Mikael Altun

Mikael Altun

Researcher | Docent
Visiting address: Nobels väg 7, 17165 Solna
Postal address: H5 Laboratoriemedicin, H5 Klin Fysiologi, 141 52 Huddinge

Research

  • The ubiquitin-proteasome system (UPS) plays a central role in most cellular processes. Recent data suggest that the UPS plays a role beyond the well-known housekeeping function of protein turnover and highlight that more needs to be done to understand the complex nature of the UPS and its functions in the cell. We are studying the UPS starting from basic cellular functions and working to understand its involvement in human diseases ranging from muscle atrophies to cancer. In addition, our efforts are focused on developing new molecular, chemical and biophysical technologies to gain insights into complex cellular processes. One focus of our work with translational potential is the “hijacking" of the UPS for targeted protein degradation with small molecules that have the potential to develop new therapeutic strategies. With this approach, we hope to unravel the “untreatable" proteome and develop a better strategy to combat diseases where therapeutic options are limited by conventional drug discovery approaches. One such targeted degradation tactic involves bifunctional molecules that recruit UPS components to degrade a target protein – better known as PROTACs (PROteolysis-TArgeting Chimeras). While conventional small molecules must block the aberrant activity of a target protein, PROTACs serve to completely eliminate the protein by directing it to the proteasome for degradation by the ubiquitin system. Since PROTACs eliminate the target protein by degradation, similar to functional genetics approaches (e.g. RNAi and CRISPR/Cas9), we can correlate molecular changes and predict cellular phenotypes much better – something that conventional therapeutics usually cannot fully recapitulate. Since conventional small molecules are always subject to off-target effects, PROTACs can greatly improve the predictability of gene function studies by mimicking the effects observed in conventional genetic ablation studies. '
    Another goal is to develop biotechnologies to answer important scientific questions that require a cellular context, such as monitoring cellular protein-ligand interactions. This research is led by my colleague Nicholas Valerie (staff.ki.se/people/nicval). Dr. Altun is a group leader at the Science for Life Laboratory (SciLifeLab) in Stockholm, an important hub for Sweden’s national life science infrastructures (https://www.scilifelab.se/researchers/mikael-altun/ [1]).


    [1] https://www.scilifelab.se/researchers/mikael-altun/

Articles

All other publications

Grants

Employments

  • Researcher, Department of Laboratory Medicine, Karolinska Institutet, 2018-
  • Postdoctoral Researcher, Department of Cell and Molecular Biology, Karolinska Institute, 2008-2009

Degrees and Education

  • Docent, Karolinska Institutet, 2020
  • Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2007
  • Master Of Medical Science, Karolinska Institutet, 2003

Supervisor

  • Seher Alam, 2024
  • Maria Joao Pires, 2020
  • Daniela Papadia, Cellular and network mechanisms in neurodegenerative disorders : neurotoxicity and rescue strategies., https://openarchive.ki.se/xmlui/handle/10616/46338, 2014
  • Johan Boström, Studying the Cell Cycle using Systems Biology and High Content Characterization of the Ubiquitin Proteasome System., https://openarchive.ki.se/xmlui/handle/10616/47323, 2014
  • Saeed Eshtad, Targeting DNA repair Pathways for Cancer Therapy., https://openarchive.ki.se/xmlui/handle/10616/45467, 2012
  • Michael Feyder, L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia., https://openarchive.ki.se/xmlui/handle/10616/42273, 2012
  • Bin Zhao, Functional studies of deubiquitinating enzymes., https://openarchive.ki.se/xmlui/handle/10616/41134, 2008

Thesis evaluation

  • Hanzhao Zhang, Examination board member, Departement of Immunology, genetics and pathology, Uppsala University, 2024
  • Johannes Gubat, Examination board member, Department of Biomedical and Clinical Sciences, Linköping University, 2024
  • Mirko Mandic, Defence chairperson, Laboratory Medicine, Karolinska Institute, Blood volume expansion following supramaximal exercise : occurrence and contribution to maximal oxygen uptake, https://openarchive.ki.se/xmlui/handle/10616/48423, 2023
  • Kristijonas Zemaitis, Examination board member, Department of Laboratory Medicine and Lund Stem Cell Center, Lund University, Unravelling mechanisms of hematopoietic stem cell expansion, 2022

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