Kamila Czene

Kamila Czene

Professor
Telephone: +46852486144
Visiting address: Nobels väg 12a, 17165 Solna
Postal address: C8 Medicinsk epidemiologi och biostatistik, C8 MEB Czene, 171 77 Stockholm
Part of:

About me

  • Current position

    • Professor in Cancer Epidemiology, Karolinska Institutet

    Recent commissions of trust

    • Member of the Nobel Assembly, from 2021
    • Member of the of Cancerföreningen, Stockholm, from 2024
    • Member of the Research Board, Swedish Cancer Society, 2018-2024
    • Member of the Faculty Board (Fakultetsnämnd), KI, 2020-2022
    • Co-Director of Cancer Research KI and StratCan, 2016-2022

Research

  • I am recognized in the global scientific community for my contributions to cancer research, particularly in the field of breast cancer. Since 2010, I have held the position of Professor of Cancer Epidemiology. I lead a dedicated research team focused on understanding the causes and consequences of breast cancer. Our success stems from our ability to effectively combine clinical, genetic, molecular, and questionnaire data with national registries and biobanking resources.

    With over 400 scientific publications and an h-index of 71, my expertise spans epidemiology, clinical studies, and experimental research. This diverse experience supports my commitment to promoting effective interdisciplinary communication, a crucial skill in my recent roles as Co-Director of Cancer Research KI and as a member of prestigious organizations such as the Nobel Assembly, the Research Committee of the Swedish Cancer Society, and the Breast Cancer Association Consortium.

    My team's research has significantly advanced the understanding of breast cancer, initially emphasizing the role of inherited genetic factors in determining risk and aggressiveness. More recently, we have explored genetic/molecular associations with breast cancer subtypes and treatment responses. We have also investigated the critical role of mammographic breast density/features in the diagnosis and prognosis of the disease.

Teaching

    • Current or previous main supervisor of 12 doctoral students and co-supervisor of 18 doctoral students
    • Current or previous supervisor of 18 post-docs
    • Supervisor of 13 exjobb- and master students in various programs: Biomedicine, Medical program, Public Health, Erasmus

Selected publications

Articles

  • Article: EBIOMEDICINE. 2026;129:106352
    Rodriguez J; Grassmann F; Kaukonen D; Humphreys K; Eriksson M; Zhang Y; Morawitz K; Gabrielson M; Hall P; Czene K
  • Article: CELL. 2026;189(11):3339-3357.e11
    Koprulu M; Smith-Byrne K; Ferolito BR; Macdonald-Dunlop E; Luan J; Hedman AK; Ogamba CF; Kuliesius J; Repetto L; Ramisch A; Abbasi F; Arnlov J; Assimes TL; Bjorck HM; Bjorkander S; Bottcher M; Butterworth AS; Chen Z; Cho K; Clarke RJ; Cox SR; Czene K; Danesh J; Dedoussis G; Elmstahl S; Eriksson N; Eriksson P; Esko T; Ferreiro-Iglesias A; Franks PW; Fu J; Gaziano JM; Ghanbari M; Gieger C; Gilly A; Grallert H; Gunter MJ; Gustafsson S; Goteson A; Hall PFL; Hansson O; Harris SE; Hayward C; Herder C; Hernandez-Pacheco N; Hijazi Z; Hillary RF; Hopewell JC; Hu S; Hwang S-J; Jern C; Johansson A; Jonsson L; Kalnapenkis A; Kerrison ND; Kho PF; Klaric L; Kohleick L; Kraft J; Landen M; Levy D; Li L; Lind L; Long J; Mattsson-Carlgren N; Melen E; Merid SK; Mertins P; Michaelsson K; Moller PL; Murgia F; Nyegaard M; Park Y-C; Pearson E; Peters J; Petrie JR; Png G; Polasek O; Prins BP; Ripke S; Roden M; Rohde PD; Said S; Shen X; Schwenk JM; Siegbahn A; Smith JG; Stanne TM; Suhre K; Sundstrom J; Thorand B; Valdes-Marquez E; Vallerga CL; van Meurs JBJ; Vinuela A; Vosa U; Wallentin L; Walters RG; Wareham NJ; Weber JE; Weersma RK; Wilson JF; Winther S; Yasmeen S; Zanetti D; Zeggini E; Zhao JH; Zhernakova A; Zhernakova DV; Ziehm M; Kessler BM; Pereira AC; Malarstig A; Pietzner M; Langenberg C
  • Article: SCIENCE TRANSLATIONAL MEDICINE. 2026;18(850):eady7414
    Eriksson M; Czene K; Scott C; Stoddard S; Smith H; Hall P; Vachon C
  • Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2026;195(5):1231-1241
    Suger AH; Chen H; Haas CB; Fan S; Scott CG; Bolla MK; Dennis J; Dunning AM; Michailidou K; Wang Q; Fasching PA; Haeberle L; Stone J; Gago-Dominguez M; Castelao JE; Murphy RA; Aronson K; Couch FJ; Yadav S; Milne RL; Hopper JL; Norman A; Eliassen AH; Tapper WJ; Eccles DM; Evans DG; Astley S; Hall P; Czene K; Pharoah PDP; Antoniou AC; Garcia-Closas M; Berrington A; Easton DF; Gierach GL; Tamimi RM; Vachon CM; Lindstrom S; Harrison TA
  • Journal article: THE LANCET OBSTETRICS GYNAECOLOGY & WOMEN'S HEALTH. 2026;2(5):e451-e459
    Zhang X; Eriksson M; Mavaddat N; Dennis J; Astley SM; Gabrielson M; Giles GG; Hart SN; Hunter DJ; Le Marchand L; Lush M; Michailidou K; Scott CG; Tamimi RM; Wang Q; Howell SJ; Naven M; Antoniou AC; Aronson KJ; Bolla MK; Castelao JE; Couch FJ; Czene K; Dunning AM; Eliassen AH; Evans DG; Gago-Dominguez M; García-Closas M; Haiman CA; Milne RL; Pharoah PDP; Southey MC; Stone J; Murphy RA; de Gonzalez AB; Vachon CM; Hall P; Easton DF
  • Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2026;:djag087
    Hall P; Hammarstrom M; Bergqvist J; Czene K; Eriksson M; Gabrielson M; Tapia J; Quay S; Nash S; Backlund M
  • Article: CANCER CAUSES & CONTROL. 2026;37(5):72
    Klintman M; Rosendahl AH; Johannesen BR; Cronin-Fenton D; Eriksson M; Czene K; Hall P; Borgquist S
  • Article: STATISTICS IN MEDICINE. 2026;45(8-9):e70504
    Orsini L; Gasparini A; Czene K; Humphreys K
  • Article: INTERNATIONAL JOURNAL OF CANCER. 2026;158(5):1184-1192
    Kaukonen D; Ploner A; Zeng E; Bergqvist J; Czene K
  • Article: BREAST. 2026;85:104619
    Billaud A; Figlioli G; Mooser C; Casamassima I; Azzoni V; Srivatsa J; Colombo M; Caleca L; Ahearn TU; Andrulis IL; Antoniou AC; Beckmann MW; Behrens S; Bermisheva M; Bogdanova NV; Bolla MK; Bonanni B; Bruning T; Camp NJ; Campbell A; Castelao JE; Cessna MH; Chang-Claude J; Czene K; Dennis J; Devilee P; Dork T; Dunning AM; Eriksson M; Evans DG; Fasching PA; Figueroa JD; Gabrielson M; Gago-Dominguez M; Gonzalez-Neira A; Guenel P; Hadjisavvas A; Hahnen E; Hamann U; Hillemanns P; Hollestelle A; Hooning MJ; Hoppe R; Howell A; Jakubowska A; Kristensen VN; Lubinski J; Lush M; Manoukian S; Mavroudis D; Milne RL; Mulligan AM; Newman WG; Obi N; Panayiotidis MI; Pita G; Rashid MU; Rhenius V; Saloustros E; Sawyer EJ; Schmutzler RK; Shah M; Southey MC; Spurdle AB; Tomlinson I; Truong T; Wang Q; Wendt C; Auer PL; Boddicker NJ; Bodelon C; Burnside ES; Chen F; Couch FJ; Domchek SM; Eliassen HA; Haiman C; Hodge JM; Hu C; Huang H; Lindstrom S; Martinez ME; Nathanson KL; Neuhausen SL; O'brien KM; Olson JE; Palmer JR; Patel AV; Ruddy KJ; Sandler DP; Teras LR; Weinberg CR; Weitzel JN; Winham SJ; Yadav S; Yao S; Zirpoli G; Janatova M; Kleibl Z; Kleiblova P; Soukupova J; Zhao Q; Devereux L; James PA; Campbell IG; Nguyen-Dumont T; Dowty JG; Andrieu N; Lesueur F; Stoppa-Lyonnet D; de la Hoya M; Radice P; Sorensen CS; Peterlongo P
  • Article: JCO PRECISION ONCOLOGY. 2026;10:e2500852
    White BL; Ficorella L; Yang X; Czene K; Eriksson M; Hall P; Archer S; Tischkowitz M; Usher-Smith JA; Easton DF; Antoniou AC
  • Article: CANCERS. 2025;17(21):3561
    Ho PJ; Loo CKY; Lim RJY; Goh MH; Abubakar M; Ahearn TU; Andrulis IL; Antonenkova NN; Aronson KJ; Augustinsson A; Behrens S; Bodelon C; Bogdanova NV; Bolla MK; Brantley KD; Brenner H; Byers H; Camp NJ; Castelao JE; Cessna MH; Chang-Claude J; Chanock SJ; Chenevix-Trench G; Choi J-Y; Colonna SV; Czene K; Daly MB; Derouane F; Dork T; Eliassen AH; Engel C; Eriksson M; Evans DG; Fletcher O; Fritschi L; Gago-Dominguez M; Genkinger JM; Geurts-Giele WRR; Glendon G; Hall P; Hamann U; Ho CYS; Ho W-K; Hooning MJ; Hoppe R; Howell A; Humphreys K; Ito H; Iwasaki M; Jakubowska A; Jernstrom H; John EM; Johnson N; Kang D; Kim S-W; Kitahara CM; Ko Y-D; Kraft P; Kwong A; Lambrechts D; Larsson S; Li S; Lindblom A; Linet M; Lissowska J; Lophatananon A; MacInnis RJ; Mannermaa A; Manoukian S; Margolin S; Matsuo K; Michailidou K; Milne RL; Mohd Taib NA; Muir KR; Murphy RA; Newman WG; O'brien KM; Obi N; Olopade OI; Panayiotidis MI; Park SK; Park-Simon T-W; Patel AV; Peterlongo P; Plaseska-Karanfilska D; Pylkas K; Rashid MU; Rennert G; Rodriguez J; Saloustros E; Sandler DP; Sawyer EJ; Scott CG; Shahi S; Shu X-O; Shulman K; Simard J; Southey MC; Stone J; Taylor JA; Teo S-H; Teras LR; Terry MB; Torres D; Vachon CM; Houdt MV; Verhoeven J; Weinberg CR; Wolk A; Yamaji T; Yip CH; Zheng W; Hartman M; Li J
  • Article: BRITISH JOURNAL OF CANCER. 2025;133(6):844-855
    Ficorella L; Yang X; Mavaddat N; Carver T; Hassan H; Dennis J; Tyrer J; Ho W-K; Teo S-H; Hartman M; Li J; Eriksson M; Czene K; Hall P; Rahman T; Bacon A; Hardy S; Stokes AE; Donoso FS; Archer S; Simard J; Pharoah PDP; Usher-Smith JA; Tischkowitz M; Easton DF; Antoniou AC
  • Article: JAMA NETWORK OPEN. 2025;8(10):e2535330
    Mao X; He W; Tapia J; Holowko N; Bergqvist J; Humphreys K; Czene K
  • Article: BMJ-BRITISH MEDICAL JOURNAL. 2025;390:e085029
    Ma Z; He W; Zhang Y; Mao X; Tapia J; Hall P; Humphreys K; Czene K
  • Article: JCO PRECISION ONCOLOGY. 2025;9:e2500203
    Ficorella L; Eriksson M; Czene K; Leslie G; Yang X; Carver T; Stokes AE; Easton DF; Hall P; Antoniou AC
  • Article: BJC REPORTS. 2025;3(1):47
    Vesterlund G; Mao X; Gissler M; Abedi-Valugerdi M; Skoog T; Heinonen S; Sparen P; Pettersson K; Kere J; Czene K; Wedenoja S
  • Article: JAMA NETWORK OPEN. 2025;8(7):e2519236
    Le Cornet C; Jung AY; Behrens S; Middha P; Truong T; Jernstrom H; Bolla MK; Wang Q; Southey MC; Freeman LEB; Koutros S; Stone J; Rennert G; Shulman K; Aronson KJ; Murphy RA; Guenel P; Patel AV; Bodelon C; Teras LR; Shahi S; Lacey JV; Dossus L; Kaaks R; Holleczek B; Brenner H; Brauch H; Hoppe R; Czene K; Hall PFL; Mannermaa A; Wu AH; Obi N; Michailidou K; Panayiotidis MI; McLean C; Haiman CA; Augustinsson A; Zheng W; Shu X-O; Perou CM; Troester MA; Van Alsten S; Eliassen AH; Abubakar M; Kraft P; Ahearn TU; Evans DG; Wolk A; Milne RL; Easton DF; Pharoah PDP; Schmidt MK; Garcia-Closas M; Vachon CM; Fortner RT; Chang-Claude J
  • Journal article: CLINICAL CANCER RESEARCH. 2025;31(12_Supplement):ps16-05-ps16-05
    Hall P; Nash S; Bäcklund M; Bergqvist J; Hammarström M; Eriksson M; Quay S; Czene K
  • Article: NATURE COMMUNICATIONS. 2025;16(1):4852
    Zanti M; O'Mahony DG; Parsons MT; Dorling L; Dennis J; Boddicker NJ; Chen W; Hu C; Naven M; Yiangou K; Ahearn TU; Ambrosone CB; Andrulis IL; Antoniou AC; Auer PL; Baynes C; Bodelon C; Bogdanova N; Bojesen SE; Bolla MK; Brantley KD; Camp NJ; Campbell A; Castelao JE; Cessna MH; Chang-Claude J; Chen F; Chenevix-Trench G; Conroy DM; Czene K; De Nicolo A; Domchek SM; Doerk T; Dunning AM; Eliassen AH; Evans DG; Fasching PA; Figueroa JD; Flyger H; Gago-Dominguez M; Garcia-Closas M; Glendon G; Gonzalez-Neira A; Grassmann F; Hadjisavvas A; Haiman CA; Hamann U; Hart SN; Hartman MBA; Ho W-K; Hodge JM; Hoppe R; Howell SJ; Jakubowska A; Khusnutdinova EK; Ko Y-D; Kraft P; Kristensen VN; Lacey JV; Li J; Lim GH; Lindstrom S; Lophatananon A; Luccarini C; Mannermaa A; Martinez ME; Mavroudis D; Milne RL; Muir K; Nathanson KL; Nunez-Torres R; Obi N; Olson JE; Palmer JR; Panayiotidis MI; Patel AV; Pharoah PDP; Polley EC; Rashid MU; Ruddy KJ; Saloustros E; Sawyer EJ; Schmidt MK; Southey MC; Tan VK-M; Teo SH; Teras LR; Torres D; Trentham-Dietz A; Truong T; Vachon CM; Wang Q; Weitzel JN; Yadav S; Yao S; Zirpoli GR; Cline MS; Devilee P; Tavtigian SV; Goldgar DE; Couch FJ; Easton DF; Spurdle AB; Michailidou K
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All other publications

  • Conference publication: 2026;:a11.1-a1a11
    White B; Ficorella L; Yang X; Eriksson M; Czene K; Hall P; Tischkowitz M; Usher-Smith J; Easton D; Antoniou A
  • Corrigendum: NATURE COMMUNICATIONS. 2025;16(1):8237
    Lawrenson K; Kar S; McCue K; Kuchenbaeker K; Michailidou K; Tyrer J; Beesley J; Ramus SJ; Li Q; Delgado MK; Lee JM; Aittomaki K; Andrulis IL; Anton-Culver H; Arndt V; Arun BK; Arver B; Bandera EV; Barile M; Barkardottir RB; Barrowdale D; Beckmann MW; Benitez J; Berchuck A; Bisogna M; Bjorge L; Blomqvist C; Blot W; Bogdanova N; Bojesen A; Bojesen SE; Bolla MK; Bonanni B; Borresen-Dale A-L; Brauch H; Brennan P; Brenner H; Bruinsma F; Brunet J; Buhari SA; Burwinkel B; Butzow R; Buys SS; Cai Q; Caldes T; Campbell I; Cannioto R; Chang-Claude J; Chiquette J; Choi J-Y; Claes KBM; Collonge-Rame M-A; Damette A; Barouk-Simonet E; Bonnet F; Bubien V; Sevenet N; Longy M; Vaur D; Berthet P; Castera L; Ferrer SF; Bignon Y-J; Uhrhammer N; Coron F; Faivre L; Baurand A; Jacquot C; Bertolone G; Lizard S; Leroux D; Dreyfus H; Rebischung C; Peysselon M; Peyrat J-P; Fournier J; Revillion F; Adenis C; Venat-Bouvet L; Leone M; Boutry-Kryza N; Calender A; Giraud S; Verny-Pierre C; Lasset C; Bonadona V; Barjhoux L; Sobol H; Bourdon V; Noguchi T; Remenieras A; Coupier I; Pujol P; Sokolowska J; Bronner M; Delnatte C; Bezieau S; Mari V; Gauthier-Villars M; Buecher B; Rouleau E; Golmard L; Moncoutier V; Belotti M; de Pauw A; Elan C; Fourme E; Birot A-M; Saule C; Laurent M; Houdayer C; Lesueur F; Mebirouk N; Coulet F; Colas C; Soubrier F; Warcoin M; Prieur F; Lebrun M; Kientz C; Muller D; Fricker J-P; Toulas C; Guimbaud R; Gladieff L; Feillel V; Mortemousque I; Bressac-de-Paillerets B; Caron O; Guillaud-Bataille M; Cook LS; Cox A; Cramer DW; Cross SS; Cybulski C; Czene K; Daly MB; Damiola F; Dansonka-Mieszkowska A; Darabi H; Dennis J; Devilee P; Diez O; Doherty JA; Domchek SM; Dorfling CM; Dork T; Dumont M; Ehrencrona H; Ejlertsen B; Ellis S; Gregory H; Miedzybrodzka Z; Morrison PJ; Donaldson A; Rogers MT; Kennedy MJ; Porteous ME; Brady A; Barwell J; Foo C; Lalloo F; Side LE; Eason J; Henderson A; Walker L; Cook J; Snape K; Murray A; Mccann E; Engel C; Lee E; Evans DG; Fasching PA; Feliubadalo L; Figueroa J; Flesch-Janys D; Fletcher O; Flyger H; Foretova L; Fostira F; Foulkes WD; Fridley BL; Friedman E; Frost D; Gambino G; Ganz PA; Garber J; Garcia-Closas M; Gentry-Maharaj A; Ghoussaini M; Giles GG; Glasspool R; Godwin AK; Goldberg MS; Goldgar DE; Gonzalez-Neira A; Goode EL; Goodman MT; Greene MH; Gronwald J; Guenel P; Haiman CA; Hall P; Hallberg E; Hamann U; Hansen TVO; Harrington PA; Hartman M; Hassan N; Healey S; Rookus MA; van Leeuwen FE; van der Kolk LE; Schmidt MK; Russell NS; de Lange JL; Wijnands R; Collee JM; Hooning MJ; Seynaeve C; van Deurzen CHM; Obdeijn IM; van Asperen CJ; Tollenaar RAEM; van Cronenburg TCTEF; Kets CM; Ausems MGEM; van der Pol CC; van Os TAM; Waisfisz Q; Meijers-Heijboer HEJ; Gomez-Garcia EB; Oosterwijk JC; Mourits MJ; de Bock GH; Vasen HF; Siesling S; Verloop J; Overbeek LIH; Heitz F; Herzog J; Hogdall E; Hogdall CK; Hogervorst FBL; Hollestelle A; Hopper JL; Hulick PJ; Huzarski T; Imyanitov EN; Fox S; Kirk J; Lindeman G; Price M; Bowtell D; Defazio A; Webb P; Isaacs C; Ito H; Jakubowska A; Janavicius R; Jensen A; John EM; Johnson N; Kabisch M; Kang D; Kapuscinski M; Karlan BY; Khan S; Kiemeney LA; Kjaer SK; Knight JA; Konstantopoulou I; Kosma V-M; Kristensen V; Kupryjanczyk J; Kwong A; de la Hoya M; Laitman Y; Lambrechts D; Le N; De Leeneer K; Lester J; Levine DA; Li J; Lindblom A; Long J; Lophatananon A; Loud JT; Lu K; Lubinski J; Mannermaa A; Manoukian S; Le Marchand L; Margolin S; Marme F; Massuger LFAG; Matsuo K; Mazoyer S; Mcguffog L; McLean C; McNeish I; Meindl A; Menon U; Mensenkamp AR; Milne RL; Montagna M; Moysich KB; Muir K; Mulligan AM; Nathanson KL; Ness RB; Neuhausen SL; Nevanlinna H; Nord S; Nussbaum RL; Odunsi K; Offit K; Olah E; Olopade OI; Olson JE; Olswold C; O'Malley D; Orlow I; Orr N; Osorio A; Park SK; Pearce CL; Pejovic T; Peterlongo P; Pfeiler G; Phelan CM; Poole EM; Pylkas K; Radice P; Rantala J; Rashid MU; Rennert G; Rhenius V; Rhiem K; Risch HA; Rodriguez G; Rossing MA; Rudolph A; Salvesen HB; Sangrajrang S; Sawyer EJ; Schildkraut JM; Schmidt MK; Schmutzler RK; Sellers TA; Seynaeve C; Shah M; Shen C-Y; Shu X-O; Sieh W; Singer CF; Sinilnikova OM; Slager S; Song H; Soucy P; Southey MC; Stenmark-Askmalm M; Stoppa-Lyonnet D; Sutter C; Swerdlow A; Tchatchou S; Teixeira MR; Teo SH; Terry KL; Terry MB; Thomassen M; Tibiletti MG; Tihomirova L; Tognazzo S; Toland AE; Tomlinson I; Torres D; Truong T; Tseng C-C; Tung N; Tworoger SS; Vachon C; van den Ouweland AMW; van Doorn HC; van Rensburg EJ; Van't Veer LJ; Vanderstichele A; Vergote I; Vijai J; Wang Q; Wang-Gohrke S; Weitzel JN; Wentzensen N; Whittemore AS; Wildiers H; Winqvist R; Wu AH; Yannoukakos D; Yoon S-Y; Yu J-C; Zheng W; Zheng Y; Khanna KK; Simard J; Monteiro AN; French JD; Couch FJ; Freedman ML; Easton DF; Dunning AM; Pharoah PD; Edwards SL; Chenevix-Trench G; Antoniou AC; Gayther SA
  • Preprint: 2025
    Vinattieri MV; Bonetti M; Czene K
  • Conference publication: BREAST CANCER RESEARCH AND TREATMENT. 2025;211(1):S26-S27
    Eriksson M; Czene K; Conant EC; Hall P
  • Preprint: MEDRXIV. 2025
    Zhang X; Eriksson M; Mavaddat N; Dennis J; Astley SM; Gabrielson M; Giles GG; Hart SN; Hunter DJ; Le Marchand L; Lush M; Michailidou K; Scott CG; Wang Q; Howell SJ; Naven M; Antoniou AC; Aronson KJ; Bolla MK; Castelao JE; Couch FJ; Czene K; Dunning AM; Evans DG; Gago-Dominguez M; García-Closas M; Haiman CA; Milne RL; Pharoah PDP; Southey MC; Stone J; Murphy RA; de Gonzalez AB; Vachon CM; Hall P; Easton DF
  • Preprint: MEDRXIV. 2025;MEDRXIV
    Ho PJ; Loo CKY; Goh MH; Abubakar M; Ahearn TU; Andrulis IL; Antonenkova NN; Aronson KJ; Augustinsson A; Behrens S; Bodelon C; Bogdanova NV; Bolla MK; Brantley K; Brenner H; Byers H; Camp NJ; Castelao JE; Cessna MH; Chang-Claude J; Chanock SJ; Chenevix-Trench G; Choi J-Y; Colonna SV; Czene K; Daly MB; Derouane F; Dörk T; Eliassen AH; Engel C; Eriksson M; Evans DG; Fletcher O; Fritschi L; Gago-Dominguez M; Genkinger JM; Geurts-Giele WRR; Glendon G; Hall P; Hamann U; Ho CYS; Ho W-K; Hooning MJ; Hoppe R; Howell A; Humphreys K; ABCTB Investigators; kConFab Investigators; SGBCC Investigators; MyBrCa Investigators; Ito H; Iwasaki M; Jakubowska A; Jernström H; John EM; Johnson N; Kang D; Kim S-W; Kitahara CM; Ko Y-D; Kraft P; Kwong A; Lambrechts D; Larsson S; Li S; Lindblom A; Linet M; Lissowska J; Lophatananon A; MacInnis RJ; Mannermaa A; Manoukian S; Margolin S; Matsuo K; Michailidou K; Milne RL; Taib NAM; Muir K; Murphy RA; Newman WG; O'Brien KM; Obi N; Olopade OI; Panayiotidis MI; Park SK; Park-Simon T-W; Patel AV; Peterlongo P; Plaseska-Karanfilska D; Pylkäs K; Rashid MU; Rennert G; Rodriguez J; Saloustros E; Sandler DP; Sawyer EJ; Scott CG; Shahi S; Shu X-O; Shulman K; Simard J; Southey MC; Stone J; Taylor JA; Teo S-H; Teras LR; Terry MB; Torres D; Vachon CM; Van Houdt M; Verhoeven J; Weinberg CR; Wolk A; Yamaji T; Yip CH; Zheng W; Hartman M; Li J
  • Preprint: MEDRXIV. 2025
    Ficorella L; Yang X; Mavaddat N; Carver T; Hassan H; Dennis J; Tyrer J; Ho W-K; Teo S-H; Hartman M; Li J; Eriksson M; Czene K; Hall P; Rahman T; Bacon A; Hardy S; Stokes AE; Donoso FS; Archer S; Simard J; Pharoah PDP; Usher-Smith JA; Tischkowitz M; Easton DF; Antoniou AC
  • Preprint: MEDRXIV. 2025
    Ficorella L; Eriksson M; Czene K; Leslie G; Yang X; Carver T; Stokes AE; Easton DF; Hall P; Antoniou AC
  • Preprint: MEDRXIV. 2024;MEDRXIV
    Zanti M; O'Mahony DG; Parsons MT; Dorling L; Dennis J; Boddicker NJ; Chen W; Hu C; Naven M; Yiangou K; Ahearn TU; Ambrosone CB; Andrulis IL; Antoniou AC; Auer PL; Baynes C; Bodelon C; Bogdanova NV; Bojesen SE; Bolla MK; Brantley KD; Camp NJ; Campbell A; Castelao JE; Cessna MH; Chang-Claude J; Chen F; Chenevix-Trench G; NBCS Collaborators; Conroy DM; Czene K; De Nicolo A; Domchek SM; Dörk T; Dunning AM; Eliassen AH; Evans DG; Fasching PA; Figueroa JD; Flyger H; Gago-Dominguez M; García-Closas M; Glendon G; González-Neira A; Grassmann F; Hadjisavvas A; Haiman CA; Hamann U; Hart SN; Hartman MBA; Ho W-K; Hodge JM; Hoppe R; Howell SJ; kConFab Investigators; Jakubowska A; Khusnutdinova EK; Ko Y-D; Kraft P; Kristensen VN; Lacey JV; Li J; Lim GH; Lindström S; Lophatananon A; Luccarini C; Mannermaa A; Martinez ME; Mavroudis D; Milne RL; Muir K; Nathanson KL; Nuñez-Torres R; Obi N; Olson JE; Palmer JR; Panayiotidis MI; Patel AV; Pharoah PDP; Polley EC; Rashid MU; Ruddy KJ; Saloustros E; Sawyer EJ; Schmidt MK; Southey MC; Tan VK-M; Teo SH; Teras LR; Torres D; Trentham-Dietz A; Truong T; Vachon CM; Wang Q; Weitzel JN; Yadav S; Yao S; Zirpoli GR; Cline MS; Devilee P; Tavtigian SV; Goldgar DE; Couch FJ; Easton DF; Spurdle AB; Michailidou K
  • Corrigendum: NATURE GENETICS. 2024;56(8):1763-1764
    Kentistou KA; Kaisinger LR; Stankovic S; Vaudel M; de Oliveira EM; Messina A; Walters RG; Liu X; Busch AS; Helgason H; Thompson DJ; Santoni F; Petricek KM; Zouaghi Y; Huang-Doran I; Gudbjartsson DF; Bratland E; Lin K; Gardner EJ; Zhao Y; Jia RY; Terao C; Riggan MJ; Bolla MK; Yazdanpanah M; Yazdanpanah N; Bradfield JP; Broer L; Campbell A; Chasman DI; Cousminer DL; Franceschini N; Franke LH; Girotto G; He C; Jarvelin M-R; Joshi PK; Kamatani Y; Karlsson R; Luan J; Lunetta KL; Maegi R; Mangino M; Medland SE; Meisinger C; Noordam R; Nutile T; Concas MP; Polasek O; Porcu E; Ring SM; Sala C; Smith AV; Tanaka T; van der Most PJ; Vitart V; Wang CA; Willemsen G; Zygmunt M; Ahearn TU; Andrulis IL; Anton-Culver H; Antoniou AC; Auer PL; Barnes CLK; Beckmann MW; de Gonzalez AB; Bogdanova NV; Bojesen SE; Brenner H; Buring JE; Canzian F; Chang-Claude J; Couch FJ; Cox A; Crisponi L; Czene K; Daly MB; Demerath EW; Dennis J; Devilee P; De Vivo I; Dork T; Dunning AM; Dwek M; Eriksson JG; Fasching PA; Fernandez-Rhodes L; Ferreli L; Fletcher O; Gago-Dominguez M; Garcia-Closas M; Garcia-Saenz JA; Gonzalez-Neira A; Grallert H; Guenel P; Haiman CA; Hall P; Hamann U; Hakonarson H; Hart RJ; Hickey M; Hooning MJ; Hoppe R; Hopper JL; Hottenga J-J; Hu FB; Huebner H; Hunter DJ; Jernstrom H; John EM; Karasik D; Khusnutdinova EK; Kristensen VN; Lacey JV; Lambrechts D; Launer LJ; Lind PA; Lindblom A; Magnusson PKE; Mannermaa A; McCarthy MI; Meitinger T; Menni C; Michailidou K; Millwood IY; Milne RL; Montgomery GW; Nevanlinna H; Nolte IM; Nyholt DR; Obi N; O'Brien KM; Offit K; Oldehinkel AJ; Ostrowski SR; Palotie A; Pedersen OB; Peters A; Pianigiani G; Plaseska-Karanfilska D; Pouta A; Pozarickij A; Radice P; Rennert G; Rosendaal FR; Ruggiero D; Saloustros E; Sandler DP; Schipf S; Schmidt CO; Schmidt MK; Small K; Spedicati B; Stampfer M; Stone J; Tamimi RM; Teras LR; Tikkanen E; Turman C; Vachon CM; Wang Q; Winqvist R; Wolk A; Zemel BS; Zheng W; van Dijk KW; Alizadeh BZ; Bandinelli S; Boerwinkle E; Boomsma DI; Ciullo M; Chenevix-Trench G; Cucca F; Esko T; Gieger C; Grant SFA; Gudnason V; Hayward C; Kolcic I; Kraft P; Lawlor DA; Martin NG; Nohr EA; Pedersen NL; Pennell CE; Ridker PM; Robino A; Snieder H; Sovio U; Spector TD; Stockl D; Sudlow C; Timpson NJ; Toniolo D; Uitterlinden A; Ulivi S; Volzke H; Wareham NJ; Widen E; Wilson JF; Pharoah PDP; Li L; Easton DF; Njolstad PR; Sulem P; Murabito JM; Murray A; Manousaki D; Juul A; Erikstrup C; Stefansson K; Horikoshi M; Chen Z; Farooqi IS; Pitteloud N; Johansson S; Day FR; Perry JRB; Ong KK
  • Preprint: MEDRXIV. 2024
    Wilcox N; Tyrer JP; Dorling L; Dennis J; Naven M; Abubakar M; Ahearn TU; Andrulis IL; Antoniou AC; Bogdanova NV; Bojesen SE; Bolla MK; Brauch H; Camp NJ; Chang-Claude J; Czene K; Dörk T; Evans DG; Fasching PA; Figueroa JD; Flyger H; Gardner EJ; González-Neira A; Guénel P; Hahnen E; Hall P; Hartman M; Hooning MJ; Jakubowska A; Khusnutdinova EK; Kristensen VN; Li J; Lindblom A; Lophatananon A; Mannermaa A; Manoukian S; Milne RL; Nuñez-Torres R; Obi N; Panayiotidis MI; Park SK; Perry JRB; Rashid MU; Saloustros E; Sawyer EJ; Schmidt MK; Southey MC; Spurdle AB; Torres D; Wang Q; Simard J; Teo SH; Dunning AM; Devilee P; Easton DF
  • Preprint: RESEARCH SQUARE. 2024
    Tapia J; Gabrielson M; Hammarström M; Wengström Y; Bergqvist J; Tuuliainen A; Eriksson M; Czene K; Hall P; Bäcklund M
  • Preprint: MEDRXIV. 2024;MEDRXIV
    Yiangou K; Mavaddat N; Dennis J; Zanti M; Wang Q; Bolla MK; Abubakar M; Ahearn TU; Andrulis IL; Anton-Culver H; Antonenkova NN; Arndt V; Aronson KJ; Augustinsson A; Baten A; Behrens S; Bermisheva M; de Gonzalez AB; Białkowska K; Boddicker N; Bodelon C; Bogdanova NV; Bojesen SE; Brantley KD; Brauch H; Brenner H; Camp NJ; Canzian F; Castelao JE; Cessna MH; Chang-Claude J; Chenevix-Trench G; Chung WK; NBCS Collaborators; Colonna SV; Couch FJ; Cox A; Cross SS; Czene K; Daly MB; Devilee P; Dörk T; Dunning AM; Eccles DM; Eliassen AH; Engel C; Eriksson M; Evans DG; Fasching PA; Fletcher O; Flyger H; Fritschi L; Gago-Dominguez M; Gentry-Maharaj A; González-Neira A; Guénel P; Hahnen E; Haiman CA; Hamann U; Hartikainen JM; Ho V; Hodge J; Hollestelle A; Honisch E; Hooning MJ; Hoppe R; Hopper JL; Howell S; Howell A; ABCTB Investigators; kConFab Investigators; Jakovchevska S; Jakubowska A; Jernström H; Johnson N; Kaaks R; Khusnutdinova EK; Kitahara CM; Koutros S; Kristensen VN; Lacey JV; Lambrechts D; Lejbkowicz F; Lindblom A; Lush M; Mannermaa A; Mavroudis D; Menon U; Murphy RA; Nevanlinna H; Obi N; Offit K; Park-Simon T-W; Patel AV; Peng C; Peterlongo P; Pita G; Plaseska-Karanfilska D; Pylkäs K; Radice P; Rashid MU; Rennert G; Roberts E; Rodriguez J; Romero A; Rosenberg EH; Saloustros E; Sandler DP; Sawyer EJ; Schmutzler RK; Scott CG; Shu X-O; Southey MC; Stone J; Taylor JA; Teras LR; van de Beek I; Willett W; Winqvist R; Zheng W; Vachon CM; Schmidt MK; Hall P; MacInnis RJ; Milne RL; Pharoah PDP; Simard J; Antoniou AC; Easton DF; Michailidou K
  • Preprint: MEDRXIV. 2023;MEDRXIV
    Kentistou KA; Kaisinger LR; Stankovic S; Vaudel M; de Oliveira EM; Messina A; Walters RG; Liu X; Busch AS; Helgason H; Thompson DJ; Santon F; Petricek KM; Zouaghi Y; Huang-Doran I; Gudbjartsson DF; Bratland E; Lin K; Gardner EJ; Zhao Y; Jia R; Terao C; Riggan M; Bolla MK; Yazdanpanah M; Yazdanpanah N; Bradfield JP; Broer L; Campbell A; Chasman DI; Cousminer DL; Franceschini N; Franke LH; Girotto G; He C; Järvelin M-R; Joshi PK; Kamatani Y; Karlsson R; Luan J; Lunetta KL; Mägi R; Mangino M; Medland SE; Meisinger C; Noordam R; Nutile T; Concas MP; Polašek O; Porcu E; Ring SM; Sala C; Smith AV; Tanaka T; van der Most PJ; Vitart V; Wang CA; Willemsen G; Zygmunt M; Ahearn TU; Andrulis IL; Anton-Culver H; Antoniou AC; Auer PL; Barnes CL; Beckmann MW; Berrington A; Bogdanova NV; Bojesen SE; Brenner H; Buring JE; Canzian F; Chang-Claude J; Couch FJ; Cox A; Crisponi L; Czene K; Daly MB; Demerath EW; Dennis J; Devilee P; Vivo ID; Dörk T; Dunning AM; Dwek M; Eriksson JG; Fasching PA; Fernandez-Rhodes L; Ferreli L; Fletcher O; Gago-Dominguez M; García-Closas M; García-Sáenz JA; González-Neira A; Grallert H; Guénel P; Haiman CA; Hall P; Hamann U; Hakonarson H; Hart RJ; Hickey M; Hooning MJ; Hoppe R; Hopper JL; Hottenga J-J; Hu FB; Hübner H; Hunter DJ; ABCTB Investigators; Jernström H; John EM; Karasik D; Khusnutdinova EK; Kristensen VN; Lacey JV; Lambrechts D; Launer LJ; Lind PA; Lindblom A; Magnusson PK; Mannermaa A; McCarthy MI; Meitinger T; Menni C; Michailidou K; Millwood IY; Milne RL; Montgomery GW; Nevanlinna H; Nolte IM; Nyholt DR; Obi N; O'Brien KM; Offit K; Oldehinkel AJ; Ostrowski SR; Palotie A; Pedersen OB; Peters A; Pianigiani G; Plaseska-Karanfilska D; Pouta A; Pozarickij A; Radice P; Rennert G; Rosendaal FR; Ruggiero D; Saloustros E; Sandler DP; Schipf S; Schmidt CO; Schmidt MK; Small K; Spedicati B; Stampfer M; Stone J; Tamimi RM; Teras LR; Tikkanen E; Turman C; Vachon CM; Wang Q; Winqvist R; Wolk A; Zemel BS; Zheng W; van Dijk KW; Alizadeh BZ; Bandinelli S; Boerwinkle E; Boomsma DI; Ciullo M; Chenevix-Trench G; Cucca F; Esko T; Gieger C; Grant SF; Gudnason V; Hayward C; Kolčić I; Kraft P; Lawlor DA; Martin NG; Nøhr EA; Pedersen NL; Pennell CE; Ridker PM; Robino A; Snieder H; Sovio U; Spector TD; Stöckl D; Sudlow C; Timpson NJ; Toniolo D; Uitterlinden A; Ulivi S; Völzke H; Wareham NJ; Widen E; Wilson JF; Lifelines Cohort Study; Danish Blood Donor study; Ovarian Cancer Association Consortium; Breast Cancer Association Consortium; Biobank Japan Project; China Kadoorie Biobank Collaborative Group; Pharoah PD; Li L; Easton DF; Njølstad P; Sulem P; Murabito JM; Murray A; Manousaki D; Juul A; Erikstrup C; Stefansson K; Horikoshi M; Chen Z; Farooqi IS; Pitteloud N; Johansson S; Day FR; Perry JR; Ong KK
  • Preprint: RESEARCH SQUARE. 2023
    Malarstig A; Grassman F; Dahl L; Dimitriou M; Mcleod D; Gabrielson M; Smith-Byrne K; Thomas C; Huang T-H; Forsberg S; Eriksson P; Ulfstedt M; Johansson M; Sokolov A; Schioth H; Hall P; Schwenk J; Czene K; Hedman A
  • Preprint: RES SQ. 2023;RES SQ
    Morra A; Schreurs MAC; Andrulis IL; Anton-Culver H; Augustinsson A; Beckmann MW; Behrens S; Bojesen SE; Bolla MK; Brauch H; Broeks A; Buys SS; Camp NJ; Castelao JE; Cessna MH; Chang-Claude J; Chung WK; Collaborators N; Colonna SV; Couch FJ; Cox A; Cross SS; Czene K; Daly MB; Dennis J; Devilee P; Dörk T; Dunning AM; Dwek M; Easton DF; Eccles DM; Eriksson M; Evans DG; Fasching PA; Fehm TN; Figueroa JD; Flyger H; Gabrielson M; Gago-Dominguez M; García-Closas M; García-Sáenz JA; Genkinger J; Grassmann F; Gündert M; Hahnen E; Haiman CA; Hamann U; Harrington PA; Hartikainen JM; Hoppe R; Hopper JL; Houlston RS; Howell A; Investigators A; Investigators K; Jakubowska A; Janni W; Jernström H; John EM; Johnson N; Jones ME; Kristensen VN; Kurian AW; Lambrechts D; Marchand LL; Lindblom A; Lubiński J; Lux MP; Mannermaa A; Mavroudis D; Mulligan AM; Muranen TA; Nevanlinna H; Nevelsteen I; Neven P; Newman WG; Obi N; Offit K; Olshan AF; Park-Simon T-W; Patel AV; Peterlongo P; Phillips K-A; Plaseska-Karanfilska D; Polley EC; Presneau N; Pylkäs K; Rack B; Radice P; Rashid MU; Rhenius V; Robson M; Romero A; Saloustros E; Sawyer EJ; Schmutzler RK; Schuetze S; Scott C; Shah M; Smichkoska S; Southey MC; Tapper WJ; Teras LR; Tollenaar RAEM; Tomczyk K; Tomlinson I; Troester MA; Vachon CM; van Veen EM; Wang Q; Wendt C; Wildiers H; Winqvist R; Ziogas A; Hall P; Pharoah PDP; Adank MA; Hollestelle A; Schmidt MK; Hooning MJ
  • Preprint: RESEARCH SQUARE. 2022
    Muranen T; Morra A; Khan S; Barnes D; Bolla M; Dennis J; Keeman R; Leslie G; Parsons M; Wang Q; Ahearn T; Aittomäki K; Andrulis I; Arun B; Behrens S; Białkowska K; Bojesen S; Camp N; Chang-Claude J; Czene K; Devilee P; Domchek S; Dunning A; Engel C; Evans G; Gago-Dominguez M; Garcia-Closas M; Gerdes A-M; Glendon G; Guénel P; Hahnen E; Hamann P; Hanson H; Hooning M; Hoppe R; Izatt L; Jakubowska A; James P; Kristensen V; Lalloo F; Lindeman G; Mannermaa A; Margolin S; Neuhausen S; Newman W; Peterlongo P; Phillips K-A; Pujana MA; Rantala J; Rønlund K; Saloustros E; Schmutzler R; schneeweiss A; Singer C; Suvanto M; Tan YY; Teixeira M; Thomassen M; Tischkowitz M; Tripathi V; Wappenschmidt B; Zhao E; Easton D; Antoniou A; Chenevix-Trench G; Pharoah P; Schmidt M; Blomqvist C; Nevanlinna H
  • Conference publication: EUROPEAN JOURNAL OF CANCER. 2022;175:S95
    Zhang Y; Lin Y; Huang X; He W; Czene K; Yang H
  • Preprint: RESEARCH SQUARE. 2022
    Giardiello D; Hooning M; Hauptmann M; Keeman R; Heemskerk-Gerritsen B; Becker H; Blomqvist C; Bojesen S; Bolla M; Camp N; Czene K; Devilee P; Eccles D; Fasching P; Figueroa J; Flyger H; García-Closas M; Haiman C; Hamann U; Hopper J; Jakubowska A; Leeuwen F; Lindblom A; Lubiński J; Margolin S; Martinez ME; Nevanlinna H; Nevelsteen I; Pelders S; Pharoah PDP; Siesling S; Southey M; Hout AVD; Hest LV; Chang-Claude J; Hall P; Easton D; Steyerberg E; Schmidt M
  • Conference publication: ANNALS OF ONCOLOGY. 2022;33:S184
    Mao X; He W; Eriksson M; Lindstrom L; Holowko N; Lagercrantz SB; Humphreys K; Easton D; Hall PF; Czene K
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Grants

  • Enhancing Interval Breast Cancer Detection: Integrating Molecular and Imaging Markers for Improved Screening Protocols
    Familjen Erling-Perssons Stiftelse
    25 February 2026 - 31 December 2028
  • Swedish Research Council
    1 January 2026 - 31 December 2029
    Mammography screening reduces breast cancer mortality, yet interval cancers - tumors diagnosed between screening rounds - constitute a major limitation, often presenting with aggressive phenotypes and poor prognoses. This project aims to identify epidemiological, biological, and imaging determinants of interval breast cancer to enhance risk stratification and screening efficacy. We will investigate the association between inherited genetic susceptibility, circulating biomarkers, mammographic features, and hormonal/lifestyle factors with interval cancer risk. Additionally, we will assess prognostic differences between interval and screen-detected cancers and develop an improved risk model for tailored screening strategies.The study is based on extensive Swedish population-based cohorts with linked screening, clinical, molecular, and epidemiological data. We will employ next-generation sequencing to analyze rare genetic variants, assess blood-based biomarkers for early risk detection, and apply AI-driven mammographic analysis to identify imaging features associated with interval cancers. Statistical approaches, including Cox proportional hazards models and machine learning-based risk prediction, will be utilized.Our research will provide new insights into the etiology of interval cancers and their missed detection in screening. The results will inform risk-adaptive screening strategies, ultimately improving early cancer detection and reducing mortality.
  • UNRAVELING GENETIC AND MAMMOGRAPHIC PATHWAYS OF BREAST CANCER PROGRESSION: FROM BENIGN LESIONS TO METASTATIC DISEASE
    Swedish Cancer Society
    1 January 2026 - 31 December 2028
  • Enhancing Interval Breast Cancer Detection: Integrating Molecular and Imaging Markers for Improved Screening Protocols.
    Sjöbergstiftelsen
    1 January 2025 - 31 December 2027
  • Enhancing Interval Breast Cancer Detection: Integrating Molecular and Imaging Markers for Improved Screening Protocols.
    Erling-Persson Foundation
    1 January 2025 - 31 December 2027
  • Application of precision health concept for improvement of mammography screening for breast cancer
    Radium Hemmets Research Funds
    1 January 2024
  • Swedish Research Council
    1 January 2024 - 31 December 2027
    The aim of breast cancer screening is early detection of breast cancers. Mammography screening is so far the only proven method that reduces mortality from breast cancer. Mortality from breast cancer is 20-40% lower in screened women compared to non-screened women.Among women attending the Swedish Mammography Screening Program approximately every third breast cancers is diagnosed with breast cancer in the interval between two screens, a so-called interval cancer. The interval cancers could be either masked by high mammographic density, missed at the previous screening round or fast growing and actually developing in between two screening rounds. Interval cancers are more common in women with dense breasts and are considered more aggressive than screen detected cancers.The risk of breast cancer and the possibility to detect a cancer differs profoundly between women. Women with mammographically dense breasts have an increased risk of breast cancer and the possibility to diagnose a prevalent breast is reduced due to “masking”. Women with dense breast are more likely to be diagnosed with an interval cancer then women with non-dense breasts.The aim of SMART, The Swedish Mammography Risk stratified Trial, is to test the effectiveness of individualised breast cancer screening. In short - does an individualised screening program identify cancers at an earlier, curable stage, compared to the current one-fits-all approach?
  • Swedish Research Council
    1 January 2024 - 31 December 2027
    We will develop and use novel, biologically-motivated statistical models of tumor progression to elucidate mechanisms of breast cancer progression and to predict the risk of (in particular, aggressive) breast cancer. The models will be estimated using data from Swedish and Norwegian studies which represent some of the world’s most detailed population-based studies of breast cancer and breast cancer screening, combining longitudinal register, questionnaire, image and molecular data. The models are extensions of prior methods that we have developed that separate out the roles of factors in screening and symptomatic detection of breast cancer, and tumor onset, growth and spread. The information we create is vital for planning and evaluating approaches to (secondary) prevention of breast cancer. Our risk prediction models are novel, and rigorously incorporate screening information.We will also study in detail the background of false-positive mammography results – i.e. recalls that do not lead to a diagnosis, but can be a considerable psychological burden for women. Moreover, we will use simulation-based approaches to evaluate the performance of new (personalised) screening strategies.Finally, we will use our novel statistical approaches with detailed prescription data to study the efficacy of hormone therapy in estrogen receptor-positive patients.
  • Swedish Research Council
    1 January 2023 - 31 December 2025
  • IDENTIFICATION OF WOMEN AT INCREASED RISK OF FATAL BREAST CANCER
    Swedish Cancer Society
    1 January 2023 - 31 December 2025
  • Swedish Cancer Society
    1 January 2023
    In Sweden, four women die of breast cancer every day. The long-term goal of our research is to reduce mortality from breast cancer through early detection of the disease and through improved identification of women at high risk of dying from the disease. In order to provide a comprehensive picture of factors associated with breast cancer prognosis, we will examine, in addition to traditional tumor factors, areas that have not been studied to the same extent, such as factors of importance for prognosis, such as hereditary genetic and mammographic characteristics. In this project, we will study genetic determinants of so-called interval cancer, an aggressive and deadly subgroup of breast cancer tumors that develop between two screening occasions. We will first investigate the importance of immune-related genetic variations in the development of interval cancer. Next, we will investigate the relationship between inherited genetics, adherence to hormonal treatment and prognostic outcome. Finally, we will investigate how mammographic breast density can be used to improve diagnostics and serve as a useful indicator of early response to hormone therapy. For the development of individualized screening of women at high risk for aggressive breast cancer, it is essential to understand the role of inherited genetics. Information about hereditary genotype will be able to be used by the doctors to optimize the hormonal treatment aimed at improved prognosis. Tracking changes in mammographic density can provide clinicians with more real-time information regarding treatment outcome than a "wait-and-see" approach can. Overall, we believe our work is important to advancing research in the field and ultimately saving or extending these women's lives.
  • Swedish Research Council
    1 January 2021 - 31 December 2023
  • Molecular and mammographic determinants of interval breast cancer
    Region Stockholm/ALF
    1 January 2021 - 1 January 2023
  • Swedish Research Council
    1 January 2020 - 31 December 2023
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2020 - 31 December 2023
  • Swedish Cancer Society
    1 January 2020 - 31 December 2022
  • Swedish Cancer Society
    1 January 2020 - 31 December 2022
  • Swedish Cancer Society
    1 January 2020
    In Sweden, a woman is diagnosed with breast cancer every hour and every six hours a woman dies from the disease. Factors that are important for the prognosis are tumor characteristics, the patient's individual characteristics, how the patient responds to treatment and any complications. In other words, there are more factors than tumor characteristics that affect the prognosis of breast cancer. In previous studies, we have found that the patient's hereditary genetic background has a significant impact on the aggressiveness of the disease. We have also shown that breast density and other mammographic factors are crucial for proper diagnosis and prognosis. The overall aim is to study genetic and mammographic factors of importance for life-threatening breast cancer. The study material is taken from population-based studies on breast cancer, with biological samples, information from questionnaires and clinical data. Our specific purposes are to identify: 1) hereditary genetic factors 2) genetic abnormalities in tumors 3) mammographic density and mammographic characteristics and analyze the relationship to prognosis. As a prognostic model for fatal breast cancer, we use interval cancers as these are aggressive and clinically interesting because they are not detected during mammography examination. In the next few years, we anticipate that we have identified even more genes that can be related to life-threatening breast cancer. In addition, we have identified prognostic markers that we have validated in the prospective KARMA study. To improve the diagnosis and prognosis of breast cancer, we see that information about breast density will be included as an obvious part of clinical practice. Our long-term goal is to develop methods for individual screening and treatment by identifying women with an increased risk of life-threatening breast cancer, which in turn will be of great importance for survival.
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2019 - 31 December 2023
  • Swedish Cancer Society
    1 January 2018 - 31 December 2019
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Employments

  • Professor, Cancer Epidemiology, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2010-
  • Researcher (50%), Biobanking Epidemiology, Wallenberg Foundation, Consortium North, Karolinska Institutet, 2000-2001
  • Phd student, Biosciences at Novum, Karolinska Institutet, 1995-1999
  • Research Assistant, Czech Academy of Sciences, 1992-1994

Degrees and Education

  • Docent, Karolinska Institutet, 2005
  • Doctor Of Philosophy, Department of Biosciences and Nutrition, Karolinska Institutet, 1999

Leadership and responsibility assignments

Distinction and awards

  • Member of the Nobel Assembly, Karolinska Institutet, 2021
  • Young Investigator Award, 6 year full research position from Swedish Cancer Society., Swedish Cancer Society, 2007

Supervision

  • Supervision to doctoral degree

    • Letizia Orsini, 2026
    • Jonas Gjesvik, 2025-
    • Paula Camargo Romera, 2024-
    • Evripidis Kapanidis, 2023-
    • Roxanna Hellgren, Beyond mammography: an evaluation of complementary modalities in breast imaging, 2023
    • Johanna Holm, Aggressive breast cancer: epidemiological studies addressing disease heterogeneity, 2023
    • Roxanna Hellgren, Beyond mammography: an evaluation of complementary modalities in breast imaging, 2023
    • Erwei Zeng, Adjuvant hormone therapy in breast cancer patients : a special focus on treatment discontinuation, 2023
    • Xinhe Mao, Epidemiological studies on breast cancer risk factors and screening, 2023
    • Ziyan Ma, 2022-
    • Rickard Strandberg, Breast cancer natural history models and risk prediction in mammography screening cohorts, 2022
    • Mattias Hammarström, Investigating the outcome of low and standard dose tamoxifen in healthy women, 2021-
    • Mikael Eriksson, Risk assessment and prevention of breast cancer, 2021
    • Shadi Azam, Determinants and influence of mammographic features on breast cancer risk, 2020
    • Emilio Ugalde Morales, Molecular epidemiology studies on risk factors for breast cancer and disease aggressiveness, 2020
    • Gabriel Isheden, Statistical models of breast cancer tumour growth and spread., 2019
    • Haomin Yang, Panorama of diseases associated with breast cancer, 2018
    • Linda Abrahamsson, Statistical models of breast cancer tumour progression for mammography screening data, 2018
    • Benedicte Delcoigne, Efficient design and analysis of extended case-control studies, 2017
    • Ruoqing Chen, The impact of parental cancer on children’s well-being– Nationwide observational studies in Sweden, 2017
    • Fredrik Strand, Determinants of interval cancer and tumor size among breast cancer screening participants, 2016
    • Myeongjee Lee, Effects of kinship and timing on family cancer risk, 2015
    • Edoardo Colzani, Health outcomes of women with breast cancer, 2014
    • Hatef Darabi, Genetic association and risk prediction of breast cancer from an epidemiological and biostatistical perspective, 2012
    • Maria Sandberg (Schelin), Contralateral Breast Cancer - Risk and Prognosis, 2012
    • Louise Eriksson, Mammographic density and breast cancer phenotypes, 2012
    • Nils Schoof, 2011
    • Jingmei Li, Genetic determinants of breast cancer risk, 2011
    • Chantal Mascarenhas (Orgéas), Endogenous and exogenous hormonal factors in female cancers – studies of risk and prognosis, 2009
    • Linda Lindström, Familial studies on common cancers – a population based approach, 2008
    • Monica Leu, Truncation and missing familial links in population-based registers, 2008
    • Mikael Hartman, Risk and prognosis of breast cancer among women at high risk of the disease, 2007
    • Michaela Prochazka, The risk of second primary lung carcinoma in breast cancer patients, 2006

  • Supervision of postdoctoral researcher

    • Damien Kaukonen, 2022-
    • Yuqi Zhang, 2022-
    • Qingyang Xiao, 2021-2024
    • Juan Rodriguez, 2020-
    • Zahra Golabkesh, 2020-2022
    • Qiaoli Wang, 2020-2021
    • Pui San Tan, 2018-2019
    • Felix Grassmann, 2018-2020
    • Natalie Holowko, 2016-2021
    • Wei He, 2013-2019
    • Judith Brand, 2012-2016
    • Daniel Klevebring, 2010-2011
    • Julia Sandberg, 2010-2011
    • Cornelis Biesheuvel, 2009-2010
    • Ulf Hannelius, 2009-2012

Committee work

  • Member, Research Board, Swedish Cancer Society, 2018-2024
  • Member, SweTRIBE, Karolinska Institutet, 2017-
  • Member, BRECT (Breast Cancer Theme Center), Karolinska Institutet, 2014-
  • Member, Breast Cancer Association Consortium (BCAC), University of Cambridge, 2007-

Visiting research fellowships

  • Postdoc, Karolinska Institutet, 2003-2004
  • Postdoc, Karolinska Institutet, 2000-2002

Editorial work

  • British Journal of Cancer, Section editor / academic editor, 2019-2021

Other expert reviewer/evaluation assignment

  • Evaluator of research applications in national competition, Scientific Council for Medicine and Health, Panel for Cancer, Swedish Research Council, 2024
  • Reviewer for international evaluations, Reviewer for the Swiss Cancer Research Foundation, Swiss Cancer League, Swiss Cancer League, 2021-2021
  • Evaluator of research applications in national competition, Member of the Expert Council, Swedish Cancer Society, 2018-2023
  • Reviewer for international evaluations, Panel member and external reviewer, programme on High-Quality and Reliable Diagnostic, Treatment and Rehabilitation, The Research Council of Norway, 2017-2017
  • Other evaluation assignments, Evaluator for numerous grants and positions at KI, Karolinska Institutet, 2016-2023
  • Evaluator of research applications in national competition, Reviewer for the Scientific Council for Medicine and Health, Panel for Public Health, Swedish Research Council, 2013-2013
  • Reviewer for international evaluations, Member of the External Advisory Board and external reviewer, Breakthrough Generation Study, 2013-2015
  • Expert reviewer of research applications, Expert evaluator for the European Commission, evaluation of scientific applications, European Commission, 2010-2010
  • Expert reviewer of research applications, Expert evaluator for the European Commission, evaluation of scientific applications, European Commission, 2007-2007

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