Larry Mansouri

Publications
Public outreach and news

Articles

Article: LEUKEMIA. 2024;38(11):2429-2442
The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia
Hagerstrand D; Oder B; Cortese D; Qu Y; Binzer-Panchal A; Osterholm C; Santos TDP; Rabbani L; Asl HF; Skaftason A; Ljungstrom V; Lundholm A; Koutroumani M; Haider Z; Jylha C; Mollstedt J; Mansouri L; Plevova K; Agathangelidis A; Scarfo L; Armand M; Muggen AF; Kay NE; Shanafelt T; Rossi D; Orre LM; Pospisilova S; Barylyuk K; Davi F; Vesterlund M; Langerak AW; Lehtio J; Ghia P; Stamatopoulos K; Sutton L-A; Rosenquist R
Article: LEUKEMIA. 2024;38(6):1287-1298
IκBε deficiency accelerates disease development in chronic lymphocytic leukemia
Bordini J; Lenzi C; Frenquelli M; Morabito A; Pseftogas A; Belloni D; Mansouri L; Tsiolas G; Perotta E; Ranghetti P; Gandini F; Genova F; Hagerstrand D; Gavriilidis G; Keisaris S; Pechlivanis N; Davi F; Kay NE; Langerak AW; Pospisilova S; Scarfo L; Makris A; Psomopoulos FE; Stamatopoulos K; Rosenquist R; Campanella A; Ghia P
Article: LEUKEMIA. 2023;37(11):2237-2249
Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma
Briest F; Noerenberg D; Hennch C; Yoshida K; Hablesreiter R; Nimo J; Sasca D; Kirchner M; Mansouri L; Inoue Y; Wiegand L; Staiger AM; Casadei B; Korkolopoulou P; Weiner J; Lopez-Guillermo A; Warth A; Schneider T; Nagy A; Klapper W; Hummel M; Kanellis G; Anagnostopoulos I; Mertins P; Bullinger L; Rosenquist R; Vassilakopoulos TP; Ott G; Ogawa S; Damm F
Article: LEUKEMIA. 2023;37(2):339-347
Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY
Mansouri L; Thorvaldsdottir B; Sutton L-A; Karakatsoulis G; Meggendorfer M; Parker H; Nadeu F; Brieghel C; Laidou S; Moia R; Rossi D; Catherwood M; Kotaskova J; Delgado J; Rodriguez-Vicente AE; Benito R; Rigolin GM; Bonfiglio S; Scarfo L; Mattsson M; Davis Z; Gogia A; Rani L; Baliakas P; Foroughi-Asl H; Jylha C; Skaftason A; Rapado I; Miras F; Martinez-Lopez J; de la Serna J; Rivas JMH; Thornton P; Larrayoz MJ; Calasanz MJ; Fesus V; Matrai Z; Bodor C; Smedby KE; Espinet B; Puiggros A; Gupta R; Bullinger L; Bosch F; Tazon-Vega B; Baran-Marszak F; Oscier D; N'Guyen-Khac F; Zenz T; Terol MJ; Cuneo A; Hernandez-Sanchez M; Pospisilova S; Mills K; Gaidano G; Niemann CU; Campo E; Strefford JC; Ghia P; Stamatopoulos K; Rosenquist R
Article: FRONTIERS IN ONCOLOGY. 2023;13:1097942
T cell receptor gene repertoire profiles in subgroups of patients with chronic lymphocytic leukemia bearing distinct genomic aberrations
Vlachonikola E; Pechlivanis N; Karakatsoulis G; Sofou E; Gkoliou G; Jeromin S; Stavroyianni N; Ranghetti P; Scarfo L; Osterholm C; Mansouri L; Notopoulou S; Siorenta A; Anagnostopoulos A; Ghia P; Haferlach C; Rosenquist R; Psomopoulos F; Kouvatsi A; Baliakas P; Stamatopoulos K; Chatzidimitriou A
Article: NATURE COMMUNICATIONS. 2022;13(1):6226
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
Herbst SA; Vesterlund M; Helmboldt AJ; Jafari R; Siavelis I; Stahl M; Schitter EC; Liebers N; Brinkmann BJ; Czernilofsky F; Roider T; Bruch P-M; Iskar M; Kittai A; Huang Y; Lu J; Richter S; Mermelekas G; Umer HM; Knoll M; Kolb C; Lenze A; Cao X; Osterholm C; Wahnschaffe L; Herling C; Scheinost S; Ganzinger M; Mansouri L; Kriegsmann K; Kriegsmann M; Anders S; Zapatka M; Del Poeta G; Zucchetto A; Bomben R; Gattei V; Dreger P; Woyach J; Herling M; Muller-Tidow C; Rosenquist R; Stilgenbauer S; Zenz T; Huber W; Tausch E; Lehtioe J; Dietrich S
Article: SEMINARS IN CANCER BIOLOGY. 2022;84:170-183
Precision diagnostics in lymphomas-Recent developments and future directions
Mansouri L; Thorvaldsdottir B; Laidou S; Stamatopoulos K; Rosenquist R
Article: GENES CHROMOSOMES AND CANCER. 2022;61(1):27-36
Transcriptome sequencing of archived lymphoma specimens is feasible and clinically relevant using exome capture technology
Skaftason A; Qu Y; Abdulla M; Nordlund J; Berglund M; Ednersson SB; Andersson P-O; Enblad G; Amini R-M; Rosenquist R; Mansouri L
Article: BLOOD ADVANCES. 2021;5(13):2788-2792
RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia
Ntoufa S; Gerousi M; Laidou S; Psomopoulos F; Tsiolas G; Moysiadis T; Papakonstantinou N; Mansouri L; Anagnostopoulos A; Stavrogianni N; Pospisilova S; Plevova K; Makris AM; Rosenquist R; Stamatopoulos K
Article: ACTA ONCOLOGICA. 2021;60(4):531-538
PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS
Abdulla M; Alexsson A; Sundstrom C; Ladenvall C; Mansouri L; Lindskog C; Berglund M; Cavelier L; Enblad G; Hollander P; Amini R-M
Article: BLOOD. 2021;137(10):1365-1376
Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL
Agathangelidis A; Chatzidimitriou A; Gemenetzi K; Giudicelli V; Karypidou M; Plevova K; Davis Z; Yan X-J; Jeromin S; Schneider C; Pedersen LB; Tschumper RC; Sutton L-A; Baliakas P; Scarfo L; van Gastel EJ; Armand M; Tausch E; Biderman B; Baer C; Bagnara D; Navarro A; de Septenville AL; Guido V; Mitterbauer-Hohendanner G; Dimovski A; Brieghel C; Lawless S; Meggendorfer M; Brazdilova K; Ritgen M; Facco M; Tresoldi C; Visentin A; Patriarca A; Catherwood M; Bonello L; Sudarikov A; Vanura K; Roumelioti M; Francova HS; Moysiadis T; Veronese S; Giannopoulos K; Mansouri L; Karan-Djurasevic T; Sandaltzopoulos R; Bodor C; Fais F; Kater A; Panovska I; Rossi D; Alshemmari S; Panagiotidis P; Costeas P; Espinet B; Antic D; Foroni L; Montillo M; Trentin L; Stavroyianni N; Gaidano G; di Celle PF; Niemann C; Campo E; Anagnostopoulos A; Pott C; Fischer K; Hallek M; Oscier D; Stilgenbauer S; Haferlach C; Jelinek D; Chiorazzi N; Pospisilova S; Lefranc M-P; Kossida S; Langerak AW; Belessi C; Davi F; Rosenquist R; Ghia P; Stamatopoulos K
Article: HAEMATOLOGICA. 2021;106(1):87-97
Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multicenter study
Leeksma AC; Baliakas P; Moysiadis T; Puiggros A; Plevova K; van der Kevie-Kersemaekers A-M; Posthuma H; Rodriguez-Vicente AE; Tran AN; Barbany G; Mansouri L; Gunnarsson R; Parker H; van den Berg E; Bellido M; Davis Z; Wall M; Scarpelli I; Osterborg A; Hansson L; Jarosova M; Ghia P; Poddighe P; Espinet B; Pospisilova S; Tam C; Ysebaert L; Nguyen-Khac F; Oscier D; Haferlach C; Schoumans J; Stevens-Kroef M; Eldering E; Stamatopoulos K; Rosenquist R; Strefford JC; Mellink C; Kater AP
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2020;191(3):426-432
Risk-adapted bendamustine plus rituximab is a tolerable treatment alternative for elderly patients with chronic lymphocytic leukaemia: a regional real-world report on 141 consecutive Swedish patients
Mattsson A; Sylvan SE; Asklid A; Wiggh J; Winqvist M; Lundin J; Mansouri L; Rosenquist R; Johansson H; Osterborg A; Hansson L
Article: CLINICAL CANCER RESEARCH. 2020;26(6):1507-1515
The Number of Signaling Pathways Altered by Driver Mutations in Chronic Lymphocytic Leukemia Impacts Disease Outcome
Brieghel C; da Cunha-Bang C; Yde CW; Schmidt AY; Kinalis S; Nadeu F; Andersen MA; Jacobsen LO; Andersen MK; Pedersen LB; Delgado J; Baumann T; Mattsson M; Mansouri L; Rosenquist R; Campo E; Nielsen FC; Niemann CU
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2020;95(1):57-67
Cell-of-origin determined by both gene expression profiling and immunohistochemistry is the strongest predictor of survival in patients with diffuse large B-cell lymphoma
Abdulla M; Hollander P; Pandzic T; Mansouri L; Ednersson SB; Andersson P-O; Hultdin M; Fors M; Erlanson M; Degerman S; Petersen HM; Asmar F; Gronbaek K; Enblad G; Cavelier L; Rosenquist R; Amini R-M
Article: CLINICAL EPIGENETICS. 2019;11(1):177
DNA methylation profiles in chronic lymphocytic leukemia patients treated with chemoimmunotherapy
Tsagiopoulou M; Papakonstantinou N; Moysiadis T; Mansouri L; Ljungstrom V; Duran-Ferrer M; Malousi A; Queiros AC; Plevova K; Bhoi S; Kollia P; Oscier D; Anagnostopoulos A; Trentin L; Ritgen M; Pospisilova S; Stavroyianni N; Ghia P; Martin-Subero JI; Pott C; Rosenquist R; Stamatopoulos K
Article: EPIGENETICS. 2019;14(11):1125-1140
EZH2 upregulates the PI3K/AKT pathway through IGF1R and MYC in clinically aggressive chronic lymphocytic leukaemia
Kosalai ST; Morsy MHA; Papakonstantinou N; Mansouri L; Stavroyianni N; Kanduri C; Stamatopoulos K; Rosenquist R; Kanduri M
Article: LEUKEMIA. 2019;33(10):2416-2428
Inhibition of SYK or BTK augments venetoclax sensitivity in SHP1-negative/BCL-2-positive diffuse large B-cell lymphoma
Sasi BK; Martines C; Xerxa E; Porro F; Kalkan H; Fazio R; Turkalj S; Bojnik E; Pyrzynska B; Stachura J; Zerrouqi A; Bobrowicz M; Winiarska M; Priebe V; Bertoni F; Mansouri L; Rosenquist R; Efremov DG
Article: INTERNATIONAL JOURNAL OF CANCER. 2019;144(11):2695-2706
Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia
Papakonstantinou N; Ntoufa S; Tsagiopoulou M; Moysiadis T; Bhoi S; Malousi A; Psomopoulos F; Mansouri L; Laidou S; Papazoglou D; Gounari M; Pasentsis K; Plevova K; Kuci-Emruli V; Duran-Ferrer M; Davis Z; Ek S; Rossi D; Gaidano G; Ritgen M; Oscier D; Stavroyianni N; Pospisilova S; Davi F; Ghia P; Hadzidimitriou A; Belessi C; Martin-Subero JI; Pott C; Rosenquist R; Stamatopoulos K
Article: HAEMATOLOGICA. 2019;104(2):360-369
Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia
Baliakas P; Moysiadis T; Hadzidimitriou A; Xochelli A; Jeromin S; Agathangelidis A; Mattsson M; Sutton L-A; Minga E; Scarfo L; Rossi D; Davis Z; Villamor N; Parker H; Kotaskova J; Stalika E; Plevova K; Mansouri L; Cortese D; Navarro A; Delgado J; Larrayoz M; Young E; Anagnostopoulos A; Smedby KE; Juliusson G; Sheehy O; Catherwood M; Strefford JC; Stavroyianni N; Belessi C; Pospisilova S; Oscier D; Gaidano G; Campo E; Haferlach C; Ghia P; Rosenquist R; Stamatopoulos K
Article: BLOOD CANCER JOURNAL. 2018;9(1):1
Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology
Went M; Sud A; Speedy H; Sunter NJ; Foersti A; Law PJ; Johnson DC; Mirabella F; Holroyd A; Li N; Orlando G; Weinhold N; van Duin M; Chen B; Mitchell JS; Mansouri L; Juliusson G; Smedby KE; Jayne S; Majid A; Dearden C; Allsup DJ; Bailey JR; Pratt G; Pepper C; Fegan C; Rosenquist R; Kuiper R; Stephens OW; Bertsch U; Broderick P; Einsele H; Gregory WM; Hillengass J; Hoffmann P; Jackson GH; Joeckel K-H; Nickel J; Noethen MM; da Silva Filho MI; Thomsen H; Walker BA; Broyl A; Davies FE; Hansson M; Goldschmidt H; Dyer MJS; Kaiser M; Sonneveld P; Morgan GJ; Hemminki K; Nilsson B; Catovsky D; Allan JM; Houlston RS
Article: SEMINARS IN CANCER BIOLOGY. 2018;51:1-11
Epigenetic deregulation in chronic lymphocytic leukemia: Clinical and biological impact
Mansouri L; Wierzbinska JA; Plass C; Rosenquist R
Article: BLOOD ADVANCES. 2018;2(6):621-625
Clinical and functional impact of recurrent S1PR1 mutations in mantle cell lymphoma
Wasik AM; Wu C; Mansouri L; Rosenquist R; Pan-Hammarstrom Q; Sander B
Article: CLINICAL CANCER RESEARCH. 2017;23(17):5292-5301
Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes
Xochelli A; Baliakas P; Kavakiotis I; Agathangelidis A; Sutton L-A; Minga E; Ntoufa S; Tausch E; Yan X-J; Shanafelt T; Plevova K; Boudjogra M; Rossi D; Davis Z; Navarro A; Sandberg Y; Vojdeman FJ; Scarfo L; Stavroyianni N; Sudarikov A; Veronese S; Tzenou T; Karan-Djurasevic T; Catherwood M; Kienle D; Chatzouli M; Facco M; Bahlo J; Pott C; Pedersen LB; Mansouri L; Smedby KE; Chu CC; Giudicelli V; Lefranc M-P; Panagiotidis P; Juliusson G; Anagnostopoulos A; Vlahavas I; Antic D; Trentin L; Montillo M; Niemann C; Doehner H; Langerak AW; Pospisilova S; Hallek M; Campo E; Chiorazzi N; Maglaveras N; Oscier D; Gaidano G; Jelinek DF; Stilgenbauer S; Chouvarda I; Darzentas N; Belessi C; Davi F; Hadzidimitriou A; Rosenquist R; Ghia P; Stamatopoulos K
Article: LEUKEMIA. 2017;31(7):1547-1554
EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia
Young E; Noerenberg D; Mansouri L; Ljungstrom V; Frick M; Sutton L-A; Blakemore SJ; Galan-Sousa J; Plevova K; Baliakas P; Rossi D; Clifford R; Roos-Weil D; Navrkalova V; Doerken B; Schmitt CA; Smedby KE; Juliusson G; Giacopelli B; Blachly JS; Belessi C; Panagiotidis P; Chiorazzi N; Davi F; Langerak AW; Oscier D; Schuh A; Gaidano G; Ghia P; Xu W; Fan L; Bernard OA; Nguyen-Khac F; Rassenti L; Li J; Kipps TJ; Stamatopoulos K; Pospisilova S; Zenz T; Oakes CC; Strefford JC; Rosenquist R; Damm F
Article: NATURE COMMUNICATIONS. 2017;8:14175
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
Law PJ; Berndt SI; Speedy HE; Camp NJ; Sava GP; Skibola CF; Holroyd A; Joseph V; Sunter NJ; Nieters A; Bea S; Monnereau A; Martin-Garcia D; Goldin LR; Clot G; Teras LR; Quintela I; Birmann BM; Jayne S; Cozen W; Majid A; Smedby KE; Lan Q; Dearden C; Brooks-Wilson AR; Hall AG; Purdue MP; Mainou-Fowler T; Vajdic CM; Jackson GH; Cocco P; Marr H; Zhang Y; Zheng T; Giles GG; Lawrence C; Call TG; Liebow M; Melbye M; Glimelius B; Mansouri L; Glenn M; Curtin K; Diver WR; Link BK; Conde L; Bracci PM; Holly EA; Jackson RD; Tinker LF; Benavente Y; Boffetta P; Brennan P; Maynadie M; McKay J; Albanes D; Weinstein S; Wang Z; Caporaso NE; Morton LM; Severson RK; Riboli E; Vineis P; Vermeulen RCH; Southey MC; Milne RL; Clavel J; Topka S; Spinelli JJ; Kraft P; Ennas MG; Summerfield G; Ferri GM; Harris RJ; Miligi L; Pettitt AR; North KE; Allsup DJ; Fraumeni JFJ; Bailey JR; Offit K; Pratt G; Hjalgrim H; Pepper C; Chanock SJ; Fegan C; Rosenquist R; de Sanjose S; Carracedo A; Dyer MJS; Catovsky D; Campo E; Cerhan JR; Allan JM; Rothman N; Houlston R; Slager SL
Article: CLINICAL CANCER RESEARCH. 2016;22(24):6217-6227
Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia
Pandzic T; Larsson J; He L; Kundu S; Ban K; Akhtar-Ali M; Hellstrom AR; Schuh A; Clifford R; Blakemore SJ; Strefford JC; Baumann T; Lopez-Guillermo A; Campo E; Ljungstrom V; Mansouri L; Rosenquist R; Sjoblom T; Hellstrom M
Article: BLOOD. 2016;128(23):2666-2670
Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
Mansouri L; Noerenberg D; Young E; Mylonas E; Abdulla M; Frick M; Asmar F; Ljungstroem V; Schneider M; Yoshida K; Skaftason A; Pandzic T; Gonzalez B; Tasidou A; Waldhueter N; Rivas-Delgado A; Angelopoulou M; Ziepert M; Arends CM; Couronne L; Lenze D; Baldus CD; Bastard C; Okosun J; Fitzgibbon J; Doerken B; Drexler HG; Roos-Weil D; Schmitt CA; Munch-Petersen HD; Zenz T; Hansmann M-L; Strefford JC; Enblad G; Bernard OA; Ralfkiaer E; Erlanson M; Korkolopoulou P; Hultdin M; Papadaki T; Gronbaek K; Lopez-Guillermo A; Ogawa S; Kuppers R; Stamatopoulos K; Stavroyianni N; Kanellis G; Rosenwald A; Campo E; Amini R-M; Ott G; Vassilakopoulos TP; Hummel M; Rosenquist R; Damm F
Article: HAEMATOLOGICA. 2016;101(8):959-967
Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors
Sutton L-A; Young E; Baliakas P; Hadzidimitriou A; Moysiadis T; Plevova K; Rossi D; Kminkova J; Stalika E; Pedersen LB; Malcikova J; Agathangelidis A; Davis Z; Mansouri L; Scarfo L; Boudjoghra M; Navarro A; Muggen AF; Yan X-J; Nguyen-Khac F; Larrayoz M; Panagiotidis P; Chiorazzi N; Niemann CU; Belessi C; Campo E; Strefford JC; Langerak AW; Oscier D; Gaidano G; Pospisilova S; Davi F; Ghia P; Stamatopoulos K; Rosenquist R
Article: ONCOTARGET. 2016;7(25):38180-38190
Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent CARD11 mutations
Wu C; de Miranda NFCC; Chen L; Wasik AM; Mansouri L; Jurczak W; Galazka K; Dlugosz-Danecka M; Machaczka M; Zhang H; Peng R; Morin RD; Rosenquist R; Sander B; Pan-Hammarstrom Q
Article: EPIGENETICS. 2016;11(6):449-455
Prognostic impact of epigenetic classification in chronic lymphocytic leukemia: The case of subset #2
Bhoi S; Ljungstrom V; Baliakas P; Mattsson M; Smedby KE; Juliusson G; Rosenquist R; Mansouri L
Article: EPIGENETICS. 2016;11(5):335-343
Epigenetic silencing of miR-26A1 in chronic lymphocytic leukemia and mantle cell lymphoma: Impact on EZH2 expression
Kopparapu PK; Bhoi S; Mansouri L; Arabanian LS; Plevova K; Pospisilova S; Wasik AM; Croci GA; Sander B; Paulli M; Rosenquist R; Kanduri M
Article: BLOOD. 2016;127(8):1007-1016
Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations
Ljungstrom V; Cortese D; Young E; Pandzic T; Mansouri L; Plevova K; Ntoufa S; Baliakas P; Clifford R; Sutton L-A; Blakemore SJ; Stavroyianni N; Agathangelidis A; Rossi D; Hoglund M; Kotaskova J; Juliusson G; Belessi C; Chiorazzi N; Panagiotidis P; Langerak AW; Smedby KE; Oscier D; Gaidano G; Schuh A; Davi F; Pott C; Strefford JC; Trentin L; Pospisilova S; Ghia P; Stamatopoulos K; Sjoblom T; Rosenquist R
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2015;212(6):833-843
Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia
Mansouri L; Sutton L-A; Ljungstrom V; Bondza S; Arngarden L; Bhoi S; Larsson J; Cortese D; Kalushkova A; Plevova K; Young E; Gunnarsson R; Falk-Sorqvist E; Lonn P; Muggen AF; Yan X-J; Sander B; Enblad G; Smedby KE; Juliusson G; Belessi C; Rung J; Chiorazzi N; Strefford JC; Langerak AW; Pospisilova S; Davi F; Hellstrom M; Jernberg-Wiklund H; Ghia P; Soderberg O; Stamatopoulos K; Nilsson M; Rosenquist R
Article: HAEMATOLOGICA. 2015;100(3):370-376
Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting
Sutton L-A; Ljungstrom V; Mansouri L; Young E; Cortese D; Navrkalova V; Malcikova J; Muggen AF; Trbusek M; Panagiotidis P; Davi F; Belessi C; Langerak AW; Ghia P; Pospisilova S; Stamatopoulos K; Rosenquist R
Article: LEUKEMIA. 2015;29(2):329-336
Recurrent mutations refine prognosis in chronic lymphocytic leukemia
Baliakas P; Hadzidimitriou A; Sutton L-A; Rossi D; Minga E; Villamor N; Larrayoz M; Kminkova J; Agathangelidis A; Davis Z; Tausch E; Stalika E; Kantorova B; Mansouri L; Scarfo L; Cortese D; Navrkalova V; Rose-Zerilli MJJ; Smedby KE; Juliusson G; Anagnostopoulos A; Makris AM; Navarro A; Delgado J; Oscier D; Belessi C; Stilgenbauer S; Ghia P; Pospisilova S; Gaidano G; Campo E; Strefford JC; Stamatopoulos K; Rosenquist R
Article: BLOOD. 2015;125(5):856-859
Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
Baliakas P; Agathangelidis A; Hadzidimitriou A; Sutton L-A; Minga E; Tsanousa A; Scarfo L; Davis Z; Yan X-J; Shanafelt T; Plevova K; Sandberg Y; Vojdeman FJ; Boudjogra M; Tzenou T; Chatzouli M; Chu CC; Veronese S; Gardiner A; Mansouri L; Smedby KE; Pedersen LB; Moreno D; Van Lom K; Giudicelli V; Francova HS; Nguyen-Khac F; Panagiotidis P; Juliusson G; Angelis L; Anagnostopoulos A; Lefranc M-P; Facco M; Trentin L; Catherwood M; Montillo M; Geisler CH; Langerak AW; Pospisilova S; Chiorazzi N; Oscier D; Jelinek DF; Darzentas N; Belessi C; Davi F; Ghia P; Rosenquist R; Stamatopoulos K
Article: THE LANCET HAEMATOLOGY. 2014;1(2):E74-E84
Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study
Baliakas P; Hadzidimitriou A; Sutton L-A; Minga E; Agathangelidis A; Nichelatti M; Tsanousa A; Scarfo L; Davis Z; Yan X-J; Shanafelt T; Plevova K; Sandberg Y; Vojdeman FJ; Boudjogra M; Tzenou T; Chatzouli M; Chu CC; Veronese S; Gardiner A; Mansouri L; Smedby KE; Pedersen LB; van Lom K; Giudicelli V; Francova HS; Nguyen-Khac F; Panagiotidis P; Juliusson G; Angelis L; Anagnostopoulos A; Lefranc M-P; Facco M; Trentin L; Catherwood M; Montillo M; Geisler CH; Langerak AW; Pospisilova S; Chiorazzi N; Oscier D; Jelinek DF; Darzentas N; Belessi C; Davi F; Rosenquist R; Ghia P; Stamatopoulos K
Article: HAEMATOLOGICA. 2014;99(8):1285-1291
MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis
Benner A; Mansouri L; Rossi D; Majid A; Willander K; Parker A; Bond G; Pavlova S; Nueckel H; Merkel O; Ghia P; Montserrat E; Kaderi MA; Rosenquist R; Gaidano G; Dyer MJS; Soederkvist P; Linderholm M; Oscier D; Tvaruzkova Z; Pospisilova S; Duehrsen U; Greil R; Doehner H; Stilgenbauer S; Zenz T
Article: EPIGENETICS. 2014;9(6):910-917
microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia
Deneberg S; Kanduri M; Ali D; Bengtzen S; Karimi M; Qu Y; Kimby E; Mansouri L; Rosenquist R; Lennartsson A; Lehmann S
Article: CLINICAL CANCER RESEARCH. 2014;20(2):323-330
IgG-Switched CLL Has a Distinct Immunogenetic Signature from the Common MD Variant: Ontogenetic Implications
Vardi A; Agathangelidis A; Sutton L-A; Chatzouli M; Scarfo L; Mansouri L; Douka V; Anagnostopoulos A; Darzentas N; Rosenquist R; Ghia P; Belessi C; Stamatopoulos K
Article: NATURE GENETICS. 2014;46(1):56-60
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
Speedy HE; Di Bernardo MC; Sava GP; Dyer MJS; Holroyd A; Wang Y; Sunter NJ; Mansouri L; Juliusson G; Smedby KE; Roos G; Jayne S; Majid A; Dearden C; Hall AG; Mainou-Fowler T; Jackson GH; Summerfield G; Harris RJ; Pettitt AR; Allsup DJ; Bailey JR; Pratt G; Pepper C; Fegan C; Rosenquist R; Catovsky D; Allan JM; Houlston RS
Article: LEUKEMIA. 2013;27(11):2196-2199
Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2
Strefford JC; Sutton L-A; Baliakas P; Agathangelidis A; Malcikova J; Plevova K; Scarfo L; Davis Z; Stalika E; Cortese D; Cahill N; Pedersen LB; di Celle PF; Tzenou T; Geisler C; Panagiotidis P; Langerak AW; Chiorazzi N; Pospisilova S; Oscier D; Davi F; Belessi C; Mansouri L; Ghia P; Stamatopoulos K; Rosenquist R
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2013;88(8):647-651
Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients
Mansouri L; Grabowski P; Degerman S; Svenson U; Gunnarsson R; Cahill N; Smedby KE; Geisler C; Juliusson G; Roos G; Rosenquist R
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2013;162(2):221-228
rs2072135, a low-penetrance variant for chronic lymphocytic leukaemia?
Sava GP; Speedy HE; Di Bernardo MC; Deaglio S; Karabon L; Frydecka I; Woszczyk D; Rossi D; Gaidano G; Mansouri L; Smedby KE; Juliusson G; Rosenquist R; Catovsky D; Houlston RS
Article: LEUKEMIA. 2013;27(1):150-158
450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments
Cahill N; Bergh A-C; Kanduri M; Goransson-Kultima H; Mansouri L; Isaksson A; Ryan F; Smedby KE; Juliusson G; Sundstrom C; Rosen A; Rosenquist R
Article: EPIGENETICS. 2012;7(12):1435-1442
Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles
Kanduri M; Marincevic M; Halldorsdottir AM; Mansouri L; Junevik K; Ntoufa S; Kultima HG; Isaksson A; Juliusson G; Andersson P-O; Ehrencrona H; Stamatopoulos K; Rosenquist R
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2012;87(7):737-740
Next generation RNA-sequencing in prognostic subsets of chronic lymphocytic leukemia
Mansouri L; Gunnarsson R; Sutton L-A; Ameur A; Hooper SD; Mayrhofer M; Juliusson G; Isaksson A; Gyllensten U; Rosenquist R
Article: CLINICAL LYMPHOMA, MYELOMA AND LEUKEMIA. 2012;12(3):201-206
IGHV3-21 Gene Frequency in a Swedish Cohort of Patients With Newly Diagnosed Chronic Lymphocytic Leukemia
Cahill N; Sutton L-A; Jansson M; Murray F; Mansouri L; Gunnarsson R; Ryan F; Smedby KE; Geisler C; Juliusson G; Rosenquist R
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2012;87(4):361-367
Mantle cell lymphoma displays a homogenous methylation profile: A comparative analysis with chronic lymphocytic leukemia
Halldorsdottir AM; Kanduri M; Marincevic M; Mansouri L; Isaksson A; Goransson H; Axelsson T; Agarwal P; Jernberg-Wiklund H; Stamatopoulos K; Sander B; Ehrencrona H; Rosenquist R
Article: ONCOIMMUNOLOGY. 2012;1(1):18-27
Lymphoblastoid cell line with B1 cell characteristics established from a chronic lymphocytic leukemia clone by in vitro EBV infection
Rosen A; Bergh A-C; Gogolak P; Evaldsson C; Myhrinder AL; Hellqvist E; Rasul A; Bjorkholm M; Jansson M; Mansouri L; Liu A; Teh BT; Rosenquist R; Klein E
Article: JOURNAL OF THORACIC ONCOLOGY. 2011;6(11):1833-1840
Gene Copy Number Aberrations Are Associated with Survival in Histologic Subgroups of Non-small Cell Lung Cancer
Micke P; Edlund K; Holmberg L; Kultima HG; Mansouri L; Ekman S; Bergqvist M; Scheibenflug L; Lamberg K; Myrdal G; Berglund A; Andersson A; Lambe M; Nyberg F; Thomas A; Isaksson A; Botling J
Article: HAEMATOLOGICA. 2011;96(8):1161-1169
Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia
Gunnarsson R; Mansouri L; Isaksson A; Goransson H; Cahill N; Jansson M; Rasmussen M; Lundin J; Norin S; Buhl AM; Smedby KE; Hjalgrim H; Karlsson K; Jurlander J; Geisler C; Juliusson G; Rosenquist R
Article: HAEMATOLOGICA. 2011;96(8):1153-1160
LPL is the strongest prognostic factor in a comparative analysis of RNA-based markers in early chronic lymphocytic leukemia
Kaderi MA; Kanduri M; Buhl AM; Sevov M; Cahill N; Gunnarsson R; Jansson M; Smedby KE; Hjalgrim H; Jurlander J; Juliusson G; Mansouri L; Rosenquist R
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Corrigendum: LEUKEMIA. 2023;37(2):504
Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY (Dec, 10.1038/s41375-022-01802-y, 2022)
Mansouri L; Thorvaldsdottir B; Sutton L-A; Karakatsoulis G; Meggendorfer M; Parker H; Nadeu F; Brieghel C; Laidou S; Moia R; Rossi D; Catherwood M; Kotaskova J; Delgado J; Rodriguez-Vicente AE; Benito R; Rigolin GM; Bonfiglio S; Scarfo L; Mattsson M; Davis Z; Gogia A; Rani L; Baliakas P; Foroughi-Asl H; Jylha C; Skaftason A; Rapado I; Miras F; Martinez-Lopez J; de la Serna J; Rivas JMH; Thornton P; Larrayoz MJ; Calasanz MJ; Fesus V; Matrai Z; Bodor C; Smedby KE; Espinet B; Puiggros A; Gupta R; Bullinger L; Bosch F; Tazon-Vega B; Baran-Marszak F; Oscier D; Nguyen-Khac F; Zenz T; Terol MJ; Cuneo A; Hernandez-Sanchez M; Pospisilova S; Mills K; Gaidano G; Niemann CU; Campo E; Strefford JC; Ghia P; Stamatopoulos K; Rosenquist R
Review: FRONTIERS IN ONCOLOGY. 2023;13:1146486
Precision diagnostics in chronic lymphocytic leukemia: Past, present and future
Mollstedt J; Mansouri L; Rosenquist R
Letter: HAEMATOLOGICA. 2018;103(4):E158-E161
No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy
Baliakas P; Mattsson M; Hadzidimitriou A; Minga E; Agathangelidis A; Sutton L-A; Scarfo L; Davis Z; Yan X-J; Plevova K; Sandberg Y; Vojdeman FJ; Tzenou T; Chu CC; Veronese S; Mansouri L; Smedby KE; Giudicelli V; Nguyen-Khac F; Panagiotidis P; Juliusson G; Anagnostopoulos A; Lefranc M-P; Trentin L; Catherwood M; Montillo M; Niemann CU; Langerak AW; Pospisilova S; Stavroyianni N; Chiorazzi N; Oscier D; Jelinek DF; Shanafelt T; Darzentas N; Belessi C; Davi F; Ghia P; Rosenquist R; Stamatopoulos K
Editorial comment: CANCER CELL. 2016;30(5):665-667
Unraveling the DNA Methylome in Mantle Cell Lymphoma: New Insights into the Cellular Origin
Mansouri L; Rosenquist R
Letter: HAEMATOLOGICA. 2016;101(9):e369-e373
ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres
Navrkalova V; Young E; Baliakas P; Radova L; Sutton L-A; Plevova K; Mansouri L; Ljungstrom V; Ntoufa S; Davis Z; Juliusson G; Smedby KE; Belessi C; Panagiotidis P; Touloumenidou T; Davi F; Langerak AW; Ghia P; Strefford JC; Oscier D; Mayer J; Stamatopoulos K; Pospisilova S; Rosenquist R; Trbusek M
Review: SEMINARS IN CANCER BIOLOGY. 2016;39:40-48
NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions
Mansouri L; Papakonstantinou N; Ntoufa S; Stamatopoulos K; Rosenquist R
Letter: HAEMATOLOGICA. 2016;101(2):e63-e65
UGT2B17 expression: a novel prognostic marker within IGHV-mutated chronic lymphocytic leukemia?
Bhoi S; Baliakas P; Cortese D; Mattsson M; Engvall M; Smedby KE; Juliusson G; Sutton L-A; Mansouri L
Letter: LEUKEMIA. 2015;29(3):748-751
Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk
Sava GP; Speedy HE; Di Bernardo MC; Dyer MJS; Holroyd A; Sunter NJ; Marr H; Mansouri L; Deaglios S; Karabon L; Frydecka I; Jamroziak K; Woszczyk D; Juliusson G; Smedby KE; Jayne S; Majid A; Wang Y; Dearden C; Hall AG; Mainou-Fowler T; Jackson GH; Summerfield G; Harris RJ; Pettitt AR; Allsup DJ; Bailey JR; Pratt G; Pepper C; Fegan C; Rosenquist R; Catovsky D; Allan JM; Houlston RS
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2014;166(4):621-625
The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors
Malcikova J; Stalika E; Davis Z; Plevova K; Trbusek M; Mansouri L; Scarfo L; Baliakas P; Gardiner A; Sutton L-A; Francova HS; Agathangelidis A; Anagnostopoulos A; Tracy I; Makris A; Smardova J; Ghia P; Belessi C; Gonzalez D; Rosenquist R; Oscier D; Pospisilova S; Stamatopoulos K
Letter: LEUKEMIA. 2014;28(3):710-713
On the way towards a 'CLL prognostic index': focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort
Cortese D; Sutton L-A; Cahill N; Smedby KE; Geisler C; Gunnarsson R; Juliusson G; Mansouri L; Rosenquist R
Letter: LEUKEMIA. 2014;28(3):694-696
Feasibility of targeted next-generation sequencing of the TP53 and ATM genes in chronic lymphocytic leukemia
Mansouri L; Sutton L-A; Ljungstrom V; Sorqvist EF; Gunnarsson R; Smedby KE; Juliusson G; Stamatopoulos K; Nilsson M; Rosenquist R
Review: LEUKEMIA AND LYMPHOMA. 2013;54(11):2351-2364
Prognostic markers and their clinical applicability in chronic lymphocytic leukemia: where do we stand?
Rosenquist R; Cortese D; Bhoi S; Mansouri L; Gunnarsson R
Review: LEUKEMIA AND LYMPHOMA. 2013;54(8):1583-1590
Exploring the genetic landscape in chronic lymphocytic leukemia using high-resolution technologies
Gunnarsson R; Mansouri L; Rosenquist R
Letter: LEUKEMIA. 2013;27(2):512-514
NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia
Mansouri L; Cahill N; Gunnarsson R; Smedby KE; Tjonnfjord E; Hjalgrim H; Juliusson G; Geisler C; Rosenquist R
Review: EXPERT REVIEW OF HEMATOLOGY. 2012;5(1):69-79
RNA-based markers as prognostic factors in chronic lymphocytic leukemia
Sevov M; Rosenquist R; Mansouri L
Letter: LEUKEMIA. 2011;25(12):1904-1908
Impact of TP53 mutation and 17p deletion in mantle cell lymphoma
Halldorsdottir AM; Lundin A; Murray F; Mansouri L; Knuutila S; Sundstrom C; Laurell A; Ehrencrona H; Sander B; Rosenquist R

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