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About me

Ljubica Matic obtained a PhD degree in Medical Biochemistry from Karolinska Institute, Sweden in 2012, and a MSc degree (Cum Laude) in Molecular Biology from Belgrade University, Serbia in 2003. Since 2012 she works as a senior researcher and Assistant Professor in the Vascular Surgery Group, Karolinska Institute. Her main focus is on novel molecular mechanisms of vascular disease particularly related to smooth muscle cells, as well as on biomarkers and therapeutic approaches in carotid atherosclerosis. She applies integrative systems analyses, combining bioinformatic and clinical data studies with murine models of vascular injury and disease, while in vitro systems based on primary cells and tissue explants are utilized for functional and mechanistic investigations. Her research has been distinguished with several grants and fellowships from the Swedish Society for Medical Research (SSMF) and Heart-Lung Foundation (HLF). Since 2004, she has also been continuously devoted to pedagogical work as a lecturer, supervisor and course leader for PhD students in the Cardiovascular Program and undergraduate students in the Medicine and Biomedicine Programs at KI. As a reviewer she is active in several journals and funding agencies, i.e. American Journal of Human Genetics, Journal of Internal Medicine, Swiss National Science Foundation (SNSF), while as a board member she contributes to the KI Respiration and Inflammation Network (KIRCNET; http://ki.se/en/research/kircnet-ki-respiration-and-circulation-network).   

Links

Publications

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques
Tomas L, Edsfeldt A, Mollet Ig, Perisic Matic L, Prehn C, Adamski J, et al
European heart journal 2018;39(24):2301-2310

Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration
Nguyen Ma, Karunakaran D, Geoffrion M, Cheng Hs, Tandoc K, Perisic Matic L, et al
Arteriosclerosis, thrombosis, and vascular biology 2018;38(1):49-63

Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis
Aldi S, Matic Lp, Hamm G, Van Keulen D, Tempel D, Holmstrøm K, et al
Molecular therapy. Methods & clinical development 2018;10():17-28

Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions
Jin H, Li Dy, Chernogubova E, Sun C, Busch A, Eken Sm, et al
Molecular therapy : the journal of the American Society of Gene Therapy 2018;26(4):1040-1055

Long non-coding RNA H19 regulates endothelial cell aging via inhibition of Stat3 signaling
Hofmann P, Sommer J, Theodorou K, Kirchhof L, Fischer A, Li Y, et al
Cardiovascular research 2018;():-

Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP
Zhu B, Rippe C, Holmberg J, Zeng S, Perisic L, Albinsson S, et al
Scientific reports 2018;8(1):13025-

Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage
Matic Lp, Jesus Iglesias M, Vesterlund M, Lengquist M, Hong Mg, Saieed S, et al
JACC. Basic to translational science 2018;3(4):464-480

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
Langley Sr, Willeit K, Didangelos A, Matic Lp, Skroblin P, Barallobre-barreiro J, et al
The Journal of clinical investigation 2017;127(4):1546-1560

Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke
Improve Study Group, Mahdessian H, Perisic Matic L, Lengquist M, Gertow K, Sennblad B, et al
Journal of internal medicine 2017;282(5):429-444

Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events
Karadimou G, Folkersen L, Berg M, Perisic L, Discacciati A, Roy J, et al
Cardiovascular research 2017;113(1):30-39

MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions
Eken Sm, Jin H, Chernogubova E, Li Y, Simon N, Sun C, et al
Circulation research 2017;120(4):633-644

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells
Kim Jb, Pjanic M, Nguyen T, Miller Cl, Iyer D, Liu B, et al
PLoS genetics 2017;13(5):e1006750-

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella Ff, et al
Nature medicine 2016;22(10):1140-1150

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Kojima Y, Volkmer Jp, Mckenna K, Civelek M, Lusis Aj, Miller Cl, et al
Nature 2016;536(7614):86-90

CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels
Nanda V, Downing Kp, Ye J, Xiao S, Kojima Y, Spin Jm, et al
Circulation research 2016;118(2):230-40

Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease
Turner Aw, Martinuk A, Silva A, Lau P, Nikpay M, Eriksson P, et al
Arteriosclerosis, thrombosis, and vascular biology 2016;36(5):972-83

Gene expression signatures, pathways and networks in carotid atherosclerosis
Perisic L, Aldi S, Sun Y, Folkersen L, Razuvaev A, Roy J, et al
Journal of internal medicine 2016;279(3):293-308

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
Miller Cl, Pjanic M, Wang T, Nguyen T, Cohain A, Lee Jd, et al
Nature communications 2016;7():12092-

miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux
Ouimet M, Hennessy Ej, Van Solingen C, Koelwyn Gj, Hussein Ma, Ramkhelawon B, et al
Arteriosclerosis, thrombosis, and vascular biology 2016;36(5):942-951

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM
Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-lleal M, Lengquist M, Miller Cl, et al
Arteriosclerosis, thrombosis, and vascular biology 2016;36(9):1947-61

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis
Karunakaran D, Geoffrion M, Wei L, Gan W, Richards L, Shangari P, et al
Science advances 2016;2(7):e1600224-

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap
Nurnberg St, Cheng K, Raiesdana A, Kundu R, Miller Cl, Kim Jb, et al
Genomics data 2015;5():36-37

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap
Nurnberg St, Cheng K, Raiesdana A, Kundu R, Miller Cl, Kim Jb, et al
PLoS genetics 2015;11(5):e1005155-

Correction: Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin
Perisic L, Rodriguez Pq, Hultenby K, Sun Y, Lal M, Betsholtz C, et al
PloS one 2015;10(5):e0126079-

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis
Karunakaran D, Thrush Ab, Nguyen Ma, Richards L, Geoffrion M, Singaravelu R, et al
Circulation research 2015;117(3):266-78

Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin
Perisic L, Rodriguez Pq, Hultenby K, Sun Y, Lal M, Betsholtz C, et al
PloS one 2015;10(3):e0122067-

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation
Miller Cl, Haas U, Diaz R, Leeper Nj, Kundu Rk, Patlolla B, et al
PLoS genetics 2014;10(3):e1004263-

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
Kojima Y, Downing K, Kundu R, Miller C, Dewey F, Lancero H, et al
The Journal of clinical investigation 2014;124(3):1083-97

Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis
Perisic L, Hedin E, Razuvaev A, Lengquist M, Osterholm C, Folkersen L, et al
Arteriosclerosis, thrombosis, and vascular biology 2013;33(10):2432-43

Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics
Perisic L, Lal M, Hulkko J, Hultenby K, Önfelt B, Sun Y, et al
Kidney international 2012;82(10):1071-83

Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik
Patrakka J, Xiao Zj, Nukui M, Takemoto M, He Lq, Oddsson A, et al
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2007;18(3):689-97

Molecular basis of Thalassemia syndromes in Serbia and Montenegro
Pavlovic S, Urosevic J, Poznanic J, Perisic Lj, Petrucev B, Tosic N, et al
ACTA HAEMATOLOGICA 2005;113(3):175-80

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