Pedro Gil

Publications
CV
Public outreach and news

Articles

Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2024;147:107220
Extensive low-density Plasmodium falciparum reservoir in the island of Príncipe, an isolated malaria pre-elimination setting.
de Sousa TN; Machado PC; Lopes I; Das Neves E; Narciso A; Pires A; Santos A; Trovoada MJ; Gil JP; Lopes D
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2024;79(8):1985-1989
Monoamine oxidase-A (MAO-A) low-expression variants and increased risk of Plasmodium vivax malaria relapses
Puca MCSDB; Rodrigues DF; Salazar YEAR; Louzada J; Fontes CJF; Daher A; Pereira DB; Vieira JLF; Carvalho LH; de Brito CFA; Gil JP; de Sousa TN
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2024;68(5):e01390-e01323
Population-specific variations in KCNH2 predispose patients to delayed ventricular repolarization upon dihydroartemisinin-piperaquine therapy
Camara MD; Zhou Y; Dara A; Tekete MM; de Sousa TN; Sissoko S; Dembele L; Ouologuem N; Togo AH; Alhousseini ML; Fofana B; Sagara I; Djimde AA; Gil PJ; Lauschke VM
Article: HUMAN GENOMICS. 2024;18(1):40
Meta-analysis of the global distribution of clinically relevant CYP2C8 alleles and their inferred functional consequences
Camara MD; Zhou Y; De Sousa TN; Gil JP; Djimde AA; Lauschke VM
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2024;68(4):e01204-e01223
Delayed gametocyte clearance in Plasmodium vivax malaria is associated with polymorphisms in the cytochrome P450 reductase (CPR)
Salazar YEAR; Louzada J; Puca MCSDB; Guimaraes LFF; Vieira JLF; de Siqueira AM; Gil JP; de Brito CFA; de Sousa TN
Article: MALARIA JOURNAL. 2022;21(1):106
Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis
Dahal P; Simpson JA; Abdulla S; Achan J; Adam I; Agarwal A; Allan R; Anvikar AR; Ashley EA; Bassat Q; Borrmann S; Bousema T; Bukirwa H; Carrara VI; Corsi M; D'Alessandro U; Davis TME; Deloron P; Desai M; Dimbu PR; Djalle D; Djimde A; Dorsey G; Drakeley CJ; Duparc S; Edstein MD; Espie E; Abul F; Falade C; Fanello C; Faucher J-F; Faye B; Fortes FDJ; Gadalla NB; Gaye O; Gil JP; Gilayeneh J; Greenwood B; Grivoyannis A; Hien TT; Hwang J; Janssens B; Juma E; Kamugisha E; Karema C; Karunajeewa HA; Kiechel JR; Kironde F; Kofoed P-E; Kremsner PG; Lee SJ; Marsh K; Martensson A; Mayxay M; Menan H; Mens P; Mutabingwa TK; Ndiaye J-L; Ngasala BE; Noedl H; Nosten F; Offianan AT; Ogutu BR; Olliaro PL; Ouedraogo JB; Piola P; Plowe CV; Plucinski MM; Pratt OJ; Premji Z; Ramharter M; Rogier C; Vitare P; Rombo L; Rosenthal PJ; Sibley C; Sirima S; Smithuis F; Staedke SG; Sutanto I; Talisuna AO; Tarning J; Taylor WRJ; Temu E; Thriemer K; Thuy-Nhien N; Udhayakumar V; Ursing JD; van Herp M; van Lenthe M; van Vugt M; William Y; Winnips C; Zaloumis S; Zongo I; White NJ; Guerin PJ; Stepniewska K; Price RN; Arinaitwe E
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:868723
Plasmodium falciparum Drug Resistance Genes pfmdr1 and pfcrt In Vivo Co-Expression During Artemether-Lumefantrine Therapy
Silva M; Malmberg M; Otienoburu SD; Bjorkman A; Ngasala B; Martensson A; Gil JP; Veiga MI
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2021;65(7):e0027521-10.1128/aac.00221
Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment
Pernaute-Lau L; Adegnika AA; Zhou Y; Zinsou JF; Gil JP; Krishna S; Kremsner PG; Lauschke VM; Velavan TP
Article: INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE. 2021;15:9-24
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions.
Ferreira MU; Nobrega de Sousa T; Rangel GW; Johansen IC; Corder RM; Ladeia-Andrade S; Gil JP
Article: MALARIA JOURNAL. 2021;20(1):90
Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate-amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar
Pernaute-Lau L; Morris U; Msellem M; Martensson A; Bjorkman A; Gil JP
Article: MBIO. 2020;11(6):e02093-e02020
Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport
Calcada C; Silva M; Baptista V; Thathy V; Silva-Pedrosa R; Granja D; Ferreira PE; Gil JP; Fidock DA; Veiga MI
Article: CLINICAL THERAPEUTICS. 2020;42(8):1595-1610.e5
Challenges and Opportunities for Clinical Pharmacogenetic Research Studies in Resource-limited Settings: Conclusions From the Council for International Organizations of Medical Sciences-Ibero-American Network of Pharmacogenetics and Pharmacogenomics Meeting
Penas-LLedo E; Teran E; Sosa-Macias M; Galaviz-Hernandez C; Gil J-P; Nair S; Diwakar S; Hernandez I; Lara-Riegos J; Ramirez-Roa R; Verde I; Tarazona-Santos E; Molina-Guarneros J; Moya G; Raego L; LLerena A
Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2020;95:399-405
Different Plasmodium falciparum clearance times in two Malian villages following artesunate monotherapy.
Kone A; Sissoko S; Fofana B; Sangare CO; Dembele D; Haidara AS; Diallo N; Coulibaly A; Traore A; Toure S; Haidara K; Sanogo K; Sagara I; Beshir KB; Gil JP; Doumbo OK; Djimde AA
Article: PHARMACOGENOMICS & PERSONALIZED MEDICINE. 2020;13:571-575
Prevalence of CYP2C8*2 and *3 among Eritreans and its Potential Impact on Artesunate/Amodiaquine Treatment
Habtemikael L; Russom M; Bahta I; Mihreteab S; Berhane A; Martensson A; Gil JP
Article: MALARIA JOURNAL. 2019;18(1):225
Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis
Dahal P; Simpson JA; Abdulla S; Achan J; Adam I; Agarwal A; Allan R; Anvikar AR; Arinaitwe E; Ashley EA; Awab GR; Bassat Q; Bjorkman A; Bompart F; Borrmann S; Bousema T; Broek I; Bukirwa H; Carrara VI; Corsi M; Cot M; D'Alessandro U; Davis TME; de Wit M; Deloron P; Desai M; Dimbu PR; Djalle D; Djimde A; Dorsey G; Doumbo OK; Drakeley CJ; Duparc S; Edstein MD; Espie E; Faiz A; Falade C; Fanello C; Faucher J-F; Faye B; Fortes FDJ; Gadalla NB; Gaye O; Gil JP; Greenwood B; Grivoyannis A; Hamed K; Hien TT; Hughes D; Humphreys G; Hwang J; Ibrahim ML; Janssens B; Jullien V; Juma E; Kamugisha E; Karema C; Karunajeewa HA; Kiechel JR; Kironde F; Kofoed P-E; Kremsner PG; Lameyre V; Lee SJ; Marsh K; Martensson A; Mayxay M; Menan H; Mens P; Mutabingwa TK; Ndiaye J-L; Ngasala BE; Noedl H; Nosten F; Offianan AT; Oguike M; Ogutu BR; Olliaro P; Ouedraogo JB; Piola P; Plowe CV; Plucinski MM; Pratt OJ; Premji Z; Ramharter M; Rogier C; Rombo L; Rosenthal PJ; Sawa P; Schramm B; Sibley C; Sinou V; Sirima S; Smithuis F; Staedke SG; Sutanto I; Talisuna AO; Tarning J; Taylor WRJ; Temu E; Thriemer KL; Thuy NN; Udhayakumar V; Ursing J; van Herp M; van Vugt M; Whitty C; William Y; Winnips C; Zongo I; Guerin P; Price RN; Stepniewska K
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2019;74(7):1890-1893
Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy
Silva M; Ferreira PE; Otienoburu SD; Calcada C; Ngasala B; Bjorkman A; Martensson A; Gil JP; Veiga MI
Article: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019;100(5):1179-1186
Prevalence of and Risk Factors Associated with Polymerase Chain Reaction-Determined Plasmodium falciparum Positivity on Day 3 after Initiation of Artemether-Lumefantrine Treatment for Uncomplicated Malaria in Bagamoyo District, Tanzania
Mwaiswelo R; Ngasala B; Jovel I; Xu W; Larsson E; Malmberg M; Gil JP; Premji Z; Mmbando BP; Martensson A
Article: LANCET. 2018;391(10128):1378-1390
Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial
Sagara I; Beavogui AH; Zongo I; Soulama I; Borghini-Fuhrer I; Fofana B; Traore A; Diallo N; Diakite H; Togo AH; Koumare S; Keita M; Camara D; Some AF; Coulibaly AS; Traore OB; Dama S; Goita S; Djimde M; Bamadio A; Dara N; Maiga H; Sidibe B; Dao F; Coulibaly M; Alhousseini ML; Niangaly H; Sangare B; Diarra M; Coumare S; Kabore MJT; Ouattara SM; Barry A; Kargougou D; Diarra A; Henry N; Sore H; Bougouma EC; Thera I; Compaore YD; Sutherland CJ; Sylla MM; Nikiema F; Diallo MS; Dicko A; Picot S; Borrmann S; Duparc S; Miller RM; Doumbo OK; Shin J; Gil JP; Bjoerkman A; Ouedraogo J-B; Sirima SB; Djimde AA
Article: MALARIA JOURNAL. 2017;16(1):383
The drug transporter ABCB1 c.3435C>T SNP influences artemether-lumefantrine treatment outcome.
Kiaco K; Rodrigues AS; do Rosário V; Gil JP; Lopes D
Article: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017;97(2):526-532
Sustained High Cure Rate of Artemether-Lumefantrine against Uncomplicated Plasmodium falciparum Malaria after 8 Years of Its Wide-Scale Use in Bagamoyo District, Tanzania
Mwaiswelo R; Ngasala B; Gil JP; Malmberg M; Jovel I; Xu W; Premji Z; Mmbando BP; Bjorkman A; Martensson A
Article: PHARMACOGENOMICS. 2017;18(10):981-985
MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy
Vos K; Lo Sciuto C; Piedade R; Ashton M; Bjorkman A; Ngasala B; Martensson A; Gil JP
Article: LANCET INFECTIOUS DISEASES. 2016;16(2):189-198
Safety and efficacy of re-treatments with pyronaridine-artesunate in African patients with malaria: a substudy of the WANECAM randomised trial
Sagara I; Beavogui AH; Zongo I; Soulama I; Borghini-Fuhrer I; Fofana B; Camara D; Some AF; Coulibaly AS; Traore OB; Dara N; Kabore MJT; Thera I; Compaore YD; Sylla MM; Nikiema F; Diallo MS; Dicko A; Gil JP; Borrmann S; Duparc S; Miller RM; Doumbo OK; Shin J; Bjorkman A; Ouedraogo J-B; Sirima SB; Djimde AA
Article: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015;92(6):1202-1206
Polymorphisms in the K13-Propeller Gene in Artemisinin-Susceptible Plasmodium falciparum Parasites from Bougoula-Hameau and Bandiagara, Mali
Ouattara A; Kone A; Adams M; Fofana B; Maiga AW; Hampton S; Coulibaly D; Thera MA; Diallo N; Dara A; Sagara I; Gil JP; Bjorkman A; Takala-Harrison S; Doumbo OK; Plowe CV; Djimde AA
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2015;59(1):96-104
Carboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of pregnane X receptor.
Piedade R; Traub S; Bitter A; Nüssler AK; Gil JP; Schwab M; Burk O
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2015;70(1):116-123
Alternatively spliced transcripts and novel pseudogenes of the Plasmodium falciparum resistance-associated locus pfcrt detected in East African malaria patients
Gadalla NB; Malmberg M; Adam I; Oguike MC; Beshir K; Elzaki S-E; Mukhtar I; Gadalla AA; Warhurst DC; Ngasala B; Martensson A; El-Sayed BB; Gil JP; Sutherland CJ
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2014;58(12):7390-7397
Complex Polymorphisms in the Plasmodium falciparum Multidrug Resistance Protein 2 Gene and Its Contribution to Antimalarial Response
Veiga MI; Osorio NS; Ferreira PE; Franzen O; Dahlstrom S; Lum JK; Nosten F; Gil JP
Article: INTERNATIONAL JOURNAL OF BIOSTATISTICS. 2013;9(1):135-148
On the Effects of Malaria Treatment on Parasite Drug Resistance - Probability Modelling of Genotyped Malaria Infections
Kum CK; Thorburn D; Ghilagaber G; Gil P; Bjorkman A
Journal article: THE INTERNATIONAL JOURNAL OF BIOSTATISTICS. 2013;9(1):14
On the Effects of Malaria Treatment on Parasite Drug Resistance – Probability Modelling of Genotyped Malaria Infections
Kum CK; Thorburn D; Ghilagaber G; Gil P; Björkman A
Article: MALARIA JOURNAL. 2013;12:106
Rapid diagnostic tests for molecular surveillance of Plasmodium falciparum malaria -assessment of DNA extraction methods and field applicability
Morris U; Aydin-Schmidt B; Shakely D; Martensson A; Jornhagen L; Ali AS; Msellem MI; Petzold M; Gil JP; Ferreira P; Bjorkman A
Article: MALARIA JOURNAL. 2013;12:103
Temporal trends of molecular markers associated with artemether-lumefantrine tolerance/resistance in Bagamoyo district, Tanzania
Malmberg M; Ngasala B; Ferreira PE; Larsson E; Jovel I; Hjalmarsson A; Petzold M; Premji Z; Gil JP; Bjorkman A; Martensson A
Article: JOURNAL OF INFECTIOUS DISEASES. 2013;207(5):842-847
Plasmodium falciparum Drug Resistance Phenotype as Assessed by Patient Antimalarial Drug Levels and Its Association With pfmdr1 Polymorphisms
Malmberg M; Ferreira PE; Tarning J; Ursing J; Ngasala B; Bjorkman A; Martensson A; Gil JP
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2013;57(2):887-892
Assessing the Cost-Benefit Effect of a Plasmodium falciparum Drug Resistance Mutation on Parasite Growth In Vitro
Froberg G; Ferreira PE; Martensson A; Ali A; Bjorkman A; Gil JP
Article: JOURNAL OF INFECTIOUS DISEASES. 2013;207(3):520-527
Quinine Treatment Selects the pfnhe-1 ms4760-1 Polymorphism in Malian Patients with Falciparum Malaria
Kone A; Mu J; Maiga H; Beavogui AH; Yattara O; Sagara I; Tekete MM; Traore OB; Dara A; Dama S; Diallo N; Kodio A; Traore A; Bjoerkman A; Gil JP; Doumbo OK; Wellems TE; Djimde AA
Article: DRUG METABOLISM AND PHARMACOKINETICS. 2013;28(6):519-521
Frequency of the Functionally Relevant Aryl Hydrocarbon Receptor Repressor (AhRR) Pro185Ala SNP in Papua New Guinea
Cavaco I; Hombhanje FW; Gil JP; Kaneko A
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2012;167(3):666-681
Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms.
Burk O; Piedade R; Ghebreghiorghis L; Fait JT; Nussler AK; Gil JP; Windshügel B; Schwab M
Article: MALARIA JOURNAL. 2012;11:321
Decreased prevalence of Plasmodium falciparum resistance markers to amodiaquine despite its wide scale use as ACT partner drug in Zanzibar
Froberg G; Jornhagen L; Morris U; Shakely D; Msellem MI; Gil JP; Bjorkman A; Martensson A
Article: TROPICAL MEDICINE & INTERNATIONAL HEALTH. 2012;17(7):854-857
Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands
Cavaco I; Piedade R; Msellem MI; Bjorkman A; Gil JP
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2012;56(7):3615-3619
pfmdr1 Amplification Is Related to Increased Plasmodium falciparum In Vitro Sensitivity to the Bisquinoline Piperaquine
Veiga MI; Ferreira PE; Malmberg M; Jornhagen L; Bjorkman A; Nosten F; Gil JP
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2012;56(4):2153-2157
PXR Variants and Artemisinin Use in Vietnamese Subjects: Frequency Distribution and Impact on the Interindividual Variability of CYP3A Induction by Artemisinin
Piedade R; Schaeffeler E; Winter S; Asimus S; Schwab M; Ashton M; Burk O; Gil JP
Article: MALARIA JOURNAL. 2011;10:380
Plasmodium falciparum population dynamics during the early phase of anti-malarial drug treatment in Tanzanian children with acute uncomplicated malaria
Carlsson AM; Ngasala BE; Dahlstrom S; Membi C; Veiga IM; Rombo L; Abdulla S; Premji Z; Gil JP; Bjorkman A; Martensson A
Article: MEMORIAS DO INSTITUTO OSWALDO CRUZ. 2011;106:123-129
Sentinel network for monitoring in vitro susceptibility of Plasmodium falciparum to antimalarial drugs in Colombia: a proof of concept
Aponte SL; Diaz G; Pava Z; Echeverry DF; Ibarguen D; Rios M; Murcia LM; Quelal C; Murillo C; Gil P; Bjorkman A; Osorio L
Article: CLINICAL INFECTIOUS DISEASES. 2011;52(7):873-882
Efficacy and Effectiveness of Artemether-Lumefantrine after Initial and Repeated Treatment in Children < 5 Years of Age with Acute Uncomplicated Plasmodium falciparum Malaria in Rural Tanzania: A Randomized Trial
Ngasala BE; Malmberg M; Carlsson AM; Ferreira PE; Petzold MG; Blessborn D; Bergqvist Y; Gil JP; Premji Z; Bjoerkman A; Martensson A
Article: MALARIA JOURNAL. 2011;10:64
Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study
Ngasala BE; Malmberg M; Carlsson AM; Ferreira PE; Petzold MG; Blessborn D; Bergqvist Y; Gil JP; Premji Z; Martensson A
Article: PLOS ONE. 2011;6(9):e23875
PfMDR1: Mechanisms of Transport Modulation by Functional Polymorphisms
Ferreira PE; Holmgren G; Veiga MI; Uhlen P; Kaneko A; Gil JP
Article: PLOS ONE. 2011;6(5):e20212
Novel Polymorphisms in Plasmodium falciparum ABC Transporter Genes Are Associated with Major ACT Antimalarial Drug Resistance
Veiga MI; Ferreira PE; Jornhagen L; Malmberg M; Kone A; Schmidt BA; Petzold M; Bjorkman A; Nosten F; Gil JP
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2010;54(11):4780-4788
Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine during Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania
Hietala SF; Martensson A; Ngasala B; Dahlstrom S; Lindegardh N; Annerberg A; Premji Z; Farnert A; Gil P; Bjorkman A; Ashton M
Article: PLOS ONE. 2010;5(8):e12408
Antimalarial Exposure Delays Plasmodium falciparum Intra-Erythrocytic Cycle and Drives Drug Transporter Genes Expression
Veiga MI; Ferreira PE; Schmidt BA; Ribacke U; Bjorkman A; Tichopad A; Gil JP
Article: JOURNAL OF INFECTIOUS DISEASES. 2009;200(9):1456-1464
Plasmodium falciparum Multidrug Resistance Protein 1 and Artemisinin-Based Combination Therapy in Africa
Dahlstrom S; Ferreira PE; Veiga MI; Sedighi N; Wiklund L; Martensson A; Farnert A; Sisowath C; Osorio L; Darban H; Andersson B; Kaneko A; Conseil G; Bjorkman A; Gil JP
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2009;53(6):2553-2556
Polymorphism in PfMRP1 (Plasmodium falciparum Multidrug Resistance Protein 1) Amino Acid 1466 Associated with Resistance to Sulfadoxine-Pyrimethamine Treatment
Dahlstrom S; Veiga MI; Martensson A; Bjorkman A; Gil JP
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2009;65(4):355-363
Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam
Veiga MI; Asimus S; Ferreira PE; Martins JP; Cavaco I; Ribeiro V; Hai TN; Petzold MG; Bjorkman A; Ashton M; Gil JP
Article: PHARMACOGENOMICS. 2008;9(10):1385-1390
Amodiaquine pharmacogenetics.
Gil JP
Article: INFECTION GENETICS AND EVOLUTION. 2008;8(3):340-345
Diversity of the sarco/endoplasmic reticulum Ca²⁺-ATPase orthologue of Plasmodium falciparum (PfATP6)
Dahlstrom S; Veiga MI; Ferreira P; Martensson A; Kaneko A; Andersson B; Bjorkman A; Gil JP
Article: THERAPEUTIC DRUG MONITORING. 2008;30(1):10-15
Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, East Africa
Ferreira PE; Veiga MI; Cavaco I; Martins JP; Andersson B; Mushin S; Ali AS; Bhattarai A; Ribeiro V; Bjorkman A; Gil JP
Article: TRENDS IN PARASITOLOGY. 2008;24(2):49-51
Carriers, channels and chloroquine efficacy in Guinea-Bissau
Ursing J; Rombo L; Kofoed P-E; Gil JP
Article: ASIAN BIOMEDICINE. 2008;2(2):117-121
Mixed-species malaria infection in high transmission areas of Thailand
Congpuong K; Gil JP; Bualombai P; Kangchaingone Y; Darakapong A; Wernsdorfer WH
Article: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2007;77(6):1034-1038
Short report:: Polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to arnodiaquine and desethylarnodiaquine
Echeverry DF; Holmgren G; Murillo C; Higuita JC; Bjorkman A; Gil JP; Osorio L
Article: INFECTION GENETICS AND EVOLUTION. 2007;7(5):562-569
Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa
Holmgren G; Hamrin J; Svard J; Martensson A; Gil JP; Bjorkman A
Article: INFECTION GENETICS AND EVOLUTION. 2007;7(5):555-561
Chloroquine resistant P-falciparum prevalence is low and unchanged between 1990 and 2005 in Guinea-Bissau:: An effect of high chloroquine dosage?
Ursing J; Schmidt BA; Lebbad M; Kofoed P-E; Dias F; Gil JP; Rombo L
Article: TROPICAL MEDICINE & INTERNATIONAL HEALTH. 2007;12(6):736-742
The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa
Sisowath C; Ferreira PE; Bustamante LY; Dahlstrom S; Martensson A; Bjorkman A; Krishna S; Gil JP
Article: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2007;76(5):844-848
Plasmodium falciparum genotypes associated with chloroquine and amodiaquine resistance in Guinea-Bissau
Ursing J; Kofoed P-E; Rodrigues A; Rombo L; Gil JP
Article: PHARMACOGENOMICS. 2007;8(2):187-198
CYP2C8 and antimalaria drug efficacy
Gill JP; Berglund EG
Article: TROPICAL MEDICINE & INTERNATIONAL HEALTH. 2006;11(12):1808-1812
Amodiaquine resistance is not related to rare findings of pfmdr1 gene amplifications in Kenya
Holmgren G; Bjorkman A; Gil JP
Article: INFECTION GENETICS AND EVOLUTION. 2006;6(4):309-314
Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y
Holmgren G; Gil JP; Ferreira PM; Veiga MI; Obonyo CO; Björkman A
Article: MOLECULAR AND CELLULAR PROBES. 2006;20(2):100-104
Multiplex PCR-RFLP methods for pfcrt, pfmdr1 and pfdhfr mutations in Plasmodium falciparum
Veiga MI; Ferreira PE; Björkman A; Gil JP
Article: ACTA TROPICA. 2006;97(3):352-356
Quinoline resistance associated polymorphisms in the pfcrt, pfmdr1 and pfmrp genes of Plasmodium falciparum in Iran
Ursing J; Zakeri S; Gil JP; Björkman A
Article: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2006;44(2):168-170
CYP2C8 polymorphism among the Portuguese.
Cavaco I; Piedade R; Gil JP; Ribeiro V
Article: CLINICAL INFECTIOUS DISEASES. 2005;41(8):1079-1086
Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania
Mårtensson A; Strömberg J; Sisowath C; Msellem MI; Gil JP; Montgomery SM; Olliaro P; Ali AS; Björkman A
Article: TROPICAL MEDICINE & INTERNATIONAL HEALTH. 2005;10(10):1060-1064
Multiple genotypes of the merozoite surface proteins 1 and 2 in Plasmodium falciparum infections in a hypoendemic area in Iran
Zakeri S; Bereczky S; Naimi P; Gil JP; Djadid ND; Färnert A; Snounou G; Björkman A
Article: JOURNAL OF INFECTIOUS DISEASES. 2005;191(6):1014-1017
In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)
Sisowath C; Strömberg J; Mårtensson A; Msellem M; Obondo C; Björkman A; Gil JP
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2005;61(1):15-18
CYP2C8 polymorphism frequencies among malaria patients in Zanzibar
Cavaco I; Strömberg-Nörklit J; Kaneko A; Msellem MI; Dahoma M; Ribeiro VL; Bjorkman A; Gil JP
Article: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2005;72(3):249-251
Short report:: Rapid DNA extraction from archive blood spots on filter paper for genotyping of Plasmodium falciparum
Bereczky S; Mårtensson A; Gil JP; Färnert A
Article: ACTA TROPICA. 2005;93(3):221-231
Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro
Mariga ST; Gil JP; Wernsdorfer WH; Björkman A
Article: TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE. 2005;99(1):62-70
In vitro recrudescence of Plasmodium falciparum parasites suppressed to dormant state by atovaquone alone and in combination with proguanil
Thapar MM; Gil JP; Björkman A
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2004;48(11):4089-4096
Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro
Mariga ST; Gil JP; Sisowath C; Wernsdorfer WH; Björkman A
Article: ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY. 2004;98(3):293-296
High frequency of the genetic polymorphisms associated with sulfadoxine-pyrimethamine resistance, among Plasmodium falciparum isolates from São Tomé and Príncipe, West Africa.
Cravo P; Figueiredo S; Nogueira F; Lopes D; Ferreira ID; Ferreira C; Gil JP; do Rosario VE
Article: MOLECULAR AND CELLULAR PROBES. 2003;17(2-3):85-89
Detection of atovaquone and Malarone™ resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb)
Gil JP; Nogueira F; Strömberg-Nörklit J; Lindberg J; Carrolo M; Casimiro C; Lopes D; Arez AP; Cravo PV; Rosário VE
Article: BMJ-BRITISH MEDICAL JOURNAL. 2003;326(7390):628-629
Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride:: case reports
Färnert A; Lindberg J; Gil P; Swedberg G; Berqvist Y; Thapar MM; Lindegårdh N; Berezcky S; Björkman A
Article: ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY. 2002;96(8):831-834
pfcrt and pfmdr1 mutations and chloroquine resistance in Plasmodium falciparum from São Tomé and Príncipe, West Africa.
Lopes D; Nogueira F; Gil JP; Ferreira C; do Rosário VE; Cravo P
Article: MALARIA JOURNAL. 2002;1:12
Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand.
Lopes D; Rungsihirunrat K; Nogueira F; Seugorn A; Gil JP; do Rosário VE; Cravo P
Article: PHARMACOGENETICS AND GENOMICS. 1999;9(1):9-15
N-acetyltransferase (NAT2) genotype and susceptibility of sporadic Alzheimer's disease.
Rocha L; Garcia C; de Mendonça A; Gil JP; Bishop DT; Lechner MC
Article: CARCINOGENESIS. 1998;19(1):37-41
Increased frequency of wild-type arylamine-N-acetyltransferase allele NAT2*4 homozygotes in Portuguese patients with colorectal cancer.
Gil JP; Lechner MC
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Letter: LANCET INFECTIOUS DISEASES. 2024;24(9):e540-e541
Alarming Plasmodium falciparum resistance to artemisinin-based combination therapy in Africa: the critical role of the partner drug
Bjorkman A; Gil P; Alifrangis M
Letter: JOURNAL OF TRAVEL MEDICINE. 2022;29(4):taac058
Ketoconazole increases atovaquone exposure following concomitant administration with Malarone® in healthy subjects
Thapar MM; Ursing J; Ashton M; Bergqvist Y; Gil JP; Bjorkman A
Review: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. 2022;18(1):39-59
An update on pharmacogenetic factors influencing the metabolism and toxicity of artemisinin-based combination therapy in the treatment of malaria
Pernaute-Lau L; Camara M; de Sousa TN; Morris U; Ferreira MU; Gil JP
Review: ACS SENSORS. 2021;6(11):3898-3911
The Future in Sensing Technologies for Malaria Surveillance: A Review of Hemozoin-Based Diagnosis
Baptista V; Costa MS; Calcada C; Silva M; Gil JP; Veiga MI; Catarino SO
Review: FRONTIERS IN PHARMACOLOGY. 2021;12:759422
Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs).
Gil JP; Fançony C
Letter: EMERGING INFECTIOUS DISEASES. 2018;24(8):1591-1593
Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
Inoue J; Silva M; Fofana B; Sanogo K; Martensson A; Sagara I; Bjorkman A; Veiga MI; Ferreira PE; Djimde A; Gil JP
Review: EXPERT REVIEW OF ANTI-INFECTIVE THERAPY. 2017;15(6):527-543
pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies.
Gil JP; Krishna S
Review: MALARIA JOURNAL. 2016;15:74
Plasmodium falciparum drug resistance in Angola.
Fançony C; Brito M; Gil JP
Review: BMC MEDICINE. 2015;13:212
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data
Abdulla S; Adam I; Adjei GO; Adjuik MA; Alemayehu B; Allan R; Arinaitwe E; Ashley EA; Ba MS; Barennes H; Barnes KI; Bassat Q; Baudin E; Berens-Riha N; Bjoerkman A; Bompart F; Bonnet M; Borrmann S; Bousema T; Brasseur P; Bukirwa H; Checchi F; Dahal P; D'Alessandro U; Desai M; Dicko A; Djimde AA; Dorsey G; Doumbo OK; Drakeley CJ; Duparc S; Eshetu T; Espie E; Etard J-F; Faiz AM; Falade CO; Fanello CI; Faucher J-F; Faye B; Faye O; Filler S; Flegg JA; Fofana B; Fogg C; Gadalla NB; Gaye O; Genton B; Gething PW; Gil JP; Gonzalez R; Grandesso F; Greenhouse B; Greenwood B; Grivoyannis A; Guerin PJ; Guthmann J-P; Hamed K; Hamour S; Hay SI; Hodel EM; Humphreys GS; Hwang J; Ibrahim ML; Jima D; Jones JJ; Jullien V; Juma E; Kachur PS; Kager PA; Kamugisha E; Kamya MR; Karema C; Kayentao K; Kiechel J-R; Kironde F; Kofoed P-E; Kremsner PG; Krishna S; Lameyre V; Lell B; Lima A; Makanga M; Malik EM; Marsh K; Martensson A; Massougbodji A; Menan H; Menard D; Menendez C; Mens PF; Meremikwu M; Moreira C; Nabasumba C; Nambozi M; Ndiaye J-L; Ngasala BE; Nikiema F; Nsanzabana C; Ntoumi F; Oguike M; Ogutu BR; Olliaro P; Omar SA; Ouedraogo J-B; Owusu-Agyei S; Penali LK; Pene M; Peshu J; Piola P; Plowe CV; Premji Z; Price RN; Randrianarivelojosia M; Rombo L; Roper C; Rosenthal PJ; Sagara I; Same-Ekobo A; Sawa P; Schallig HDFH; Schramm B; Seck A; Shekalaghe SA; Sibley CH; Sinou V; Sirima SB; Som FA; Sow D; Staedke SG; Stepniewska K; Sutherland CJ; Swarthout TD; Sylla K; Talisuna AO; Taylor WRJ; Temu EA; Thwing JI; Tine RCK; Tinto H; Tommasini S; Toure OA; Ursing J; Vaillant MT; Valentini G; Van den Broek I; Van Vugt M; Ward SA; Winstanley PA; Yavo W; Yeka A; Zolia YM; Zongo I
Review: LANCET INFECTIOUS DISEASES. 2015;15(6):692-702
The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data
Anstey NM; Price RN; Davis TME; Karunajeewa HA; Mueller I; Karunajeewa HA; D'Alessandro U; Massougbodji A; Nikiema F; Ouedraogo J-B; Tinto H; Zongo I; Ouedraogo J-B; Tinto H; Same-Ekobo A; Kone M; Menan H; Toure AO; Yavo W; Yavo W; Kofoed P-E; Alemayehu BH; Jima D; Baudin E; Espie E; Nabasumba C; Pinoges L; Schramm B; Cot M; Deloron P; Faucher J-F; Cot M; Deloron P; Faucher J-F; Faucher J-F; Guthmann J-P; Lell B; Borrmann S; Lell B; Adjei GO; Kofoed P-E; Ursing J; Tjitra E; Borrmann S; Marsh K; Peshu J; Juma E; Ogutu BR; Omar SA; Sawa P; Talisuna AO; Talisuna AO; Khanthavong M; Mayxay M; Newton PN; Mayxay M; Piola P; Djimde AA; Doumbo OK; Fofana B; Sagara I; Bassat Q; Gonzalez R; Menendez C; Smithuis F; Smithuis F; Bousema T; Kager PA; Mens PF; Mens PF; Schallig HDFH; Van den Broek I; Van Vugt M; Ibrahim ML; Falade CO; Meremikwu M; Meremikwu M; Gil JP; Karema C; Ba MS; Faye B; Faye O; Gaye O; Ndiaye J-L; Pene M; Sow D; Sylla K; Tine RCK; Penali LK; Barnes KI; Workman LJ; Barnes KI; Workman LJ; Bassat Q; Gonzalez R; Menendez C; Mueller I; Lima A; Adam I; Gadalla NB; Malik EFM; Bjorkman A; Gil JP; Martensson A; Ngasala BE; Ursing J; Rombo L; Rombo L; Rombo L; Aliu P; Duparc S; Filler S; Genton B; Genton B; Hodel EM; Olliaro P; Abdulla S; Kamugisha E; Ngasala BE; Premji Z; Shekalaghe SA; Shekalaghe SA; Ashley EA; Carrara VI; McGready R; Nosten F; Ashley EA; Faiz AM; Lee SJ; White NJ; Carrara VI; Dondorp AM; Smith JJ; D'Alessandro U; Tarning J; Achan J; Bukirwa H; Yeka A; Arinaitwe E; Staedke SG; Kamya MR; Kironde F; Nabasumba C; Bousema T; Drakeley CJ; Gadalla NB; Oguike M; Sutherland CJ; Checchi F; Dahal P; Flegg JA; Guerin PJ; Moreira C; Newton PN; Nsanzabana C; Price RN; Sibley CH; Stepniewska K; Tarning J; Dahal P; Dondorp AM; Flegg JA; Guerin PJ; Lee SJ; Marsh K; McGready R; Moreira C; Newton PN; Nosten F; Nsanzabana C; Olliaro P; Price RN; Tarning J; White NJ; Gething PW; Hay SI; Greenwood B; Hodel EM; Ward SA; Staedke SG; Van den Broek I; Winstanley PA; Dorsey G; Greenhouse B; Rosenthal PJ; Gadalla NB; Gil JP; Grivoyannis A; Hamed K; Hwang J; Kachur PS; Hwang J; Sibley CH; Nambozi M
Review: TRENDS IN PARASITOLOGY. 2013;29(7):318-320
Artemisinin resistance in Plasmodium falciparum: what is it really?
Ferreira PE; Culleton R; Gil JP; Meshnick SR
Editorial comment: PHARMACOGENOMICS. 2013;14(7):707-710
Malaria pharmacogenomics: return to the future.
Gil JP
Letter: JOURNAL OF INFECTIOUS DISEASES. 2013;207(4):687-688
CYP2C8 Status of Patients With Malaria Influences Selection of Plasmodium falciparum pfmdr1 Alleles After Amodiaquine-Artesunate Treatment
Cavaco I; Martensson A; Froberg G; Msellem M; Bjorkman A; Gil JP
Review: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. 2011;7(10):1185-1200
The pharmacogenetics of antimalaria artemisinin combination therapy.
Piedade R; Gil JP
Review: LANCET INFECTIOUS DISEASES. 2009;9(12):760-774
Pharmacogenetics of antimalarial drugs: effect on metabolism and transport.
Kerb R; Fux R; Mörike K; Kremsner PG; Gil JP; Gleiter CH; Schwab M
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2009;199(5):750-757
In Vivo Selection of Plasmodium falciparum Parasites Carrying the Chloroquine-Susceptible pfcrt K76 Allele after Treatment with Artemether-Lumefantrine in Africa
Sisowath C; Petersen I; Veiga MI; Martensson A; Premji Z; Bjorkman A; Fidock DA; Gil JP
Review: PERSONALIZED MEDICINE. 2008;5(6):627-639
Pharmacogenetic tools for malaria and TB in the Developing World.
Ferreira PE; Cavaco I; Gil JP
Letter: CLINICAL CHEMISTRY. 2007;53(11):1977-1979
The Vietnamese Khin population harbors particular N-acetyltransferase 2 allele frequencies
Cavaco I; Asimus S; Peyrard-Janvid M; Ferreira PE; Veiga MI; Hai TN; Ribeiro V; Ashton M; Gil JP
Letter: JOURNAL OF INFECTIOUS DISEASES. 2006;194(5):716-718
No pfmdr1 amplifications in samples from Guinea-Bissau and Liberia collected between 1981 and 2004
Ursing J; Kofoed P-E; Rombo L; Gil JP
Letter: JOURNAL OF INFECTIOUS DISEASES. 2005;192(7):1304-1305
Coartem (Artemether-Lumefantrine) in Africa:: The beginning of the end?: Response
Gil JP; Sisowath C; Björkman A
Letter: JOURNAL OF INFECTIOUS DISEASES. 2003;187(11):1828-1829
High prevalence of double Plasmodium falciparum dhfr mutations at codons 108 and 59 in the Sistan-Baluchistan province, Iran
Zakeri S; Gil JP; Bereckzy S; Djadid ND; Bjorkman A
Published conference paper: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2003;41(4):606-609
CYP3A4*1B and NAT2*14 alleles in a native African population.
Cavaco I; Reis R; Gil JP; Ribeiro V
Published conference paper: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2003;41(10):1345-1350
CYP3A4 and MDR1 alleles in a Portuguese population.
Cavaco I; Gil JP; Gil-Berglund E; Ribeiro V
Review: TROPICAL MEDICINE & INTERNATIONAL HEALTH. 2002;7(5):395-408
Genetic diversity of Plasmodium falciparum: asexual stages.
Meyer CG; May J; Arez AP; Gil JP; Do Rosario V
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Principal Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2022-2025

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Docent, Karolinska Institutet, 2014

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