Katharina Schmidt-Mende

Katharina Schmidt-Mende

Affiliated to Research | Docent
Visiting address: Alfred Nobels Allé 23, 14183 Huddinge
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Allmänmedicin och primärvård, 171 77 Stockholm

About me

  • I am general practitioner and specialist in internal medicine and work clinically in home health care. Since february 2025, I am associate professor in General Practice with affiliation both to the Academic primary health care centre, region Stockholm, and to the Department of Neurobiology, Care Sciences and Society, Division of family Medicine and Primary Care.

    The driving force in my scientific and clinical work is the idea of equal and high-quality care for patients who have difficulties to make themselves heard. One such group is frail older adults with multimorbidity living at home, whom I care for as a general practitioner in primary care. Research in this population is sparse. Frail older people are generally excluded from randomized trials, leading to a significant mismatch between guidelines and their applicability in this patient group. My scientific research and clinical practice are interconnected, with research questions often emerging from my clinical experiences.

    The region-based HAMPUS research group I lead - Holistic Approaches to Multimorbidity in Primary Care: Unveiling Sustainable Solutions - was established 2018 and is dedicated to improving care for older adults with multimorbidity, with primary care as the foundation for long-term support. We believe care should be coordinated, evidence-based, and centered on patients’ needs, preferences, and well-being. 

    The Hampus research group with 9 members consists of both senior and junior researchers. Hampus has expertise in primary care, emergency care, nursing, epidemiology, qualitative methodology, clinical pharmacology, teaching, pedagogical research and digital decision support.

    Hampus members are affiliated to the Academic primary health care center, the Divisions of Family Medicine and Primary Care and Nursing at the Department of Neurobiology, Care sciences and Society, the Division of Clinical Pharmacology at the Department of Laboratory Medicine, the Institute of Environmental medicine and Healthcare Services Board at either Region Stockholm or Karolinska Institutet. 

    Group members are: 

    Pia Bastholm Rahmner, PhD, behavioural scientist 

    Monica Bergqvist, PhD, registered nurse 

    Hanna Bring, MD, PhD student, resident GP 

    Eric Chen, MD, PhD student, resident GP 

    Birgit Eiermann, MScPharm, PhD, pharmacist 

    Lars L Gustafsson, Professor in Clinical Pharmacology 

    Clare Tazzeo, PhD, post doc researcher in epidemiology 

    Anikó Vég, PhD, special educator 

     

    Through this multidisciplinary approach, HAMPUS creates sustainable solutions that improve care and enhance the quality of life for older adults with multimorbidity - shaping a more responsive and effective primary care system. 

    We have established national and international collaborations. 

    At KI: 

    Associate professor Karin Modig at Institute of Environmental Medicine 

    Associate Professor and specialist in cardiology Carolina Szummer, Karolinska University Hospital 

    In Sweden: 

    Professor Björn Wettermark, MScPharm, Uppsala University 

    Internationally: 

    UK: Professor Bruce Guthrie, Professor Stewart Mercer, both GPs, University of Edinburgh 

    Denmark: Professor Jens Søndergaard, GP and clinical pharmacologist, University of Southern Denmark 

    Germany: Associate Professor Marcus Ebeling, Dr. rer. Pol, Max Planck Institute for Demographic Research and Rostock University 

    The group has raised >30 million SEK in national and regional funding since 2018. 

    National:  

    Swedish Research Council, FORTE, King Gustaf V and Queen Victoria’s Foundation 

    Regional:  Center for Innovative MEDicine, ALF, NSV, regional grants for clinical researchers and PhD students 

Research

  • We address two main research areas: 

    1. Rethinking Primary Care for Aging Populations: Models to Reduce Emergency Visits and Improve Outcomes

    We explore how primary care can better support older adults with multiple conditions by developing care models that reduce emergency visits and improve outcomes. By analysing current practices—needs assessment, service coordination, and communication—we identify gaps such as fragmented care and conflicting treatments. These insights guide interventions that enhance collaboration and actively involve patients, caregivers, and home care staff. 

    2. From Guidelines to Practice: Developing Real-World Solutions for Frailty and Multimorbidity in Primary Care

    Most clinical guidelines target single diseases, overlooking frail patients with multiple coexisting conditions. HAMPUS develops and evaluates strategies for multimorbidity, aiming for safe, practical interventions in everyday primary care. Using quantitative and qualitative methods, we assess management of complex conditions—such as heart failure or dementia—to better understand how illnesses and treatments interact and affect frail older adults. Our work strengthens the evidence base for multimorbidity care and translates it into practice. We share results with healthcare providers, policymakers, and community organisations through training and policy recommendations. By combining clinical, epidemiological, and qualitative perspectives, we ensure our research remains directly relevant to primary care. 

Articles

All other publications

Grants

  • Optimizing heart failure treatment in older patients with comorbidities: bridging the gap between guidelines and clinical practice in primary care
    Svenska Läkaresällskapet (SLS Projektanslag - Multisjuklighet)
    1 January 2026 - 31 December 2027
  • Keeping frail Older Adults Out of the emergency department – PROACT, a Complex Intervention in Swedish Home and Primary Care
    Region Stockholm - klinisk forskare
    1 January 2026 - 31 December 2027
  • Keeping frail older adults out of the emergency department – Exploring the roles of primary care professionals and opportunities for task reallocation
    Region Stockholm (NSV Projektmedel)
    1 January 2026 - 31 December 2028
  • Prevention of emergency visits among frail older patients in primary care - development of a complex intervention in Swedish healthcare (P)
    Centrum för innovativ medicin CIMED
    1 January 2025 - 31 December 2027
  • Does primary care follow drug treatment recommendations in older multi-diseased heart failure patients, and does it make a difference? A mixed-methods project in Swedish primary care
    ALF Region Stockholm
    1 January 2024 - 31 December 2025
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2024 - 31 December 2026
    Research problem and specific questions: Fall injuries among older adults are one of few public health problems that have not decreased with better health care and lifestyles, the number of falls will instead increase with an ageing population. A fall injury often leads to loss of independence and reduced quality of life. In addition, one fall often leads to more falls, leaving a vulnerable group of patients with increasing difficulty maintaining their independence.  Prognosis after a fall injury likely depends on an accumulation of sociodemographic- medical- and social factors. A combination of factors that either makes an individual vulnerable or resilient after a fall injury. Despite this, we know very little about the types of fall injuries that lead to more, worse injuries. In addition, the research focus is on individual risk factors for poor prognosis, lacking a focus on healthy factors and a real-world perspective that acknowledges health complexity and synergy of multiple factors.The aim of this project is to 1) identify the types of fall injuries that affect different groups of older people and which injuries lead to more fall injuries, identifying patterns of factors that make an individual 2) extra vulnerable after a fall, and 3) more resilient, who despite a fall injury regain independence.Data and method: Using a combination of national registries and survey data, we can follow individuals over many years to study patterns of fall injuries but also resilience after a fall injury in terms of medical care, medications, and home care. Using data on medical- and socio-economic factors - as well as personality and health behaviors in a sample of the older population - we can also get a picture of what characterizes vulnerability and resilience.Relevance: Fall injuries are the main cause of years with disability among people over 70 years in Sweden. The economic costs are high, with a fall leading to a serious injury costing the society around 273 600 SEK/person. Thus, falls among older adults are a major public health problem that will increase in magnitude and cost in the future. Our project will provide evidence to improve the prognosis after a fall injury, which can benefit both the individual and society.Plan for project realization: The project will be carried out at the Unit of Epidemiology, IMM, KI. We will use advanced machine learning methods to answer the research questions in linked national registers. The main cost is personnel costs.
  • PhD grant: Does primary care follow drug treatment recommendations in older multi-diseased heart failure patients, and does it make a difference? A mixed-methods project in Swedish primary care
    Region Stockholm and Karolinska Institutet
    8 October 2023 - 31 October 2029
  • Swedish Research Council for Health Working Life and Welfare
    1 July 2023 - 30 June 2026
    Dementia is a major public health problem not only for affected individuals but also their families. In Sweden, care for people with dementia is regulated by national guidelines. However, previous research as well as an evaluation by the National Board of Health and Welfare have pointed to limited adherence to these guidelines with regards to both diagnostic processes and provided care. The National Board of Health and Welfare identifies several areas for improvement, two of which are addressed in this application: better conditions for people with dementia in primary care and a need for more qualitative data describing the content and quality of provided care.Primary care is often the first point of contact with health care and plays a key role both in the diagnostic process and in the provision and coordination of care for older people with dementia. Yet, there is little research on primary care for older people with dementia in Sweden. One reason is the lack of a primary care register at the national level.With the use of both quantitative and qualitative methods, this project aims to explore barriers to dementia diagnosis in primary care as well as the extent to which dementia is underdiagnosed in primary but also specialist care in different population subgroups. Furthermore, we aim to explore co-morbidity at the time of dementia diagnosis across the population and whether older individuals’ health is related to specified dementia diagnoses.Our project aims to examine to which extent people with dementia and their relatives have similar views on dementia care as care providers, specifically general practitioners, nurses, and home care staff. We will describe care trajectories for people with a diagnosis of dementia and how they vary across population groups. We know that family members play an important role in the care of older people. Therefore, we aim to highlight older people without close relatives and examine to which extent formal care for older people succeeds in compensating for the potential lack of informal support.The project is based on a large register database with national coverage for specialist care, and regional coverage for primary care. This is complemented by focus group discussions with healthcare providers, and individual interviews with people with dementia and their relatives. The research team includes a general practitioner, nurses, ageing epidemiologists, behavioral scientists and qualitative researchers.
  • PhD grant: Potentially preventable emergency department visits in frail older patients in Region Stockholm: trigger factors and variation between primary care practices
    1 October 2022 - 31 October 2028
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2022 - 31 December 2024
  • Post doc grant: Prevention of emergency visits among frail older patients in primary care - development of a complex intervention in Swedish healthcare
    Stockholm Regional Council
    1 January 2022 - 31 December 2025
  • Why and how often do older home care patients need emergency care, and how may it be prevented? A mixed-methods project in Region Stockholm
    Nätverksjukvård
    1 January 2021 - 31 December 2024

Employments

  • Affiliated to Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2024-2026
  • Specialist in General Practice, Stockholm Health Care Services, 2009-2012

Degrees and Education

  • Docent, General Medicine, Karolinska Institutet, 2025
  • Degree Of Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2019
  • Specialist in Internal Medicine, Socialstyrelsen, 2009

Distinction and awards

  • Stipendium, Awarded 700.000 SEK over 4 years as PI, 2021-2025, King Gustaf V and Queen Victoria’s Masonic Foundation for Aging Research (Kung Gustaf V och Drottning Victorias Frimurarstiftelse för åldersforskning), 2021

Visiting research fellowships

  • Clinical postdoc funded by KI and Region Stockholm (SLSO:s FoUU- kommitté). Topic: Prevention of emergency department visits among frail older patients in primary care – a complex intervention in Swedish healthcare., Stockholm region, 2023-2025

Conference/event participation

News from KI

Events from KI