Nicola Crosetto
Principal Researcher
E-mail: nicola.crosetto@ki.se
Telephone: +46852485258
Visiting address: Tomtebodavägen 23A (Gamma4), 17165 Solna
Postal address: C1 Mikrobiologi, tumör- och cellbiologi, C1 SciLife Bienko, 171 77 Stockholm
About me
- I graduated in Medicine at the University of Pavia, Italy in 2003 and
specialized in Medical Oncology at the University of Turin, Italy in 2007.
From 2008 until 2010, I worked in Ivan Dikic’s lab at the Goethe University
in Frankfurt, Germany and in 2011 I obtained a PhD in Bioengineering and
Bioinformatics at the University of Pavia, Italy. From 2011 until 2014 I was
a postdoc in Alexander van Oudenaarden’s lab at MIT, where I worked on
developing novel single-molecule microscopy methods. Since 2015, I have been
leading my own research group at Karolinska Institutet, with a major focus on
developing microscopy- and sequencing-based methods to investigate genome
fragility and genome organization in healthy and pathological cell states.
Since 2022 I also lead the Genomic Technologies Development Unit in the
Genomics Research Centre at Human Technopole in Milan, Italy.
Over the years, I have developed numerous molecular methods, including the
first method for genome-wide mapping of DNA double-strand breaks (BLESS, /Nat
Meth/ 2013) and its downstream improvements (BLISS, /Nat Commun/ 2017;
sBLISS, /Nat Prot/ 2020), as well as a variety of sequencing- (CUTseq, /Nat
Commun/ 2019; GPSeq, /Nat Biotechnol/ 2020; COVseq, /Nat Commun/ 20221) and
microscopy-based methods (HD-FISH, /Nat Meth/ 2013; FuseFISH, /Cell Rep/
2014; RollFISH, /Comm Bio/ 2018; iFISH, /Nat Commun/ 2019; FRET-FISH, /Nat
Commun/ 2022) for studying various aspects of genome organization and
fragility.
Research
- Our main research interest is in understanding how the nucleus of eukaryotic
cells is spatially organized, and how the three-dimensional (3D) architecture
of the genome influences gene expression regulation and genome integrity.
We are particularly interested in understanding the role of 3D genome
architecture and genome fragility in the context of cancer, aiming at
developing improved diagnostic and patient stratification approaches.
Towards these goals, we combine high-end microscopy methods, next-generation
sequencing techniques, and advanced computational tools, to assess
chromosomal contacts, chromatin modifications, DNA breaks, chromosomal
rearrangements and gene expression levels in cultured cells and
patient-derived tissue samples.
Articles
- Article: CELL DEATH & DISEASE. 2025;16(1):187Sberna S; Filipuzzi M; Bianchi N; Croci O; Fardella F; Soriani C; Rohban S; Carnevali S; Albertini AA; Crosetto N; Rodighiero S; Chiesa A; Curti L; Campaner S
- Article: CURRENT OPINION IN CELL BIOLOGY. 2024;90:102409Pedrotti S; Castiglioni I; Perez-Estrada C; Zhao L; Chen JP; Crosetto N; Bienko M
- Article: NATURE COMMUNICATIONS. 2024;15(1):7100Curti L; Rohban S; Bianchi N; Croci O; Andronache A; Barozzi S; Mattioli M; Ricci F; Pastori E; Sberna S; Bellotti S; Accialini A; Ballarino R; Crosetto N; Wade M; Parazzoli D; Campaner S
- Article: NATURE METHODS. 2024;21(7):1245-1256Wernersson E; Gelali E; Girelli G; Wang S; Castillo D; Langseth CM; Verron Q; Nguyen HQ; Chattoraj S; Martinez Casals A; Blom H; Lundberg E; Nilsson M; Marti-Renom MA; Wu C-T; Crosetto N; Bienko M
- Article: NATURE COMMUNICATIONS. 2024;15(1):3475Zhang N; Harbers L; Simonetti M; Diekmann C; Verron Q; Berrino E; Bellomo SE; Longo GMC; Ratz M; Schultz N; Tarish F; Su P; Han B; Wang W; Onorato S; Grassini D; Ballarino R; Giordano S; Yang Q; Sapino A; Frisen J; Alkass K; Druid H; Roukos V; Helleday T; Marchio C; Bienko M; Crosetto N
- Journal article: NATURE COMMUNICATIONS. 2024;15(1):3390Chen JP; Diekmann C; Wu H; Chen C; Della Chiara G; Berrino E; Georgiadis KL; Bouwman BAM; Virdi M; Harbers L; Bellomo SE; Marchio C; Bienko M; Crosetto N
- Article: NATURE COMMUNICATIONS. 2024;15(1):1768Chen JP; Diekmann C; Wu H; Chen C; Della Chiara G; Berrino E; Georgiadis KL; Bouwman BAM; Virdi M; Harbers L; Bellomo SE; Marchio C; Bienko M; Crosetto N
- Journal article: MOLECULAR CELL. 2024;84(1):12-13Georgiades E; Crosetto N; Bienko M
- Article: SCIENCE ADVANCES. 2023;9(45):eadi2095Chatzinikolaou G; Stratigi K; Siametis A; Goulielmaki E; Akalestou-Clocher A; Tsamardinos I; Topalis P; Austin C; Bouwman BAM; Crosetto N; Altmueller J; Garinis GA
- Article: BIOLOGY OPEN. 2023;12(10):bio060113Mastropasqua F; Oksanen M; Soldini C; Alatar S; Arora A; Ballarino R; Molinari M; Agostini F; Poulet A; Watts M; Rabkina I; Becker M; Li D; Anderlid B-M; Isaksson J; Remnelius KL; Moslem M; Jacob Y; Falk A; Crosetto N; Bienko M; Santini E; Borgkvist A; Bo''lte S; Tammimies K
- Journal article: NATURE METHODS. 2023;20(5):641-642Jimenez C; Crosetto N
- Article: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2023;78:102020Bouwman BAM; Crosetto N; Bienko M
- Article: JTO CLINICAL AND RESEARCH REPORTS. 2022;3(12):100435Nicos M; Harbers L; Patrucco E; Kramer-Drauberg M; Zhang X; Voena C; Kowalczyk A; Bozyk A; Peksa R; Jarosz B; Szumilo J; Simonetti M; Zuk M; Wasag B; Reszka K; Duchnowska R; Milanowski J; Chiarle R; Bienko M; Krawczyk P; Jassem J; Ambrogio C; Crosetto N
- Article: NATURE COMMUNICATIONS. 2022;13(1):6680Mota A; Berezicki S; Wernersson E; Harbers L; Li-Wang X; Gradin K; Peuckert C; Crosetto N; Bienko M
- Article: BMC CANCER. 2022;22(1):1001Raczkowski L; Pasnik I; Kukielka M; Nicos M; Budzinska MA; Kucharczyk T; Szumilo J; Krawczyk P; Crosetto N; Szczurek E
- Article: GENOME MEDICINE. 2022;14(1):98Berrino E; Annaratone L; Bellomo SE; Ferrero G; Gagliardi A; Bragoni A; Grassini D; Guarrera S; Parlato C; Casorzo L; Panero M; Sarotto I; Giordano S; Cereda M; Montemurro F; Ponzone R; Crosetto N; Naccarati A; Sapino A; Marchio C
- Article: SCIENTIFIC DATA. 2022;9(1):400Ballarino R; Bouwman BAM; Agostini F; Harbers L; Diekmann C; Wernersson E; Bienko M; Crosetto N
- Article: SCIENTIFIC DATA. 2022;9(1):47Mota A; Schweitzer M; Wernersson E; Crosetto N; Bienko M
- Article: CURRENT OPINION IN CELL BIOLOGY. 2022;74:7-12Bouwman BAM; Crosetto N; Bienko M
- Article: MOLECULAR CELL. 2021;81(24):5007-5024.e9Wiegard A; Kuzin V; Cameron DP; Grosser J; Ceribelli M; Mehmood R; Ballarino R; Valant F; Grochowski R; Karabogdan I; Crosetto N; Lindqvist A; Bizard AH; Kouzine F; Natsume T; Baranello L
- Article: MOLECULAR CELL. 2021;81(23):4907-4923.e8Zampetidis CP; Galanos P; Angelopoulou A; Zhu Y; Polyzou A; Karamitros T; Kotsinas A; Lagopati N; Mourkioti I; Mirzazadeh R; Polyzos A; Garnerone S; Mizi A; Gusmao EG; Sofiadis K; Gal Z; Larsen DH; Pefani D-E; Demaria M; Tsirigos A; Crosetto N; Maya-Mendoza A; Papaspyropoulos A; Evangelou K; Bartek J; Papantonis A; Gorgoulis VG
- Article: NPJ BREAST CANCER. 2021;7(1):144Zerdes I; Simonetti M; Matikas A; Harbers L; Acs B; Boyaci C; Zhang N; Salgkamis D; Agartz S; Moreno-Ruiz P; Bai Y; Rimm DL; Hartman J; Mezheyeuski A; Bergh J; Crosetto N; Foukakis T
- Article: FRONTIERS IN ONCOLOGY. 2021;11:700568Harbers L; Agostini F; Nicos M; Poddighe D; Bienko M; Crosetto N
- Article: NATURE COMMUNICATIONS. 2021;12(1):3903Simonetti M; Zhang N; Harbers L; Milia MG; Brossa S; Nguyen TTH; Cerutti F; Berrino E; Sapino A; Bienko M; Sottile A; Ghisetti V; Crosetto N
- Article: VACCINES. 2021;9(3):235Merlano MC; Abbona A; Paccagnella M; Falletta A; Granetto C; Ricci V; Fea E; Denaro N; Ruatta F; Merlotti A; Bertetto O; Crosetto N; Galizia D; Basirico M; Gammaitoni L; Sangiolo D; Aglietta M; Garrone O
- Article: METHODS IN MOLECULAR BIOLOGY. 2021;2162:261-281Ballarino R; Bouwman BAM; Crosetto N
- Article: NATURE PROTOCOLS. 2020;15(12):3894-3941Bouwman BAM; Agostini F; Garnerone S; Petrosino G; Gothe HJ; Sayols S; Moor AE; Itzkovitz S; Bienko M; Roukos V; Crosetto N
- Article: ESMO OPEN. 2020;5(5):e000876Garrone O; Michelotti A; Paccagnella M; Montemurro F; Vandone AM; Abbona A; Geuna E; Vanella P; De Angelis C; Lo Nigro C; Falletta A; Crosetto N; Di Maio M; Merlano M
- Journal article: TUMORI JOURNAL. 2020;106(5):427-431Garrone O; Denaro N; Ruatta F; Vanella P; Granetto C; Vandone AM; Occelli M; Cauchi C; Ricci V; Fea E; Di Costanzo G; Colantonio I; Crosetto N; Merlano MC
- Article: NATURE BIOTECHNOLOGY. 2020;38(10):1184-1193Girelli G; Custodio J; Kallas T; Agostini F; Wernersson E; Spanjaard B; Mota A; Kolbeinsdottir S; Gelali E; Crosetto N; Bienko M
- Article: NATURE MEDICINE. 2020;26(7):1063-1069Dziubanska-Kusibab PJ; Berger H; Battistini F; Bouwman BAM; Iftekhar A; Katainen R; Cajuso T; Crosetto N; Orozco M; Aaltonen LA; Meyer TF
- Article: NATURE COMMUNICATIONS. 2019;10(1):4732Zhang X; Garnerone S; Simonetti M; Harbers L; Nicos M; Mirzazadeh R; Venesio T; Sapino A; Hartman J; Marchio C; Bienko M; Crosetto N
- Article: CELL REPORTS. 2019;29(3):560-572.e4Hazan I; Monin J; Bouwman BAM; Crosetto N; Aqeilan RI
- Article: MOLECULAR CELL. 2019;75(2):267-283.e12Gothe HJ; Bouwman BAM; Gusmao EG; Piccinno R; Petrosino G; Sayols S; Drechsel O; Minneker V; Josipovic N; Mizi A; Nielsen CF; Wagner E-M; Takeda S; Sasanuma H; Hudson DF; Kindler T; Baranello L; Papantonis A; Crosetto N; Roukos V
- Article: NATURE GENETICS. 2019;51(6):1011-1023Dellino GI; Palluzzi F; Chiariello AM; Piccioni R; Bianco S; Furia L; De Conti G; Bouwman BAM; Melloni G; Guido D; Giaco L; Luzi L; Cittaro D; Faretta M; Nicodemi M; Crosetto N; Pelicci PG
- Article: NATURE COMMUNICATIONS. 2019;10(1):1636Gelali E; Girelli G; Matsumoto M; Wernersson E; Custodio J; Mota A; Schweitzer M; Ferenc K; Li X; Mirzazadeh R; Agostini F; Schell JP; Lanner F; Crosetto N; Bienko M
- Article: GENOME BIOLOGY. 2019;20(1):28Ballinger TJ; Bouwman BAM; Mirzazadeh R; Garnerone S; Crosetto N; Semple CA
- Article: CELL. 2018;173(4):879-893.e13Kim C; Gao R; Sei E; Brandt R; Hartman J; Hatschek T; Crosetto N; Foukakis T; Navin NE
- Article: COMMUNICATIONS BIOLOGY. 2018;1:209Wu C; Simonetti M; Rossell C; Mignardi M; Mirzazadeh R; Annaratone L; Marchio C; Sapino A; Bienko M; Crosetto N; Nilsson M
- Article: COMMUNICATIONS BIOLOGY. 2018;1:181Biernacka A; Zhu Y; Skrzypczak M; Forey R; Pardo B; Grzelak M; Nde J; Mitra A; Kudlicki A; Crosetto N; Pasero P; Rowicka M; Ginaiski K
- Article: METHODS IN MOLECULAR BIOLOGY. 2018;1766:303-333Gelali E; Custodio J; Girelli G; Wernersson E; Crosetto N; Bienko M
- Article: METHODS IN MOLECULAR BIOLOGY. 2018;1672:167-194Mirzazadeh R; Kallas T; Bienko M; Crosetto N
- Article: NATURE COMMUNICATIONS. 2017;8(1):374Asim M; Tarish F; Zecchini HI; Sanjiv K; Gelali E; Massie CE; Baridi A; Warren AY; Zhao W; Ogris C; McDuffus L-A; Mascalchi P; Shaw G; Dev H; Wadhwa K; Wijnhoven P; Forment JV; Lyons SR; Lynch AG; O'Neill C; Zecchini VR; Rennie PS; Baniahmad A; Tavare S; Mills IG; Galanty Y; Crosetto N; Schultz N; Neal D; Helleday T
- Article: NATURE COMMUNICATIONS. 2017;8(1):228Gao R; Kim C; Sei E; Foukakis T; Crosetto N; Chan L-K; Srinivasan M; Zhang H; Meric-Bernstam F; Navin N
- Article: NATURE BIOTECHNOLOGY. 2017;35(8):789-792Gao L; Cox DBT; Yan WX; Manteiga JC; Schneider MW; Yamano T; Nishimasu H; Nureki O; Crosetto N; Zhang F
- Article: NATURE COMMUNICATIONS. 2017;8:15656Iannelli F; Galbiati A; Capozzo I; Nguyen Q; Magnuson B; Michelini F; D'Alessandro G; Cabrini M; Roncador M; Francia S; Crosetto N; Ljungman M; Carninci P; di Fagagna FD
- Article: NATURE COMMUNICATIONS. 2017;8:15058Yan WX; Mirzazadeh R; Garnerone S; Scott D; Schneider MW; Kallas T; Custodio J; Wernersson E; Li Y; Gao L; Federova Y; Zetsche B; Zhang F; Bienko M; Crosetto N
- Article: BLOOD. 2017;129(18):2479-2492Shi W; Vu T; Boucher D; Biernacka A; Nde J; Pandita RK; Straube J; Boyle GM; Al-Ejeh F; Nag P; Jeffery J; Harris JL; Bain AL; Grzelak M; Skrzypczak M; Mitra A; Dojer N; Crosetto N; Cloonan N; Becherel OJ; Finnie J; Skaar JR; Walkley CR; Pandita TK; Rowicka M; Ginalski K; Lane SW; Khanna KK
- Article: ONCOTARGET. 2017;8(12):18680-18698Annaratone L; Simonetti M; Wernersson E; Marchio C; Garnerone S; Scalzo MS; Bienko M; Chiarle R; Sapino A; Crosetto N
- Article: NATURE BIOTECHNOLOGY. 2016;34(8):852-856Mooijman D; Dey SS; Boisset J-C; Crosetto N; van Oudenaarden A
- Article: NATURE MEDICINE. 2016;22(3):270-277Ambrogio C; Gomez-Lopez G; Falcone M; Vidal A; Nadal E; Crosetto N; Blasco RB; Fernandez-Marcos PJ; Sanchez-Cespedes M; Ren X; Wang Z; Ding K; Hidalgo M; Serrano M; Villanueva A; Santamaria D; Barbacid M
- Article: BLOOD CANCER JOURNAL. 2014;4(10):e249Barreca A; Martinengo C; Annaratone L; Righi L; Chiappella A; Ladetto M; Demurtas A; Chiusa L; Stacchini A; Crosetto N; van Oudenaarden A; Chiarle R
- Article: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2014;8(5):396-406Ceccarelli G; Benedetti L; Galli D; Prè D; Silvani G; Crosetto N; Magenes G; Cusella De Angelis MG
- Article: CELL REPORTS. 2014;6(1):18-23Semrau S; Crosetto N; Bienko M; Boni M; Bernasconi P; Chiarle R; van Oudenaarden A
- Article: NATURE METHODS. 2013;10(4):361-365Crosetto N; Mitra A; Silva MJ; Bienko M; Dojer N; Wang Q; Karaca E; Chiarle R; Skrzypczak M; Ginalski K; Pasero P; Rowicka M; Dikic I
- Article: NATURE METHODS. 2013;10(2):122-124Bienko M; Crosetto N; Teytelman L; Klemm S; Itzkovitz S; van Oudenaarden A
- Article: ONCOGENE. 2012;31(43):4599-4608Pareja F; Ferraro DA; Rubin C; Cohen-Dvashi H; Zhang F; Aulmann S; Ben-Chetrit N; Pines G; Navon R; Crosetto N; Köstler W; Carvalho S; Lavi S; Schmitt F; Dikic I; Yakhini Z; Sinn P; Mills GB; Yarden Y
- Article: CARDIOVASCULAR TOXICOLOGY. 2012;12(2):135-142Garrone O; Crosetto N; Lo Nigro C; Catzeddu T; Vivenza D; Monteverde M; Merlano M; Feola M
- Article: JOURNAL OF PROTEOME RESEARCH. 2011;10(5):2140-2153Pfeiffer MJ; Siatkowski M; Paudel Y; Balbach ST; Baeumer N; Crosetto N; Drexler HCA; Fuellen G; Boiani M
- Article: ANNALS OF ONCOLOGY. 2011;22(3):712-717Merlano M; Russi E; Benasso M; Corvò R; Colantonio I; Vigna-Taglianti R; Vigo V; Bacigalupo A; Numico G; Crosetto N; Gasco M; Lo Nigro C; Vitiello R; Violante S; Garrone O
- Article: CELL. 2010;143(5):677-681Ikeda F; Crosetto N; Dikic I
- Article: MOLECULAR CELL. 2010;37(3):396-407Bienko M; Green CM; Sabbioneda S; Crosetto N; Matic I; Hibbert RG; Begovic T; Niimi A; Mann M; Lehmann AR; Dikic I
- Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2010;54(11-12):1649-1657Pfeiffer MJ; Balbach ST; Esteves TC; Crosetto N; Boiani M
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(50):35173-35185Crosetto N; Bienko M; Hibbert RG; Perica T; Ambrogio C; Kensche T; Hofmann K; Sixma TK; Dikic I
- Journal article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2008;52(7):801-809Adjaye JA; Byskov AG; Cibelli JB; De Maria R; Minger S; Sampaolesi M; Testa G; Verfaillie C; Zernicka-Goetz M; Schöler H; Boiani M; Crosetto N; Redi CA
- Article: BLOOD. 2007;110(3):1004-1012Sargin B; Choudhary C; Crosetto N; Schmidt MHH; Grundler R; Rensinghoff M; Thiessen C; Tickenbrock L; Schwäble J; Brandts C; August B; Koschmieder S; Bandi SR; Duyster J; Berdel WE; Müller-Tidow C; Dikic I; Serve H
- Article: EUROPEAN JOURNAL OF CANCER. 2006;42(18):3095-3102Dikic I; Crosetto N; Calatroni S; Bernasconi P
- Article: NATURE CELL BIOLOGY. 2006;8(2):163-169Hoeller D; Crosetto N; Blagoev B; Raiborg C; Tikkanen R; Wagner S; Kowanetz K; Breitling R; Mann M; Stenmark H; Dikic I
- Article: SCIENCE. 2005;310(5755):1821-1824Bienko M; Green CM; Crosetto N; Rudolf F; Zapart G; Coull B; Kannouche P; Wider G; Peter M; Lehmann AR; Hofmann K; Dikic I
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(31):32786-32795Kowanetz K; Crosetto N; Haglund K; Schmidt M; Heldin C-H; Dikic I
- Article: LEUKEMIA. 2003;17(11):2107-2112Bernasconi P; Cavigliano PM; Boni M; Calatroni S; Klersy C; Giardini I; Rocca B; Crosetto N; Caresana M; Lazzarino M; Bernasconi C
- Article: BRITISH JOURNAL OF HAEMATOLOGY. 2002;118(2):545-549Bernasconi P; Cavigliano PM; Boni M; Astori C; Calatroni S; Giardini I; Rocca B; Caresana M; Crosetto N; Lazzarino M; Bernasconi C
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All other publications
- Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2023;11:1303862Della Chiara G; Jimenez C; Virdi M; Crosetto N; Bienko M
- Review: TRENDS IN GENETICS. 2022;38(10):1062-1075Bouwman BAM; Crosetto N; Bienko M
- Review: FRONTIERS IN ONCOLOGY. 2020;10:569202Nicos M; Krawczyk P; Crosetto N; Milanowski J
- Review: FRONTIERS IN GENETICS. 2020;11:33Crosetto N; Bienko M
- Review: GENES. 2018;9(12):E632-632Bouwman BAM; Crosetto N
- Corrigendum: METHODS IN MOLECULAR BIOLOGY. 2018;1766:E1Gelali E; Custodio J; Girelli G; Wernersson E; Crosetto N; Bienko M
- Review: NATURE REVIEWS GENETICS. 2015;16(1):57-66Crosetto N; Bienko M; van Oudenaarden A
- Other: EUROPEAN JOURNAL OF HISTOCHEMISTRY. 2008;52(1):79-81Boiani M; Crosetto N; Redi CA
- Review: MOLECULAR CANCER RESEARCH. 2006;4(12):899-904Crosetto N; Bienko M; Dikic I
- Review: FEBS LETTERS. 2005;579(15):3231-3238Crosetto N; Tikkanen R; Dikic I