Lorena Fernández de la Cruz
- Department of Clinical Neuroscience
- Centre for Psychiatry Research at CNS
- Obsessive - Compulsive and Related Disorders Across the Lifespan – David Mataix-Cols research group
- Health consequences and lifestyle modification – Lorena Fernandez de la Cruz's team
About me
I completed my PhD in psychiatry and clinical psychology and defended my thesis with honors in 2013 at the Universitat Autònoma de Barcelona. In my dissertation, I explored the clinical heterogeneity of obsessive-compulsive disorder (OCD) in children and adolescents. For four years, I worked at the Institute of Psychiatry (IoP), King's College London. During my last year at the IoP, I completed a one-year postdoc in the Mood and Development Laboratory at the Department of Child and Adolescent Psychiatry. I moved to Stockholm in 2014 for a second postdoc at the Obsessive-Compulsive and Related Disorders Across the Lifespan research group at the Department of Clinical Neuroscience (CNS), led by Professor David Mataix-Cols, where I started working with psychiatric epidemiology designs. Currently, I am a Lektor / Senior Lecturer (Associate Professor) at CNS. I am also the Equal Treatment Representative (Ombud för Lika Villkor) for the Department and the Dissemination and Outreach Coordinator for BUP Forsknings och Utvecklingscentrum (BUP FoUU) at the Stockholm Mental Health Services (SLSO), Region Stockholm.
Research
I am the team leader of the “Health consequences and lifestyle modification group”, within the larger Obsessive-Compulsive and Related Disorders Across the Lifespan research group. My team aims to study health outcomes, life expectancy, and causes of mortality in OCD and related conditions, such as tic disorders and anxiety disorders. We also study societal outcomes (e.g., educational attainment, labour market participation) in these disorders. We mainly use epidemiological methods in order to respond to our research questions.
Building upon the results from our epidemiological research on the association between OCD and health-related disorders, we have developed and are currently testing a lifestyle intervention to reduce cardiometabolic risk factors in individuals with OCD in an randomized controlled trial, now open for recruitment.
I am also interested in the development and dissemination of evidence-based treatments for OCD and related conditions. We are currently recruiting participants to take part in a clinical trial for adolescents with body dysmorphic disorder.
Teaching
I am a frequent lecturer on OCD and related disorders, as well as methodological aspects of clinical research, for undergraduate (psychology and medical programs), MSc, and PhD students at Karolinska Institutet and for psychologists and psychiatrists within the Stockholm healthcare services. I have been course leader of the KI PhD courses "Clinical Research in Child and Adolescent Psychiatry: Methods and Practice" (2022-2024, 3 occasions) and "How to Conduct Clinical Research in Psychiatry: From Theory to Practice" (2006- ; 1 occasion).
I am main supervisor for one PhD student (Sofia Asplund) and co-supervisor for five PhD students (Sofia Jägholm, Anita Birovecz, Moa Warnström, Dimitar Krastev, and Lisa Gunarsson) at Karolinska Institutet. I am Dr Anna Holmberg's postdoc supervisor.
Previous students that have already completed their doctoral studies under my main supervision include Alba Vilaplana Pérez (2021), Laura Sevilla Cermeño (2021), Tianyang Zhang (2022), Daniel Rautio (2024), and Anna Holmberg (2026). I was also doctoral co-supervisor for Per Andrén (2022) and Martina Gumpert (2025). Additionally, I have been postdoc supervisor for Dr. Maral Jolstedt (2022-2024).
Articles
- Journal article: BMC DIGITAL HEALTH. 2026;4(1):53Ivanova E; Birovecz A; Andren P; Flygare O; Mataix-Cols D; Fernandez de la Cruz L; Ivanov VZ; Andersson E; Ruck C
- Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS. 2026;201(5):321-330Wootton RE; Crowley JJ; Pol-fuster J; Holmberg A; Ruck C; Mataix-Cols D; Fernandez de la Cruz L
- Article: LANCET CHILD & ADOLESCENT HEALTH. 2026;10(7):533-540Familial confounding and causal inference in child and adolescent neurodevelopment and mental healthMataix-Cols D; Pol-Fuster J; Fernandez de la Cruz L; Lichtenstein P; D Onofrio BM; Brander G; Gardner R
- Article: BRAIN. 2026;:awag198Beucke JC; May L; Diez I; Franke J; Kaufmann C; Pol-Fuster J; Fernandez de la Cruz L; de Schipper E; Brander G; Lundin Remnelius K; Neufeld J; Fransson P; Sepulcre J; van den Heuvel OA; Bolte S; Mataix-Cols D
- Journal article: NATURE MENTAL HEALTH. 2026;4(5):829-836Pol-Fuster J; Fernandez de la Cruz L; Kuja-Halkola R; de Schipper E; Lichtenstein P; Chang Z; Brikell I; D'Onofrio BM; Larsson H; Ruck C; Brander G; Beucke JC; Valdimarsdottir UA; Mataix-Cols D
- Article: PSYCHOTHERAPY AND PSYCHOSOMATICS. 2026;:1-6Pol-Fuster J; Fernandez de la Cruz L; Rautio D; Rietz ED; Chang Z; D Onofrio BM; Larsson H; Lichtenstein P; Kuja-Halkola R; Mataix-Cols D
- Article: PSYCHOLOGICAL MEDICINE. 2026;56:e108Pol-Fuster J; Vasiljevic S; Fernandez de la Cruz L; Beucke JC; Hesselmark E; Crowley JJ; Brikell I; de Schipper E; D'Onofrio BM; Chang Z; Larsson H; Tedroff K; Lichtenstein P; Kuja-Halkola R; Idring S; Mataix-Cols D
- Article: PLOS ONE. 2026;21(3):e0346303Lenhard F; Fernandez de la Cruz L; Nerini FF; Axelsson K; Mataix-Cols D
- Article: EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES. 2026;35:e13Fernandez de la Cruz L; Isomura K; Kuja-Halkola R; Pol-Fuster J; Chang Z; D'Onofrio BM; Larsson H; Lichtenstein P; Sidorchuk A; Mataix-Cols D
- Article: BIOLOGICAL PSYCHIATRY. 2026;:S0006-3223(26)01102-9Pol-Fuster J; Fernández de la Cruz L; Rautio D; Crowley JJ; Halvorsen M; Du Rietz E; Chang Z; Larsson H; Phillips KA; Rück C; Lichtenstein P; Kuja-Halkola R; Mataix-Cols D
- Article: BMC PSYCHIATRY. 2026;26(1):291Asplund S; Holmberg A; Olofsdotter Lauri K; Lenninger D; Ivanova E; Lidin M; Ruck C; Martinsson L; Mataix-Cols D; Fernandez de la Cruz L
- Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2026;40(2):305-315Wang X; Chang Z; Molero Y; Isomura K; Fernandez de la Cruz L; Lichtenstein P; Kuja-Halkola R; D'Onofrio BM; Quinn PD; Larsson H; Brikell I; Hellner C; Hasselstrom J; Jayaram-Lindstrom N; Mataix-Cols D; Sidorchuk A
- Article: CHILD PSYCHIATRY & HUMAN DEVELOPMENT. 2026;:1-12Gumpert M; Ragnarsson EH; Birovecz A; Rautio D; Lundgren T; Fernandez de la Cruz L; Mataix-Cols D; Jansson-Frojmark M; Ingvarsson S
- Article: PSYCHOLOGICAL MEDICINE. 2026;56:e22Isomura K; Osterman S; Hedman-Lagerlof E; Kuja-Halkola R; Brikell I; Chang Z; D'onofrio BM; Larsson H; Lichtenstein P; Mataix-Cols D; Fernandez de la Cruz L; Ivanov V; Sidorchuk A
- Article: LANCET REGIONAL HEALTH-EUROPE. 2026;60:101504Grossmann L; Johansson F; Fazel S; Kuja-Halkola R; Brastad B; Mataix-Cols D; Fernandez de la Cruz L; Runeson B; Lichtenstein P; Chang Z; Larsson H; Brikell I; D'onofrio B; Pingel R; Ruck C; Wallert J
- Article: MOVEMENT DISORDERS. 2025;40(12):2830-2835Razaz N; Fernandez de la Cruz L
- Article: COGNITIVE BEHAVIOUR THERAPY. 2025;54(6):794-812Gumpert M; Rautio D; Birovecz A; Jolstedt M; Lundgren T; Fernandez de la Cruz L; Mataix-Cols D; Jansson-Frojmark M
- Article: BIOLOGICAL PSYCHIATRY GLOBAL OPEN SCIENCE. 2025;5(6):100605Farhat LC; Isomura K; Kuja-Halkola R; Brikell I; Chang Z; D'Onofrio BM; Larsson H; Lichtenstein P; Fernandez de la Cruz L; Sidorchuk A; Mataix-Cols D
- Article: BMJ MENTAL HEALTH. 2025;28(1):e301959Johansson F; Gunnarsson L; Grossmann L; Mataix-Cols D; Fernandez de la Cruz L; Fazel S; Gardner RM; Dalman C; Wallert J; Ruck C
- Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2025;99:219Wootton R; Crowley J; Pol-Fuster J; Holmberg A; Ruck C; Mataix-Cols D; Fernandez de la Cruz L
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All other publications
- Preprint: PSYARXIV. 2026Lenhard F; Fernández de la Cruz L; Nerini FF; Axelsson K; Mataix-Cols D
- Editorial: BMJ-BRITISH MEDICAL JOURNAL. 2026;392:s472Isung J; Fernandez de la Cruz L; Mataix-Cols D
- Preprint: PSYARXIV. 2026Lenhard F; Fernández de la Cruz L; Nerini FF; Axelsson K; Mataix-Cols D
- Preprint: PSYARXIV. 2026Lenhard F; Fernández de la Cruz L; Axelsson K; Nerini FF; Mataix-Cols D
- Preprint: OSF PREPRINTS. 2025Lenhard F; Fernández de la Cruz L; Nerini FF; Axelsson K; Mataix-Cols D
- Preprint: OSF PREPRINTS. 2025Lenhard F; Fernández de la Cruz L; Nerini FF; Axelsson K; Mataix-Cols D
- Preprint: MEDRXIV. 2025Wootton R; Crowley J; Pol-Fuster J; Holmberg A; Rück C; Psychiatry Genomics Consortium–Obsessive-Compulsiv; Mataix-Cols D; Fernández de la Cruz L
- Preprint: OSF PREPRINTS. 2025Asplund S; Holmberg A; Lauri K; Lenninger D; Ivanova E; Lidin M; Ruck C; Martinsson L; Mataix-Cols D; Fernández de la Cruz L
- Editorial: WORLD PSYCHIATRY. 2025;24(1):138-139Cervin M; Storch EA; Farrell L; Andersson E; Ruck C; Geller DA; OCD Severity Benchmark Consortium D; Mataix-Cols D
- Preprint: RESEARCH SQUARE. 2025Cruz LFDL; Rautio D; Wickberg F; Gordan C; Silverberg-Mörse M; Mataix-Cols D
- Preprint: OSF PREPRINTS. 2024Holmberg A; Lidin M; Lenninger D; Asplund S; Lavebratt C; Ruck C; Martinsson L; Mataix-Cols D; Fernández de la Cruz L
- Preprint: OSF PREPRINTS. 2024Lenhard F; Amnéus LW; Viklund I; Hultstrand T; Lundholm L; Tegenmark T; Skånberg J; Fernández de la Cruz L; Landén M; Öst L-G
- Review: NATURE REVIEWS DISEASE PRIMERS. 2024;10(1):92Ruck C; Mataix-Cols D; Feusner JD; Shavitt RG; Veale D; Krebs G; Fernandez de la Cruz L
- Preprint: MEDRXIV. 2024Wang X; Chang Z; Molero Y; Isomura K; de la Cruz LF; Lichtenstein P; Kuja-Halkola R; D’Onofrio B; Quinn P; Larsson H; Brikell I; Hellner C; Hasselström J; Jayaram-Lindström N; Mataix-Cols D; Sidorchuk A
- Letter: BMJ MENTAL HEALTH. 2024;27(1):e301203Pol-Fuster J; Kuja-Halkola R; Fernandez de la Cruz L; Brikell I; Chang Z; D'Onofrio BM; Larsson H; Lichtenstein P; Beucke JC; De Schipper E; Mataix-Cols D
- Review: JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 2024;65(8):1119-1131Krebs G; Rautio D; Fernandez de la Cruz L; Hartmann AS; Jassi A; Martin A; Stringaris A; Mataix-Cols D
- Preprint: OSF PREPRINTS. 2024Ivanova EN; Birovecz A; Andrén P; Flygare O; Mataix-Cols D; Fernández de la Cruz L; Ivanov VZ; Andersson E; Ruck C
- Letter: JAMA PSYCHIATRY. 2024;81(6):631-632Mataix-Cols D; Fernandez de la Cruz L; Beucke JC; De Schipper E; Kuja-Halkola R; Lichtenstein P; Pol-Fuster J
- Study protocol: TRIALS. 2023;24(1):483Jagholm S; Lindstedt S; Andersson E; Mataix-Cols D; Fernandez de la Cruz L; Ruck C; Ivanov VZ
- Preprint: RESEARCH SQUARE. 2023Holmberg A; Martinsson L; Lidin M; Rück C; Mataix-Cols D; Cruz LFDL
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Grants
- Emotion Regulation Group Therapy for Adolescents with Deliberate Self-Harm: A randomised controlled study.ALF Medicin 202731 January 2027 - 1 January 2027
- The Swedish Research Council (Vetenskapsrådet)1 January 2026 - 31 December 2029
- The Swedish Research Council (Vetenskapsrådet)1 January 2026 - 31 December 2028
- Swedish Research Council1 December 2025 - 31 December 2030Self-harm is a serious and growing public health concern among adolescents, strongly associated with suicide risk and mental health problems. It imposes significant societal costs through increased demand for psychiatric and emergency medical care, school absenteeism, and parental sick leave, both short- and long-term. Early interventions, including parental support and psychological treatment focused on emotion regulation may help prevent further deterioration. There is a clear need for brief, accessible treatments tailored to patients within child and adolescent psychiatry services (CAMHS), as well as for effective collaboration models between families and CAMHS. Following a promising feasibility study, we now want to assess the effectiveness of a novel group-based intervention, ERGT-A, for self-harming adolescents and their parents in a single blinded clinical randomized controlled effectiveness study including 166 adolescents (ages 13–18). The control group will receive TAU and cross over to ERGT-A treatment after the primary end-point. This study combines quantitative measures and repeated assessments to identify change processes and long-term effects. This project involves parents, and bridges the gap between research and practice, promoting early intervention and long-term health for a vulnerable and growing patient group.
- The Swedish Research Council (Vetenskapsrådet)1 December 2025 - 31 December 2028
- Breaking the silence: an integrated treatment of adolescent self-harm through collaboration between psychiatry, school and parents.Swedish Research Council for Health Working Life and Welfare1 July 2025 - 31 December 2030Research problem and specific questions Self-harm in adolescents is a serious and growing concern, inked to increased risk of suicide attempts, psychiatric disorders, substance use, and inpatient care. Early detection and intervention is crucial for improving long-term outcomes and well-being. Although clinical guidelines recommend treatments focusing on emotion regulation, access remains largely restricted to specialist clinics, leaving many adolescents at risk of receiving no or non-specific care. To adress this, we have developed a group-based emotion regulation treatment for self-harming adolescents, showing promising results. The group format integrates well into healthcare structures, fosters social skills training, and reduces stigma – key challenges for this patient group. Schools are primary environments in adolescents' lives and often the first to identify self-harm. However, limited knowledge of appropriate responses and concerns about contagion effects creates barriers to effective management. Strengthening collaboration between healthcare and schools is essential to enhance early detection and support. Data and Method A single-blind randomized controlled trial will be conducted to evaluate the effectiveness of this novel treatment. Adolescents (N=166) age 13–17, will be randomized to emotion regulation treatment plus treatment-as-usual (TAU) or TAU only. The content of TAU will be carefully monitored. Cost-effectiveness, mechanisms of change, and treatment effects up to 12 months post-treatment will be assessed. Focus group interviews with school health professionals will be conducted to identify collaboration needs between schools and healthcare. Societal Relevance and utilization This unique project addresses a critical scientific and clinical challenge by increasing access to treatment for self-harming adolescents. By mitigating the long-term health and social consequences associated with self-harm the project aims to improve outcomes for affected youth. Strengthening collaboration between healthcare, families and schools will enhance early detection and timely interventions. Plan for project realisation The project team consists of researchers with expertise in self-harm, emotion regulation, clinical trials, and child and adolescent psychiatry. Feasibility has been tested, infrastructure is being developed, and recruitment will be carried out through established collaboration with regional and national child and adolescent psychiatry clinics.
- The Swedish Research Council (Vetenskapsrådet)1 January 2025 - 31 December 2028
- Translating genomic findings for early onset obsessive-compulsive disorder into etiological insightsThe Swedish Research Council (Vetenskapsrådet)1 January 2025 - 31 December 2028
- Forte1 January 2025 - 31 December 2025
- Forte1 December 2023 - 30 November 2026
- The Heart and Lung Foundation (Hjärt-Lungfonden)1 January 2023 - 31 December 2025
- The Swedish Research Council (Vetenskapsrådet)1 January 2023 - 31 December 2025
- Folksam's Research Foundation (Folksams Forskningsstiftelse)1 January 2023 - 31 December 2024
- Forte1 January 2022 - 31 December 2024
- The Swedish Research Council (Vetenskapsrådet)1 January 2022 - 31 December 2024
- The Swedish Research Council (Vetenskapsrådet)1 December 2021 - 30 November 2024
- Forte1 January 2020 - 31 December 2022
- The Swedish Research Council (Vetenskapsrådet)1 January 2019 - 31 December 2021
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Employments
- Senior Lecturer, Child and Adolescence Psychiatric Science, Department of Clinical Neuroscience, Karolinska Institutet, 2024-
- Dissemination and Outreach Coordinator, Child and Adolescent Psychiatry Research Center, Stockholm Health Care Services, 2019-
Degrees and Education
- Docent, Karolinska Institutet, 2021
- PhD, Universitat Autònoma de Barcelona, 2013
- Specialist in Clinical Psychology (3-year training program), Consorci Sanitari de Terrassa, 2010
- MSc, Psychiatry and Clinical Psychology in Children and Adolescents, Universitat de Barcelona, 2006
- BSc, Psychology, Universitat Autònoma de Barcelona, 2004
Supervision
Supervision to doctoral degree
- Anna Holmberg, Somatic health and lifestyle habits in obsessive-compulsive disorder, 2026
- Martina Gumpert, Body dysmorphic disorder in children and adolescents : advancing the assessment, treatment, and clinician training, 2025
- Daniel Rautio, Clinical characteristics and treatment outcomes in body dysmorphic disorder, 2024
- Tianyang Zhang, Perinatal risk factors for mental disorders in the offspring and in their mothers, 2022
- Per Andrén, Improving access to behaviour therapy for young people with Tourette syndrome, 2022
- Alba Vilaplana-Pérez, Educational impairment in social anxiety disorder and posttraumatic stress disorder, 2021
- Laura Sevilla-Cermeño, Insomnia in obsessive-compulsive disorder and body dysmorphic disorder, 2021
Editorial work
- JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS, Associate editor, 2022-2026
- JCPP Advances, Editorial board member, 2021-2026