Keith Humphreys
Professor | Docent
E-mail: keith.humphreys@ki.se
Telephone: +46852486887
Visiting address: Nobels väg 12a, 17165 Solna
Postal address: C8 Medicinsk epidemiologi och biostatistik, C8 MEB Humphreys, 171 77 Stockholm
About me
- I obtained my doctoral degree in Statistics at Southampton University (U.K.) in 1996. In 2005, I was appointed Senior Lecturer in Biostatistics at Karolinska Institutet at the Department of Medical Epidemiology and Biostatistics. In 2019, I was appointed as Professor in Biostatistics in the same department.
Education:
1996, PhD (Social Statistics), Southampton University, U.K.
1997, Postdoc (Statistics/Psychometrics), Stockholm University
1999, Postdoc (Statistics), Glasgow University, U.K.
2002, Docent (Biostatistics), Karolinska Institutet
Research
- I am involved in a number of research projects which have a general aim to contribute to the understanding of breast cancer tumour progression and to the identification of women with high risk for breast cancer, in particular that which is aggressive/has poor prognosis. We develop novel statistical approaches and apply them to large, and detailed, studies of breast cancer/mammography screening. My research builds on previous work on the identification of genetic variants for breast cancer, the development of statistical models of breast cancer risk and tumour growth and the development of novel approaches for measuring mammographic density.
Current supervision of PhD students and Postdoctoral researcher
Letizia Orsini (PhD student)
Evripidis Kapanidis (PhD student)
Alessandro Gasparini (Postdoc)
Teaching
- I am course director for the Biostatistics course on the master program for Molecular Techniques in the Life Sciences.
Selected publications
- Article: JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS (JCGS). 2023;32(4):1393-1401
- Article: CANCERS. 2023;15(3):912
- Article: STATISTICAL METHODS IN MEDICAL RESEARCH. 2022;31(12):2415-2430
- Article: MATHEMATICAL BIOSCIENCES. 2022;353:108897
- Article: STATISTICAL METHODS IN MEDICAL RESEARCH. 2022;31(5):862-881
- Article: BIOMETRICS. 2022;78(1):376-387
- Article: INTERNATIONAL JOURNAL OF CANCER. 2021;149(6):1348-1357
- Article: STATISTICAL METHODS IN MEDICAL RESEARCH. 2020;29(2):374-395
- Article: MATHEMATICAL BIOSCIENCES. 2019;318:108270
- Article: STATISTICAL METHODS IN MEDICAL RESEARCH. 2019;28(12):3822-3842
- Review: MEDICAL PHYSICS. 2019;46(4):1938-1946
- Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2017;186(9):1065-1073
- Article: CANCER EPIDEMIOLOGY. 2017;46:50-56
- Article: STATISTICAL METHODS IN MEDICAL RESEARCH. 2016;25(4):1620-1637
- Article: BREAST CANCER RESEARCH. 2015;17:116
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2014;23(7):1314-1323
- Article: BREAST CANCER RESEARCH. 2012;14(1):R25
- Article: PLOS ONE. 2011;6(8):e22547
- Article: INTERNATIONAL JOURNAL OF BIOSTATISTICS. 2010;6(1):Article-20
- Article: STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY. 2009;8(1):Article-35
- Article: GENETIC EPIDEMIOLOGY. 2007;31(6):528-540
- Article: PSYCHOMETRIKA. 2003;68(3):391-412
- Article: JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY. 2002;64:549-564
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Articles
- Article: STATISTICS IN MEDICINE. 2024;43(15):2957-2971
- Article: ESMO OPEN. 2024;9(4):102972
- Article: JAMA ONCOLOGY. 2024;10(1):63-70
- Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2023;115(11):1310-1317
- Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2023;75:S239-S240
- Article: STATISTICS IN MEDICINE. 2023;42(21):3816-3837
- Article: EUROPEAN JOURNAL OF CANCER. 2023;191:112953
- Article: SCIENTIFIC REPORTS. 2023;13(1):14194
- Article: CANCERS. 2023;15(13):3313
- Article: BREAST CANCER RESEARCH. 2023;25(1):64
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31(5):578-587
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2023;110(3):475-486
- Journal article: CANCER RESEARCH. 2023;83(5_Supplement):p4-03-09-p4-03-09
- Article: JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK : JNCCN. 2023;21(2):143-152.e4
- Journal article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31(5):578-587
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2022;31(3):569-577
- Article: BREAST CANCER RESEARCH. 2022;24(1):15
- Article: EUROPEAN JOURNAL OF CANCER. 2022;162:194-205
- Article: INTERNATIONAL JOURNAL OF CANCER. 2021;148(6):1351-1359
- Article: INTERNATIONAL JOURNAL OF CANCER. 2021;148(4):884-894
- Article: NEW ENGLAND JOURNAL OF MEDICINE. 2021;384(5):428-439
- Article: GENETIC EPIDEMIOLOGY. 2020;44(5):442-468
- Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2020;49(1):216-232
- Journal article: EPIDEMIOLOGIC METHODS. 2020;9(1):20190022
- Article: SCIENTIFIC REPORTS. 2019;9(1):14604
- Article: NATURE COMMUNICATIONS. 2019;10(1):1741
- Article: STATISTICAL METHODS IN MEDICAL RESEARCH. 2019;28(3):681-702
- Article: BRITISH JOURNAL OF CANCER. 2019;120(6):647-657
- Article: BREAST CANCER RESEARCH. 2019;21(1):8
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2019;104(1):21-34
- Article: JNCI CANCER SPECTRUM. 2018;2(3):pky051
- Article: INTERNATIONAL JOURNAL OF CANCER. 2018;143(5):1093-1104
- Article: NATURE GENETICS. 2018;50(7):968-978
- Article: BREAST CANCER RESEARCH. 2018;20(1):31
- Article: BREAST CANCER RESEARCH. 2018;20(1):30
- Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2018;47(2):526-536
- Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2017;46(6):1814-1822
- Article: NATURE GENETICS. 2017;49(12):1767-1778
- Article: NATURE. 2017;551(7678):92-94
- Article: BREAST CANCER RESEARCH. 2017;19(1):103
- Article: JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION : JAMIA. 2017;24(5):950-957
- Article: SCIENTIFIC REPORTS. 2017;7(1):5942
- Article: CLINICAL CANCER RESEARCH. 2017;23(10):2584-2592
- Article: CANCER. 2017;123(3):468-475
- Article: INTERNATIONAL JOURNAL OF CANCER. 2017;140(1):34-40
- Article: INTERNATIONAL JOURNAL OF CANCER. 2016;139(11):2415-2425
- Article: JOURNAL OF MEDICAL GENETICS. 2016;53(12):800-811
- Article: CLINICAL CANCER RESEARCH. 2016;22(21):5249-5255
- Article: BREAST CANCER RESEARCH. 2016;10(1):100
- Article: NATURE COMMUNICATIONS. 2016;7:11375
- Journal article: JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS. 2016;6(2):380-386
- Article: NATURE GENETICS. 2016;48(4):374-386
- Article: CANCER CAUSES AND CONTROL. 2016;27(4):481-491
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2016;34(3):251-U109
- Journal article: PROCEDIA COMPUTER SCIENCE. 2016;90:169-174
- Article: NATURE GENETICS. 2015;47(11):1294-1303
- Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(11):djv219
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2015;97(1):22-34
- Article: BREAST CANCER RESEARCH. 2015;17(1):75
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2015;24(6):985-991
- Article: HUMAN MOLECULAR GENETICS. 2015;24(10):2966-2984
- Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(5):djv081
- Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(5):djv036
- Article: BREAST CANCER RESEARCH. 2015;17(1):58
- Article: NATURE GENETICS. 2015;47(4):373-380
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2015;33(9):1030-1037
- Article: INTERNATIONAL JOURNAL OF CANCER. 2015;136(6):E685-E696
- Article: BREAST CANCER RESEARCH. 2015;17(1):18
- Article: CARCINOGENESIS. 2015;36(2):256-271
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2015;96(1):5-20
- Article: HUMAN MOLECULAR GENETICS. 2015;24(1):285-298
- Article: HUMAN MOLECULAR GENETICS. 2014;23(22):6034-6046
- Article: HUMAN MOLECULAR GENETICS. 2014;23(22):6096-6111
- Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2014;106(12):dju334
- Article: BMC MEDICAL GENETICS. 2014;15:113
- Article: NATURE COMMUNICATIONS. 2014;5:4999
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2014;23(9):1764-1772
- Article: NATURE COMMUNICATIONS. 2014;5:4051
- Article: BRITISH JOURNAL OF CANCER. 2014;110(7):1908-1916
- Article: PLOS GENETICS. 2014;10(4):e1004285
- Article: HUMAN MOLECULAR GENETICS. 2014;23(7):1934-1946
- Article: BRITISH JOURNAL OF CANCER. 2014;110(4):1088-1100
- Article: PLOS ONE. 2014;9(11):e109973
- Article: PLOS ONE. 2014;9(10):e110690
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2013;93(6):1046-1060
- Article: JOURNAL OF MEDICAL GENETICS. 2013;50(10):666-673
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2013;93(1):167-172
- Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2013;28(7):589-595
- Article: BREAST CANCER RESEARCH. 2013;15(3):R48
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2013;31(18):2249-2U50
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2013;92(4):489-503
- Article: NATURE GENETICS. 2013;45(4):371-384
- Article: NATURE GENETICS. 2013;45(4):353-361
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2013;138(2):543-548
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2013;138(2):529-542
- Article: BREAST CANCER RESEARCH. 2013;15(5):R93
- Article: BREAST CANCER RESEARCH. 2013;15(4):R57
- Article: BREAST CANCER RESEARCH. 2013;15(4):R56
- Article: BMC GENOMICS. 2012;13:516
- Article: BREAST CANCER RESEARCH. 2012;14(4):R114
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2012;134(2):859-866
- Article: DEVELOPMENTAL PSYCHOLOGY. 2012;48(3):836-843
- Article: PLOS ONE. 2012;7(8):e42445
- Article: HUMAN MOLECULAR GENETICS. 2011;20(16):3289-3303
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2011;127(2):503-509
- Article: BREAST CANCER RESEARCH. 2011;13(3):R49
- Article: DEVELOPMENTAL SCIENCE. 2011;14(3):591-601
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2011;126(3):717-727
- Article: PLOS GENETICS. 2011;7(4):e1001378
- Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2011;103(3):250-263
- Article: BREAST CANCER RESEARCH. 2011;13(1):R10
- Article: HUMAN HEREDITY. 2011;71(1):11-22
- Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2011;173(1):48-54
- Article: BIOLOGICAL PSYCHIATRY. 2010;68(12):1120-1125
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2010;18(12):1322-1326
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2010;19(9):2143-2151
- Article: NATURE GENETICS. 2010;42(8):661-664
- Journal article: THE INTERNATIONAL JOURNAL OF BIOSTATISTICS. 2010;6(1):1-31A Stochastic EM Type Algorithm for Parameter Estimation in Models with Continuous Outcomes, under Complex Ascertainment
- Article: PLOS GENETICS. 2010;6(7):e1001012
- Journal article: THE INTERNATIONAL JOURNAL OF BIOSTATISTICS. 2010;6(1):1-37A Principal Stratification Approach to Assess the Differences in Prognosis between Cancers Caused by Hormone Replacement Therapy and by Other Factors
- Article: CANCER CAUSES AND CONTROL. 2010;21(5):759-769
- Article: INTERNATIONAL JOURNAL OF BIOSTATISTICS. 2010;6(1):Article-23
- Article: BREAST CANCER RESEARCH. 2010;12(6):R93
- Article: BREAST CANCER RESEARCH. 2010;12(2):R23
- Article: BREAST CANCER RESEARCH. 2010;12(2):R19
- Article: DEVELOPMENTAL NEUROPSYCHOLOGY. 2009;35(1):81-95
- Journal article: STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY. 2009;8(1):1-44Ancestral Recombination Graphs under Non-Random Ascertainment, with Applications to Gene Mapping
- Article: BIOMETRICS. 2009;65(2):514-520
- Article: BRITISH JOURNAL OF CANCER. 2009;100(8):1358-1364
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2009;17(4):533-536
- Article: COMPUTATIONAL STATISTICS AND DATA ANALYSIS. 2009;53(5):1802-1817
- Article: DIABETES, OBESITY AND METABOLISM. 2009;11(Suppl 1):17-24
- Article: GENES AND IMMUNITY. 2009;10(1):56-67
- Article: BMC CANCER. 2008;8:322
- Article: GENETIC EPIDEMIOLOGY. 2008;32(5):425-433
- Article: STATISTICS IN MEDICINE. 2008;27(14):2635-2650
- Article: PLOS GENETICS. 2008;4(4):e1000054
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2008;32(3):407-412
- Article: BREAST CANCER RESEARCH. 2008;10(1):r15
- Article: ANNALS OF HUMAN GENETICS. 2007;71(Pt 6):815-827
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2007;16(9):1775-1783
- Article: HUMAN MOLECULAR GENETICS. 2007;16(2):154-164
- Article: PHARMACOGENETICS AND GENOMICS. 2006;16(12):881-889
- Article: PLOS MEDICINE. 2006;3(6):e168-903
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2006;15(2):258-265
- Article: BREAST CANCER RESEARCH. 2006;8(6):R67
- Article: BREAST CANCER RESEARCH. 2005;7(6):R890-R896
- Article: STATISTICS IN MEDICINE. 2004;23(11):1767-1780
- Article: CARCINOGENESIS. 2003;24(9):1533-1539
- Article: MULTIVARIATE BEHAVIORAL RESEARCH. 2000;35(1):89-118
- Article: SOCIOLOGICAL METHODS & RESEARCH. 1998;26(3):269-299
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All other publications
- Corrigendum: ESMO OPEN. 2024;9(5):103462
- Preprint: MEDRXIV. 2024;MEDRXIV
- Conference publication: ANNALS OF ONCOLOGY. 2022;33:S184
- Preprint: ARXIV. 2021
- Preprint: ARXIV. 2021
- Other: JNCI CANCER SPECTRUM. 2018;2(4):pky071
- Conference publication: CANCER RESEARCH. 2017;77:p2-03-03-p2-03-03
- Review: GYNECOLOGIC ONCOLOGY. 2016;141(2):386-401
- Published conference paper: STATISTICS IN MEDICINE. 2016;35(7):1193-1209
- Editorial comment: OBSTETRICAL AND GYNECOLOGICAL SURVEY. 2015;70(12):758-762
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2015;51:S167-S168
- Conference publication: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2013;177:S121
- Conference publication: GENETIC EPIDEMIOLOGY. 2012;36(2):166
- Conference publication: EUROPEAN JOURNAL OF CANCER. 2012;48:S78-S79
- Letter: BREAST CANCER RESEARCH AND TREATMENT. 2012;131(1):347-350
- Meeting abstract: BREAST. 2011;20:S30
- Conference publication: CANCER RESEARCH. 2009;69(24):818S-819S
- Conference publication: GENETIC EPIDEMIOLOGY. 2007;31(6):631
- Conference publication: DIABETOLOGIA. 2006;49:207
- Published conference paper: BMC GENETICS. 2005;6(Suppl 1):S92
- Published conference paper: BMC GENETICS. 2005;6(Suppl 1):S74
- Published conference paper: DIABETES. 2004;53:S31-S35
- Review: BREAST CANCER RESEARCH. 2004;6(4):R437-R449
- Conference publication: BREAST CANCER RESEARCH AND TREATMENT. 2002;76:S29
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Grants
- Swedish Research Council1 January 2024 - 31 December 2027
- Swedish Research Council1 January 2023 - 31 December 2025
- Swedish Research Council1 January 2022 - 31 December 2024
- Swedish Research Council1 January 2021 - 31 December 2023
- Swedish Research Council1 December 2019 - 31 December 2023
- Swedish Research Council for Health Working Life and Welfare1 January 2019 - 31 December 2021
- Modeling of tumor growth, lymph node spread, presence of metastases and survival in breast cancer patientsSwedish Cancer Society1 January 2018
- Swedish Research Council1 January 2018 - 31 December 2021
- Modeling of tumor growth, lymph node spread, presence of metastases and survival in breast cancer patientsSwedish Cancer Society1 January 2017
- Swedish Research Council1 January 2017 - 31 December 2020
- Swedish Research Council for Health Working Life and Welfare1 January 2017 - 31 December 2019
- Improvement of prediction of risk for breast cancer by modeling of tumor growth and new measurement methods of mammographic density.Swedish Cancer Society1 January 2016
- Improvement of prediction of risk for breast cancer by modeling of tumor growth and new measurement methods of mammographic density.Swedish Cancer Society1 January 2015
- Swedish Research Council1 January 2015 - 31 December 2018
- Improvement of prediction of risk for breast cancer by modeling of tumor growth and new measurement methods of mammographic density.Swedish Cancer Society1 January 2014
- Swedish Research Council1 January 2012 - 31 December 2015
- Swedish Research Council1 January 2012 - 31 December 2014
- Swedish Research Council1 January 2010 - 31 December 2012
- Swedish Research Council1 January 2009 - 31 December 2011
- Swedish Research Council1 January 2009 - 31 December 2011
Employments
- Professor, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2019-
Degrees and Education
- Docent, Karolinska Institutet, 2002
Supervisor
- Evripidis Kapanidis, 2023
- Ziyan Ma, 2022
- Letizia Orsini, 2022
- Emilio Ugalde Morales, Molecular epidemiology studies on risk factors for breast cancer and disease aggressiveness, 2015
- Fredrik Strand, Determinants of interval cancer and tumor size among breast cancer screening participants, 2014
- Johanna Holm, Aggressive breast cancer: epidemiological studies addressing disease heterogeneity, 2012
- Linda Abrahamsson, Statistical models of breast cancer tumour progression for mammography screening data, 2012
- Hatef Darabi, Genetic association and risk prediction of breast cancer from an epidemiological and biostatistical perspective, 2008
- Louise Eriksson, Mammographic density and breast cancer phenotypes, 2007
- Gabriel Isheden, Statistical models of breast cancer tumour growth and spread.
- Rickard Strandberg, Breast cancer natural history models and risk prediction in mammography screening cohorts
- Jingmei Li, Genetic determinants of breast cancer risk
- Xinhe Mao, Epidemiological studies on breast cancer risk factors and screening
- Kristjana Einarsdottir, Genetic determinants of postmenopausal breast and endometrial cancer
Other expert reviewer/evaluation assignment
- Reviewer for international evaluations, Panel member and external reviewer, programme on High-Quality and Reliable Diagnostic, Treatment and Rehabilitation, The Research Council of Norway, 2017-2017