Maja Jagodic

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About me

Maja Jagodic is Professor of Neuroinflammation, Associate Professor in Experimental Medicine, and research group leader for research on epigenetics of Multiple Sclerosis at the Department of Clinical Neuroscience, and the Center for Molecular Medicine.

Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):6419
A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis
Kakhki MP; Giordano A; Cucuzza CS; Badam TVS; Samudyata S; Lemee MV; Stridh P; Gkogka A; Shchetynsky K; Harroud A; Gyllenberg A; Liu Y; Boddul S; James T; Sorosina M; Filippi M; Esposito F; Wermeling F; Gustafsson M; Casaccia P; Hillert J; Olsson T; Kockum I; Sellgren CM; Golzio C; Kular L; Jagodic M
Article: ACTA NEUROPATHOLOGICA. 2024;147(1):82
Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS
Windener F; Grewing L; Thomas C; Dorion M-F; Otteken M; Kular L; Jagodic M; Antel J; Albrecht S; Kuhlmann T
Article: NATURE IMMUNOLOGY. 2024;25(3):432-447
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
Linnerbauer M; Loesslein L; Vandrey O; Peter A; Han Y; Tsaktanis T; Wogram E; Needhamsen M; Kular L; Nagel L; Zissler J; Andert M; Meszaros L; Hanspach J; Zuber F; Naumann UJ; Diebold M; Wheeler MA; Beyer T; Nirschl L; Cirac A; Laun FB; Guenther C; Winkler J; Baeuerle T; Jagodic M; Hemmer B; Prinz M; Quintana FJ; Rothhammer V
Article: NATURE COMMUNICATIONS. 2024;15(1):383
The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34
Berglund R; Cheng Y; Piket E; Adzemovic MZ; Zeitelhofer M; Olsson T; Guerreiro-Cacais AO; Jagodic M
Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2023;79:104991
Smoking affects epigenetic ageing of lung bronchoalveolar lavage cells in Multiple Sclerosis
Klose D; Needhamsen M; Ringh MV; Hagemann-Jensen M; Jagodic M; Kular L
Article: LEUKEMIA. 2023;37(9):1830-1841
Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells
Palau A; Segerberg F; Lidschreiber M; Lidschreiber K; Naughton AJ; Needhamsen M; Jung LA; Jagodic M; Cramer P; Lehmann S; Carlsten M; Lennartsson A
Article: NEUROLOGY. 2023;101(7):e679-e689
Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis
Maltby V; Xavier A; Ewing E; Campagna M-P; Sampangi S; Scott RJ; Butzkueven H; Jokubaitis V; Kular L; Bos S; Slee M; van der Mei IA; Taylor BV; Ponsonby A-L; Jagodic M; Lea R; Lechner-Scott J
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(16):12576
DNA Methylation Signatures of Multiple Sclerosis Occur Independently of Known Genetic Risk and Are Primarily Attributed to B Cells and Monocytes
Xavier A; Maltby VE; Ewing E; Campagna MP; Burnard SM; Tegner JN; Slee M; Butzkueven H; Kockum I; Kular L; Jokubaitis VG; Kilpatrick T; Alfredsson L; Jagodic M; Ponsonby A-L; Taylor BV; Scott RJ; Lea RA; Lechner-Scott J
Article: NATURE. 2023;619(7969):323-331
Locus for severity implicates CNS resilience in progression of multiple sclerosis
Harroud A; Stridh PJ; McCauley JH; Saarela J; van den Bosch AMR; Engelenburg H; Beecham A; Alfredsson L; Alikhani K; Amezcua L; Andlauer TFM; Ban M; Barcellos L; Barizzone N; Berge T; Berthele A; Bittner S; Bos S; Briggs FBS; Caillier S; Calabresi P; Caputo D; Carmona-Burgos D; Cavalla P; Celius E; Cerono G; Chinea A; Chitnis T; Clarelli F; Comabella M; Comi G; Cotsapas C; Cree BCA; D'Alfonso S; Dardiotis E; De Jager P; Delgado S; Dubois B; Engel S; Esposito F; Fabis-Pedrini M; Filippi M; Fitzgerald K; Gasperi C; Gomez L; Gomez R; Hadjigeorgiou G; Hamann J; Held F; Henry R; Hillert J; Huang J; Huitinga I; Islam T; Isobe N; Jagodic M; Kermode AL; Khalil M; Kilpatrick T; Konidari I; Kreft K; Lechner-Scott J; Leone M; Luessi F; Malhotra S; Manouchehrinia A; Manrique C; Martinelli-Boneschi F; Martinez A; Martinez-Maldonado V; Mascia E; Metz L; Midaglia L; Montalban X; Oksenberg J; Olsson T; Oturai A; Paakkonen K; Parnell GP; Patsopoulos N; Pericak-Vance M; Piehl F; Rubio J; Santaniello A; Santoro S; Schaefer C; Sellebjerg F; Shams H; Shchetynsky K; Silva C; Siokas V; Sondergaard H; Sorosina M; Taylor B; Vandebergh M; Vasileiou E; Vecchio D; Voortman M; Weiner H; Wever D; Yong VW; Hafler D; Stewart G; Compston A; Zipp F; Harbo H; Hemmer B; Goris A; Smolders J; Hauser S; Kockum I; Sawcer S; Baranzini S; Jonsdottir I; Blanco Y; Llufriu S; Madireddy L; Saiz A; Villoslada P; Stefansson K; Harbo HF; Hemmer B; Goris A; Kockum I; Sawcer SJ; Baranzini SE
Article: NEUROLOGY: NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2023;10(1):e200056
Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis
Starvaggi Cucuzza C; Longinetti E; Ruffin N; Evertsson B; Kockum I; Jagodic M; Al Nimer F; Frisell T; Piehl F
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1251772
Simultaneous detection of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing
Kalomoiri M; Prakash CR; Lagstroem S; Hauschulz K; Ewing E; Shchetynsky K; Kular L; Needhamsen M; Jagodic M
Article: EPIGENETICS. 2022;17(11):1311-1330
DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients
Kular L; Ewing E; Needhamsen M; Kakhki MP; Covacu R; Gomez-Cabrero D; Brundin L; Jagodic M
Article: EPIGENETICS. 2022;17(10):1195-1204
Comparison of EM-seq and PBAT methylome library methods for low-input DNA
Han Y; Zheleznyakova GY; Marincevic-Zuniga Y; Kakhki MP; Raine A; Needhamsen M; Jagodic M
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:916128
RNA-sequencing and mass-spectrometry proteomic time-series analysis of T-cell differentiation identified multiple splice variants models that predicted validated protein biomarkers in inflammatory diseases
Magnusson R; Rundquist O; Kim MJ; Hellberg S; Na CH; Benson M; Gomez-Cabrero D; Kockum I; Tegner JN; Piehl F; Jagodic M; Mellergard J; Altafini C; Ernerudh J; Jenmalm MC; Nestor CE; Kim M-S; Gustafsson M
Article: FRONTIERS IN GENETICS. 2022;13:1042483
Integration of small RNAs from plasma and cerebrospinal fluid for classification of multiple sclerosis
Needhamsen M; Khoonsari PE; Zheleznyakova GY; Piket E; Hagemann-Jensen M; Han Y; Gierlich J; Ekman D; Jagodic M
Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:926468
Epigenetic clock indicates accelerated aging in glial cells of progressive multiple sclerosis patients
Kular L; Klose D; Urdanoz-Casado A; Ewing E; Planell N; Gomez-Cabrero D; Needhamsen M; Jagodic M
Article: EPIGENOMICS. 2021;13(20):1607-1618
Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients
Fernandes SJ; Ericsson M; Khademi M; Jagodic M; Olsson T; Gomez-Cabrero D; Kockum I; Tegner J
Article: BMC GENOMICS. 2021;22(1):631
A validated generally applicable approach using the systematic assessment of disease modules by GWAS reveals a multi-omic module strongly associated with risk factors in multiple sclerosis
Badam TVS; de Weerd HA; Martinez-Enguita D; Olsson T; Alfredsson L; Kockum I; Jagodic M; Lubovac-Pilav Z; Gustafsson M
Article: MULTIPLE SCLEROSIS JOURNAL. 2021;27(7):1014-1026
Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking
Ringh MV; Hagemann-Jensen M; Needhamsen M; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Jagodic M; Ekstrom TJ; Ockinger J; Kular L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(17):e2011574118
Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology
Zheleznyakova GY; Piket E; Needhamsen M; Hagemann-Jensen M; Ekman D; Han Y; James T; Khademi M; Al Nimer F; Scicluna P; Huang J; Kockum I; Faridani OR; Olsson T; Piehl F; Jagodic M
Article: FRONTIERS IN GENETICS. 2021;12:620453
STATegra: Multi-Omics Data Integration - A Conceptual Scheme With a Bioinformatics Pipeline
Planell N; Lagani V; Sebastian-Leon P; van der Kloet F; Ewing E; Karathanasis N; Urdangarin A; Arozarena I; Jagodic M; Tsamardinos I; Tarazona S; Conesa A; Tegner J; Gomez-Cabrero D
Article: SCIENCE IMMUNOLOGY. 2020;5(52):eabb5077
Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation.
Berglund R; Guerreiro-Cacais AO; Adzemovic MZ; Zeitelhofer M; Lund H; Ewing E; Ruhrmann S; Nutma E; Parsa R; Thessen-Hedreul M; Amor S; Harris RA; Olsson T; Jagodic M
Article: BMC BIOINFORMATICS. 2020;21(1):443
GeneSetCluster: a tool for summarizing and integrating gene-set analysis results
Ewing E; Planell-Picola N; Jagodic M; Gomez-Cabrero D
Article: NATURE COMMUNICATIONS. 2020;11(1):4071
Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis
Carlstrom KE; Zhu K; Ewing E; Krabbendam IE; Harris RA; Falcao AM; Jagodic M; Castelo-Branco G; Piehl F
Article: EPIGENETICS. 2020;15(6-7):646-663
Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression
Ciuculete DM; Voisin S; Kular L; Welihinda N; Jonsson J; Jagodic M; Mwinyi J; Schioth HB
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(2):838-852
C-type lectin receptors Mcl and Mincle contro development of multiple sclerosis like neuroinflammation
N'diaye M; Brauner S; Flytzani S; Kular L; Warnecke A; Adzemovic MZ; Piket E; Min J-H; Edwards W; Mela F; Choi HY; Magg V; James T; Linden M; Reichardt HM; Daws MR; van Horssen J; Kockum I; Harris RA; Olsson T; Guerreiro-Cacais AO; Jagodic M
Article: FRONTIERS IN NEUROLOGY. 2020;11:600401
Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)
Hochmeister S; Aeinehband S; Dorris C; Berglund R; Haindl MT; Velikic V; Gustafsson SA; Olsson T; Piehl F; Jagodic M; Zeitelhofer M; Adzemovic MZ
Article: SCIENCE. 2019;365(6460):eaav7188
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
Patsopoulos NA; Baranzini SE; Santaniello A; Shoostari P; Cotsapas C; Wong G; Beecham AH; James T; Replogle J; Vlachos IS; McCabe C; Pers TH; Brandes A; White C; Keenan B; Cimpean M; Winn P; Panteliadis I-P; Robbins A; Andlauer TFM; Zarzycki O; Dubois B; Goris A; Sondergaard HB; Sellebjerg F; Sorensen PS; Ullum H; Thorner LW; Saarela J; Cournu-Rebeix I; Damotte V; Fontaine B; Guillot-Noel L; Lathrop M; Vukusic S; Berthele A; Pongratz V; Pongratz V; Gasperi C; Graetz C; Grummel V; Hemmer B; Hoshi M; Knier B; Korn T; Lill CM; Luessi F; Muehlau M; Zipp F; Dardiotis E; Agliardi C; Amoroso A; Barizzone N; Benedetti MD; Bernardinelli L; Cavalla P; Clarelli F; Comi G; Cusi D; Esposito F; Ferre L; Galimberti D; Guaschino C; Leone MA; Martinelli V; Moiola L; Salvetti M; Sorosina M; Vecchio D; Zauli A; Santoro S; Mancini N; Zuccala M; Mescheriakova J; van Duijn C; Bos SD; Celius EG; Spurkland A; Comabella M; Montalban X; Alfredsson L; Bomfim IL; Gomez-Cabrero D; Hillert J; Jagodic M; Linden M; Piehl F; Jelcic I; Martin R; Sospedra M; Baker A; Ban M; Hawkins C; Hysi P; Kalra S; Karpe F; Khadake J; Lachance G; Molyneux P; Neville M; Thorpe J; Bradshaw E; Caillier SJ; Calabresi P; Cree BAC; Cross A; Davis M; de Bakker PWI; Delgado S; Dembele M; Edwards K; Fitzgerald K; Frohlich IY; Gourraud P-A; Haines JL; Hakonarson H; Kimbrough D; Isobe N; Konidari I; Lathi E; Lee MH; Li T; An D; Zimmer A; Madireddy L; Manrique CP; Mitrovic M; Olah M; Patrick E; Pericak-Vance MA; Piccio L; Schaefer C; Weiner H; Lage K; Scott RJ; Lechner-Scott J; Leal R; Moscato P; Booth DR; Stewart GJ; Vucic S; Pame G; BamettO M; Mason D; GriffithS L; Broadley S; Tajouri L; Baxter A; Slee M; Taylor BV; Charlesworth J; Kilpatrick TJ; Rubio J; Jokubaitis V; Wiley J; Butzkueven H; Leslie S; Motyer A; Stankovich J; Carroll WM; Kermode AG; Edrin M; Barclay M; Peyrin-Biroulet L; Chamaillard M; Colombe J-F; Cottone M; Croft A; D'Inca R; Halfvarson J; Hanigan K; Henderson P; Hugot J-P; Karban A; Kennedy NA; Khan MA; Lemann M; Levine A; Massey D; Milla M; Motoey GW; Ng SME; Oikonomnou J; Peeters H; Proctor DD; Rahier J-F; Roberts R; Rutgeerts P; Seibold F; Stronati L; Taylor KM; Torkvist L; Ublick K; Van Limbergen J; Van Gossum A; Vatn MH; Zhang H; Zhang W; Donnelly P; Barroso I; Blackwe JM; Bramon E; Brown MA; Casas JP; Corvin A; Deloukas P; Duncanson A; Jankowski J; Markus HS; Mathew CG; Palmer CNA; Plomin R; Rautanen A; Sawcer SJ; Trembath RC; Viswanathan AC; Wood NW; Spencer CCA; Band G; Bellenguez C; Freeman C; Hellenthal G; Giannoulatou E; Pirinen M; Pearson R; Strange A; Sul Z; Vukcevic DA; Donnelly P; Langford C; Hunt SE; Edkins S; Gwilliam R; Blackburn H; Bumpstead SJ; Dronov S; Gillman M; Gray E; Hammond N; Jayakumar A; McCann OT; Liddle J; Potter SC; Ravindrarajah R; Ricketts M; Waller M; Weston P; Widaa S; Whittaker P; Barroso I; Deloukas P; Mathew CG; Blackwe JM; Brown MA; Corvin A; Spencer CCA; Compston A; Hafler D; Harbo HF; Hauser SL; Stewart G; D'Alfonso S; Hadjigeorgiou G; Taylor B; Barcellos LF; Booth D; Hintzen R; Kockum I; Martinelli-Boneschi F; McCauley JL; Oksenberg JR; Oturai A; Sawcer S; Ivinson AJ; Olsson T; De Jager PL
Article: EPIGENOMICS. 2019;11(12):1429-1439
Different epigenetic clocks reflect distinct pathophysiological features of multiple sclerosis
Theodoropoulou E; Alfredsson L; Piehl F; Marabita F; Jagodic M
Article: SCIENTIFIC REPORTS. 2019;9(1):11996
Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients
Fernandes SJ; Morikawa H; Ewing E; Ruhrmann S; Joshi RN; Lagani V; Karathanasis N; Khademi M; Planell N; Schmidt A; Tsamardinos I; Olsson T; Piehl F; Kockum I; Jagodic M; Tegner J; Gomez-Cabrero D
Article: JOURNAL OF IMMUNOLOGY. 2019;203(4):888-898
IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis
Lindahl H; Guerreiro-Cacais AO; Bedri SK; Linnerbauer M; Linden M; Abdelmagid N; Tandre K; Hollins C; Irving L; Glover C; Jones C; Alfredsson L; Ronnblom L; Kockum I; Khademi M; Jagodic M; Olsson T
Article: EBIOMEDICINE. 2019;46:290-304
Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells
Ringh MV; Hagemann-Jensen M; Needhamsen M; Kular L; Breeze CE; Sjoholm LK; Slavec L; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Liu Y; Almgren M; Jagodic M; Ockinger J; Ekstrom TJ
Article: NATURE COMMUNICATIONS. 2019;10(1):3081
Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
Carlstrom KE; Ewing E; Granqvist M; Gyllenberg A; Aeinehband S; Enoksson SL; Checa A; Badam TVS; Huang J; Gomez-Cabrero D; Gustafsson M; Al Nimer F; Wheelock CE; Kockum I; Olsson T; Jagodic M; Piehl F
Article: JOURNAL OF AUTOIMMUNITY. 2019;101:17-25
Small non-coding RNAs as important players, biomarkers and therapeutic targets in multiple sclerosis: A comprehensive overview
Piket E; Zheleznyakova GY; Kular L; Jagodic M
Article: CLINICAL EPIGENETICS. 2019;11(1):86
Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis
Kular L; Needhamsen M; Adzemovic MZ; Kramarova T; Gomez-Cabrero D; Ewing E; Piket E; Tegner J; Beck S; Piehl F; Brundin L; Jagodic M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(19):9443-9452
Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration
Li D; Kular L; Vij M; Herter EK; Li X; Wang A; Chu T; Toma M-A; Zhang L; Liapi E; Mota A; Blomqvist L; Serezal IG; Rollman O; Wikstrom JD; Bienko M; Berglund D; Stahle M; Sommar P; Jagodic M; Landen NX
Article: EBIOMEDICINE. 2019;43:411-423
Combining evidence from four immune cell types identifies DNA methylation patterns that implicate functionally distinct pathways during Multiple Sclerosis progression
Ewing E; Kular L; Fernandes SJ; Karathanasis N; Lagani V; Ruhrmann S; Tsamardinos I; Tegner J; Piehl F; Gomez-Cabrero D; Jagodic M
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(2):313-322
miR-31 regulates energy metabolism and is suppressed in Tcells from patients with Sjogren's syndrome
Johansson A; Nyberg WA; Sjostrand M; Moruzzi N; Bergman P; Khademi M; Andersson M; Piehl F; Berggren P-O; Covacu R; Jagodic M; Espinosa A
Article: NATURE COMMUNICATIONS. 2018;9(1):4845
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Overby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
Article: MULTIPLE SCLEROSIS JOURNAL. 2018;24(10):1288-1300
Hypermethylation of MIR21 in CD4+T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes
Ruhrmann S; Ewing E; Piket E; Kular L; Lorenzi JCC; Fernandes SJ; Morikawa H; Aeinehband S; Sayols-Baixeras S; Aslibekyan S; Absher DM; Arnett DK; Tegner J; Gomez-Cabrero D; Piehl F; Jagodic M
Article: NEUROLOGY: NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2018;5(5):e491
Identification of MS-specific serum miRNAs in an international multicenter study
Regev K; Healy BC; Paul A; Diaz-Cruz C; Mazzola MA; Raheja R; Glanz BI; Kivisakk P; Chitnis T; Jagodic M; Piehl F; Olsson T; Khademi M; Hauser S; Oksenberg J; Khoury SJ; Weiner HL; Gandhi R
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2018;102:44-51
Changes in methylation within the STK32B promoter are associated with an increased risk for generalized anxiety disorder in adolescents
Ciuculete DM; Bostrom AE; Tuunainen A-K; Sohrabi F; Kular L; Jagodic M; Voisin S; Mwinyi J; Schioth HB
Article: NATURE COMMUNICATIONS. 2018;9(1):2397
DNA methylation as a mediator of HLA-DRB1^☆15:01 and a protective variant in multiple sclerosis
Kular L; Liu Y; Ruhrmann S; Zheleznyakova G; Marabita F; Gomez-Cabrero D; James T; Ewing E; Linden M; Gornikiewicz B; Aeinehband S; Stridh P; Link J; Andlauer TFM; Gasperi C; Wiendl H; Zipp F; Gold R; Tackenberg B; Weber F; Hemmer B; Strauch K; Heilmann-Heimbach S; Rawal R; Schminke U; Schmidt CO; Kacprowski T; Franke A; Laudes M; Dilthey AT; Celius EG; Sondergaard HB; Tegner J; Harbo HF; Oturai AB; Olafsson S; Eggertsson HP; Halldorsson BV; Hjaltason H; Olafsson E; Jonsdottir I; Stefansson K; Olsson T; Piehl F; Ekstroem TJ; Kockum I; Feinberg AP; Jagodic M
Article: NATURE IMMUNOLOGY. 2018;19(5):1-7
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Kular L; Han J; Zhu K; Nijssen J; Hedlund E; Needhamsen M; Ruhrmann S; Guerreiro-Cacais AO; Berglund R; Forteza MJ; Ketelhuth DFJ; Butovsky O; Jagodic M; Zhang X-M; Harris RA
Article: MOLECULAR THERAPY. 2018;26(4):1040-1055
Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions
Jin H; Li DY; Chernogubova E; Sun C; Busch A; Eken SM; Saliba-Gustafsson P; Winter H; Winski G; Raaz U; Schellinger IN; Simon N; Hegenloh R; Matic LP; Jagodic M; Ehrenborg E; Pelisek J; Eckstein H-H; Hedin U; Backlund A; Maegdefessel L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(4):882-892
Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis
Lohcharoenkal W; Das Mahapatra K; Pasquali L; Crudden C; Kular L; Ulum YZA; Zhang L; Landen NX; Girnita L; Jagodic M; Stahle M; Sonkoly E; Pivarcsi A
Article: HUMAN MOLECULAR GENETICS. 2018;27(5):912-928
Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients
James T; Linden M; Morikawa H; Fernandes SJ; Ruhrmann S; Huss M; Brandi M; Piehl F; Jagodic M; Tegner J; Khademi M; Olsson T; Gomez-Cabrero D; Kockum I
Article: BMC BIOINFORMATICS. 2017;18(1):486
Usability of human Infinium MethylationEPIC BeadChip for mouse DNA methylation studies
Needhamsen M; Ewing E; Lund H; Gomez-Cabrero D; Harris RA; Kular L; Jagodic M
Article: SCIENTIFIC REPORTS. 2017;7(1):14589
Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship
Marabita F; Almgren M; Sjoholm LK; Kular L; Liu Y; James T; Kiss NB; Feinberg AP; Olsson T; Kockum I; Alfredsson L; Ekstrom TJ; Jagodic M
Article: ARTHRITIS RESEARCH & THERAPY. 2017;19(1):71
DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis
Meng W; Zhu Z; Jiang X; Too CL; Uebe S; Jagodic M; Kockum I; Murad S; Ferrucci L; Alfredsson L; Zou H; Klareskog L; Feinberg AP; Ekstrom TJ; Padyukov L; Liu Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(9):E1678-E1687
Functional genomics analysis of vitamin D effects on CD4+T cells in vivo in experimental autoimmune encephalomyelitis
Zeitelhofer M; Adzemovic MZ; Gomez-Cabrero D; Bergman P; Hochmeister S; N'diaye M; Paulson A; Ruhrmann S; Almgren M; Tegner JN; Ekstrom TJ; Guerreiro-Cacais AO; Jagodic M
Article: GENES AND IMMUNITY. 2017;18(1):48-56
VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis
Guerreiro-Cacais AO; Norin U; Gyllenberg A; Berglund R; Beyeen AD; Petit-Teixeira E; Cornelis F; Saoudi A; Fournie GJ; Holmdahl R; Alfredsson L; Klareskog L; Jagodic M; Olsson T; Kockum I; Padyukov L
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2016;213(8):1537-1553
BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Guerreiro-Cacais AO; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
Article: NEUROLOGY: NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2016;3(3):e219
Circulating miR-150 in CSF is a novel candidate biomarker for multiple sclerosis
Bergman P; Piket E; Khademi M; James T; Brundin L; Olsson T; Piehl F; Jagodic M
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;99(3):437-446
Rat bone marrow-derived dendritic cells generated with GM-CSF/IL-4 or FLT3L exhibit distinct phenotypical and functional characteristics
N'diaye M; Warnecke A; Flytzani S; Abdelmagid N; Ruhrmann S; Olsson T; Jagodic M; Harris RA; Guerreiro-Cacais AO
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1304:3-24
Positional Gene Cloning in Experimental Populations.
Jagodic M; Stridh P
Article: JOURNAL OF NEUROINFLAMMATION. 2015;12:194
MOG-induced experimental autoimmune encephalomyelitis in the rat species triggers anti-neurofascin antibody response that is genetically regulated
Flytzani S; Guerreiro-Cacais AO; N'diaye M; Lindner M; Linington C; Meinl E; Stridh P; Jagodic M; Olsson T
Article: NEUROBIOLOGY OF DISEASE. 2014;71:220-233
Acute treatment with valproic acid and L-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats
Castelo-Branco G; Stridh P; Guerreiro-Cacais AO; Adzemovic MZ; Falcao AM; Marta M; Berglund R; Gillett A; Hamza KH; Lassmann H; Hermanson O; Jagodic M
Article: GENES AND IMMUNITY. 2014;15(7):457-465
The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation
Laaksonen H; Guerreiro-Cacais AO; Adzemovic MZ; Parsa R; Zeitelhofer M; Jagodic M; Olsson T
Article: BMC GENOMICS. 2014;15(1):391
Identification of candidate risk gene variations by whole-genome sequence analysis of four rat strains commonly used in inflammation research
Backdahl L; Ekman D; Jagodic M; Olsson T; Holmdahl R
Article: PLOS GENETICS. 2014;10(3):e1004265
Parent-of-Origin Effects Implicate Epigenetic Regulation of Experimental Autoimmune Encephalomyelitis and Identify Imprinted Dlk1 as a Novel Risk Gene
Stridh P; Ruhrmann S; Bergman P; Hedreul MT; Flytzani S; Beyeen AD; Gillett A; Krivosija N; Ockinger J; Ferguson-Smith AC; Jagodic M
Article: PLOS GENETICS. 2014;10(2):e1004151
Natural Polymorphisms in Tap2 Influence Negative Selection and CD4:CD8 Lineage Commitment in the Rat
Tuncel J; Haag S; Yau ACY; Norin U; Baud A; Lonnblom E; Maratou K; Ytterberg AJ; Ekman D; Thordardottir S; Johannesson M; Gillett A; Stridh P; Jagodic M; Olsson T; Fernandez-Teruel A; Zubarev RA; Mott R; Aitman TJ; Flint J; Holmdahl R
Article: SCIENTIFIC DATA. 2014;1:140011
Genomes and phenomes of a population of outbred rats and its progenitors
Baud A; Guryev V; Hummel O; Johannesson M; Flint J
Article: HUMAN MOLECULAR GENETICS. 2013;22(24):4952-4966
Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity
Hedreul MT; Moeller S; Stridh P; Gupta Y; Gillett A; Beyeen AD; Oeckinger J; Flytzani S; Diez M; Olsson T; Jagodic M
Article: NATURE GENETICS. 2013;45(11):1353-1360
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Beecham AH; Patsopoulos NA; Xifara DK; Davis MF; Kemppinen A; Cotsapas C; Shah TS; Spencer C; Booth D; Goris A; Oturai A; Saarela J; Fontaine B; Hemmer B; Martin C; Zipp F; D'Alfonso S; Martinelli-Boneschi F; Taylor B; Harbo HF; Kockum I; Hillert J; Olsson T; Ban M; Oksenberg JR; Hintzen R; Barcellos LF; Agliardi C; Alfredsson L; Alizadeh M; Anderson C; Andrews R; Sondergaard HB; Baker A; Band G; Baranzini SE; Barizzone N; Barrett J; Bellenguez C; Bergamaschi L; Bernardinelli L; Berthele A; Biberacher V; Binder TMC; Blackburn H; Bomfim IL; Brambilla P; Broadley S; Brochet B; Brundin L; Buck D; Butzkueven H; Caillier SJ; Camu W; Carpentier W; Cavalla P; Celius EG; Coman I; Comi G; Corrado L; Cosemans L; Cournu-Rebeix I; Cree BAC; Cusi D; Damotte V; Defer G; Delgado SR; Deloukas P; di Sapio A; Dilthey AT; Donnelly P; Dubois B; Duddy M; Edkins S; Elovaara I; Esposito F; Evangelou N; Fiddes B; Field J; Franke A; Freeman C; Frohlich IY; Galimberti D; Gieger C; Gourraud P-A; Graetz C; Graham A; Grummel V; Guaschino C; Hadjixenofontos A; Hakonarson H; Halfpenny C; Hall G; Hall P; Hamsten A; Harley J; Harrower T; Hawkins C; Hellenthal G; Hillier C; Hobart J; Hoshi M; Hunt SE; Jagodic M; Jelcic I; Jochim A; Kendall B; Kermode A; Kilpatrick T; Koivisto K; Konidari I; Korn T; Kronsbein H; Langford C; Larsson M; Lathrop M; Lebrun-Frenay C; Lechner-Scott J; Lee MH; Leone MA; Leppa V; Liberatore G; Lie BA; Lill CM; Linden M; Link J; Luessi F; Lycke J; Macciardi F; Mannisto S; Manrique CP; Martin R; Martinelli V; Mason D; Mazibrada G; McCabe C; Mero I-L; Mescheriakova J; Moutsianas L; Myhr K-M; Nagels G; Nicholas R; Nilsson P; Piehl F; Pirinen M; Price SE; Quach H; Reunanen M; Robberecht W; Robertson NP; Rodegher M; Rog D; Salvetti M; Schnetz-Boutaud NC; Sellebjerg F; Selter RC; Schaefer C; Shaunak S; Shen L; Shields S; Siffrin V; Slee M; Sorensen PS; Sorosina M; Sospedra M; Spurkland A; Strange A; Sundqvist E; Thijs V; Thorpe J; Ticca A; Tienari P; van Duijn C; Visser EM; Vucic S; Westerlind H; Wiley JS; Wilkins A; Wilson JF; Winkelmann J; Zajicek J; Zindler E; Haines JL; Pericak-Vance MA; Ivinson AJ; Stewart G; Hafler D; Hauser SL; Compston A; McVean G; De Jager P; Sawcer SJ; McCauley JL
Article: EXPERIMENTAL NEUROLOGY. 2013;249:39-48
Efficacy of vitamin D in treating multiple sclerosis-like neuroinflammation depends on developmental stage
Adzemovic MZ; Zeitelhofer M; Hochmeister S; Gustafsson SA; Jagodic M
Article: GENES AND IMMUNITY. 2013;14(7):409-419
Anti-MOG antibodies are under polygenic regulation with the most significant control coming from the C-type lectin-like gene locus
Flytzani S; Stridh P; Guerreiro-Cacais AO; Marta M; Hedreul MT; Jagodic M; Olsson T
Article: NATURE GENETICS. 2013;45(7):767-775
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats
Baud A; Hermsen R; Guryev V; Stridh P; Graham D; McBride MW; Foroud T; Calderari S; Diez M; Ockinger J; Beyeen AD; Gillett A; Abdelmagid N; Guerreiro-Cacais AO; Jagodic M; Tuncel J; Norin U; Beattie E; Ngan H; Miller WH; Koller DL; Alam I; Falak S; Osborne-Pellegrin M; Martinez-Membrives E; Canete T; Blazquez G; Vicens-Costa E; Mont-Cardona C; Diaz-Moran S; Tobena A; Hummel O; Zelenika D; Saar K; Patone G; Bauerfeind A; Bihoreau M-T; Heinig M; Lee Y-A; Rintisch C; Schulz H; Wheeler DA; Worley KC; Muzny DM; Gibbs RA; Lathrop M; Lansu N; Toonen P; Ruzius FP; de Bruijn E; Hauser H; Adams DJ; Keane T; Atanur SS; Aitman TJ; Flicek P; Malinauskas T; Jones EY; Ekman D; Lopez-Aumatell R; Dominiczak AF; Johannesson M; Holmdahl R; Olsson T; Gauguier D; Hubner N; Fernandez-Teruel A; Cuppen E; Mott R; Flint J
Article: MULTIPLE SCLEROSIS JOURNAL. 2013;19(7):863-870
Multiple sclerosis risk genotypes correlate with an elevated cerebrospinal fluid level of the suggested prognostic marker CXCL13
Linden M; Khademi M; Bomfim IL; Piehl F; Jagodic M; Kockum I; Olsson T
Article: JOURNAL OF IMMUNOLOGY. 2013;190(8):4066-4075
Next-Generation Sequencing Identifies MicroRNAs that Associate with Pathogenic Autoimmune Neuroinflammation in Rats
Bergman P; James T; Kular L; Ruhrmann S; Kramarova T; Kvist A; Supic G; Gillett A; Pivarcsi A; Jagodic M
Article: EPIGENETICS. 2013;8(3):333-346
An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform
Marabita F; Almgren M; Lindholm ME; Ruhrmann S; Fagerstrom-Billai F; Jagodic M; Sundberg CJ; Ekstrom TJ; Teschendorff AE; Tegner J; Gomez-Cabrero D
Article: PLOS ONE. 2013;8(5):e63300
A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis
Mechelli R; Umeton R; Policano C; Annibali V; Coarelli G; Ricigliano VAG; Vittori D; Fornasiero A; Buscarinu MC; Romano S; Salvetti M; Ristori G
Article: PLOS ONE. 2013;8(12):e81912
A Silent Exonic SNP in Kdm3a Affects Nucleic Acids Structure but Does Not Regulate Experimental Autoimmune Encephalomyelitis
Gillett A; Bergman P; Parsa R; Bremges A; Giegerich R; Jagodic M
Article: EPIGENETICS. 2012;7(6):585-593
Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity
Esteki-Zadeh A; Karimi M; Straat K; Ammerpohl O; Zeitelhofer M; Jagodic M; Mehrab-Mohseni M; Sjoholm L; Rahbar A; Soderberg-Naucler C; Ekstrom TJ
Article: PLOS ONE. 2012;7(7):e39794
Expression of Ccl11 Associates with Immune Response Modulation and Protection against Neuroinflammation in Rats
Adzemovic MZ; Ockinger J; Zeitelhofer M; Hochmeister S; Beyeen AD; Paulson A; Gillett A; Hedreul MT; Covacu R; Lassmann H; Olsson T; Jagodic M
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2011;208(11):2183-2191
The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development
Colacios C; Casemayou A; Dejean AS; Gaits-Iacovoni F; Pedros C; Bernard I; Lagrange D; Deckert M; Lamouroux L; Jagodic M; Olsson T; Liblau RS; Fournie GJ; Saoudi A
Article: NATURE. 2011;476(7359):214-219
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Sawcer S; Hellenthal G; Pirinen M; Spencer CCA; Patsopoulos NA; Moutsianas L; Dilthey A; Su Z; Freeman C; Hunt SE; Edkins S; Gray E; Booth DR; Potter SC; Goris A; Band G; Oturai AB; Strange A; Saarela J; Bellenguez C; Fontaine B; Gillman M; Hemmer B; Gwilliam R; Zipp F; Jayakumar A; Martin R; Leslie S; Hawkins S; Giannoulatou E; D'alfonso S; Blackburn H; Boneschi FM; Liddle J; Harbo HF; Perez ML; Spurkland A; Waller MJ; Mycko MP; Ricketts M; Comabella M; Hammond N; Kockum I; McCann OT; Ban M; Whittaker P; Kemppinen A; Weston P; Hawkins C; Widaa S; Zajicek J; Dronov S; Robertson N; Bumpstead SJ; Barcellos LF; Ravindrarajah R; Abraham R; Alfredsson L; Ardlie K; Aubin C; Baker A; Baker K; Baranzini SE; Bergamaschi L; Bergamaschi R; Bernstein A; Berthele A; Boggild M; Bradfield JP; Brassat D; Broadley SA; Buck D; Butzkueven H; Capra R; Carroll WM; Cavalla P; Celius EG; Cepok S; Chiavacci R; Clerget-Darpoux F; Clysters K; Comi G; Cossburn M; Cournu-Rebeix I; Cox MB; Cozen W; Cree BAC; Cross AH; Cusi D; Daly MJ; Davis E; de Bakker PIW; Debouverie M; D'hooghe MB; Dixon K; Dobosi R; Dubois B; Ellinghaus D; Elovaara I; Esposito F; Fontenille C; Foote S; Franke A; Galimberti D; Ghezzi A; Glessner J; Gomez R; Gout O; Graham C; Grant SFA; Guerini FR; Hakonarson H; Hall P; Hamsten A; Hartung H-P; Heard RN; Heath S; Hobart J; Hoshi M; Infante-Duarte C; Ingram G; Ingram W; Islam T; Jagodic M; Kabesch M; Kermode AG; Kilpatrick TJ; Kim C; Klopp N; Koivisto K; Larsson M; Lathrop M; Lechner-Scott JS; Leone MA; Leppa V; Liljedahl U; Bomfim IL; Lincoln RR; Link J; Liu J; Lorentzen AR; Lupoli S; Macciardi F; Mack T; Marriott M; Martinelli V; Mason D; McCauley JL; Mentch F; Mero I-L; Mihalova T; Montalban X; Mottershead J; Myhr K-M; Naldi P; Ollier W; Page A; Palotie A; Pelletier J; Piccio L; Pickersgill T; Piehl F; Pobywajlo S; Quach HL; Ramsay PP; Reunanen M; Reynolds R; Rioux J; Rodegher M; Roesner S; Rubio JP; Rueckert I-M; Salvetti M; Salvi E; Santaniello A; Schaefer CA; Schreiber S; Schulze C; Scott RJ; Sellebjerg F; Selmaj KW; Sexton D; Shen L; Simms-Acuna B; Skidmore S; Sleiman PMA; Smestad C; Sorensen PS; Sondergaard HB; Stankovich J; Strange RC; Sulonen A-M; Sundqvist E; Syvaenen A-C; Taddeo F; Taylor B; Blackwell JM; Tienari P; Bramon E; Tourbah A; Brown MA; Tronczynska E; Casas JP; Tubridy N; Corvin A; Vickery J; Jankowski J; Villoslada P; Markus HS; Wang K; Mathew CG; Wason J; Palmer CNA; Wichmann H-E; Plomin R; Willoughby E; Rautanen A; Winkelmann J; Wittig M; Trembath RC; Yaouanq J; Viswanathan AC; Zhang H; Wood NW; Zuvich R; Deloukas P; Langford C; Duncanson A; Oksenberg JR; Pericak-Vance MA; Haines JL; Olsson T; Hillert J; Ivinson AJ; De Jager PL; Peltonen L; Stewart GJ; Hafler DA; Hauser SL; McVean G; Donnelly P; Compston A
Article: JOURNAL OF IMMUNOLOGY. 2010;185(11):6883-6890
IL-22RA2 Associates with Multiple Sclerosis and Macrophage Effector Mechanisms in Experimental Neuroinflammation
Beyeen AD; Adzemovic MZ; Ockinger J; Stridh P; Becanovic K; Laaksonen H; Lassmann H; Harris RA; Hillert J; Alfredsson L; Celius EG; Harbo HF; Kockum I; Jagodic M; Olsson T
Article: PLOS ONE. 2010;5(9):e12716
Fine-Mapping Resolves Eae23 into Two QTLs and Implicates ZEB1 as a Candidate Gene Regulating Experimental Neuroinflammation in Rat
Stridh P; Hedreul MT; Beyeen AD; Adzemovic MZ; Laaksonen H; Gillett A; Ockinger J; Marta M; Lassmann H; Becanovic K; Jagodic M; Olsson T
Article: JOURNAL OF IMMUNOLOGY. 2010;185(6):3574-3582
Maternal MHC Regulates Generation of Pathogenic Antibodies and Fetal MHC-Encoded Genes Determine Susceptibility in Congenital Heart Block
Strandberg LS; Ambrosi A; Jagodic M; Dzikaite V; Janson P; Khademi M; Salomonsson S; Ottosson L; Klauninger R; Aden U; Sonesson S-E; Sunnerhagen M; de Graaf KL; Kuchroo VK; Achour A; Winqvist O; Olsson T; Wahren-Herlenius M
Article: MULTIPLE SCLEROSIS JOURNAL. 2010;16(9):1056-1065
Interleukin 18 Receptor 1 expression distinguishes patients with multiple sclerosis
Gillett A; Hedreul MT; Khademi M; Espinosa A; Beyeen AD; Jagodic M; Kockum I; Harris RA; Olsson T
Article: JOURNAL OF IMMUNOLOGY. 2010;185(1):442-450
TNF Production in Macrophages Is Genetically Determined and Regulates Inflammatory Disease in Rats
Gillett A; Marta M; Jin T; Tuncel J; Leclerc P; Nohra R; Lange S; Holmdahl R; Olsson T; Harris RA; Jagodic M
Article: GENES AND IMMUNITY. 2010;11(4):279-293
RGMA and IL21R show association with experimental inflammation and multiple sclerosis
Nohra R; Beyeen AD; Guo JP; Khademi M; Sundqvist E; Hedreul M; Sellebjerg F; Smestad C; Oturai AB; Harbo HF; Wallstrom E; Hillert J; Alfredsson L; Kockum I; Jagodic M; Lorentzen J; Olsson T
Article: MOLECULAR AND CELLULAR BIOLOGY. 2010;30(5):1199-1216
Mutational Analysis of the Poly(ADP-Ribosyl)ation Sites of the Transcription Factor CTCF Provides an Insight into the Mechanism of Its Regulation by Poly(ADP-Ribosyl)ation
Farrar D; Rai S; Chernukhin I; Jagodic M; Ito Y; Yammine S; Ohlsson R; Murrell A; Klenova E
Article: GENES AND IMMUNITY. 2010;11(2):142-154
Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis
Ockinger J; Stridh P; Beyeen AD; Lundmark F; Seddighzadeh M; Oturai A; Sorensen PS; Lorentzen AR; Celius EG; Leppa V; Koivisto K; Tienari PJ; Alfredsson L; Padyukov L; Hillert J; Kockum I; Jagodic M; Olsson T
Article: GENES AND IMMUNITY. 2010;11(1):21-36
Multiple loci comprising immune-related genes regulate experimental neuroinflammation
Marta M; Stridh P; Becanovic K; Gillett A; Ockinger J; Lorentzen JC; Jagodic M; Olsson T
Article: SCIENCE TRANSLATIONAL MEDICINE. 2009;1(10):10ra21
A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
Jagodic M; Colacios C; Nohra R; Dejean AS; Beyeen AD; Khademi M; Casemayou A; Lamouroux L; Duthoit C; Papapietro O; Sjoholm L; Bernard I; Lagrange D; Dahlman I; Lundmark F; Oturai AB; Soendergaard HB; Kemppinen A; Saarela J; Tienari PJ; Harbo HF; Spurkland A; Ramagopalan SV; Sadovnick DA; Ebers GC; Seddighzadeh M; Klareskog L; Alfredsson L; Padyukov L; Hillert J; Clanet M; Edan G; Fontaine B; Fournie GJ; Kockum I; Saoudi A; Olsson T
Article: ANNALS OF THE RHEUMATIC DISEASES. 2009;68(12):1925-1932
Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case-control association data
Backdahl L; Guo JP; Jagodic M; Becanovic K; Ding B; Olsson T; Lorentzen JC
Article: PLOS ONE. 2009;4(11):e7773
Alternative Splicing and Transcriptome Profiling of Experimental Autoimmune Encephalomyelitis Using Genome-Wide Exon Arrays
Gillett A; Maratou K; Fewings C; Harris RA; Jagodic M; Aitman T; Olsson T
Article: JOURNAL OF NEUROIMMUNOLOGY. 2009;212(1-2):82-92
Identification of gene regions regulating inflammatory microglial response in the rat CNS after nerve injury
Diez M; Abdelmagid N; Harnesk K; Strom M; Lidman O; Swanberg M; Lindblom R; Al-Nimer F; Jagodic M; Olsson T; Piehl F
Article: JOURNAL OF NEUROIMMUNOLOGY. 2009;210(1-2):30-39
Characterization of Multiple Sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis
Hedreul MT; Gillett A; Olsson T; Jagodic M; Harris RA
Article: JOURNAL OF IMMUNOLOGY. 2009;182(7):4432-4438
Advanced Intercross Line Mapping Suggests That Ncf1 (Ean6) Regulates Severity in an Animal Model of Guillain-Barre Syndrome
Huberle A; Beyeen AD; Ockinger J; Ayturan M; Jagodic M; de Graaf KL; Fissolo N; Marta M; Olofsson P; Hultqvist M; Holmdahl R; Olsson T; Weissert R
Article: HUMAN MOLECULAR GENETICS. 2008;17(17):2633-2643
Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer.
Ito Y; Koessler T; Ibrahim AEK; Rai S; Vowler SL; Abu-Amero S; Silva A-L; Maia A-T; Huddleston JE; Uribe-Lewis S; Woodfine K; Jagodic M; Nativio R; Dunning A; Moore G; Klenova E; Bingham S; Pharoah PDP; Brenton JD; Beck S; Sandhu MS; Murrell A
Article: JOURNAL OF IMMUNOLOGY. 2006;177(11):7923-7929
Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice
Johansson MH; Taylor MA; Jagodic M; Tus K; Schatzle JD; Wakeland EK; Bennett M
Article: GENOMICS. 2006;88(6):737-744
Combined-cross analysis of genome-wide linkage scans for experimental autoimmune encephalomyelitis in rat
Jagodic M; Olsson T
Article: GENETICS. 2006;173(3):1539-1545
Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice
Ockinger J; Serrano-Fernandez P; Moeller S; Ibrahim SM; Olsson T; Jagodic M
Article: JOURNAL OF IMMUNOLOGY. 2006;176(10):6055-6064
Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis
Becanovic K; Jagodic M; Sheng JR; Dahlman I; Aboul-Enein F; Wallstrom E; Olofsson P; Holmdahl R; Lassmann H; Olsson T
Article: JOURNAL OF NEUROINFLAMMATION. 2005;2:26
Cytokine responses during chronic denervation
Ruohonen S; Khademi M; Jagodic M; Taskinen H-S; Olsson T; Roytta M
Article: NITRIC OXIDE - BIOLOGY AND CHEMISTRY. 2005;13(3):188-195
Effects of long term NOS inhibition on disease and the immune system in MOG induced EAE
Danilov AI; Jagodic M; Wiklund NP; Olsson T; Brundin L
Article: GENETICS. 2005;170(1):283-289
Eae19, a new locus on rat chromosome 15 regulating experimental autoimmune encephalomyelitis
Sheng JR; Jagodic M; Dahlman I; Becanovic K; Nohra R; Marta M; Iacobaeus E; Olsson T; Wallström E
Article: NATURE GENETICS. 2005;37(5):486-494
MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
Swanberg M; Lidman O; Padyukov L; Eriksson P; Åkesson E; Jagodic M; Lobell A; Khademi M; Borjesson O; Lindgren CM; Lundman P; Brookes AJ; Kere J; Luthman H; Alfredsson L; Hillert J; Klareskog L; Hamsten A; Piehl F; Olsson T
Article: JOURNAL OF IMMUNOLOGY. 2005;174(2):918-924
Resolution of a 16.8-mb autoimmunity-regulating rat chromosome 4 region into multiple encephalomyrelitis quantitative trait loci and evidence for epistasis
Jagodic M; Marta M; Becanovic K; Sheng JR; Nohra R; Olsson T; Lorentzen JC
Article: JOURNAL OF IMMUNOLOGY. 2004;173(2):1366-1373
An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci
Jagodic M; Becanovic K; Sheng JR; Wu XC; Bäckdahl L; Lorentzen JC; Wallström E; Olsson T
Article: JOURNAL OF NEUROTRAUMA. 2004;21(7):969-975
Distinct expression of TGF-β1 mRNA in the endo- and epineurium after nerve injury
Taskinen HS; Ruohonen S; Jagodic M; Khademi M; Olsson T; Röyttä M
Article: NEUROSCIENCE LETTERS. 2003;350(3):165-168
Myelin oligodendrocyte glycoprotein is expressed in the peripheral nervous system of rodents and primates
Pagany M; Jagodic M; Schubart A; Pham-Dinh D; Bachelin C; van Evercooren AB; Lachapelle F; Olsson T; Linington C
Article: JOURNAL OF NEUROIMMUNOLOGY. 2003;139(1-2):1-8
Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis
Pagany M; Jagodic M; Bourquin C; Olsson T; Linington C
Article: JOURNAL OF NEUROIMMUNOLOGY. 2002;132(1-2):11-17
Contralateral non-operated nerve to transected rat sciatic nerve shows increased expression of IL-1β, TGF-β1, TNF-α, and IL-10
Ruohonen S; Jagodi M; Khademi M; Taskinen HS; Ojala P; Olsson T; Röyttä M
Article: IMMUNOGENETICS. 2001;53(5):410-415
Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
Jagodic M; Kornek B; Weissert R; Lassmann H; Olsson T; Dahlman I
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Review: JOURNAL OF INTERNAL MEDICINE. 2020;288(1):82-102
Epigenetic insights into multiple sclerosis disease progression
Kular L; Jagodic M
Corrigendum: SCIENTIFIC REPORTS. 2018;8(1):4340
Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship (vol 7, 14589, 2017)
Marabita F; Almgren M; Sjoholm LK; Kular L; Liu Y; James T; Kiss NB; Feinberg AP; Olsson T; Kockum I; Alfredsson L; Ekstrom TJ; Jagodic M
Review: PHYSIOLOGICAL GENOMICS. 2017;49(9):447-461
Epigenetic research in multiple sclerosis: progress, challenges, and opportunities
Zheleznyakova GY; Piket E; Marabita F; Kakhki MP; Ewing E; Ruhrmann S; Needhamsen M; Jagodic M; Kular L
Letter: EXPERIMENTAL DERMATOLOGY. 2017;26(5):444-446
IL-22 binding protein regulates murine skin inflammation
Lindahl H; Martini E; Brauner S; Nikamo P; Serezal IG; Guerreiro-Cacais AO; Jagodic M; Eidsmo L; Stahle M; Olsson T
Corrigendum: GENES AND IMMUNITY. 2017;18(2):109
VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis (vol 18, pg 48, 2017)
Guerreiro-Cacais AO; Norin U; Gyllenberg A; Berglund R; Beyeen AD; Petit-Teixeira E; Cornelis F; Saoudi A; Fournie GJ; Holmdahl R; Alfredsson L; Klareskog L; Jagodic M; Olsson T; Kockum I; Padyukov L
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2015;67:49-57
Genomic imprinting: A missing piece of the Multiple Sclerosis puzzle?
Ruhrmann S; Stridh P; Kular L; Jagodic M
Editorial comment: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2015;356(1-2):3-4
MicroRNAs as promising novel biomarkers and potential drug targets for inflammatory neurological diseases
Piehl F; Jagodic M
Review: JOURNAL OF INFLAMMATION RESEARCH. 2015;8:211-225
Translational utility of experimental autoimmune encephalomyelitis: recent developments.
Guerreiro-Cacais AO; Laaksonen H; Flytzani S; N'diaye M; Olsson T; Jagodic M
Review: NUTRITION AND CANCER. 2013;65(6):781-792
Epigenetics: A New Link Between Nutrition and Cancer
Supic G; Jagodic M; Magic Z
Editorial comment: NATURE GENETICS. 2013;45(2):116-118
Nurture your scientific curiosity early in your research career
Jagodic M; Stridh P; Gad AKB; Paine A; Udekwu KI; Sjoholm LK; Svensson M; Pan-Hammarstrom Q
Review: CURRENT OPINION IN IMMUNOLOGY. 2006;18(6):643-649
Genetics of autoimmune neuroinflammation
Olsson T; Jagodic M; Piehl F; Wallstrom E
Thesis / dissertation: 2004
The complex genetics of experimental autoimmune neuroinflammation
Jagodic, Maja
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;60(1-2):39-51
Current gene-mapping strategies in experimental models of multiple sclerosis
Becanovic K; Jagodic M; Wallström E; Olsson T

Employments

Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2021-

Degrees and Education

Docent, Karolinska Institutet, 2014
Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2004

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