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About me

I am Professor of Experimental Neurogeriatrics and study cellular mechanisms in Alzheimer's disease. I am the head of the Division of Neurogeriatrics, NVS and one of three leaders of the Center for Alzheimer Research, KI. During the 2012-2017 I was a director of doctoral education at NVS, and at present I am faculty representative in the Board of Doctoral Education (FUS). This is a very interesting, stimulating and important mission. I have taken part in the design of the electronic individual study plan, and I am a representative of the KID steering committee, where we partially reformed the review and decision-making process. Through my long involvement in doctoral education at KI, I have gained extensive experience in board and committee work. Driving issues that I am passionate about and being a part of developing KI are both interesting and fun.

I am currently a regular member of:

The Board of Doctoral Education (FUS) 

KI Nomination Assembly, KI

The Electoral Assembly, Swedish Research Council

 

Publications

Beyond the critical point: An overview of excitotoxicity, calcium overload and the downstream consequences
Bano D, Ankarcrona M
Neuroscience letters 2018;663():79-85

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
Connolly Nmc, Theurey P, Adam-vizi V, Bazan Ng, Bernardi P, Bolaños Jp, et al
Cell death and differentiation 2018;25(3):542-572

Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin
Teixeira Pf, Masuyer G, Pinho Cm, Branca Rmm, Kmiec B, Wallin C, et al
Journal of molecular biology 2018;430(3):348-362

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer
Filadi R, Leal Ns, Schreiner B, Rossi A, Dentoni G, Pinho Cm, et al
Current biology : CB 2018;28(3):369-382.e6

Isolation of Mitochondria-Associated Membranes (MAM) from Mouse Brain Tissue
Schreiner B, Ankarcrona M
Methods in molecular biology (Clifton, N.J.) 2017;1567():53-68

Current and future treatment of amyloid diseases
Ankarcrona M, Winblad B, Monteiro C, Fearns C, Powers Et, Johansson J, et al
Journal of internal medicine 2016;280(2):177-202

Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production
Leal Ns, Schreiner B, Pinho Cm, Filadi R, Wiehager B, Karlström H, et al
Journal of cellular and molecular medicine 2016;20(9):1686-95

Amyloid-β peptides are generated in mitochondria-associated endoplasmic reticulum membranes
Schreiner B, Hedskog L, Wiehager B, Ankarcrona M
Journal of Alzheimer's disease : JAD 2015;43(2):369-74

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models
Hedskog L, Pinho Cm, Filadi R, Rönnbäck A, Hertwig L, Wiehager B, et al
Proceedings of the National Academy of Sciences of the United States of America 2013;110(19):7916-21

Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene
Hedskog L, Brohede J, Wiehager B, Pinho Cm, Revathikumar P, Lilius L, et al
Journal of Alzheimer's disease : JAD 2012;31(3):527-36

Identification of two novel synaptic gamma-secretase associated proteins that affect amyloid beta-peptide levels without altering Notch processing
Frykman S, Teranishi Y, Hur Jy, Sandebring A, Yamamoto Ng, Ankarcrona M, et al
NEUROCHEMISTRY INTERNATIONAL 2012;61(1):108-18

Strategic Role for Mitochondria in Alzheimer's Disease and Cancer
Hedskog L, Zhang St, Ankarcrona M
ANTIOXIDANTS & REDOX SIGNALING 2012;16(12):1476-91

Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease
Westerlund M, Behbahani H, Gellhaar S, Forsell C, Belin Ac, Anvret A, et al
FASEB JOURNAL 2011;25(4):1345-52

gamma-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular A beta(42)/A beta(40) ratio
Hedskog L, Petersen Cah, Svensson Ai, Welander H, Tjernberg Lo, Karlstrom H, et al
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2011;15(10):2150-63

Mitochondrial gamma-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein
Pavlov Pf, Wiehager B, Sakai J, Frykman S, Behbahani H, Winblad B, et al
FASEB JOURNAL 2011;25(1):78-88

Association of Omi/HtrA2 with gamma-secretase in mitochondria
Behbahani H, Pavlov Pf, Wiehager B, Nishimura T, Winblad B, Ankarcrona M
NEUROCHEMISTRY INTERNATIONAL 2010;57(6):668-75

Dimebon (Latrepirdine) Enhances Mitochondrial Function and Protects Neuronal Cells from Death
Zhang St, Hedskog L, Petersen Cah, Winblad B, Ankarcrona M
JOURNAL OF ALZHEIMERS DISEASE 2010;21(2):389-402

Rethinking Alzheimer's Disease Therapy: Are Mitochondria the Key?
Ankarcrona M, Mangialasche F, Winblad B
JOURNAL OF ALZHEIMERS DISEASE 2010;:S579-90

Mitochondria and Alzheimer's disease: amyloid-beta peptide uptake and degradation by the presequence protease, hPreP
Alikhani N, Ankarcrona M, Glaser E
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 2009;41(5):447-51

Mitochondrial accumulation of APP and A beta: significance for Alzheimer disease pathogenesis
Pavlov Pf, Petersen Ch, Glaser E, Ankarcrona M
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2009;13(10):4137-45

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
Petersen Cah, Alikhani N, Behbahani H, Wiehager B, Pavlov Pf, Alafuzoff I, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008;105(35):13145-50

Presenilin-mediated signal transduction
Cowburn Rf, Popescu Bo, Ankarcrona M, Dehvari N, Cedazo-minguez A
PHYSIOLOGY & BEHAVIOR 2007;92(1-2):93-7

Studies on brain volume, Alzheimer-related proteins and cytokines in mice with chronic overexpression of IL-1 receptor antagonist
Oprica M, Hjorth E, Spulber S, Popescu Bo, Ankarcrona M, Winblad B, et al
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2007;11(4):810-25

Caspase cleaved presenilin-1 is part of active gamma-secretase complexes
Hansson Ca, Popescu Bo, Laudon H, Cedazo-minguez A, Popescu Lm, Winblad B, et al
JOURNAL OF NEUROCHEMISTRY 2006;97(2):356-64

COPI-mediated retrograde transport is required for efficient gamma-secretase cleavage of the amyloid precursor protein
Selivanova A, Winblad B, Farmery Mr, Dantuma Np, Ankarcrona M
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2006;350(1):220-6

Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP
Falkevall A, Alikhani N, Bhushan S, Pavlov Pf, Busch K, Johnson Ka, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2006;281(39):29096-104

Differential role of presenilin-1 and-2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts
Behbahani H, Shabalina Ig, Wiehager B, Concha H, Hultenby K, Petrovic N, et al
JOURNAL OF NEUROSCIENCE RESEARCH 2006;84(4):891-902

PTEN, Akt, and GSK3 beta signalling in rat primary cortical neuronal cultures following tumor necrosis factor-alpha and trans-4-hydroxy-2-nonenal treatments
Rickle A, Behbahani H, Ankarcrona M, Winblad B, Cowburn Rf
JOURNAL OF NEUROSCIENCE RESEARCH 2006;84(3):596-605

Biomarkers for apoptosis in Alzheimer's disease
Ankarcrona M, Winblad B
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY 2005;20(2):101-5

Flow cytometry as a method for studying effects of stressors on primary rat neurons
Behbahani H, Rickle A, Concha H, Ankarcrona M, Winblad B, Cowburn Rf
JOURNAL OF NEUROSCIENCE RESEARCH 2005;82(3):432-41

gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction
Popescu Bo, Cedazo-minguez A, Benedikz E, Nishimura T, Winblad B, Ankarcrona M, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2004;279(8):6455-64

Localization of nicastrin/presenilin/APH-1/PEN-2 complexes to mitochondria
Hansson Ca, Frykman S, Farmery Mr, Tjernberg Lo, Nilsberth C, Winblad B, et al
NEUROBIOLOGY OF AGING 2004;:S549-S549

Mechanisms of cell death in Alzheimer's disease: Role of presenilins
Popescu Bo, Ankarcrona M
JOURNAL OF ALZHEIMERS DISEASE 2004;6(2):123-8

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
Hansson Ca, Frykman S, Farmery Mr, Tjernberg Lo, Nilsberth C, Pursglove Se, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2004;279(49):51654-60

The proteasome regulates presenilin 1 levels during apoptosis
Ankarcrona M, Cedazo-minguez A, Winblad B, Popescu Bo
NEUROBIOLOGY OF AGING 2004;:S525-S525

Alzheimer's disease: mutations, apoptosis and cellular signalling
Vestling M, Cowburn Rf, Winblad B, Ankarcrona M
CURRENT OPINION IN PSYCHIATRY 2002;15(4):395-401

Mutated presenilin 1 alters cholinergic signaling in neuroblastoma cells
Popescu Bo, Cedazo-minguez A, Ankarcrona M, Cowburn Rf
EUROPEAN NEUROPSYCHOPHARMACOLOGY 2002;:S56-S56

Presenilin-1 expression during differentiation of human cortical neurons
Ankarcrona M, Sundstrom E
NEUROBIOLOGY OF AGING 2002;23(1):S220-S221

Presenilin-1 is located in rat mitochondria
Ankarcrona M, Hultenby K
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2002;295(3):766-70

The presenilin 1 Delta E9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations
Cedazo-minguez A, Popescu Bo, Ankarcrona M, Nishimura T, Cowburn Rf
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(39):36646-55

The presenilin-1 delta E9 mutation gives enhanced phospholipase C activity and a resultant increase in intracellular calcium concentrations
Popescu Bo, Cedazo-minguez A, Ankarcrona M, Nishimura T, Cowburn Rf
NEUROBIOLOGY OF AGING 2002;23(1):S215-S215

Calcium ionophore A23187 specifically decreases the secretion of beta-secretase cleaved amyloid precursor protein during apoptosis in primary rat cortical cultures
Sennvik K, Benedikz E, Fastbom J, Sundstrom E, Winblad B, Ankarcrona M
JOURNAL OF NEUROSCIENCE RESEARCH 2001;63(5):429-37

Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells
Popescu Bo, Cedazo-minguez A, Popescu Lm, Winblad B, Cowburn Rf, Ankarcrona M
JOURNAL OF NEUROSCIENCE RESEARCH 2001;66(1):122-34

Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis
Tanii H, Ankarcrona M, Flood F, Nilsberth C, Mehta Nd, Perez-tur J, et al
NEUROSCIENCE 2000;95(2):593-601

Neurons bearing presenilins: weapons for defense or suicide?
Popescu Bo, Ankarcrona M
Journal of cellular and molecular medicine 2000;4(4):249-261

Glutamate induced cell death: Apoptosis or necrosis?
Ankarcrona M
GLUTAMATE SYNAPSE AS A THERAPEUTICAL TARGET: MOLECULAR ORGANIZATION AND PATHOLOGY OF THE GLUTAMATE SYNAPSE 1998;:265-72

AMPA neurotoxicity in cultured cerebellar granule neurons: Mode of cell death
Cebers G, Zhivotovsky B, Ankarcrona M, Liljequist S
BRAIN RESEARCH BULLETIN 1997;43(4):393-403

Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress
Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S, Lipton Sa
Advances in neurology 1997;72():95-101

Calcineurin and mitochondrial function in glutamate-induced neuronal cell death
Ankarcrona M, Dypbukt Jm, Orrenius S, Nicotera P
FEBS LETTERS 1996;394(3):321-4

Lamin and beta-tubulin fragmentation precede chromatin degradation in glutamate-induced neuronal apoptosis
Ankarcrona M, Zhivotovsky B, Holmstrom T, Diana A, Eriksson Je, Orrenius S, et al
NEUROREPORT 1996;7(15-17):2659-64

Mechanisms of calcium-related cell death
Orrenius S, Ankarcrona M, Nicotera P
CELLULAR AND MOLECULAR MECHANISMS OF ISCHEMIC BRAIN DAMAGE 1996;:137-49

APOPTOSIS AND NECROSIS - 2 DISTINCT EVENTS INDUCED, RESPECTIVELY, BY MILD AND INTENSE INSULTS WITH N-METHYL-D-ASPARTATE OR NITRIC-OXIDE SUPEROXIDE IN CORTICAL CELL-CULTURES
Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton Sa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1995;92(16):7162-6

GLUTAMATE-INDUCED NEURONAL DEATH - A SUCCESSION OF NECROSIS OR APOPTOSIS DEPENDING ON MITOCHONDRIAL-FUNCTION
Ankarcrona M, Dypbukt Jm, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton Sa, et al
NEURON 1995;15(4):961-73

MULTIPLE PROTEASES ARE INVOLVED IN THYMOCYTE APOPTOSIS
Zhivotovsky B, Gahm A, Ankarcrona M, Nicotera P, Orrenius S
EXPERIMENTAL CELL RESEARCH 1995;221(2):404-12

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