Mikael Sundin

I’m born in Sweden 1981 and graduated from Medical School 2005 (Karolinska Institutet). In 2008, I defended my PhD-thesis “Mesenchymal Stromal Cell Transplantation: Possible Viral Complications and Alloimmunity” (Karolinska Institutet) and in 2016, I was appointed Associate Professor of Pediatrics (Karolinska Institutet).

My clinical training (Internship and Residency) took place at the Karolinska University Hospital and the Astrid Lindgren Children’s Hospital. Currently, I work as Senior Consultant in Pediatric Hematology/Oncology and Medical Officer for the Immunodeficiency (incl. SCID newborn screening) and the HCT programs at the Section for Pediatric Hematology/Immunology/Hematopoietic Cell Transplantation (HCT) at Astrid Lindgren Children’s Hospital, Karolinska University Hospital. Between 2013 – 2020, I served as Head of Section.

I’m Research Group Leader (PI) at the Division of Pediatrics, CLINTEC, Karolinska Institutet – see below. My research interest covers immune recovery post-HCT and diagnostics (incl. whole genome sequencing) of bone marrow failure and immunodeficiency.

We are working with clinical research within pediatric hematology, immunology and hematopoietic cell transplantation (HCT, aka bone marrow transplantation) with the aim to expand the knowledge and to contribute to better diagnostics and treatments. We take on our research questions by clinical, epidemiologic and experimental methods. Our main research areas are:

• Allogeneic HCT – immune recovery and complications in the short and long term
• Diagnostics of hematologic conditions and bone marrow failure disorders
• Rare hematologic cancer in children – e.g., myelodysplastic syndrome (MDS), myeloproliferative disorders (MPD) and chronic myeloid leukemia (CML).
• Diagnostics and clinical care in inborn errors of immunity

Coworkers (alphabetic order):

Petra Byström, MD, Senior Consultant in Pediatric Hematology/Oncology and PhD student
The project ”Routine analyses and modern methods in pediatric hematologic diagnostics” is about evaluating basic and modern analyses, i.e., everything from full blood counts to whole genome sequencing, in the diagnostics of hematologic conditions and after HCT.
Petra's page – https://ki.se/en/people/petra-bystrom 

Henric Lindqvist, MD, Consultant in Hematology and PhD student
The project “Myeloid cell function and importance in pediatric allogeneic HCT” is about studying granulocyte recovery, numeric and functional, after allogeneic HCT and its possible dysfunction in relation to other immune function.
Henrics page – https://ki.se/en/people/henric-lindqvist

Lotta Pramanik-Jonsson, MD, PhD, Resident in Pediatrics and Postdoc
The project ”Early and late complications in relation to the conditioning regimen in pediatric allogeneic HCT” is about studying complications to HCT in relation to etoposide pharmacogenetics and the occurrence of acute (subclinical) brain injury.
Lottas page – https://ki.se/en/people/lotta-pramanikjonsson 

Magnus Wallner (ex Hansson), MD, Consultant in Family Medicine and PhD student
The project “Vitamin D and iron status in pediatric allogeneic HCT: importance for GvHD, immune recovery and immunity” is about studying the impact of micronutrients on the immune system in the context of allogeneic HCT.

Christofer Äng, MD, Resident in Pediatrics and PhD student
The project "From severe combined immunodeficiency to impact of low lymphopoietic output at newborn screening – a Swedish nationwide perspective" is about studying clinical aspects of severe combined immunodeficiency (SCID) and the impact of newborn lymphocyte function (output) for future health and family wellbeing.
Christofer's page – https://ki.se/en/people/christofer-ang