Mohammad Alzrigat

Publications
Public outreach and news

Articles

Article: MOLECULAR PHARMACEUTICS. 2025;22(6):3479-3490
Engineered Peptide Coacervates Enable Efficient Intracellular Delivery of the MYC Inhibitor omoMYC
Cerrato CP; Krkoska M; Sun Y; Liano-Pons J; Neo QY; Vosselman T; Alzrigat M; Vojtesek B; Lane DP; Henriksson MA; Miserez A; Landreh M
Article: CELL DEATH & DISEASE. 2024;15(11):836
EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial sarcoma
Mushtaq M; Liano-Pons J; Wang J; Alzrigat M; Yuan Y; Ruiz-Perez MV; Chen Y; Kashuba E; de Flon FH; Brodin B; Arsenian-Henriksson M
Article: CANCERS. 2023;15(18):4599
Target Genes of c-MYC and MYCN with Prognostic Power in Neuroblastoma Exhibit Different Expressions during Sympathoadrenal Development
Yuan Y; Alzrigat M; Rodriguez-Garcia A; Wang X; Bexelius TS; Johnsen JI; Arsenian-Henriksson M; Liano-Pons J; Bedoya-Reina OC
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(9):8141
MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma
Agarwal P; Glowacka A; Mahmoud L; Bazzar W; Larsson L-G; Alzrigat M
Article: NATURE COMMUNICATIONS. 2022;13(1):5093
HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection
Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(3):182-201
MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickstrom M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(2):110-130
MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
Masso-Valles D; Beaulieu M-E; Jauset T; Giuntini F; Zacarias-Fluck MF; Foradada L; Martinez-Martin S; Serrano E; Martin-Fernandez G; Casacuberta-Serra S; Cano VC; Kaur J; Lopez-Estevez S; Morcillo MA; Alzrigat M; Mahmoud L; Luque-Garcia A; Escorihuela M; Guzman M; Arribas J; Serra V; Larsson L-G; Whitfield JR; Soucek L
Article: CELL CYCLE. 2021;20(1):23-38
Pharmacological inactivation of CDK2 inhibits MYC/BCL-XL-driven leukemia in vivo through induction of cellular senescence
Bazzar W; Bocci M; Hejll E; Hogqvist Tabor V; Hydbring P; Grandien A; Alzrigat M; Larsson L-G
Article: METHODS IN MOLECULAR BIOLOGY. 2021;2318:241-254
Methods to Study Myc-Regulated Cellular Senescence: An Update.
Zhang F; Bazzar W; Alzrigat M; Larsson L-G
Article: EPIGENOMES. 2018;2(3):16
Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity
Alzrigat M; Jernberg-Wiklund H; Licht JD
Article: ONCOTARGET. 2017;8(61):103731-103743
The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains
Alzrigat M; Parraga AA; Majumder MM; Ma A; Jin J; Osterborg A; Nahi H; Nilsson K; Heckman CA; Oberg F; Kalushkova A; Jernberg-Wiklund H
Article: ONCOTARGET. 2017;8(6):10213-10224
EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions
Alzrigat M; Parraga AA; Agarwal P; Zureigat H; Osterborg A; Nahi H; Ma A; Jin J; Nilsson K; Oberg F; Kalushkova A; Jernberg-Wiklund H
Article: RNA & DISEASE. 2017;4(2):e1529
The miR-125a and miR-320c are potential tumor suppressor microRNAs epigenetically silenced by the polycomb repressive complex 2 in multiple myeloma.
Alzrigat M; Jernberg-Wiklund H
Article: ONCOTARGET. 2016;7(6):6809-6823
Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target
Agarwal P; Alzrigat M; Parraga AA; Enroth S; Singh U; Ungerstedt J; Osterborg A; Brown PJ; Ma A; Jin J; Nilsson K; Oberg F; Kalushkova A; Jernberg-Wiklund H
Article: JOURNAL OF CELL BIOLOGY. 2012;199(1):49-63
PML promotes MHC class II gene expression by stabilizing the class II transactivator
Ulbricht T; Alzrigat M; Horch A; Reuter N; von Mikecz A; Steimle V; Schmitt E; Kraemer OH; Stamminger T; Hemmerich P

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