Lynn Butler

About me
Publications
Public outreach and news

Research

The primary focus of my research group is the study of endothelial cells that
line the inside of all blood vessels. These cells have many functions, such
as providing an anti-thrombotic surface to prevent blood clotting and
controlling leukocyte recruitment to tissue during inflammation. Our research
is based around the identification of genes that are highly specifically
expressed in endothelial cells (compared to other cell types) and the role of
these genes in vascular function. Through this work, we identify potential
plasma biomarker candidates for the clinical assessment of vascular health
and risk stratification, diagnosis and prognosis of diseases of the
cardiovascular system, such as venous and arterial thrombosis and COVID-19
complications.

Articles

Article: BMC BIOLOGY. 2024;22(1):36
A human stomach cell type transcriptome atlas
Oling S; Struck E; Noreen-Thorsen M; Zwahlen M; von Feilitzen K; Odeberg J; Ponten F; Lindskog C; Uhlen M; Dusart P; Butler LM
Article: JOURNAL OF IMMUNOLOGY. 2024;212(1):117-129
Global Transcriptome Analysis Reveals Distinct Phases of the Endothelial Response to TNF
Struck EC; Belova T; Hsieh P-H; Odeberg JO; Kuijjer ML; Dusart PJ; Butler LM
Article: NATURE COMMUNICATIONS. 2023;14(1):3280
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
Iglesias MJ; Sanchez-Rivera L; Ibrahim-Kosta M; Naudin C; Munsch G; Goumidi L; Farm M; Smith PM; Thibord F; Kral-Pointner JB; Hong M-G; Suchon P; Germain M; Schrottmaier W; Dusart P; Boland A; Kotol D; Edfors F; Koprulu M; Pietzner M; Langenberg C; Damrauer SM; Johnson AD; Klarin DM; Smith NL; Smadja DM; Holmstrom M; Magnusson M; Silveira A; Uhlen M; Renne T; Martinez-Perez A; Emmerich J; Deleuze J-F; Antovic J; Soria Fernandez JM; Assinger A; Schwenk JM; Souto Andres JC; Morange P-E; Butler LM; Tregouet D-A; Odeberg J
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1181761
Targeting NETs using dual-active DNase1 variants
Englert H; Goebel J; Khong D; Omidi M; Wolska N; Konrath S; Frye M; Mailer RK; Beerens M; Gerwers JC; Preston RJS; Odeberg J; Butler LM; Maas C; Stavrou EX; Fuchs TA; Renne T
Article: CELL REPORTS. 2022;40(2):111046
A human adipose tissue cell-type transcriptome atlas
Norreen-Thorsen M; Struck EC; Oling S; Zwahlen M; Von Feilitzen K; Odeberg J; Lindskog C; Ponten F; Uhlen M; Dusart PJ; Butler LM
Article: RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS. 2022;6(3):e12706
Proteomics in thrombosis research
Edfors F; Iglesias MJ; Butler LM; Odeberg J
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:1008410
Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood
Konrath S; Mailer RK; Beerens M; Englert H; Frye M; Kuta P; Preston RJS; Maas C; Butler LM; Roest M; de Laat B; Renne T
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2021;41(12):2990-3004
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors
Iglesias MJ; Kruse LD; Sanchez-Rivera L; Enge L; Dusart P; Hong M-G; Uhlen M; Renne T; Schwenk JM; Bergstrom G; Odeberg J; Butler LM
Article: NATURE COMMUNICATIONS. 2021;12(1):5596
Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
Heestermans M; Naudin C; Mailer RK; Konrath S; Klaetschke K; Jamsa A; Frye M; Deppermann C; Pula G; Kuta P; Friese MA; Gelderblom M; Sickmann A; Preston RJS; Nofer J-R; Rose-John S; Butler LM; Salomon O; Stavrou EX; Renne T
Article: SCIENCE ADVANCES. 2021;7(31):eabh2169
A single-cell type transcriptomics map of human tissues
Karlsson M; Zhang C; Mear L; Zhong W; Digre A; Katona B; Sjoestedt E; Butler L; Odeberg J; Dusart P; Edfors F; Oksvold P; von Feilitzen K; Zwahlen M; Arif M; Altay O; Li X; Ozcan M; Mardonoglu A; Fagerberg L; Mulder J; Luo Y; Ponten F; Uhlen M; Lindskog C
Article: SCIENTIFIC REPORTS. 2021;11(1):14015
An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism
Razzaq M; Iglesias MJ; Ibrahim-Kosta M; Goumidi L; Soukarieh O; Proust C; Roux M; Suchon P; Boland A; Daiain D; Olaso R; Havervall S; Thalin C; Butler L; Deleuze J-F; Odeberg J; Morange P-E; Tregouet D-A
Article: BLOOD. 2021;137(10):1392-1405
Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate
Mailer RK; Allende M; Heestermans M; Schweizer M; Deppermann C; Frye M; Pula G; Odeberg J; Gelderblom M; Rose-John S; Sickmann A; Blankenberg S; Huber TB; Kubisch C; Maas C; Gambaryan S; Firsov D; Stavrou EX; Butler LM; Renne T
Article: CELL REPORTS. 2019;29(6):1690-1706.e4
A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes
Dusart P; Hallstrom BM; Renne T; Odeberg J; Uhlen M; Butler LM
Article: CELLULAR AND MOLECULAR BIOENGINEERING. 2019;12(1):15-32
Molecular Imaging of a New Multimodal Microbubble for Adhesion Molecule Targeting
Ahmed M; Gustafsson B; Aldi S; Dusart P; Egri G; Butler LM; Bone D; Dahne L; Hedin U; Caidahl K
Article: CYTOKINE. 2018;111:563-566
Human cytomegalovirus replication induces endothelial cell interleukin-11
Gustafsson KLR; Renne T; Soderberg-Naucler C; Butler LM
Article: SCIENTIFIC REPORTS. 2018;8(1):14668
A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein
Dusart P; Fagerberg L; Perisic L; Civelek M; Struck E; Hedin U; Uhlen M; Tregouet D-A; Renne T; Odeberg J; Butler LM
Article: BLOOD. 2016;128(23):e59-e66
PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study
Bruzelius M; Iglesias MJ; Hong M-G; Sanchez-Rivera L; Gyorgy B; Carlos Souto J; Franberg M; Fredolini C; Strawbridge RJ; Holmstrom M; Hamsten A; Uhlen M; Silveira A; Manuel Soria J; Smadja DM; Butler LM; Schwenk JM; Morange P-E; Tregouet D-A; Odeberg J
Article: CELL SYSTEMS. 2016;3(3):287-301.e3
Analysis of Body-wide Unfractionated Tissue Data to Identify a Core Human Endothelial Transcriptome
Butler LM; Hallstrom BM; Fagerberg L; Ponten F; Uhlen M; Renne T; Odeberg J
Article: NATURE COMMUNICATIONS. 2016;7:12616
Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
Labberton L; Kenne E; Long AT; Nickel KF; Di Gennaro A; Rigg RA; Hernandez JS; Butler L; Maas C; Stavrou EX; Renne T
Article: THROMBOSIS RESEARCH. 2016;141:S4-S7
The polyphosphate/factor XII pathway in cancer-associated thrombosis: novel perspectives for safe anticoagulation in patients with malignancies
Nickel KF; Labberton L; Long AT; Langer F; Fuchs TA; Stavrou EX; Butler LM; Renne T
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1430:231-248
Static and Dynamic Assays of Cell Adhesion Relevant to the Vasculature.
Butler LM; McGettrick HM; Nash GB
Article: OPEN FORUM INFECTIOUS DISEASES. 2015;2(4):ofv155
Human Cytomegalovirus Up-Regulates Endothelin Receptor Type B: Implication for Vasculopathies?
Yaiw K-C; Mohammad A-A; Costa H; Taher C; Badrnya S; Assinger A; Wilhelmi V; Ananthaseshan S; Estekizadeh A; Davoudi B; Ovchinnikova O; Shlyakhto E; Rafnsson A; Khan Z; Butler L; Rahbar A; Pernow J; Söderberg-Nauclér C
Article: JOURNAL OF GENERAL VIROLOGY. 2015;96(12):3598-3612
Direct infection of primary endothelial cells with human cytomegalovirus prevents angiogenesis and migration
Gustafsson RKL; Jeffery HC; Yaiw K-C; Wilhelmi V; Kostopoulou ON; Davoudi B; Rahbar A; Benard M; Renne T; Soderberg-Naucler C; Butler LM
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;135(4):1031-1043.e6
Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions
Sala-Cunill A; Bjoerkqvist J; Senter R; Guilarte M; Cardona V; Labrador M; Nickel KF; Butler L; Luengo O; Kumar P; Labberton L; Long A; Di Gennaro A; Kenne E; Jaemsae A; Krieger T; Schlueter H; Fuchs T; Flohr S; Hassiepen U; Cumin F; McCrae K; Maas C; Stavrou E; Renne T
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2014;25(8):1669-1678
Human Cytomegalovirus Inhibits Erythropoietin Production
Butler LM; Dzabic M; Bakker F; Davoudi B; Jeffery H; Religa P; Bojakowski K; Yaiw K-C; Rahbar A; Soederberg-Naucler C
Article: THROMBOSIS AND HAEMOSTASIS. 2014;112(2):332-341
Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) triggers platelet activation and boosts platelet-leukocyte proinflammatory responses
Assinger A; Wang Y; Butler LM; Hansson GK; Yan Z-Q; Soderberg-Naucler C; Ketelhuth DFJ
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2014;34(4):801-809
Human Cytomegalovirus-Platelet Interaction Triggers Toll-Like Receptor 2-Dependent Proinflammatory and Proangiogenic Responses
Assinger A; Kral JB; Yaiw KC; Schrottmaier WC; Kurzejamska E; Wang Y; Mohammad A-A; Religa P; Rahbar A; Schabbauer G; Butler LM; Soderberg-Naucler C
Article: BASIC RESEARCH IN CARDIOLOGY. 2014;109(2):401
Human cytomegalovirus induces upregulation of arginase II: possible implications for vasculopathies
Yaiw K-C; Mohammad A-A; Taher C; Wilhelmi V; Davoudi B; Straat K; Assinger A; Ovchinnikova O; Shlyakhto E; Rahbar A; Koutonguk O; Religa P; Butler L; Khan Z; Streblow D; Pernow J; Soderberg-Naucler C
Article: HERPESVIRIDAE. 2013;4(1):3
High prevalence of human cytomegalovirus in carotid atherosclerotic plaques obtained from Russian patients undergoing carotid endarterectomy.
Yaiw K-C; Ovchinnikova O; Taher C; Mohammad A-A; Davoudi B; Shlyakhto E; Rotar O; Konradi A; Wilhelmi V; Rahbar A; Butler L; Assinger A; Söderberg-Nauclér C
Article: JOURNAL OF VIROLOGICAL METHODS. 2013;193(1):251-259
Infection and transmission dynamics of rKSHV.219 in primary endothelial cells
Jeffery HC; Wheat RL; Blackbourn DJ; Nash GB; Butler LM
Article: IMMUNOBIOLOGY. 2013;218(8):1034-1040
Human cytomegalovirus particles directly suppress CD4 T-lymphocyte activation and proliferation
Fornara O; Odeberg J; Khan Z; Stragliotto G; Peredo I; Butler L; Soderberg-Naucler C
Article: JOURNAL OF VIROLOGY. 2013;87(11):6530-6535
Human Cytomegalovirus Induces a Biphasic Inflammatory Response in Primary Endothelial Cells
Jeffery HC; Soderberg-Naucler C; Butler LM
Article: JOURNAL OF IMMUNOLOGY. 2013;190(2):678-688
MicroRNA-31 Is Overexpressed in Psoriasis and Modulates Inflammatory Cytokine and Chemokine Production in Keratinocytes via Targeting Serine/Threonine Kinase 40
Xu N; Meisgen F; Butler LM; Han G; Wang X-J; Soderberg-Naucler C; Stahle M; Pivarcsi A; Sonkoly E
Article: THROMBOSIS AND HAEMOSTASIS. 2012;108(4):719-729
Platelets directly enhance neutrophil transmigration in response to oxidised low-density lipoprotein
Badrnya S; Butler LM; Soderberg-Naucler C; Volf I; Assinger A
Article: JOURNAL OF VIROLOGY. 2012;86(13):7158-7166
Kaposi's sarcoma-associated herpesvirus inhibits expression and function of endothelial cell major histocompatibility complex class II via suppressor of cytokine signaling 3.
Butler LM; Jeffery HC; Wheat RL; Long HM; Rae PC; Nash GB; Blackbourn DJ
Article: JOURNAL OF GENERAL VIROLOGY. 2011;92(Pt 10):2394-2398
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3.
Mutocheluh M; Hindle L; Aresté C; Chanas SA; Butler LM; Lowry K; Shah K; Evans DJ; Blackbourn DJ
Article: JOURNAL OF VIROLOGY. 2011;85(14):7321-7332
Kaposi's Sarcoma-Associated Herpesvirus Infection of Endothelial Cells Inhibits Neutrophil Recruitment through an Interleukin-6-Dependent Mechanism: a New Paradigm for Viral Immune Evasion
Butler LM; Jeffery HC; Wheat RL; Rae PC; Townsend K; Alkharsah KR; Schulz TF; Nash GB; Blackbourn DJ
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(3):276-292
Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture.
Burton VJ; Butler LM; McGettrick HM; Stone PC; Jeffery HC; Savage CO; Rainger GE; Nash GB
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(48):37641-37649
Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.
Durrington HJ; Upton PD; Hoer S; Boname J; Dunmore BJ; Yang J; Crilley TK; Butler LM; Blackbourn DJ; Nash GB; Lehner PJ; Morrell NW
Article: EXPERIMENTAL CELL RESEARCH. 2009;315(19):3433-3441
A role for the endothelial glycosaminoglycan hyaluronan in neutrophil recruitment by endothelial cells cultured for prolonged periods.
Butler LM; Rainger GE; Nash GB
Article: METHODS IN MOLECULAR BIOLOGY. 2009;467:211-228
Static and dynamic assays of cell adhesion relevant to the vasculature.
Butler LM; McGettrick HM; Nash GB
Article: CRITICAL CARE MEDICINE. 2008;36(5):1536-1542
Mechanisms of the anti-inflammatory effects of hydroxyethyl starch demonstrated in a flow-based model of neutrophil recruitment by endothelial cells.
Matharu NM; Butler LM; Rainger GE; Gosling P; Vohra RK; Nash GB
Article: CELLULAR IMMUNOLOGY. 2008;251(1):56-61
Effects of endothelial basement membrane on neutrophil adhesion and migration.
Butler LM; Khan S; Ed Rainger G; Nash GB
Article: THROMBOSIS AND HAEMOSTASIS. 2007;97(5):814-821
Sequential adhesion of platelets and leukocytes from flowing whole blood onto a collagen-coated surface: requirement for a GpVI-binding site in collagen.
Butler LM; Metson-Scott T; Felix J; Abhyankar A; Rainger GE; Farndale RW; Watson SP; Nash GB
Article: METHODS IN MOLECULAR BIOLOGY. 2007;370:37-54
Analysis of leukocyte migration through monolayers of cultured endothelial cells.
McGettrick HM; Butler LM; Nash GB
Article: BIORHEOLOGY. 2006;43(1):71-82
An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31.
Chakravorty SJ; McGettrick HM; Butler LM; Buckley CD; Rainger GE; Nash GB
Article: EXPERIMENTAL CELL RESEARCH. 2005;310(1):22-32
Prolonged culture of endothelial cells and deposition of basement membrane modify the recruitment of neutrophils.
Butler LM; Rainger GE; Rahman M; Nash GB
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Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):7752
Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Iglesias MJ; Sanchez-Rivera L; Ibrahim-Kosta M; Naudin C; Munsch G; Goumidi L; Farm M; Smith PM; Thibord F; Kral-Pointner JB; Hong M-G; Suchon P; Germain M; Schrottmaier W; Dusart P; Boland A; Kotol D; Edfors F; Koprulu M; Pietzner M; Langenberg C; Damrauer SM; Johnson AD; Klarin DM; Smith NL; Smadja DM; Holmström M; Magnusson M; Silveira A; Uhlén M; Renné T; Martinez-Perez A; Emmerich J; Deleuze J-F; Antovic J; Soria Fernandez JM; Assinger A; Schwenk JM; Souto Andres JC; Morange P-E; Butler LM; Trégouët D-A; Odeberg J
Preprint: BIORXIV. 2023
Temporal transcriptome analysis of the endothelial response to tumour necrosis factor
Struck EC; Belova T; Hsieh P; Odeberg J; Kuijjer ML; Dusart P; Butler LM
Preprint: BIORXIV. 2023
A human stomach cell type transcriptome atlas
Öling S; Struck E; Thorsen MN; Zwahlen M; Feilitzen V; Odeberg J; Pontén F; Lindskog C; Uhlén M; Dusart P; Butler LM
Preprint: BIORXIV. 2023
A tissue centric atlas of cell type transcriptome enrichment signatures
Dusart P; Öling S; Struck E; Norreen-Thorsen M; Zwahlen M; von Feilitzen K; Oksvold P; Bosic M; Iglesias MJ; Renne T; Odeberg J; Pontén F; Lindskog C; Uhlén M; Butler LM
Preprint: BIORXIV. 2022
Genome-wide single cell annotation of the human protein-coding genes
Karlsson M; Álvez MB; Shi M; Méar L; Schutten R; Hikmet F; Digre A; Katona B; Vuu J; Bosic M; Sjöstedt E; Edfors F; Oksvold P; von Feilitzen K; Zwahlen M; Forsberg M; Johansson F; Mulder J; Hökfelt T; Luo Y; Butler L; Zhong W; Mardinoglu A; Sivertsson Å; Ponten F; Zhang C; Lindskog C; Fagerberg L; Uhlén M
Preprint: MEDRXIV. 2022
Elevated plasma Complement Factor H Regulating Protein 5 is associated with venous thromboembolism and COVID-19 severity
Sanchez-Rivera L; Iglesias MJ; Ibrahim-Kosta M; Kral-Pointner JB; Havervall S; Goumidi L; Farm M; Munsch G; Germain M; Smith P; Hong M-G; Suchon P; Naudin C; Boland A; Smadja D; Holmström M; Magnusson M; Silveira A; Uhlén M; Renné T; Martinez-Perez A; Emmerich J; Deleuze J-F; Antovic J; Assinger A; Fernandez JMS; Thålin C; Schwenk J; Andres JCS; Morange P-E; Butler LM; Trégouët D-A; Odeberg J
Preprint: MEDRXIV. 2021
Identification of endothelial-derived proteins in plasma associated with cardiovascular risk factors
Iglesias MJ; Kruse LD; Sanchez-Rivera L; Enge L; Dusart P; Hong MG; Uhlén M; Renné T; Schwenk JM; Bergstrom G; Odeberg J; Butler LM
Book chapter: COMPUTATIONAL METHODS IN SYSTEMS BIOLOGY: LECTURE NOTES IN COMPUTER SCIENCE (INCLUDING SUBSERIES LECTURE NOTES IN ARTIFICIAL INTELLIGENCE AND LECTURE NOTES IN BIOINFORMATICS). 2021;p. 108-121
Explainable Artificial Neural Network for Recurrent Venous Thromboembolism Based on Plasma Proteomics
Razzaq M; Goumidi L; Iglesias M-J; Munsch G; Bruzelius M; Ibrahim-Kosta M; Butler L; Odeberg J; Morange P-E; Tregouet DA
Preprint: MEDRXIV. 2020
An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism
Razzaq M; Iglesias MJ; Ibrahim-Kosta M; Goumidi L; Soukarieh O; Proust C; Roux M; Suchon P; Boland A; Daiain D; Olaso R; Butler L; Deleuze J-F; Odeberg J; Morange P-E; Trégouët D-A
Preprint: BIORXIV. 2019
A systems-based map of human brain cell-type enriched genes and malignancy-associated endothelial changes
Dusart P; Hallström B; Renne T; Odeberg J; Uhlén M; Butler L
Preprint: SSRN ELECTRONIC JOURNAL. 2019
A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes
Dusart P; Hallström BM; Renne T; Odeberg J; Uhlen M; Butler L
Review: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2017;43(8):814-826
Factor XII Contact Activation
Naudin C; Burillo E; Blankenberg S; Butler L; Renne T
Review: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2017;37(1):13-20
Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases
Nickel KF; Long AT; Fuchs TA; Butler LM; Renne T
Review: ANNALS OF TRANSLATIONAL MEDICINE. 2015;3(17):247
The factor XIIa blocking antibody 3F7: a safe anticoagulant with anti-inflammatory activities.
Worm M; Köhler EC; Panda R; Long A; Butler LM; Stavrou EX; Nickel KF; Fuchs TA; Renné T
Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2015;13:954
Verema - an affinity proteomics study to identify and translate plasma biomarkers for venous thromboembolism
Bruzelius M; Iglesias MJ; Hong M-G; Tregouet DA; Souto JC; Holmstrom M; Franberg M; Strawbridge RJ; Sabater-Lleal M; Sennblad B; Silveira A; Soria JM; Morange PE; Butler L; Schwenk JM; Hamsten A; Odeberg J
Review: JOURNAL OF LEUKOCYTE BIOLOGY. 2012;91(3):385-400
Tissue stroma as a regulator of leukocyte recruitment in inflammation
McGettrick HM; Butler LM; Buckley CD; Rainger GE; Nash GB
Conference publication: NEURO-ONCOLOGY. 2012;14:52
CYTOMEGALOVIRUS INFECTION OF PRIMARY GLIOBLASTOMA CELLS INDUCES STEMNESS THROUGH A NOTCH-DEPENDENT PATHWAY
Fornara O; Mirza S; Khan Z; Odeberg J; Stragliotto G; Butler L; Soderberg-Naucler C

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