Hirsh S; Lindefors N
Meeting abstract: SCHIZOPHRENIA RESEARCH. 1998;29(1-2):199-200
Evidence for an alteration in the balance between dopamine and serotonin transmission in the medial prefrontal cortex of the conscious rat following repeated ketamine administration
O'Connor WT; Lindefors N
Meeting abstract: SCHIZOPHRENIA RESEARCH. 1998;29(1-2):168-169
CCK receptors in the brain as targets for new antipsychotic drugs
Lindefors N

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