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About me

Associate Professor of Exp Pathology and senior researcher in Prof. Jiri Bartek group at MBB Dept, Sci Life Lab, Karolinska Institutet in Stockholm.

Cell phone: +46 (0) 709989566

Education

MSc, Biomedicine, 1999, Karolinska Institutet, Stockholm, Sweden

PhD, Oncology-Experimental Oncology, 2004, Karolinska Institutet, Stockholm, Sweden

Docent, Experimental Pathology, 2012, Karolinska Institutet, Stockholm, Sweden

Research description

Our main goal is to understand the regulation of ribosome biogenesis in human cancer cells and how it is different from normal cells. Better knowledge about cellular growth control will help to develop strategies for therapeutic intervention targeting aberrant cancer cell growth.

Publications

DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy
Bennetzen Mv, Kosar M, Bunkenborg J, Payne Mr, Bartkova J, Lindström Ms, et al
Cell cycle (Georgetown, Tex.) 2018;17(17):2146-2163

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
Lindström Ms, Jurada D, Bursac S, Orsolic I, Bartek J, Volarevic S
Oncogene 2018;37(18):2351-2366

Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype
Goudarzi Km, Espinoza Ja, Guo M, Bartek J, Nistér M, Lindström Ms, et al
Cancer research 2018;78(20):5901-5916

Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes
Kostopoulou On, Wilhelmi V, Raiss S, Ananthaseshan S, Lindström Ms, Bartek J, et al
Oncotarget 2017;8(57):96536-96552

Induction of the 5S RNP-Mdm2-p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia
Jaako P, Ugale A, Wahlestedt M, Velasco-hernandez T, Cammenga J, Lindström Ms, et al
Leukemia 2017;31(1):213-221

Role of ribosomal protein mutations in tumor development (Review)
Goudarzi Km, Lindström Ms
International journal of oncology 2016;48(4):1313-24

Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia
Jaako P, Debnath S, Olsson K, Zhang Y, Flygare J, Lindström Ms, et al
Leukemia 2015;29(11):2221-9

NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape
Holmberg Olausson K, Elsir T, Moazemi Goudarzi K, Nistér M, Lindström Ms
Scientific reports 2015;5():16495-

Loss of Nucleolar Histone Chaperone NPM1 Triggers Rearrangement of Heterochromatin and Synergizes with a Deficiency in DNA Methyltransferase DNMT3A to Drive Ribosomal DNA Transcription
Olausson Kh, Nister M, Lindstrom Ms
JOURNAL OF BIOLOGICAL CHEMISTRY 2014;289(50):34601-19

mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels
Goudarzi Km, Nister M, Lindstrom Ms
CANCER BIOLOGY & THERAPY 2014;15(11):1499-514

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53
Kelly Gl, Grabow S, Glaser Sp, Fitzsimmons L, Aubrey Bj, Okamoto T, et al
GENES & DEVELOPMENT 2014;28(1):58-70

Elucidation of motifs in ribosomal protein S9 that mediate its nucleolar localization and binding to NPM1/nucleophosmin
Lindström Ms
PloS one 2012;7(12):e52476-

p53 -Dependent and -Independent Nucleolar Stress Responses
Holmberg Olausson K, Nistér M, Lindström Ms
Cells 2012;1(4):774-98

PDGF and PDGF receptors in glioma
Nazarenko I, Hede Sm, He Xb, Hedren A, Thompson J, Lindstrom Ms, et al
UPSALA JOURNAL OF MEDICAL SCIENCES 2012;117(2):99-112

Transcription factor PROX1: its role in development and cancer
Elsir T, Smits A, Lindström Ms, Nistér M
Cancer metastasis reviews 2012;31(3-4):793-805

Brain Abnormalities and Glioma-Like Lesions in Mice Overexpressing the Long Isoform of PDGF-A in Astrocytic Cells
Nazarenko I, Hedren A, Sjodin H, Orrego A, Andrae J, Afink Gb, et al
PLOS ONE 2011;6(4):e18303-

Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors
Hede Sm, Nazarenko I, Nistér M, Lindström Ms
Journal of oncology 2011;2011():852970-

NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling
Lindström Ms
Biochemistry research international 2011;2011():195209-

PROX1 is a predictor of survival for gliomas WHO grade II
Elsir T, Qu M, Berntsson Sg, Orrego A, Olofsson T, Lindstrom Ms, et al
BRITISH JOURNAL OF CANCER 2011;104(11):1747-54

Uncoupling of the ER alpha regulated morphological phenotype from the cancer stem cell phenotype in human breast cancer cell lines
Gadalla Se, Alexandraki A, Lindstrom Ms, Nister M, Ericsson C
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2011;405(4):581-7

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction
Macias E, Jin Aw, Deisenroth C, Bhat K, Mao H, Lindstrom Ms, et al
CANCER CELL 2010;18(3):231-43

Expression of PROX1 Is a Common Feature of High-Grade Malignant Astrocytic Gliomas
Elsir T, Eriksson A, Orrego A, Lindstrom Ms, Nister M
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 2010;69(2):129-38

PROX1 IS A PREDICTOR OF SURVIVAL FOR ASTROCYTIC GLIOMAS BUT NOT FOR OLIGODENDROGLIOMAS GRADE II
Elsir T, Qu M, Berntsson S, Orrego A, Olofsson T, Lindstrom M, et al
NEURO-ONCOLOGY 2010;:51-51

Silencing of Ribosomal Protein S9 Elicits a Multitude of Cellular Responses Inhibiting the Growth of Cancer Cells Subsequent to p53 Activation
Lindstrom Ms, Nister M
PLOS ONE 2010;5(3):e9578-

Emerging functions of ribosomal proteins in gene-specific transcription and translation
Lindstrom Ms
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2009;379(2):167-70

Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation
Lindstrom Ms, Zhang Yp
JOURNAL OF BIOLOGICAL CHEMISTRY 2008;283(23):15568-76

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation
Lindstrom Ms, Jin Aw, Deisenroth C, Wolf Gw, Zhang Yp
MOLECULAR AND CELLULAR BIOLOGY 2007;27(3):1056-68

Putting a finger on growth surveillance - Insight into MDM2 zinc finger-ribosomal protein interactions
Lindstrom Ms, Deisenroth C, Zhang Yp
CELL CYCLE 2007;6(4):434-7

Targeted inactivation of mdm2 RING finger e3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
Itahana K, Mao H, Jin Aw, Itahana Y, Clegg Hv, Lindstrom Ms, et al
CANCER CELL 2007;12(4):355-66

B23 and ARF - Friends or foes?
Lindstrom Ms, Zhang Yp
CELL BIOCHEMISTRY AND BIOPHYSICS 2006;46(1):79-90

Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability
Enomoto T, Lindstrom Ms, Jin Aw, Ke Hm, Zhang Yp
JOURNAL OF BIOLOGICAL CHEMISTRY 2006;281(27):18463-72

p16(INK4a) and laminin-5 gamma 2 chain expression during the progression of cervical neoplasia
Wang Jl, Andersson S, Li X, Hellstrom Ac, Auer G, Angstrom T, et al
ACTA ONCOLOGICA 2006;45(6):676-84

p16INK4A and p14ARF expression pattern by immunohistochemistry in human papillomavirus-related cervical neoplasia
Wang Jl, Zheng By, Li Xd, Nokelainen K, Angstrom T, Lindstrom Ms, et al
MODERN PATHOLOGY 2005;18(5):629-37

Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer
Wang Jl, Zheng By, Li Xd, Angstrom T, Lindstrom Ms, Wallin Kl
CLINICAL CANCER RESEARCH 2004;10(7):2407-14

Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts
Lindstrom Ms, Wiman Kg
ONCOGENE 2003;22(32):4993-5005

A melanoma-predisposing germline CDKN2A mutation with functional significance for both p16 and p14ARF
Hashemi J, Lindstrom Ms, Asker C, Platz A, Hansson J, Wiman Kg
CANCER LETTERS 2002;180(2):211-21

Role of genetic and epigenetic changes in Burkitt lymphoma
Lindstrom Ms, Wiman Kg
SEMINARS IN CANCER BIOLOGY 2002;12(5):381-7

Inactivation of Myc-induced p53-dependent apoptosis in human tumors
Henriksson M, Selivanova G, Lindstrom M, Wiman Kg
APOPTOSIS 2001;6(1-2):133-7

MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation
Jackson Mw, Lindstrom Ms, Berberich Sj
JOURNAL OF BIOLOGICAL CHEMISTRY 2001;276(27):25336-41

p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53
Lindstrom Ms, Klangby U, Wiman Kg
ONCOGENE 2001;20(17):2171-7

Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus
Lindstrom Ms, Klangby U, Inoue R, Pisa P, Wiman Kg, Asker Ce
EXPERIMENTAL CELL RESEARCH 2000;256(2):400-10

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Science for Life Laboratory
Stockholm