Niklas Zethraeus

About me
Publications
CV
Public outreach and news

About me

I'm an associate professor of health economics, working at MMC, LIME at
Karolinska Institutet. I'm also program director of the Master's programme of
health economics, policy and management.

Research

The focus of my research is on economic evaluation studies in different areas
such as congestive heart failure, gallstone disease, osteoporosis and hormone
replacement therapy. I'm also doing research in behavioural (health)
economics, e.g., analysing the effects of hormones on economic behaviour and
clinical outcomes.
Research group web page: Health Economics and Economic Evaluation [1].
[1] https://ki.se/en/lime/health-economics-and-economic-evaluation

Articles

Article: EVOLUTION AND HUMAN BEHAVIOR. 2025;46(5):106713
Oral contraceptives and women's preferences for facial masculinity and symmetry: Evidence from a double-blind randomized controlled trial
Ranehill E; Zethraeus N; Apicella CL; Blomberg L; von Schoultz B; Hirschberg AL; Johannesson M; Dreber A
Article: BMC MUSCULOSKELETAL DISORDERS. 2025;26(1):190
Effectiveness and cost-effectiveness of chiropractic and physiotherapy for chronic low back pain: a multicenter RCT in Sweden
Gedin F; Skeppholm M; Sparring V; Zethraeus N
Article: JOURNAL OF MEDICAL ECONOMICS. 2024;27(1):193-200
Validation of overall survival extrapolations made by TLV in the assessment of cost-effectiveness of oncology drugs in Sweden - A pilot study comparing extrapolated and observed life-years gained
Bjornerstedt J; Almqvist H; Lundin D; Zethraeus N
Article: NORDIC JOURNAL OF PSYCHIATRY. 2024;78(2):137-145
Association between pulse width and health-related quality of life after electroconvulsive therapy in patients with unipolar or bipolar depression: an observational register-based study
Ernstsson O; Heintz E; Nordenskjold A; Johnson JA; Korkmaz S; Zethraeus N
Article: PAIN REPORTS. 2023;8(6):e1107
Real-world outcomes in spinal cord stimulation: predictors of reported effect and explantation using a comprehensive registry-based approach
Kirketeig T; Soreskog E; Jacobson T; Karlsten R; Zethraeus N; Borgstrom F
Article: PAIN. 2023;164(3):666-673
Impact of spinal cord stimulation on sick leave and disability pension in patients with chronic neuropathic pain: a real-world evidence study in Sweden
Soreskog E; Jacobson T; Kirketeig T; Fritzell P; Karlsten R; Zethraeus N; Borgstrom F
Article: DISABILITY AND REHABILITATION. 2022;44(26):8471-8479
Health-related quality of life in patients with lower limb amputation - an assessment of the measurement properties of EQ-5D-3L and EQ-5D-5L using data from the Swedish Amputation and Prosthetics Registry
Ernstsson O; Hagberg K; Janssen MF; Bonsel GJ; Korkmaz S; Zethraeus N; Heintz E
Journal article: VALUE IN HEALTH. 2022;25(12):s237
HPR29 Assessing the Feasibility of Implementing Indication-Based Pricing in Sweden: A Qualitative Analysis
Viollet J; Williams I; Zethraeus N
Article: MEDICINE. 2021;100(46):e27828
Health care costs associated with clinic visits for prevention of mother-to-child transmission of HIV in Dar es Salaam, Tanzania
Naburi HE; Mujinja P; Kilewo C; Biberfeld G; Barnighausen T; Manji K; Lyatuu G; Urrio R; Zethraeus N; Orsini N; Ekstrom AM
Article: BMJ OPEN. 2021;11(8):e051233
Observational study of the implementation of telephone advice nursing in Sweden: did callers follow recommendations and did the rate of healthcare visits change?
Sundberg A; Wahlberg AC; Zethraeus N; Karampampa K
Article: BMJ OPEN. 2020;10(8):e036638
Productivity losses among people with back pain and among population-based references: a register-based study in Sweden
Gedin F; Alexanderson K; Zethraeus N; Karampampa K
Article: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES. 2019;22(4):545-554
Cost-effectiveness of an adherence-enhancing intervention for gout based on real-world data
Lin LW; Teng GG; Lim AYN; Yoong JS-Y; Zethraeus N; Wee H-L
Article: APPLIED HEALTH ECONOMICS AND HEALTH POLICY. 2019;17(1):15-24
Standardized Questionnaire for the Measurement, Valuation, and Estimation of Costs of Informal Care Based on the Opportunity Cost and Proxy Good Method
Landfeldt E; Zethraeus N; Lindgren P
Article: JOURNAL OF THE ECONOMIC SCIENCE ASSOCIATION. 2019;5(2):149-169
The digit ratio (2D:4D) and economic preferences: no robust associations in a sample of 330 women
Parslow E; Ranehill E; Zethraeus N; Blomberg L; von Schoultz B; Hirschberg AL; Johannesson M; Dreber A
Article: MANAGEMENT SCIENCE. 2018;64(10):4515-4532
Hormonal Contraceptives Do Not Impact Economic Preferences: Evidence from a Randomized Trial
Ranehill E; Zethraeus N; Blomberg L; von Schoultz B; Hirschberg AL; Johannesson M; Dreber A
Article: FRONTIERS IN ENDOCRINOLOGY. 2018;9:104
Economic Evaluation of PRIMROSE - A Trial-Based Analysis of an Early Childhood Intervention to Prevent Obesity
Doring N; Zethraeus N; Tynelius P; de Munter J; Sonntag D; Rasmussen F
Article: TRIALS. 2017;18(1):613
Effectiveness, costs and cost-effectiveness of chiropractic care and physiotherapy compared with information and advice in the treatment of non-specific chronic low back pain: study protocol for a randomised controlled trial
Gedin F; Skeppholm M; Burstrom K; Sparring V; Tessma M; Zethraeus N
Article: FERTILITY AND STERILITY. 2017;107(5):1238-1245
A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial
Zethraeus N; Dreber A; Ranehill E; Blomberg L; Labrie F; von Schoultz B; Johannesson M; Hirschberg AL
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2016;101(11):4046-4053
Combined Oral Contraceptives and Sexual Function in Women-a Double-Blind, Randomized, Placebo-Controlled Trial
Zethraeus N; Dreber A; Ranehill E; Blomberg L; Labrie F; von Schoultz B; Johannesson M; Hirschberg AL
Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. 2016;23(4):420-427
Cost-effectiveness of case-based training for primary care physicians in evidence-based medicine of patients with coronary heart disease
Groot-Jensen S; Kiessling A; Zethraeus N; Bjornstedt-Bennermo M; Henriksson P
Article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2015;25(6):1035-1042
Cost and effects of a universal parenting programme delivered to parents of preschoolers
Sampaio F; Sarkadi A; Salari R; Zethraeus N; Feldman I
Article: QUALITY OF LIFE RESEARCH. 2015;24(12):2963-2970
Assessment of the Swedish EQ-5D experience-based value sets in a total hip replacement population
Nemes S; Burstrom K; Zethraeus N; Eneqvist T; Garellick G; Rolfson O
Journal article: PLOS ONE. 2015;10(8):e0135534
Barriers to and Facilitators of Compliance with Clinic-Based Cervical Cancer Screening: Population-Based Cohort Study of Women Aged 23-60 Years (vol 10, e0128270, 2015)
Oestensson E; Alder S; Elfstroem KM; Sundstroem K; Zethraeus N; Arbyn M; Andersson S
Article: PLOS ONE. 2015;10(9):e0139062
Cost of Preventing, Managing, and Treating Human Papillomavirus (HPV)-Related Diseases in Sweden before the Introduction of Quadrivalent HPV Vaccination
Ostensson E; Froberg M; Leval A; Hellstrom A-C; Backlund M; Zethraeus N; Andersson S
Article: PLOS ONE. 2015;10(5):e0128270
Barriers to and Facilitators of Compliance with Clinic-Based Cervical Cancer Screening: Population-Based Cohort Study of Women Aged 23-60 Years
Ostensson E; Alder S; Elfstrom KM; Sundstrom K; Zethraeus N; Arbyn M; Andersson S
Article: QUALITY OF LIFE RESEARCH. 2014;23(2):431-442
Swedish experience-based value sets for EQ-5D health states
Burstrom K; Sun S; Gerdtham U-G; Henriksson M; Johannesson M; Levin L-A; Zethraeus N
Article: EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE. 2014;6(1):29-38
Integrative medicine for back and neck pain: Exploring cost-effectiveness alongside a randomized clinical pilot trial
Sundberg T; Hagberg L; Zethraeus N; Wandell P; Falkenberg T
Journal article: EUROPEAN HEART JOURNAL. 2013;34(suppl_1):p3345
Long-term cost effectiveness of case-based training of evidence-based clinical practice in primary care patients with coronary heart disease
Groot-Jensen S; Kiessling A; Zethraeus N; Bjoernstedt-Bennermo M; Henriksson P
Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2013;92(7):830-840
Projected cost-effectiveness of repeat high-risk human papillomavirus testing using self-collected vaginal samples in the Swedish cervical cancer screening program
Ostensson E; Hellstrom A-C; Hellman K; Gustavsson I; Gyllensten U; Wilander E; Zethraeus N; Andersson S
Article: FERTILITY AND STERILITY. 2011;95(1):152-157
A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women
Kocoska-Maras L; Zethraeus N; Raddestad AF; Ellingsen T; von Schoultz B; Johannesson M; Hirschberg AL
Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2010;89(10):1316-1325
Economic analysis of human papillomavirus triage, repeat cytology, and immediate colposcopy in management of women with minor cytological abnormalities in Sweden
Ostensson E; Froberg M; Hjerpe A; Zethraeus N; Andersson S
Article: ITALIAN JOURNAL OF PEDIATRICS. 2010;36:61
Health-care cost reduction resulting from primary-care allergy testing in children in Italy
Zethraeus N; Petersson CJ; Dozzi M; Borres MP; Vignati G; Fiocchi A
Journal article: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS. 2009;107(S2):s654
P848 A randomised trial of the effect of oestrogen and testosterone on economic behaviour
Zethraeus N; Kocoska‐Maras L; Johannesson M; Hirschberg AL; Von Schoultz B
Article: JOURNAL OF WOMENS HEALTH. 2009;18(10):1669-1677
Cost-Effectiveness of Hormone Therapy in the United States
Lekander I; Borgstrom F; Strom O; Zethraeus N; Kanis JA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(16):6535-6538
A randomized trial of the effect of estrogen and testosterone on economic behavior
Zethraeus N; Kocoska-Maras L; Ellingsen T; von Schoultz B; Hirschberg AL; Johannesson M
Article: MENOPAUSE INTERNATIONAL. 2009;15(1):19-25
Cost-effectiveness of hormone replacement therapy for menopausal symptoms in the UK.
Lekander I; Borgström F; Ström O; Zethraeus N; Kanis JA
Article: OSTEOPOROSIS INTERNATIONAL. 2008;19(6):819-827
The cost-effectiveness of the treatment of high risk women with osteoporosis, hypertension and hyperlipidaemia in Sweden
Zethraeus N; Strom O; Borgstrom F; Kanis JA; Jonsson B
Article: ACTA ORTHOPAEDICA. 2008;79(2):269-280
Long-term cost and effect on quality of life of osteoporosis-related fractures in Sweden
Strom O; Borgstrom F; Zethraeus N; Johnell O; Lidgren L; Ponzer S; Svensson O; Abdon P; Ornstein E; Ceder L; Thorngren KG; Sernbo I; Jonsson B
Article: BONE. 2008;42(2):294-306
Cost effectiveness of hormone therapy in women at high risks of fracture in Sweden, the US and the UK -: Results based on the Women's Health Initiative randomised controlled trial
Lekander I; Borgstrom F; Strom O; Zethraeus N; Kanis JA
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2006;24(18_suppl):16020
The use of innovative oncology drugs in Europe
Wilking NE; Svedman C; Jönsson B; Zethraeus N
Article: PHLEBOLOGY. 2006;21(2):90-95
Cost consequences of preoperative duplex examination before varicose vein surgery:: a randomized clinical trial
Blomgren L; Zethraeus N; Johansson G; Jonsson B; Bergqvist D
Article: OSTEOPOROSIS INTERNATIONAL. 2006;17(5):637-650
Costs and quality of life associated with osteoporosis-related fractures in Sweden
Borgström F; Zethraeus N; Johnell O; Lidgren L; Ponzer S; Svensson O; Abdon P; Ornstein E; Lunsjö K; Thorngren KG; Sernbo I; Rehnberg C; Jönsson B
Article: BONE. 2005;36(1):22-32
Intervention thresholds for osteoporosis in the UK
Kanis JA; Borgsrom F; Zethraeus N; Johnell O; Oden A; Jönsson B
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 2005;21(2):180-186
Cost of lipid lowering in patients with coronary artery disease by Case Method Learning
Kiessling A; Zethraeus N; Henriksson P
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 2004;21(4):433-441
Reassessment of the cost-effectiveness of hormone replacement therapy in Sweden: Results based on the Women's Health Initiative randomized controlled trial
Zethraeus N; Borgström F; Jönsson B; Kanis J
Article: BONE. 2004;34(6):1064-1071
Cost effectiveness of alendronate for the treatment of male osteoporosis in Sweden
Borgström F; Johnell O; Jöhnsson B; Zethraeus N; Sen SS
Article: OSTEOPOROSIS INTERNATIONAL. 2004;15(1):20-26
The risk and burden of vertebral fractures in Sweden
Kanis JA; Johnell O; Oden A; Borgstrom F; Zethraeus N; De Laet C; Jonsson B
Article: UGESKRIFT FOR LAEGER. 2003;165(43):4112-4116
[Cost-effectiveness of alendronate treatment of osteoporosis in Denmark. An economic evaluation based on the Fracture Intervention Trial].
Jönsson L; Borgström F; Zethraeus N
Article: JOURNAL OF ORTHOPAEDIC TRAUMA. 2003;17(8 Suppl):S17-S21
Quality of life related to fracture displacement among elderly patients with femoral neck fractures treated with internal fixation. 2002.
Tidermark J; Zethraeus N; Svensson O; Törnkvist H; Ponzer S
Article: LAKARTIDNINGEN. 2003;100(1-2):36-40
[Economic assessment based on a clinical study of risedronate. Fracture prevention in elderly women with osteoporosis is cost-effective].
Borgström F; Zethraeus N
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 2003;19(3):507-512
Predicting survival in cost-effectiveness analyses based on clinical trials
Gerdtham UG; Zethraeus N
Article: EUROPEAN JOURNAL OF HEART FAILURE. 2003;5(1):101-108
Intravenous levosimendan treatment is cost-effective compared with dobutamine in severe low-output heart failure: an analysis based on the international LIDO trial
Cleland JGF; Takala A; Apajasalo M; Zethraeus N; Kobelt G
Article: QUALITY OF LIFE RESEARCH. 2002;11(5):473-481
Femoral neck fractures in the elderly:: Functional outcome and quality of life according to EuroQol
Tidermark J; Zethraeus N; Svensson O; Törnkvist H; Ponzer S
Journal article: LAKARTIDNINGEN. 2002;99(7):646-650
[Cost-effectiveness of bisoprolol in chronic heart failure].
Ekman M; Zethraeus N; Dahlström U; Höglund C
Article: JOURNAL OF ORTHOPAEDIC TRAUMA. 2002;16(1):34-38
Quality of life related to fracture displacement among elderly patients with femoral neck fractures treated with internal fixation
Tidermark J; Zethraeus T; Svensson O; Törnkvist H; Ponzer S
Journal article: VALUE IN HEALTH. 2001;4(6):492
PCV11: THE COST-EFFECTIVENESS OF LEVOSIMENDAN IN SEVERE LOW-OUTPUT HEART FAILURE COMPARED TO DOBUTAMINE BASED ON AN INTERNATIONAL CLINICAL TRIAL (LIDO)
Cleland J; Takala A; Apajasalo M; Zethraeus N; Kobelt G
Article: PHARMACOECONOMICS. 2001;19(9):901-916
Cost effectiveness of bisoprolol in the treatment of chronic congestive heart failure in Sweden -: Analysis using data from the cardiac insufficiency bisoprolol study II trial
Ekman M; Zethraeus N; Jönsson B
Article: HEALTH ECONOMICS. 2000;9(7):623-630
Definition, interpretation and calculation of cost-effectiveness acceptability curves
Löthgren M; Zethraeus N
Article: HEALTH ECONOMICS. 1999;8(6):541-545
A comparison of patient and social tariff values derived from the time trade-off method
Zethraeus N; Johannesson M
Article: JOURNAL OF INTERNAL MEDICINE. 1999;246(2):151-159
Costs of coronary heart disease and stroke:: the case of Sweden
Zethraeus N; Molin T; Henriksson P; Jönsson B
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 1999;15(2):352-365
A computer model to analyze the cost-effectiveness of hormone replacement therapy
Zethraeus N; Johannesson M; Jönsson B
Article: MEDICAL DECISION MAKING. 1998;18(3):330-336
Nonparametric willingness-to-pay measures and confidence statements
Tambour M; Zethraeus N
Article: HEALTH ECONOMICS. 1998;7(2):143-147
Bootstrap confidence intervals for cost-effectiveness ratios: Some simulation results
Tambour M; Zethraeus N
Article: HEALTH ECONOMICS. 1998;7(1):31-38
Willingness to pay for hormone replacement therapy
Zethraeus N
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 1998;14(3):467-471
A note on confidence intervals in cost-effectiveness analysis
Tambour M; Zethraeus N; Johannesson M
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 1998;14(2):255-267
Estimating the costs of hip fracture and potential savings
Zethraeus N; Gerdtham UG
Article: BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 1997;104(10):1191-1195
The impact of hormone replacement therapy on quality of life and willingness to pay
Zethraeus N; Johannesson M; Henriksson P; Strand RT
Article: ACTA ORTHOPAEDICA. 1997;68(1):13-17
The cost of a hip fracture - Estimates for 1,709 patients in Sweden
Zethraeus N; Stromberg L; Jonsson B; Svensson O; Ohlen G
Article: AMERICAN JOURNAL OF SURGERY. 1996;172(4):305-310
A cost-minimization analysis of laparoscopic cholecystectomy versus open cholecystectomy
Berggren U; Zethraeus N; Arvidsson D; Haglund U; Jonsson B
Article: HEALTH POLICY. 1995;34(2):135-143
VALUE FOR MONEY - A CONTINGENT VALUATION STUDY OF THE OPTIMAL SIZE OF THE SWEDISH HEALTH-CARE BUDGET
ECKERLUND I; JOHANNESSON M; JOHANSSON PO; TAMBOUR M; ZETHRAEUS N
Show more

Employments

Principal Researcher, Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2012

Supervision

Emma Söreskog, Health Economics of the treatment and prevention of chronic pain and pancreatic cancer: four case studies based on Swedish register data, 2023

About me

Research

Articles

Employments

Degrees and Education

Supervision

News from KI

Events from KI