Mattias Svensson

Mattias Svensson

Principal Researcher | Docent
Visiting address: Alfred Nobels allé 8, plan 7, 14152 Huddinge
Postal address: H7 Medicin, Huddinge, H7 CIM Svensson, 171 77 Stockholm
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About me

  • Expertise in preclinical research in the field of immunology and infection,
    myeloid immune cells, host pathogen interactions and cell biology.
    Conduct translational projects based on preclinical science. This includes
    participation in the two international projects, PerAID and PERMIT, which
    focus on personalized medicine for infectious diseases (2019-2024).
    Particular interest in: Infection and immunology, as well as human myeloid
    immune cells such as monocytes, dendritic cells and macrophages in acute and
    chronic tissue inflammation.
    Current position: Research group leader, associate professor.
    Is Director of Doctoral Education at the Department of Medicine, Huddinge and
    Chairman of the Dissertation Committee at Karolinska Institutet.
    1995, MSc, Biology, Lund University, Sweden
    2000, PhD, Immunology, Lund University, Sweden
    2001-2004, Post doctoral Fellow, London School of Hygiene and Tropical
    Medicin, London, UK
    2010, Associate Professor, Immunology, Karolinska Institutet, Sweden

Research

  • Our research group [1] at the Center for Infectious Medicine (CIM [2]),
    Department of Medicine, Huddinge conducts research aimed at understanding how
    the tissue microenvironment affects bacterial properties, immune cell
    responses and immune-mediated pathology with special focus on tissue-specific
    cells' ability to form myeloid cell functions in bacterial infections and
    chronic inflammatory conditions.
    We strive to identify proteins and metabolites that are important for
    tissue-specific cells, such as fibroblasts, to shape the microenvironment for
    the function of myeloid immune cells and the specific properties of bacteria.
    The goal is to:
    1. Develop customized human organotypic models for disease mechanism
    identification, biomarker detection, and validation of interventions in sever
    bacterial infectious diseases
    2. Utilize identified disease mechanisms to develop tailored therapy and
    implement personalized medicine in sever infectious diseases.
    3. Identify central host-derived mediators which in the tissue environment
    drives bacteria behavior and characteristics, such as biofilm formation and
    persistence.
    Of particular interest are the two gram-positive bacteria Streptococcus
    pyogenes and Staphylococcus aureus. Both of these gram-positive bacteria can
    cause very aggressive invasive infections such as toxic shock, necrotizing
    pneumonia and necrotizing fasciitis which are associated with significant
    morbidity and mortality.
    [1] https://ki.se/en/medh/mattias-svensson-group-studies-of-tissue-microbiology-and-immunology
    [2] https://ki.se/en/medh/center-for-infectious-medicine-cim

Articles

All other publications

Grants

Employments

  • Principal Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2022-

Degrees and Education

  • Docent, Karolinska Institutet, 2010

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