Nicolas Ruffin

Publications
CV
Public outreach and news

Articles

Journal article: NATURE. 2023
Preprint clubs: why it takes a village to do peer review.
Richter FC; Gea-Mallorquí E; Mortha A; Ruffin N; Vabret N
Article: ISCIENCE. 2023;26(2):106019
Article Single-cell RNA-seq analysis reveals dual sensing of HIV-1 in blood Axl⁺ dendritic cells
Brouiller F; Nadalin F; Bonte P-E; Ait-Mohamed O; Delaugerre C; Lelievre J-D; Ginhoux F; Ruffin N; Benaroch P
Article: NEUROLOGY: NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2023;10(1):e200056
Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis
Starvaggi Cucuzza C; Longinetti E; Ruffin N; Evertsson B; Kockum I; Jagodic M; Al Nimer F; Frisell T; Piehl F
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29(11):3317-3328
B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patients
Hogelin KA; Ruffin N; Pin E; Hober S; Nilsson P; Cucuzza CS; Khademi M; Olsson T; Piehl F; Al Nimer F
Article: ELIFE. 2022;11:e74065
Correlation between leukocyte phenotypes and prognosis of amyotrophic lateral sclerosis
Cui C; Ingre C; Yin L; Li X; Andersson J; Seitz C; Ruffin N; Pawitan Y; Piehl F; Fang F
Article: ISCIENCE. 2021;24(9):103078
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis
Hogelin KA; Ruffin N; Pin E; Manberg A; Hober S; Gafvelin G; Gronlund H; Nilsson P; Khademi M; Olsson T; Piehl F; Al Nimer F
Journal article: MEDECINE/SCIENCES. 2020;36(4):316-319
A new population of blood precursors of dendritic cells endowed with specific properties regarding HIV-1
Brouiller F; Ruffin N; Benaroch P
Journal article: FRONTIERS IN MICROBIOLOGY. 2020;11:1603
HIV-2-Infected Macrophages Produce and Accumulate Poorly Infectious Viral Particles
Gea-Mallorqui E; Zablocki-Thomas L; Maurin M; Jouve M; Rodrigues V; Ruffin N; Benaroch P
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(43):21685-21693
Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursors.
Ruffin N; Gea-Mallorquí E; Brouiller F; Jouve M; Silvin A; See P; Dutertre C-A; Ginhoux F; Benaroch P
Journal article: PLOS PATHOGENS. 2019;15(6):e1007868
Proliferative memory SAMHD1^low CD4⁺ T cells harbour high levels of HIV-1 with compartmentalized viral populations
Hani L; Chaillon A; Nere M-L; Ruffin N; Alameddine J; Salmona M; Lopez Zaragoza J-L; Smith DM; Schwartz O; Lelievre J-D; Delaugerre C; Levy Y; Seddiki N
Journal article: SCIENCE. 2017;356(6342):eaag3009
Mapping the human DC lineage through the integration of high-dimensional techniques
See P; Dutertre C-A; Chen J; Gunther P; McGovern N; Irac SE; Gunawan M; Beyer M; Handler K; Duan K; Bin Sumatoh HR; Ruffin N; Jouve M; Gea-Mallorqui E; Hennekam RCM; Lim T; Yip CC; Wen M; Malleret B; Low I; Shadan NB; Fen CFS; Tay A; Lum J; Zolezzi F; Larbi A; Poidinger M; Chan JKY; Chen Q; Renia L; Haniffa M; Benaroch P; Schlitzer A; Schultze JL; Newell EW; Ginhoux F
Journal article: IMMUNOLOGY. 2017;151(2):137-145
From dendritic cells to B cells dysfunctions during HIV-1 infection: T follicular helper cells at the crossroads
Ruffin N; Hani L; Seddiki N
Journal article: FRONTIERS IN IMMUNOLOGY. 2017;8:1698
Myeloid Cell Interaction with HIV: A Complex Relationship
Rodrigues V; Ruffin N; San-Roman M; Benaroch P
Journal article: AIDS. 2015;29(5):519-530
Low SAMHD1 expression following T-cell activation and proliferation renders CD4⁺ T cells susceptible to HIV-1
Ruffin N; Brezar V; Ayinde D; Lefebyre C; Zur Wiesch JS; van Lunzen J; Bockhorn M; Schwartz O; Hocini H; Lelievre J-D; Banchereau J; Levy Y; Seddiki N
Journal article: PLOS PATHOGENS. 2015;11(3):e1004752
Decreased HIV-Specific T-Regulatory Responses Are Associated with Effective DC-Vaccine Induced Immunity
Brezar V; Ruffin N; Richert L; Surenaud M; Lacabaratz C; Palucka K; Thiebaut R; Banchereau J; Levy Y; Seddiki N
Journal article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30(S1):a173-a174
Regulatory T-cells Represent an Important Fraction of HIV-specific T-cells: What Is their Impact on Vaccination?
Brezar V; Ruffin N; Surenaud M; Lacabaratz C; Palucka K; Banchereau J; Lévy Y; Seddiki N
Journal article: JOURNAL OF IMMUNOLOGICAL METHODS. 2014;411:70-75
A highly relevant and efficient single step method for simultaneous depletion and isolation of human regulatory T cells in a clinical setting
Brezar V; Ruffin N; Levy Y; Seddiki N
Journal article: IMMUNOLOGY. 2014;142(1):32-38
Role of miR-155 in the regulation of lymphocyte immune function and disease
Seddiki N; Brezar V; Ruffin N; Levy Y; Swaminathan S
Article: AIDS. 2013;27(8):1209-1217
B-cell subset alterations and correlated factors in HIV-1 infection
Pensieroso S; Galli L; Nozza S; Ruffin N; Castagna A; Tambussi G; Hejdeman B; Misciagna D; Riva A; Malnati M; Chiodi F; Scarlatti G
Article: VACCINE. 2013;31(18):2231-2237
Relation of activation-induced deaminase (AID) expression with antibody response to A(H1N1)pdm09 vaccination in HIV-1 infected patients
Cagigi A; Pensieroso S; Ruffin N; Sammicheli S; Thorstensson R; Pan-Hammarstrom Q; Hejdeman B; Nilsson A; Chiodi F
Article: JOURNAL OF INTERNAL MEDICINE. 2012;272(5):492-503
Immune activation and increased IL-21R expression are associated with the loss of memory B cells during HIV-1 infection
Ruffin N; Lantto R; Pensieroso S; Sammicheli S; Hejdeman B; Rethi B; Chiodi F
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2012;10:144
Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011
Ruffin N; Borggren M; Euler Z; Fiorino F; Grupping K; Hallengard D; Javed A; Mendonca K; Pollard C; Reinhart D; Saba E; Sheik-Khalil E; Skold A; Ziglio S; Scarlatti G; Gotch F; Wahren B; Shattock RJ
Article: JOURNAL OF AUTOIMMUNITY. 2012;38(4):304-314
IL-7 modulates B cells survival and activation by inducing BAFF and CD70 expression in T cells
Sammicheli S; Ruffin N; Lantto R; Vivar N; Chiodi F; Rethi B
Article: JOURNAL OF INFECTIOUS DISEASES. 2011;203(11):1658-1667
Survival and Proliferation of CD28^- T Cells During HIV-1 Infection Relate to the Amplitude of Viral Replication
Vivar N; Ruffin N; Sammicheli S; Hejdeman B; Rethi B; Chiodi F
Article: TRANSPLANTATION. 2011;91(9):946-951
The Involvement of Epithelial Fas in a Human Model of Graft Versus Host Disease
Ruffin N; Ahmed SS; Osorio LM; Wang XN; Jackson GH; Collin MP; Ekre H-P; Chiodi F; Dickinson AM
Article: PLOS ONE. 2011;6(12):e28629
IL-7 Promotes CD95-Induced Apoptosis in B Cells via the IFN-γ/STAT1 Pathway
Sammicheli S; Linh DVP; Ruffin N; Thang PH; Lantto R; Vivar N; Chiodi F; Rethi B
Article: FRONTIERS IN IMMUNOLOGY. 2011;2:90
The impact of inflammation and immune activation on B cell differentiation during HIV-1 infection
Ruffin N; Pham HT; Rethi B; Nilsson A; Chiodi F
Article: PLOS NEGLECTED TROPICAL DISEASES. 2010;4(10):e844
Systemic FasL and TRAIL Neutralisation Reduce Leishmaniasis Induced Skin Ulceration
Tasew G; Nylen S; Lieke T; Lemu B; Meless H; Ruffin N; Wolday D; Asseffa A; Yagita H; Britton S; Akuffo H; Chiodi F; Eidsmo L
Article: JOURNAL OF INTERNAL MEDICINE. 2010;268(2):181-193
The role of IL-1β in reduced IL-7 production by stromal and epithelial cells: a model for impaired T-cell numbers in the gut during HIV-1 infection
Thang PH; Ruffin N; Brodin D; Rethi B; Cam PD; Hien NT; Lopalco L; Vivar N; Chiodi F
Article: BLOOD. 2008;112(4):1195-1204
Priming of T cells to Fas-mediated proliferative signals by interleukin-7
Rethi B; Vivar N; Sammicheli S; Fluur C; Ruffin N; Atlas A; Rajnavolgyi E; Chiodi F
Article: AMERICAN JOURNAL OF PATHOLOGY. 2007;170(1):227-239
FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major
Eidsmo L; Fluur C; Rethi B; Ygberg SE; Ruffin N; De Milito A; Akuffo H; Chiodi F
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All other publications

Preprint: BIORXIV. 2024
Single-nuclei histone modification profiling of the adult human central nervous system unveils epigenetic memory of developmental programs
Kabbe M; Agirre E; Carlström K; Baldivia Pohl F; Ruffin N; van Bruggen D; Meijer M; Seeker L; Bestard-Cuche N; Lederer A; Zhang J; Ahola V; Goldman S; Bartosovic M; Jagodic M; Williams A; Castelo-Branco G
Editorial comment: EMBO REPORTS. 2023;24(6):e57258
The Preprint Club A blueprint for community-based peer review
Richter FC; Gea-Mallorqui E; Mortha A; Ruffin N; Vabret N
Preprint: BIORXIV. 2023
The Preprint Club - A cross-institutional, community-based approach to peer reviewing
Richter FC; Gea-Mallorquí E; Ruffin N; Vabret N
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:241-242
The immune response to EBV viral infection in untreated persons with Multiple Sclerosis and after B cell depletion
Hogelin KA; Kakhki MP; Gao Y; Margerie L; Ruffin N; Khademi M; Jagodic M; Olsson T; Buggert M; Al Nimer F
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:942-944
The MultipleMS prospective cohort study: Induced changes in monocytes, T cells, and B cells from multiple sclerosis immunomodulatory treatments are associated with long-term disability progression and relapses
Moylett S; Neumann J; Berge T; Ruffin N; d'alfonso S; Leone M; Cavalla P; Gallo A; Gajofatto A; Vecchio D; Esposito F; Ferre L; Santoro S; Giordano A; Filippi M; Giovanni MBF; Kockum I; Piehl F; Moridi T; Granberg T; Jagodic M; Khademi M; Al Nimer F; Gustavsen S; Olsson AG; Soendergaard HB; Berg-Hansen P; Hogestol E; Flinstad HH; Bos-Haugen SD; Villoslada P; Llufriu S; Saiz A; Hemmer B; Humblet-Baron S; Goris A; Dubois B
Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2022;22(12):715
Dynamics of antigen retention by follicular dendritic cells
Ruffin N; Gea-Mallorqui E
Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2022;22(2):74
A PAN-CANCER SIGNATURE FOR DYSFUNCTIONAL T CELLS
Ruffin N; Guerreiro-Cacais AO
Preprint: BIORXIV. 2022
Single-cell RNA-Seq analysis reveals dual sensing of HIV-1 in blood Axl⁺ dendritic cells
Brouiller F; Nadalin F; Mohamed OA; Bonté P-E; Delaugerre C; Lelièvre J-D; Ginhoux F; Ruffin N; Benaroch P
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):327
Sustained low relapse rate with highly variable B cell re-population dynamics with extended rituximab dosing intervals in multiple sclerosis
Cucuzza CS; Longinetti E; Ruffin N; Evertsson B; Kockum I; Jagodic M; Al Nimer F; Frisell T; Piehl F
Preprint: MEDRXIV. 2021
Correlation between leukocyte phenotypes and prognosis of amyotrophic lateral sclerosis: a longitudinal cohort study
Cui C; Ingre C; Yin L; Li X; Andersson J; Seitz C; Ruffin N; Pawitan Y; Piehl F; Fang F
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):551
Retained efficacy with extended rituximab dosing intervals in relapsing-remitting multiple sclerosis: a Swedish single-centre observational study
Cucuzza CS; Ruffin N; Kockum I; Jagodic M; Al Nimer F; Frisell T; Piehl F
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):351
No evidence of rebound MS disease activity with presence of CD20⁺ T cells at B-cell reconstitution after treatment with rituximab
Ruffin N; Asplund-Hogelin K; Khademi M; Al Nimer F; Piehl F
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):348
Impact of B-cell depleting treatments on development of humoral and cellular immunological memory against SARS-CoV-2
Hogelin KA; Ruffin N; Jiang X; Pin E; Manberg A; Hober S; Gafvelin G; Gronlund H; Frisell T; Nilsson P; Khademi M; Olsson T; Piehl F; Al Nimer F
Preprint: SSRN ELECTRONIC JOURNAL. 2021
Development of Humoral and Cellular Immunological Memory Against SARS-CoV-2 Despite B-Cell Depleting Treatment in Multiple Sclerosis
Asplund Högelin K; Ruffin N; Pin E; Månberg A; Hober S; Gafvelin G; Grönlund H; Nilsson P; Khademi M; Olsson T; Piehl F; Al Nimer F
Preprint: BIORXIV. 2019
Constitutive Siglec-1 expression by human dendritic cell precursors enables HIV-1 replication and transmission
Ruffin N; Gea-Mallorquí E; Brouiller F; Jouve M; Silvin A; See P; Dutertre C-A; Ginhoux F; Benaroch P
Review: AIDS. 2013;27(15):2323-2334
Impairment of B-cell functions during HIV-1 infection
Amu S; Ruffin N; Rethi B; Chiodi F
Review: JOURNAL OF TRANSLATIONAL MEDICINE. 2011;9:40
Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010
Brinckmann S; da Costa K; van Gils MJ; Hallengard D; Klein K; Madeira L; Mainetti L; Palma P; Raue K; Reinhart D; Reudelsterz M; Ruffin N; Seifried J; Schaefer K; Sheik-Khalil E; Skold A; Uchtenhagen H; Vabret N; Ziglio S; Scarlatti G; Shattock R; Wahren B; Gotch F

Employments

Senior Research Specialist, Department of Clinical Neuroscience, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2023
Degree Of Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2012

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