Nanna Theresia Fyhrquist

Nanna Theresia Fyhrquist

Principal Researcher
Telephone: +46852487034
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 Systemtoxikologi Alenius, 171 77 Stockholm
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About me

  • Group leader and researcher at the Institute of Environmental Medicine,
    Karolinska Institutet.
    I am a biologist, who graduated with a major in animal physiology and
    neurosciences. Later on my focus has shifted to the immune system, epithelial
    barrier biology and the role of host-microbe interplay in the tuning of host
    immune responses to external exposures and mechanisms underlying immune
    tolerance and susceptibility to chronic inflammatory disease.
    MSc 1997 University of Helsinki
    PhD 1999 University of Helsinki
    Docent 2015 University of Helsinki

Research

  • My research team explores the impact of modern lifestyle on immune tolerance
    and the risk of developing chronic inflammatory disease, such as allergies.
    I lead a project which identifies biomarkers to discriminate between irritant
    and allergic contact dermatitis for the purpose of developing improved
    diagnostics.

Teaching

  • I am yearly involved in teaching basic immunology, immune toxicology,
    bacteriology and epithelial barrier biology at Karolinska Institutet and at
    the University of Helsinki.

Articles

All other publications

  • Dataset: KI DATA REPOSITORY. 2025
    Bergström A; Pershagen G; Fyhrquist N; Dühr H
  • Preprint: MEDRXIV. 2025
    Watts K; Hübenthal M; Szymczak S; Cherry H; Xing H; Federico A; Lopata O; Acencio M; Hofner M; Lessard S; Battram T; Teder-Laving M; Thomas L; Ytterberg K; Krishna A; Brumpton B; Hartmann J; Ramessur R; Saklatvala J; Watkins S; Ouwerkerk W; Hup MM; Chatelain C; De Rinaldis E; Kettunen J; Huilaja L; Khader S; Liu Z; Zhang B; Klinger K; Tasanen K; Hveem K; FinnGen EBRT; Dai C; Buyx A; Fritzsche M-C; Langan S; Langreder N; Eyerich S; Van den Bogaard E; Hoof I; Lovato P; Page K; Macdonald-Dunlop E; Bosma AL-A; Roth L; Bruno S; Kolbinger F; Kingo K; Schmitt J; Werfel T; Jacobsson B; Solé-Navais P; Løset M; Hicks A; Satagopam V; Min J; Dand N; Weidinger S; Greco D; Vierlinger K; Ostaszewski M; Fyhrquist N; Bowcutt R; Ghosh S; Rastrick J; Brown SJ; Smith C; Paternoster L
  • Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2025;156(1):24-40.e4
    Fyhrquist N; Yang Y; Karisola P; Alenius H
  • Preprint: MEDRXIV. 2025
    Duehr H; Paernaenen K; Kucharikova N; Werner P; Pershagen G; Lahti L; Alenius H; Bergstroem A; Ruuskanen M; Fyhrquist N
  • Letter: BRITISH JOURNAL OF DERMATOLOGY. 2025;192(5):931-933
    Sinkko H; Olah P; Yang Y; Maia G; Barrientos-Somarribas M; Radai Z; Maenpaa K; Soratto T; Salava A; Lauerma A; Barker J; Ranki A; Homey B; Andersson B; Fyhrquist N; Alenius H; MAARS Consortium J
  • Book chapter: THE SKIN MICROBIOME MANUAL. 2025;p. 155-161
    Fyhrquist N; Lauerma A
  • Book chapter: THE SKIN MICROBIOME MANUAL. 2025;p. 173-182
    Salava A; Fyhrquist N
  • Letter: OPEN RESEARCH EUROPE. 2024;4:194
    Hakomäki H; Pitkänen S; Levonen A-L; Honkakoski P; Greco D; D'Alessandro N; Saarimäki LA; Viegas S; Godinho C; Fyhrquist N; Wincent E; Lauschke VM; Hukkanen J; Hakkola J; Vallier L; Fortino V; Afantitis A; Sawatani T; Guzman TJ; Cnop M; Nawrot T; Harlid S; Vinnars M-T; Tardon A; Grimalt JO; Küblbeck J; Rysä J
  • Preprint: BIORXIV. 2023
    Braun G; Schaier M; Werner P; Theiner S; Zanghellini J; Wisgrill L; Fyhrquist N; Koellensperger G
  • Preprint: RESEARCH SQUARE. 2023
    Federico A; Möbus L; Al-Abdulraheem Z; Pavel A; Fortino V; Giudice GD; Alenius H; Fyhrquist N; Greco D
  • Review: ALLERGY. 2023;78(5):1169-1203
    Bousquet J; Melen E; Haahtela T; Koppelman GH; Togias A; Valenta R; Akdis CA; Czarlewski W; Rothenberg M; Valiulis A; Wickman M; Akdis M; Aguilar D; Bedbrook A; Bindslev-Jensen C; Bosnic-Anticevich S; Boulet LP; Brightling CE; Brussino L; Burte E; Bustamante M; Canonica GW; Cecchi L; Celedon JC; Chaves Loureiro C; Costa E; Cruz AA; Erhola M; Gemicioglu B; Fokkens WJ; Garcia-Aymerich J; Guerra S; Heinrich J; Ivancevich JC; Keil T; Klimek L; Kuna P; Kupczyk M; Kvedariene V; Larenas-Linnemann DE; Lemonnier N; Carlsen KCL; Louis R; Makela M; Makris M; Maurer M; Momas I; Morais-Almeida M; Mullol J; Naclerio RN; Nadeau K; Nadif R; Niedoszytko M; Okamoto Y; Ollert M; Papadopoulos NG; Passalacqua G; Patella V; Pawankar R; Pham-Thi N; Pfaar O; Regateiro FS; Ring J; Rouadi PW; Samolinski B; Sastre J; Savoure M; Scichilone N; Shamji MH; Sheikh A; Siroux V; Sousa-Pinto B; Standl M; Sunyer J; Taborda-Barata L; Toppila-Salmi S; Torres MJ; Tsiligianni I; Valovirta E; Vandenplas O; Ventura MT; Weiss S; Yorgancioglu A; Zhang L; Latiff AHA; Aberer W; Agache I; Al-Ahmad M; Alobid I; Ansotegui IJ; Arshad SH; Asayag E; Barbara C; Baharudin A; Battur L; Bennoor KS; Berghea EC; Bergmann KC; Bernstein D; Bewick M; Blain H; Bonini M; Braido F; Buhl R; Bumbacea RS; Bush A; Calderon M; Calvo-Gil M; Camargos P; Caraballo L; Cardona V; Carr W; Carreiro-Martins P; Casale T; Cepeda Sarabia AM; Chandrasekharan R; Charpin D; Chen YZ; Cherrez-Ojeda I; Chivato T; Chkhartishvili E; Christoff G; Chu DK; Cingi C; Correia de Sousa J; Corrigan C; Custovic A; D'Amato G; Del Giacco S; De Blay F; Devillier P; Didier A; do Ceu Teixeira M; Dokic D; Douagui H; Doulaptsi M; Durham S; Dykewicz M; Eiwegger T; El-Sayed ZA; Emuzyte R; Fiocchi A; Fyhrquist N; Gomez RM; Gotua M; Guzman MA; Hagemann J; Hamamah S; Halken S; Halpin DMG; Hofmann M; Hossny E; Hrubisko M; Irani C; Ispayeva Z; Jares E; Jartti T; Jassem E; Julge K; Just J; Jutel M; Kaidashev I; Kalayci O; Kalyoncu AF; Kardas P; Kirenga B; Kraxner H; Kull I; Kulus M; La Grutta S; Lau S; Thi LLT; Levin M; Lipworth B; Lourenco O; Mahboub B; Martinez-Infante E; Matricardi P; Miculinic N; Migueres N; Mihaltan F; Mohammad Y; Moniuszko M; Montefort S; Neffen H; Nekam K; Nunes E; Tshipukane DN; O'Hehir R; Ogulur I; Ohta K; Okubo K; Ouedraogo S; Olze H; Pali-Schoell I; Palomares O; Palosuo K; Panaitescu C; Panzner P; Park HS; Pitsios C; Plavec D; Popov TA; Puggioni F; Quirce S; Recto M; Repka-Ramirez MS; Robalo Cordeiro C; Roche N; Rodriguez-Gonzalez M; Romantowski J; Rosario Filho N; Rottem M; Sagara H; Serpa FS; Sayah Z; Scheire S; Schmid-Grendelmeier P; Sisul JC; Sole D; Soto-Martinez M; Sova M; Sperl A; Spranger O; Stelmach R; Ulrik CS; Thomas M; To T; Todo-Bom A; Tomazic PV; Urrutia-Pereira M; Valentin-Rostan M; Van Ganse E; van Hage M; Vasankari T; Vichyanond P; Viegi G; Wallace D; Wang DY; Williams S; Worm M; Yiallouros P; Yusuf O; Zaitoun F; Zernotti M; Zidarn M; Zuberbier J; Fonseca JA; Zuberbier T; Anto JM
  • Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(5):S178
    Olah P; Radai Z; Smits JP; Gomez-Casado C; Consortium EM; Sinkko H; Fyhrquist N; Andersson B; Alenius H; Homey B
  • Review: FRONTIERS IN ALLERGY. 2023;4:1152927
    Haahtela T; Alenius H; Auvinen P; Fyhrquist N; von Hertzen L; Jousilahti P; Karisola P; Laatikainen T; Lehtimaki J; Paalanen L; Ruokolainen L; Saarinen K; Valovirta E; Vasankari T; Vlasoff T; Erhola M; Bousquet J; Vartiainen E; Makela MJJ
  • Conference publication: 2023
    Fortino V; Wisgrill L; Werner P; Suomela S; Linder N; Lauerma A; Aalto-Korte K; Greco D; Fyhrquist N
  • Editorial: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(3 PT A):509-512
    Lauerma A; Werner P; Wisgrill L; Fyhrquist N
  • Conference publication: ACTA DERMATO-VENEREOLOGICA. 2022;102:16
    Fyhrquist N
  • Book chapter: ARTIFICIAL INTELLIGENCE IN MEDICINE. 2022;p. 1411-1423
    Wisgrill L; Werner P; Fortino V; Fyhrquist N
  • Review: ALLERGY. 2021;76(12):3613-3626
    Haahtela T; Alenius H; Lehtimaki J; Sinkkonen A; Fyhrquist N; Hyoty H; Ruokolainen L; Makela MJ
  • Review: EXPERIMENTAL DERMATOLOGY. 2021;30(10):1517-1531
    Alenius H; Sinkko H; Moitinho-Silva L; Rodriguez E; Broderick C; Alexander H; Reiger M; Hjelmso MH; Fyhrquist N; Olah P; Bryce P; Smith C; Koning F; Eyerich K; Greco D; van den Bogaard EH; Neumann AU; Traidl-Hoffmann C; Homey B; Flohr C; Bonnelykke K; Stokholm J; Weidinger S
  • Letter: ALLERGY. 2021;76(4):1280-1284
    Riskumaki M; Tessas I; Ottman N; Suomalainen A; Werner P; Karisola P; Lauerma A; Ruokolainen L; Karkman A; Wisgrill L; Sinkko H; Lehtimaki J; Alenius H; Fyhrquist N
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Grants

  • 1 January 2024 - 31 December 2028
  • European Commission
    1 January 2024 - 31 December 2028
    Endocrine-disrupting chemicals (EDCs) disturb lipid and glucose metabolism in several metabolically active organs such as liver and pancreas besides being able to interfere with many aspects of hormonal action. There is accumulating evidence linking EDCs or their mixtures with an increased incidence of obesity, atherosclerosis, and type 2 diabetes. Developmental exposure to EDCs can exert life-long, even transgenerational effects and affects the susceptibility to many diseases. However, the metabolic effects of EDCs are still poorly understood and the lack of mechanistic data and predictive models of adverse metabolic outcomes of EDCs hinders their risk assessment. The “Novel Effect biomarkers for MEtabolic disruptorS: evidence on health Impacts to science and policy needS” (NEMESIS) consortium brings together experts in toxicology, medicine, risk assessment, and social sciences and humanities to respond to the unmet regulatory needs of EDCs within silico, in vitro, in vivo, epidemiological and systems biology data on EDC-mediated metabolic effects in multifactorial models. We will assess mechanistic data on metabolic disruption in liver and pancreas and how EDCs or their mixtures affect the microbiota, enhanced with data on dose-response relationships and the causality of these actions. In addition, NEMESIS will provide human exposure data of EDCs and explore effect biomarkers for metabolic disruption. NEMESIS’ results will improve assessment of metabolic endpoints in testing guidelines and adopt alternative models to animal testing. Adverse Outcome Pathways (AOP)s and Integrated Approaches to Testing and Assessment (IATA) approaches will be developed to assess adverse metabolic effects of EDCs and improve the risk assessment towards a more holistic approach. Citizens are engaged from the beginning of the project to develop effective risk communication practices on EDCs and to maximize the science-to-policy impact of NEMESIS together with relevant stakeholders.
  • Swedish Research Council
    1 January 2021 - 31 December 2024
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2019 - 31 December 2022
  • Swedish Research Council
    1 January 2018 - 31 December 2020
  • Regulatory mechanisms in a murine model of T-cell mediated skin
    Research Council of Finland
    8 January 2005 - 31 December 2008
  • Regulatory mechanisms in a murine model of T-cell mediated skin
    Research Council of Finland
    8 January 2005 - 31 December 2008

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