Nanna Fyhrquist

About me
Publications
Grants
Public outreach and news

About me

Group leader and researcher at the Institute of Environmental Medicine,
Karolinska Institutet.
I am a biologist, who graduated with a major in animal physiology and
neurosciences. Later on my focus has shifted to the immune system, epithelial
barrier biology and the role of host-microbe interplay in the tuning of host
immune responses to external exposures and mechanisms underlying immune
tolerance and susceptibility to chronic inflammatory disease.
MSc 1997 University of Helsinki
PhD 1999 University of Helsinki
Docent 2015 University of Helsinki

Research

My research team explores the impact of modern lifestyle on immune tolerance
and the risk of developing chronic inflammatory disease, such as allergies.
I lead a project which identifies biomarkers to discriminate between irritant
and allergic contact dermatitis for the purpose of developing improved
diagnostics.

Teaching

I am yearly involved in teaching basic immunology, immune toxicology,
bacteriology and epithelial barrier biology at Karolinska Institutet and at
the University of Helsinki.

Articles

Journal article: OPEN RESEARCH EUROPE. 2024;4:194
Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies
Hakomäki H; Pitkänen S; Levonen A-L; Honkakoski P; Greco D; Saarimäki LA; Viegas S; Godinho C; Fyhrquist N; Wincent E; Lauschke VM; Hukkanen J; Hakkola J; Vallier L; Fortino V; Afantitis A; Sawatani T; Guzman TJ; Cnop M; Nawrot T; Harlid S; Vinnars M-T; Tardon A; Grimalt JO; Küblbeck J; Rysä J
Article: EBIOMEDICINE. 2024;105:105222
Exploratory multi-omics analysis reveals host-microbe interactions associated with disease severity in psoriatic skin
Yang Y; Olah P; Radai Z; Maia G; Salava A; Salo V; Barker J; Lauerma A; Andersson B; Homey B; Fyhrquist N; Alenius H
Journal article: JACS AU. 2024;4(6):2197-2210
MeXpose-A Modular Imaging Pipeline for the Quantitative Assessment of Cellular Metal Bioaccumulation
Braun G; Schaier M; Werner P; Theiner S; Zanghellini J; Wisgrill L; Fyhrquist N; Koellensperger G
Journal article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;:3062-3081
Network analysis reveals age- and virus-specific circuits in nasal epithelial cells of extremely premature infants
Wisgrill L; Martens A; Kasbauer R; Eigenschink M; Pummer L; Redlberger-Fritz M; Vegvari A; Warth B; Berger A; Fyhrquist N; Alenius H
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2024;22(1):64
Integrative network analysis suggests prioritised drugs for atopic dermatitis
Federico A; Mobus L; Al-Abdulraheem Z; Pavel A; Fortino V; del Giudice G; Alenius H; Fyhrquist N; Greco D
Journal article: CURRENT OPINION IN TOXICOLOGY. 2023;35:100420
Host-microbiome interactions in atopic and allergic diseases
Fyhrquist N; Werner P; Alenius H
Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(5):s178
1038 Host transcriptomes that define microbiota during cutaneous homeostasis and inflammation
Olah P; Radai Z; Smits JP; Gomez-Casado C; Consortium EM; Sinkko H; Fyhrquist N; Andersson B; Alenius H; Homey B
Article: BRITISH JOURNAL OF DERMATOLOGY. 2023;188(2):278-287
Cobalt nanoparticles cause allergic contact dermatitis in humans
Midander K; Werner P; Isaksson M; Wisgrill L; Liden C; Fyhrquist N; Julander A
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2022;52(8):929-941
Bet v 1 triggers antiviral-type immune signalling in birch-pollen-allergic individuals
Wisgrill L; Fyhrquist N; Ndika J; Paalanen L; Berger A; Laatikainen T; Karisola P; Haahtela T; Alenius H
Article: JOURNAL OF DERMATOLOGICAL SCIENCE. 2022;106(3):132-140
Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation
Olah P; Szlavicz E; Kuchner M; Nemmer J; Zeeuwen P; Lefevre-Utile A; Fyhrquist N; Prast-Nielsen S; Skoog T; Serra A; Rodriguez E; Raap U; Meller S; Gyulai R; Hupe P; Kere J; Levi-Schaffer F; Tsoka S; Alexander H; Nestle FO; Schroeder JM; Weidinger S; van den Bogaard E; Soumelis V; Greco D; Barker J; Lauerma A; Ranki A; Andersson B; Alenius H; Homey B
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;77(5):1486-1498
Transcriptome-based identification of novel endotypes in adult atopic dermatitis
Lefevre-Utile A; Saichi M; Olah P; Delord M; Homey B; Soumelis V
Article: FRONTIERS IN ALLERGY. 2022;3:878862
Epigenetic Differences in Long Non-coding RNA Expression in Finnish and Russian Karelia Teenagers With Contrasting Risk of Allergy and Asthma
Ndika J; Karisola P; Lahti V; Fyhrquist N; Laatikainen T; Haahtela T; Alenius H
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: IN PRACTICE. 2021;9(5):1892-1901.e1
A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy: Efficacy and Humoral Immune Responses in 50 Children
Palosuo K; Karisola P; Savinko T; Fyhrquist N; Alenius H; Makela MJ
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;76(4):1173-1187
Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites
Ottman N; Barrientos-Somarribas M; Fyhrquist N; Alexander H; Wisgrill L; Olah P; Tsoka S; Greco D; Levi-Schaffer F; Soumelis V; Schroeder JM; Kere J; Nestle FO; Barker J; Ranki A; Lauerma A; Homey B; Andersson B; Alenius H
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;76(3):804-815
Integrative transcriptome analysis deciphers mechanisms of nickel contact dermatitis
Wisgrill L; Werner P; Jalonen E; Berger A; Lauerma A; Alenius H; Fyhrquist N
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(3):1031-1040
Shared DNA methylation signatures in childhood allergy: The MeDALL study
Xu C-J; Gruzieva O; Qi C; Esplugues A; Gehring U; Bergstroem A; Mason D; Chatzi L; Porta D; Carlsen KCL; Baiz N; Madore A-M; Alenius H; van Rijkom B; Jankipersadsing SA; van der Vlies P; Kull I; van Hage M; Bustamante M; Lertxundi A; Torrent M; Santorelli G; Fantini MP; Hovland V; Pesce G; Fyhrquist N; Laatikainen T; Nawijn MC; Li Y; Wijmenga C; Netea MG; Bousquet J; Anto JM; Laprise C; Haahtela T; Annesi-Maesano I; Carlsen K-H; Gori D; Kogevinas M; Wright J; Soederhaell C; Vonk JM; Sunyer J; Melen E; Koppelman GH
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:704633
Integrative Transcriptomics Reveals Activation of Innate Immune Responses and Inhibition of Inflammation During Oral Immunotherapy for Egg Allergy in Children
Karisola P; Palosuo K; Hinkkanen V; Wisgrill L; Savinko T; Fyhrquist N; Alenius H; Makela MJ
Article: JOURNAL OF IMMUNOTOXICOLOGY. 2021;18(1):74-84
Impact of mono-culture vs. Co-culture of keratinocytes and monocytes on cytokine responses induced by important skin sensitizers
Karri V; Liden C; Fyhrquist N; Hogberg J; Karlsson HL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(52):33474-33485
Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis
Fortino V; Wisgrill L; Werner P; Suomela S; Linder N; Jalonen E; Suomalainen A; Marwah V; Kero M; Pesonen M; Lundin J; Lauerma A; Aalto-Korte K; Greco D; Alenius H; Fyhrquist N
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2020;50(10):1148-1158
Immune-microbiota interaction in Finnish and Russian Karelia young people with high and low allergy prevalence
Ruokolainen L; Fyhrquist N; Laatikainen T; Auvinen P; Fortino V; Scala G; Jousilahti P; Karisola P; Vendelin J; Karkman A; Markelova O; Makela MJ; Lehtimaki S; Ndika J; Ottman N; Paalanen L; Paulin L; Vartiainen E; von Hertzen L; Greco D; Haahtela T; Alenius H
Article: ALLERGOLOGIE. 2020;43(4):153-163
The roadmap for the Allergology specialty and allergy care in Europe and adjacent countries. An EAACI position paper
Fyhrquist N; Werfel T; Bilo MB; Muelleneisen N; van Wijk RG
Article: SCIENTIFIC REPORTS. 2019;9(1):20069
An optimized, robust and reproducible protocol to generate well-differentiated primary nasal epithelial models from extremely premature infants
Martens A; Amann G; Schmidt K; Gaupmann R; Boehm B; Dehlink E; Szepfalusi Z; Foerster-Waldl E; Berger A; Fyhrquist N; Alenius H; Wisgrill L
Article: NATURE COMMUNICATIONS. 2019;10(1):4703
Microbe-host interplay in atopic dermatitis and psoriasis
Fyhrquist N; Muirhead G; Prast-Nielsen S; Jeanmougin M; Olah P; Skoog T; Jules-Clement G; Feld M; Barrientos-Somarribas M; Sinkko H; van den Bogaard EH; Zeeuwen PLJM; Rikken G; Schalkwijk J; Niehues H; Daeubener W; Eller SK; Alexander H; Pennino D; Suomela S; Tessas I; Lybeck E; Baran AM; Darban H; Gangwar RS; Gerstel U; Jahn K; Karisola P; Yan L; Hansmann B; Katayama S; Meller S; Bylesjo M; Hupe P; Levi-Schaffer F; Greco D; Ranki A; Schroeder JM; Barker J; Kere J; Tsoka S; Lauerma A; Soumelis V; Nestle FO; Homeyl B; Andersson B; Alenius H
Article: GASTROENTEROLOGY CLINICS OF NORTH AMERICA. 2019;48(3):377-387
The Human Microbiota and Its Relationship with Allergies
Fyhrquist N
Article: CLINICAL INFECTIOUS DISEASES. 2019;68(11):1904-1910
Cutavirus DNA in Malignant and Nonmalignant Skin of Cutaneous T-Cell Lymphoma and Organ Transplant Patients but Not of Healthy Adults
Vaisanen E; Fu Y; Koskenmies S; Fyhrquist N; Wang Y; Keinonen A; Makisalo H; Vakeva L; Pitkanen S; Ranki A; Hedman K; Soederlund-Venermo M
Article: TRANSPLANT INTERNATIONAL. 2019;32(5):516-522
Occurrence of newly discovered human polyomaviruses in skin of liver transplant recipients and their relation with squamous cell carcinoma in situ and actinic keratosis - a single-center cohort study
Wang Y; Keinonen A; Koskenmies S; Pitkanen S; Fyhrquist N; Sadeghi M; Makisalo H; Soderlund-Venermo M; Hedman K
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(3):1198-1206.e12
Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model
Ottman N; Ruokolainen L; Suomalainen A; Sinkko H; Karisola P; Lehtimaki J; Lehto M; Hanski I; Alenius H; Fyhrquist N
Article: THE LANCET RESPIRATORY MEDICINE. 2018;6(5):379-388
DNA methylation in childhood asthma: an epigenome-wide meta-analysis
Xu C-J; Soderhall C; Bustamante M; Baiz N; Gruzieva O; Gehring U; Mason D; Chatzi L; Basterrechea M; Llop S; Torrent M; Forastiere F; Fantini MP; Carlsen KCL; Haahtela T; Morin A; Kerkhof M; Merid SK; van Rijkom B; Jankipersadsing SA; Bonder MJ; Ballereau S; Vermeulen CJ; Aguirre-Gamboa R; de Jongste JC; Smit HA; Kumar A; Pershagen G; Guerra S; Garcia-Aymerich J; Greco D; Reinius L; McEachan RRC; Azad R; Hovland V; Mowinckel P; Alenius H; Fyhrquist N; Lemonnier N; Pellet J; Auffray C; van der Vlies P; van Diemen CC; Li Y; Wijmenga C; Netea MG; Moffatt MF; Cookson WOCM; Anto JM; Bousquet J; Laatikainen T; Laprise C; Carlsen K-H; Gori D; Porta D; Iniguez C; Bilbao JR; Kogevinas M; Wright J; Brunekreef B; Kere J; Nawijn MC; Annesi-Maesano I; Sunyer J; Melen E; Koppelman GH
Article: EXPERIMENTAL DERMATOLOGY. 2018;27(1):30-36
Isotretinoin and lymecycline treatments modify the skin microbiota in acne
Kelhala H-L; Aho VTE; Fyhrquist N; Pereira PAB; Kubin ME; Paulin L; Palatsi R; Auvinen P; Tasanen K; Lauerma A
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(5):1288-1298
Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis
Ndika J; Airaksinen L; Suojalehto H; Karisola P; Fyhrquist N; Puustinen A; Alenius H
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2017;47(5):665-674
Significant disparities in allergy prevalence and microbiota between the young people in Finnish and Russian Karelia
Ruokolainen L; Paalanen L; Karkman A; Laatikainen T; von Hertzen L; Vlasoff T; Markelova O; Masyuk V; Auvinen P; Paulin L; Alenius H; Fyhrquist N; Hanski I; Makela MJ; Zilber E; Jousilahti P; Vartiainen E; Haahtela T
Article: ANNALES ZOOLOGICI FENNICI. 2017;54(1-4):39-49
Holistic view on health: two protective layers of biodiversity
Ruokolainen L; Lehtimaki J; Karkman A; Haahtela T; von Hertzen L; Fyhrquist N
Article: JOURNAL OF INNATE IMMUNITY. 2017;9(1):65-82
Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation
Nurmi K; Kareinen I; Virkanen J; Rajamaki K; Kouri V-P; Vaali K; Levonen A-L; Fyhrquist N; Matikainen S; Kovanen PT; Eklund KK
Article: EXPERIMENTAL DERMATOLOGY. 2016;25(6):477-478
Isotretinoin treatment reduces acne lesions but not directly lesional acne inflammation
Kelhala H-L; Fyhrquist N; Palatsi R; Lehtimaki S; Ayrynen JPV; Kubin ME; Kallioinen M; Alenius H; Tasanen K; Lauerma A
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2015;45(5):891-901
Hunt for the origin of allergy - comparing the Finnish and Russian Karelia
Haahtela T; Laatikainen T; Alenius H; Auvinen P; Fyhrquist N; Hanski I; von Hertzen L; Jousilahti P; Kosunen TU; Markelova O; Makela MJ; Pantelejev V; Uhanov M; Zilber E; Vartiainen E
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;70(2):195-202
Green areas around homes reduce atopic sensitization in children
Ruokolainen L; von Hertzen L; Fyhrquist N; Laatikainen T; Lehtomaki J; Auvinen P; Karvonen AM; Hyvarinen A; Tillmann V; Niemela O; Knip M; Haahtela T; Pekkanen J; Hanski I
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;134(6):1301-1309.e11
Acinetobacter species in the skin microbiota protect against allergic sensitization and inflammation
Fyhrquist N; Ruokolainen L; Suomalainen A; Lehtimaki S; Veckman V; Vendelin J; Karisola P; Lehto M; Savinko T; Jarva H; Kosunen TU; Corander J; Auvinen P; Paulin L; von Hertzen L; Laatikainen T; Makela M; Haahtela T; Greco D; Hanski I; Alenius H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(12):2928-2937
Complex 2B4 Regulation of Mast Cells and Eosinophils in Murine Allergic Inflammation
Elishmereni M; Fyhrquist N; Gangwar RS; Lehtimaki S; Alenius H; Levi-Schaffer F
Article: IMMUNITY, INFLAMMATION AND DISEASE. 2014;2(3):162-165
Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice.
Mayer CT; Lahl K; Milanez-Almeida P; Watts D; Dittmer U; Fyhrquist N; Huehn J; Kopf M; Kretschmer K; Rouse B; Sparwasser T
Article: PLOS ONE. 2014;9(9):e107801
A Robust and Accurate Method for Feature Selection and Prioritization from Multi-Class OMICs Data
Fortino V; Kinaret P; Fyhrquist N; Alenius H; Greco D
Article: PLOS ONE. 2014;9(8):e105238
IL-17/Th17 Pathway Is Activated in Acne Lesions
Kelhala H-L; Palatsi R; Fyhrquist N; Lehtimaki S; Vayrynen JP; Kallioinen M; Kubin ME; Greco D; Tasanen K; Alenius H; Bertino B; Carlavan I; Mehul B; Deret S; Reiniche P; Martel P; Marty C; Blume-Peytavi U; Voegel JJ; Lauerma A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2013;133(4):964-972
Toll-Like Receptor Activation during Cutaneous Allergen Sensitization Blocks Development of Asthma through IFN-Gamma-Dependent Mechanisms
Haapakoski R; Karisola P; Fyhrquist N; Savinko T; Lehtimaki S; Wolff H; Lauerma A; Alenius H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(12):2744-2751
The Temporal and Spatial Dynamics of Foxp3+Treg Cell-Mediated Suppression during Contact Hypersensitivity Responses in a Murine Model
Lehtimaki S; Savinko T; Lahl K; Sparwasser T; Wolff H; Lauerma A; Alenius H; Fyhrquist N
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(6):1672-1680
Foxp3+ Cells Control Th2 Responses in a Murine Model of Atopic Dermatitis
Fyhrquist N; Lehtimaki S; Lahl K; Savinko T; Lappetelainen A-M; Sparwasser T; Wolff H; Lauerma A; Alenius H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(21):8334-8339
Environmental biodiversity, human microbiota, and allergy are interrelated
Hanski I; von Hertzen L; Fyhrquist N; Koskinen K; Torppa K; Laatikainen T; Karisola P; Auvinen P; Paulin L; Makela MJ; Vartiainen E; Kosunen TU; Alenius H; Haahtela T
Article: PLOS ONE. 2012;7(8):e41038
CD8+T Cell Migration to the Skin Requires CD4+Help in a Murine Model of Contact Hypersensitivity
Fyhrquist N; Wolff H; Lauerma A; Alenius H
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2011;44(5):639-647
Intradermal Cytosine-Phosphate-Guanosine Treatment Reduces Lung Inflammation but Induces IFN-γ-Mediated Airway Hyperreactivity in a Murine Model of Natural Rubber Latex Allergy
Haapakoski R; Karisola P; Fyhrquist N; Savinko T; Wolff H; Turjanmaa K; Palosuo T; Reunala T; Lauerma A; Alenius H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010;130(12):2743-2751
Absence of CCR4 Exacerbates Skin Inflammation in an Oxazolone-Induced Contact Hypersensitivity Model
Lehtimaki S; Tillander S; Puustinen A; Matikainen S; Nyman T; Fyhrquist N; Savinko T; Majuri M-L; Wolff H; Alenius H; Lauerma A
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(3):581-9.e1-20-U306
MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4
Sonkoly E; Janson P; Majuri M-L; Savinko T; Fyhrquist N; Eidsmo L; Xu N; Meisgen F; Wei T; Bradley M; Stenvang J; Kauppinen S; Alenius H; Lauerma A; Homey B; Winqvist O; Stahle M; Pivarcsi A
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010;151(2):155-167
Smad3 Regulates Dermal Cytokine and Chemokine Expression and Specific Antibody Production in Murine Responses to a Respiratory Chemical Sensitizer
Anthoni M; Fyhrquist N; Lehtimaki S; Alenius H; Wolff H; Lauerma A
Article: BRITISH JOURNAL OF DERMATOLOGY. 2008;159(3):546-554
Transforming growth factor-β/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity
Anthoni M; Fyhrquist-Vanni N; Wolff H; Alenius H; Lauerma A
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2008;147(1):41-51
Immunostimulatory sequence CpG elicits Th1-type immune responses in inflammatory skin lesions in an atopic dermatitis murine model
Wang G; Fyhrquist-Vanni N; Wolff H; Dieu-Nosjean M-C; Kemeny L; Homey B; Lauerma AI; Alenius H
Article: DERMATOLOGIC CLINICS. 2007;25(4):613-x
Contact dermatitis
Fyhrquist-Vanni N; Alenius H; Lauerma A
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2006;173(5):512-518
Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice
Leino MS; Alenius HT; Fyhrquist-Vanni N; Wolff HJ; Reijula KE; Hintikka EL; Salkinoja-Salonen MS; Haahtela T; Mäkelä MJ
Article: JOURNAL OF IMMUNOLOGY. 2005;175(12):8320-8326
Topical superantigen exposure induces epidermal accumulation of CD8⁺ T cells, a mixed Th1/Th2-type dermatitis and vigorous production of IgE antibodies in the murine model of atopic dermatitis
Savinko T; Lauerma A; Lehtimäki S; Gombert M; Majuri ML; Fyhrquist-Vanni N; Dieu-Nosjean MC; Kemeny L; Wolff H; Homey B; Alenius H
Article: JOURNAL OF COMPARATIVE PHYSIOLOGY A: NEUROETHOLOGY, SENSORY, NEURAL, AND BEHAVIORAL PHYSIOLOGY. 2005;191(9):837-844
The photoactivation energy of the visual pigment in two spectrally different populations of Mysis relicta (Crustacea, Mysida)
Pahlberg J; Lindström M; Ala-Laurila P; Fyhrquist-Vanni N; Koskelainen A; Donner K
Article: JOURNAL OF EXPERIMENTAL BIOLOGY. 2003;206(15):2611-2617
Polymorphism of the rod visual pigment between allopatric populations of the sand goby (Pomatoschistus minutus):: a microspectrophotometric study
Jokela M; Vartio A; Paulin L; Fyhrquist-Vanni N; Donner K
Article: VISUAL NEUROSCIENCE. 2000;17(4):509-528
In search of the visual pigment template
Govardovskii VI; Fyhrquist N; Reuter T; Kuzmin DG; Donner K
Article: NATURE. 2000;403(6766):220-223
Measurement of thermal contribution to photoreceptor sensitivity
Koskelainen A; Ala-Laurila P; Fyhrquist N; Donner K
Article: EXPERIMENTAL EYE RESEARCH. 1998;66(3):295-305
Rhodopsins from three frog and toad species: Sequences and functional comparisons
Fyhrquist N; Donner K; Hargrave PA; McDowell JH; Popp MP; Smith WC
Article: VISION RESEARCH. 1998;38(4):483-486
Rod pigment and rod noise in the European toad Bufo bufo
Fyhrquist N; Govardovskii V; Leibrock C; Reuter T
Journal article: PERCEPTION. 1997;26(1_suppl):149
Rhodopsins with Similar Absorbance Characteristics but Different Rates of Thermal Activation: Amino Acid Sequences
Fyhrquist N; Donner K; Hargrave PA; McDowell JH; Popp MP; Smith WC
Article: VISION RESEARCH. 1996;36(20):3253-3264
The effect of background luminance on visual responses to strong flashes: Perceived brightness and the early rise of photoreceptor responses
Djupsund K; Fyhrquist N; Hariyama T; Donner K
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All other publications

Preprint: BIORXIV. 2023
MeXpose - A modular imaging pipeline for the quantitative assessment of cellular metal bioaccumulation
Braun G; Schaier M; Werner P; Theiner S; Zanghellini J; Wisgrill L; Fyhrquist N; Koellensperger G
Preprint: RESEARCH SQUARE. 2023
Integrative network analysis suggests prioritised drugs for atopic dermatitis
Federico A; Möbus L; Al-Abdulraheem Z; Pavel A; Fortino V; Giudice GD; Alenius H; Fyhrquist N; Greco D
Review: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;78(5):1169-1203
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis
Bousquet J; Melen E; Haahtela T; Koppelman GH; Togias A; Valenta R; Akdis CA; Czarlewski W; Rothenberg M; Valiulis A; Wickman M; Akdis M; Aguilar D; Bedbrook A; Bindslev-Jensen C; Bosnic-Anticevich S; Boulet LP; Brightling CE; Brussino L; Burte E; Bustamante M; Canonica GW; Cecchi L; Celedon JC; Chaves Loureiro C; Costa E; Cruz AA; Erhola M; Gemicioglu B; Fokkens WJ; Garcia-Aymerich J; Guerra S; Heinrich J; Ivancevich JC; Keil T; Klimek L; Kuna P; Kupczyk M; Kvedariene V; Larenas-Linnemann DE; Lemonnier N; Lodrup Carlsen KC; Louis R; Makela M; Makris M; Maurer M; Momas I; Morais-Almeida M; Mullol J; Naclerio RN; Nadeau K; Nadif R; Niedoszytko M; Okamoto Y; Ollert M; Papadopoulos NG; Passalacqua G; Patella V; Pawankar R; Pham-Thi N; Pfaar O; Regateiro FS; Ring J; Rouadi PW; Samolinski B; Sastre J; Savoure M; Scichilone N; Shamji MH; Sheikh A; Siroux V; Sousa-Pinto B; Standl M; Sunyer J; Taborda-Barata L; Toppila-Salmi S; Torres MJ; Tsiligianni I; Valovirta E; Vandenplas O; Ventura MT; Weiss S; Yorgancioglu A; Zhang L; Abdul Latiff AH; Aberer W; Agache I; Al-Ahmad M; Alobid I; Ansotegui IJ; Arshad SH; Asayag E; Barbara C; Baharudin A; Battur L; Bennoor KS; Berghea EC; Bergmann KC; Bernstein D; Bewick M; Blain H; Bonini M; Braido F; Buhl R; Bumbacea RS; Bush A; Calderon M; Calvo-Gil M; Camargos P; Caraballo L; Cardona V; Carr W; Carreiro-Martins P; Casale T; Cepeda Sarabia AM; Chandrasekharan R; Charpin D; Chen YZ; Cherrez-Ojeda I; Chivato T; Chkhartishvili E; Christoff G; Chu DK; Cingi C; Correia de Sousa J; Corrigan C; Custovic A; D'Amato G; Del Giacco S; De Blay F; Devillier P; Didier A; do Ceu Teixeira M; Dokic D; Douagui H; Doulaptsi M; Durham S; Dykewicz M; Eiwegger T; El-Sayed ZA; Emuzyte R; Fiocchi A; Fyhrquist N; Gomez RM; Gotua M; Guzman MA; Hagemann J; Hamamah S; Halken S; Halpin DMG; Hofmann M; Hossny E; Hrubisko M; Irani C; Ispayeva Z; Jares E; Jartti T; Jassem E; Julge K; Just J; Jutel M; Kaidashev I; Kalayci O; Kalyoncu AF; Kardas P; Kirenga B; Kraxner H; Kull I; Kulus M; La Grutta S; Lau S; Le Tuyet Thi L; Levin M; Lipworth B; Lourenco O; Mahboub B; Martinez-Infante E; Matricardi P; Miculinic N; Migueres N; Mihaltan F; Mohammad Y; Moniuszko M; Montefort S; Neffen H; Nekam K; Nunes E; Nyembue Tshipukane D; O'Hehir R; Ogulur I; Ohta K; Okubo K; Ouedraogo S; Olze H; Pali-Schoell I; Palomares O; Palosuo K; Panaitescu C; Panzner P; Park HS; Pitsios C; Plavec D; Popov TA; Puggioni F; Quirce S; Recto M; Repka-Ramirez MS; Robalo Cordeiro C; Roche N; Rodriguez-Gonzalez M; Romantowski J; Rosario Filho N; Rottem M; Sagara H; Serpa FS; Sayah Z; Scheire S; Schmid-Grendelmeier P; Sisul JC; Sole D; Soto-Martinez M; Sova M; Sperl A; Spranger O; Stelmach R; Suppli Ulrik C; Thomas M; To T; Todo-Bom A; Tomazic PV; Urrutia-Pereira M; Valentin-Rostan M; Van Ganse E; van Hage M; Vasankari T; Vichyanond P; Viegi G; Wallace D; Wang DY; Williams S; Worm M; Yiallouros P; Yusuf O; Zaitoun F; Zernotti M; Zidarn M; Zuberbier J; Fonseca JA; Zuberbier T; Anto JM
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(5):S178
Host transcriptomes that define microbiota during cutaneous homeostasis and inflammation
Olah P; Radai Z; Smits JP; Gomez-Casado C; Consortium EM; Sinkko H; Fyhrquist N; Andersson B; Alenius H; Homey B
Conference publication: 2023
Machine-Learning-Driven Biomarker Discovery for the Discrimination between Allergic and Irritant Contact Dermatitis
Fortino V; Wisgrill L; Werner P; Suomela S; Linder N; Lauerma A; Aalto-Korte K; Greco D; Fyhrquist N
Review: FRONTIERS IN ALLERGY. 2023;4:1152927
A short history from Karelia study to biodiversity and public health interventions
Haahtela T; Alenius H; Auvinen P; Fyhrquist N; von Hertzen L; Jousilahti P; Karisola P; Laatikainen T; Lehtimaki J; Paalanen L; Ruokolainen L; Saarinen K; Valovirta E; Vasankari T; Vlasoff T; Erhola M; Bousquet J; Vartiainen E; Makela MJJ
Editorial comment: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(3 PT A):509-512
New Key Players in Irritant Contact Dermatitis: Residential Skin Cells and Neutrophils Drive Inflammation
Lauerma A; Werner P; Wisgrill L; Fyhrquist N
Conference publication: ACTA DERMATO-VENEREOLOGICA. 2022;102:16
INTERACTIVITY BETWEEN COMPONENTS OF THE MICROBIOME IN PSORIASIS AND ATOPIC ECZEMA
Fyhrquist N
Book chapter: ARTIFICIAL INTELLIGENCE IN MEDICINE. 2022;p. 1411-1423
AIM in Allergy
Wisgrill L; Werner P; Fortino V; Fyhrquist N
Review: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;76(12):3613-3626
Immunological resilience and biodiversity for prevention of allergic diseases and asthma
Haahtela T; Alenius H; Lehtimaki J; Sinkkonen A; Fyhrquist N; Hyoty H; Ruokolainen L; Makela MJ
Review: EXPERIMENTAL DERMATOLOGY. 2021;30(10):1517-1531
The power and potential of BIOMAP to elucidate host-microbiome interplay in skin inflammatory diseases
Alenius H; Sinkko H; Moitinho-Silva L; Rodriguez E; Broderick C; Alexander H; Reiger M; Hjelmso MH; Fyhrquist N; Olah P; Bryce P; Smith C; Koning F; Eyerich K; Greco D; van den Bogaard EH; Neumann AU; Traidl-Hoffmann C; Homey B; Flohr C; Bonnelykke K; Stokholm J; Weidinger S
Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;76(4):1280-1284
Interplay between skin microbiota and immunity in atopic individuals
Riskumaki M; Tessas I; Ottman N; Suomalainen A; Werner P; Karisola P; Lauerma A; Ruokolainen L; Karkman A; Wisgrill L; Sinkko H; Lehtimaki J; Alenius H; Fyhrquist N
Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;76(4):1257-1261
Identification of novel miRNA-mRNA regulatory networks in contact dermatitis by integrated microarray analysis
Werner P; Wisgrill L; Riskumaki M; Jalonen E; Vendelin J; Suomela S; Lauerma A; Alenius H; Fyhrquist N
Preprint: AUTHOREA. 2021
Immunological resilience and biodiversity for prevention
Haahtela T; Alenius H; Lehtimäki J; Sinkkonen A; Fyhrquist N; Hyoty H; Ruokolainen L; Makela M
Book chapter: ARTIFICIAL INTELLIGENCE IN MEDICINE. 2021;p. 1-13
AIM in Allergy
Wisgrill L; Werner P; Fortino V; Fyhrquist N
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(4):1139-1140
The role of soil exposure in asthma prevention during neonatal period Reply
Ottman N; Fyhrquist N
Meeting abstract: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(9):S257
Influence of filaggrin loss-of-function mutations in hostemicrobe interactions during atopic skin inflammation
Olah P; Szlavicz E; Consortium E; Rodriguez E; Weidinger S; Fyhrquist N; Alenius H; Lauerma A; Andersson B; Homey B
Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;74(7):1377-1380
CD300a expression is modulated in atopic dermatitis and could influence the inflammatory response
Karra L; Gangwar RS; Puzzovio PG; Fyhrquist N; Minai-Fleminger Y; Landolina N; Simon H-U; Alenius H; Leibovici V; Simon D; Levi-Schaffer F
Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;74(3):617-621
Tape-stripping alters the microbe-host correlations in mouse skin
Karisola P; Suomalainen A; Fortino V; Ottman N; Vendelin J; Wolff HJ; Ruokolainen L; Greco D; Fyhrquist N; Alenius H
Review: CLINICAL AND TRANSLATIONAL ALLERGY. 2019;9:3
The roadmap for the Allergology specialty and allergy care in Europe and adjacent countries. An EAACI position paper
Fyhrquist N; Werfel T; Bilo MB; Muelleneisen N; van Wijk RG
Conference publication: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;73:834
Key genes distinguishing irritant and allergic contact dermatitis from other types of dermatitis
Fortino V; Suomela S; Suomalainen A; Marwah V; Lehto E; Vendelin J; Lauerma A; Pesonen M; Aalto-Korte K; Greco D; Alenius H; Fyhrquist N
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(2):ab238
CD300a: A New Player in Atopic Dermatitis?
Karra L; Gangwar RS; Levi T; Minai-Fleminger Y; Fyhrquist N; Leibovic V; Simon D; Levi-Schaffer F
Conference publication: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;72:497
The living environment shapes intestinal microbial communities and immune responses in a mouse model
Ottman N; Ruokolainen L; Suomalainen A; Karisola P; Lehtimaki J; Lehto M; Hanski I; Alenius H; Fyhrquist N
Review: CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY. 2016;16(5):421-426
The rich and the poor: environmental biodiversity protecting from allergy
Ruokolainen L; Fyhrquist N; Haahtela T
Meeting abstract: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(9):s232
Isotretinoin and lymecycline treatments modify the skin microbiota in acne
Kelhala H; Aho V; Fyhrquist N; Pereira P; Kubin M; Paulin L; Palatsi R; Auvinen P; Tasanen K; Lauerma A
Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2016;16(5):40
Skin Biomes
Fyhrquist N; Salava A; Auvinen P; Lauerma A
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;83(5):380-381
Microbe-host interplay in atopic dermatitis and psoriasis
Fyhrquist N; Andersson B; Kere J; Muirhead G; Prast-Nielsen S; Jeanmougin M; Barker J; Lauerma A; Homey B; Schroeder J; Soumelis V; Nestle F; Alenius H
Review: CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY. 2014;14(5):430-435
New findings in allergic contact dermatitis
Fyhrquist N; Lehto E; Lauerma A
Conference publication: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;67:139-140
The temporal and spatial dynamics of Treg cell-mediated suppression during contact hypersensitivity responses in a murine model
Fyhrquist N; Lehtimaki S; Savinko T; Lahl K; Sparwasser T; Wolff H; Lauerma A; Alenius H
Editorial comment: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010;130(2):342-344
MK2 Signaling: Lessons on Tissue Specificity in Modulation of Inflammation
Fyhrquist N; Matikainen S; Lauerma A
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010;130:S3
MiR-155 is overexpressed in atopic dermatitis and modulates T cell proliferative responses by targeting CTLA-4
Sonkoly E; Janson P; Majuri M-L; Savinko T; Fyhrquist N; Eidsmo L; Xu N; Meisgen F; Wei T; Bradley M; Stenvang J; Kauppinen S; Alenius H; Lauerma A; Homey B; Winqvist O; Stahle M; Pivarcsi A
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010;130:S34
CD8+T cell migration to hapten exposed skin sites requires CD4+help in a murine model
Fyhrquist N; Wolff H; Lauerma A; Alenius H
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(1):s3
Cutaneous CpG administration reduces Th2-type airway inflammation but induces airway hyperreactivity
Haapakoski R; Fyhrquist-Vanni N; Savinko T; Wolff H; Turjanmaa K; Palosuo T; Reunala T; Lauerma A; Alenius H
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(1):S284
The role of STAT6 in the murine model of atopic dermatitis
Alenius H; Savinko T; Lehtimaki S; Fyhrquist-Vanni N; Wolff H; Lauerma A
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;117(2):s245
The role of T cells in a murine model of contact hypersensitivity
Fyhrquist-Vanni N; Lauerma A; Alenius H
Conference publication: PERCEPTION. 1997;26:14-15
Rhodopsins with similar absorbance characteristics but different rates of thermal activation: amino acid sequences
Fyhrquist N; Donner K; Hargrave PA; McDowell JH; Popp MP; Smith WC
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Grants

Interaction between living environment, human microbiome and immune system related to allergy
Swedish Research Council
1 January 2021 - 31 December 2024
Toward improved diagnostics of allergic and irritant contact dermatitis
Swedish Research Council for Health Working Life and Welfare
1 January 2019 - 31 December 2021
Impact of the living environment and the human microbiota on immune homeostasis and immune dysregulation leading to allergy: Karelia Allergy Study
Swedish Research Council
1 January 2018 - 31 December 2020
Regulatory mechanisms in a murine model of T-cell mediated skin
Academy of Finland
8 January 2005 - 31 December 2008
Regulatory mechanisms in a murine model of T-cell mediated skin
Academy of Finland
8 January 2005 - 31 December 2008

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